Mir199a2 (microRNA 199a-2) - Rat Genome Database

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Gene: Mir199a2 (microRNA 199a-2) Rattus norvegicus
Analyze
Symbol: Mir199a2
Name: microRNA 199a-2
RGD ID: 2325378
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including negative regulation of metabolic process; negative regulation of signal transduction; and negative regulation of transport. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; cellular response to lipopolysaccharide; and negative regulation of metabolic process. Orthologous to human MIR199A2 (microRNA 199a-2); INTERACTS WITH 2,5-hexanedione; 6-propyl-2-thiouracil; atrazine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA 199a; microRNA mir-199a; Mir199a; rno-mir-199a
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,116,225 - 77,116,334 (+)NCBIGRCr8
mRatBN7.21374,582,954 - 74,583,063 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,582,954 - 74,583,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,152,211 - 77,152,320 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,459,598 - 78,459,707 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01375,719,453 - 75,719,562 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,125,487 - 80,125,596 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,125,487 - 80,125,596 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,019,397 - 85,019,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1374,334,592 - 74,334,701 (+)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid stimulus  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to hypoxia  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
fatty acid oxidation  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of endoplasmic reticulum unfolded protein response  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of fatty acid oxidation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hepatocyte growth factor production  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of low-density lipoprotein particle clearance  (ISO)
negative regulation of matrix metallopeptidase secretion  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of receptor internalization  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of vascular endothelial growth factor production  (ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (ISO)
ossification  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of myoblast differentiation  (ISO)
positive regulation of myoblast proliferation  (ISO)
response to oxygen levels  (ISO)
sensory perception of sound  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16766679   PMID:17604727   PMID:18723672   PMID:19147652   PMID:20403161   PMID:20439489   PMID:20548288   PMID:21247879   PMID:21807947   PMID:21993888   PMID:22079324  
PMID:23646144   PMID:24011070   PMID:24149516   PMID:25751060   PMID:26359097   PMID:26430741   PMID:29703907   PMID:29948551   PMID:30504847   PMID:31059047   PMID:31186138   PMID:31382062  
PMID:31682476   PMID:32572931   PMID:32586178   PMID:32869899   PMID:33410908   PMID:34507247   PMID:35253153   PMID:35432725   PMID:35935584   PMID:36322021   PMID:37194082   PMID:37349971  
PMID:37804593   PMID:38605440   PMID:38662168  


Genomics

Comparative Map Data
Mir199a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,116,225 - 77,116,334 (+)NCBIGRCr8
mRatBN7.21374,582,954 - 74,583,063 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,582,954 - 74,583,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,152,211 - 77,152,320 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,459,598 - 78,459,707 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01375,719,453 - 75,719,562 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,125,487 - 80,125,596 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,125,487 - 80,125,596 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,019,397 - 85,019,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1374,334,592 - 74,334,701 (+)NCBICelera
Cytogenetic Map13q22NCBI
MIR199A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,144,535 - 172,144,644 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,144,535 - 172,144,644 (-)EnsemblGRCh38hg38GRCh38
GRCh371172,113,675 - 172,113,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,380,297 - 170,380,406 (-)NCBINCBI36Build 36hg18NCBI36
Celera1145,223,106 - 145,223,215 (-)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1143,337,667 - 143,337,776 (-)NCBIHuRef
CHM1_11173,535,852 - 173,535,961 (-)NCBICHM1_1
T2T-CHM13v2.01171,501,254 - 171,501,363 (-)NCBIT2T-CHM13v2.0
Mir199a-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,045,383 - 162,045,492 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,045,383 - 162,045,492 (+)EnsemblGRCm39 Ensembl
GRCm381162,217,814 - 162,217,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,217,814 - 162,217,923 (+)EnsemblGRCm38mm10GRCm38
MGSCv371164,147,945 - 164,148,054 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1164,668,176 - 164,668,285 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.06NCBI
MIR199-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1726,812,766 - 26,812,824 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl726,812,735 - 26,812,838 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha726,343,394 - 26,343,452 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0726,563,538 - 26,563,596 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1726,474,458 - 26,474,516 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0726,545,286 - 26,545,344 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0726,695,244 - 26,695,302 (+)NCBIUU_Cfam_GSD_1.0
MIR199A-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9114,533,777 - 114,533,880 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19114,533,783 - 114,533,858 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29126,105,251 - 126,105,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Ube2irno-miR-199a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20965886

Predicted Targets
Summary Value
Count of predictions:10013
Count of gene targets:6020
Count of transcripts:6488
Interacting mature miRNAs:rno-miR-199a-3p, rno-miR-199a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat

Markers in Region
BE116196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21374,583,374 - 74,583,535 (+)MAPPERmRatBN7.2
Rnor_6.01380,125,908 - 80,126,068NCBIRnor6.0
Rnor_5.01385,019,818 - 85,019,978UniSTSRnor5.0
RGSC_v3.41377,911,188 - 77,911,348UniSTSRGSC3.4
Celera1374,335,013 - 74,335,173UniSTS
RH 3.4 Map13452.7UniSTS
Cytogenetic Map13q22UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000054483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1374,582,954 - 74,583,063 (+)Ensembl
Rnor_6.0 Ensembl1380,125,487 - 80,125,596 (+)Ensembl
RefSeq Acc Id: NR_031914
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,116,225 - 77,116,334 (+)NCBI
mRatBN7.21374,582,954 - 74,583,063 (+)NCBI
Rnor_6.01380,125,487 - 80,125,596 (+)NCBI
Rnor_5.01385,019,397 - 85,019,506 (+)NCBI
Celera1374,334,592 - 74,334,701 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325378 AgrOrtholog
BioCyc Gene G2FUF-17665 BioCyc
Ensembl Genes ENSRNOG00000036364 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000054483 ENTREZGENE
miRBase MI0000941 ENTREZGENE
NCBI Gene 100314245 ENTREZGENE
PhenoGen Mir199a2 PhenoGen
RatGTEx ENSRNOG00000036364 RatGTEx
RNAcentral URS00003F2D94 RNACentral
  URS0000554A4F RNACentral
  URS000075E63B RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-25 Mir199a2  microRNA 199a-2  Mir199a  microRNA 199a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-14 Mir199a  microRNA 199a  Mir199a  microRNA mir-199a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir199a  microRNA mir-199a      Symbol and Name status set to provisional 70820 PROVISIONAL