Nampt (nicotinamide phosphoribosyltransferase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Nampt (nicotinamide phosphoribosyltransferase) Rattus norvegicus
Analyze
Symbol: Nampt
Name: nicotinamide phosphoribosyltransferase
RGD ID: 631365
Description: Enables several functions, including cytokine activity; identical protein binding activity; and nicotinamide phosphoribosyltransferase activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to oxygen-glucose deprivation; and negative regulation of cellular senescence. Located in cytoplasm; nucleus; and plasma membrane. Used to study middle cerebral artery infarction and transient cerebral ischemia. Biomarker of kidney failure; periodontitis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase); PARTICIPATES IN niacin metabolic pathway; nicotinamide adenine dinucleotide biosynthesis, the salvage pathway; monoterpenoid biosynthetic pathway; INTERACTS WITH (S)-nicotine; 1-methylnicotinamide; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: NAmPRTase; Pbef; Pbef1; pre-B-cell colony enhancing factor 1; pre-B-cell colony-enhancing factor; pre-B-cell colony-enhancing factor 1 homolog; visfatin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2649,425,316 - 49,462,109 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl649,424,332 - 49,462,100 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx649,728,050 - 49,763,075 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0650,042,969 - 50,077,994 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0649,480,294 - 49,514,732 (+)NCBIRnor_WKY
Rnor_6.0652,122,085 - 52,156,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl652,122,085 - 52,156,472 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,753,125 - 61,787,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4651,129,160 - 51,166,514 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1651,132,285 - 51,169,639 (+)NCBI
Celera648,619,485 - 48,654,540 (+)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methylnicotinamide  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acetic acid  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzofurans  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorendic acid  (EXP)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chlorpromazine  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazoxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
estriol  (ISO)
ethylbenzene  (ISO)
eugenol  (ISO)
fenofibrate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hydralazine  (ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
letrozole  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
mitoxantrone  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nefazodone  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP)
nifedipine  (ISO)
nimesulide  (EXP)
NMN zwitterion  (EXP,ISO)
p-anisidine  (ISO)
paclitaxel  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
progesterone  (ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thiram  (ISO)
Tolmetin glucuronide  (ISO)
toluene  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell junction  (ISO)
cytoplasm  (IDA,IEA,ISO)
extracellular space  (IEA)
nuclear speck  (ISO)
nucleus  (IDA,IEA)
plasma membrane  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Circadian rhythm of the Leydig cells endocrine function is attenuated during aging. Baburski AZ, etal., Exp Gerontol. 2016 Jan;73:5-13. doi: 10.1016/j.exger.2015.11.002. Epub 2015 Nov 4.
2. NAMPT inhibitor protects ischemic neuronal injury in rat brain via anti-neuroinflammation. Chen CX, etal., Neuroscience. 2017 Jul 25;356:193-206. doi: 10.1016/j.neuroscience.2017.05.022. Epub 2017 May 19.
3. Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension. Chen J, etal., Circulation. 2017 Apr 18;135(16):1532-1546. doi: 10.1161/CIRCULATIONAHA.116.024557. Epub 2017 Feb 15.
4. Effect of PPAR-delta agonist on the expression of visfatin, adiponectin, and resistin in rat adipose tissue and 3T3-L1 adipocytes. Choi KC, etal., Biochem Biophys Res Commun. 2007 May 25;357(1):62-7. Epub 2007 Mar 28.
5. Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization. Dahl TB, etal., Circulation. 2007 Feb 27;115(8):972-80. Epub 2007 Feb 5.
6. Inhibition of nicotinamide phosphoribosyltransferase by pyridine nucleotides. Dietrich LS and Muniz O, Biochemistry. 1972 Apr 25;11(9):1691-5.
7. Nampt/PBEF/visfatin exerts neuroprotective effects against ischemia/reperfusion injury via modulation of Bax/Bcl-2 ratio and prevention of caspase-3 activation. Erfani S, etal., J Mol Neurosci. 2015 May;56(1):237-43. doi: 10.1007/s12031-014-0486-1. Epub 2015 Jan 22.
8. Increased plasma levels of visfatin/pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome. Filippatos TD, etal., J Endocrinol Invest. 2007 Apr;30(4):323-6.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Houtkooper RH, etal., Endocr Rev. 2010 Apr;31(2):194-223. doi: 10.1210/er.2009-0026. Epub 2009 Dec 9.
12. Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats. Hu Q, etal., Stroke. 2017 Jun;48(6):1655-1664. doi: 10.1161/STROKEAHA.116.015753. Epub 2017 May 11.
13. Salidroside protects PC12 cells from Aß1-40-induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway. Huang X, etal., Mol Med Rep. 2017 Sep;16(3):2700-2706. doi: 10.3892/mmr.2017.6931. Epub 2017 Jul 5.
14. Localization pattern of visfatin (NAMPT) in d-galactose induced aged rat testis. Jeremy M, etal., Ann Anat. 2017 May;211:46-54. doi: 10.1016/j.aanat.2017.01.009. Epub 2017 Feb 3.
15. Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat. Josephs T, etal., J Endocrinol. 2007 Aug;194(2):305-12.
16. Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866. Kim MK, etal., J Mol Biol. 2006 Sep 8;362(1):66-77. Epub 2006 Aug 9.
17. Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor. Kitani T, etal., FEBS Lett 2003 Jun 5;544(1-3):74-8.
18. Visfatin: gene expression in isolated adipocytes and sequence analysis in obese WOKW rats compared with lean control rats. Kloting N and Kloting I, Biochem Biophys Res Commun. 2005 Jul 15;332(4):1070-2.
19. Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. Kowalska I, etal., Hum Reprod. 2007 Jul;22(7):1824-9.
20. Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease. Li C, etal., Acta Cir Bras. 2016 Nov;31(11):706-713. doi: 10.1590/S0102-865020160110000001.
21. Periodontitis contributes to aberrant metabolism in type 2 diabetes mellitus rats by stimulating the expression of adipokines. Luo S, etal., J Periodontal Res. 2016 Aug;51(4):453-61. doi: 10.1111/jre.12322. Epub 2015 Oct 12.
22. Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1. Ma C, etal., PLoS One. 2017 Jan 26;12(1):e0170930. doi: 10.1371/journal.pone.0170930. eCollection 2017.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Protective effect of P7C3 on retinal ganglion cells from optic nerve injury. Oku H, etal., Jpn J Ophthalmol. 2017 Mar;61(2):195-203. doi: 10.1007/s10384-016-0493-6. Epub 2016 Dec 28.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
27. Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study. Retnakaran R, etal., Clin Endocrinol (Oxf). 2008 Dec;69(6):885-93. Epub 2008 Apr 10.
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Sleep restriction induced energy, methylation and lipogenesis metabolic switches in rat liver. Sengupta A, etal., Int J Biochem Cell Biol. 2017 Dec;93:129-135. doi: 10.1016/j.biocel.2017.08.014. Epub 2017 Aug 30.
31. Visfatin: a new player in mesangial cell physiology and diabetic nephropathy. Song HK, etal., Am J Physiol Renal Physiol. 2008 Nov;295(5):F1485-94. Epub 2008 Sep 3.
32. The renoprotective effect of curcumin in cisplatin-induced nephrotoxicity. Ugur S, etal., Ren Fail. 2015 Mar;37(2):332-6. doi: 10.3109/0886022X.2014.986005. Epub 2015 Jan 16.
33. Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. Wang P, etal., Cardiovasc Res. 2009 Feb 1;81(2):370-80. Epub 2008 Oct 24.
34. Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats. Wu GC, etal., Respir Res. 2017 Apr 24;18(1):71. doi: 10.1186/s12931-017-0557-2.
35. Nicotinamide Phosphoribosyltransferase Upregulation by Phenylephrine Reduces Radiation Injury in Submandibular Gland. Xiang B, etal., Int J Radiat Oncol Biol Phys. 2016 Nov 1;96(3):538-46. doi: 10.1016/j.ijrobp.2016.06.2442. Epub 2016 Jul 1.
36. Nicotinamide phosphoribosyltransferase inhibitor APO866 induces C6 glioblastoma cell death via autophagy. Yang P, etal., Pharmazie. 2015 Oct;70(10):650-5.
37. Serum concentration of visfatin in obese women. Zahorska-Markiewicz B, etal., Metabolism. 2007 Aug;56(8):1131-4.
38. NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity. Zou XD, etal., Mol Med Rep. 2016 May;13(5):4058-64. doi: 10.3892/mmr.2016.5034. Epub 2016 Mar 21.
Additional References at PubMed
PMID:12477932   PMID:15381699   PMID:15489334   PMID:16783373   PMID:16783377   PMID:17889652   PMID:17983582   PMID:18401839   PMID:19263259   PMID:19299583   PMID:19533035   PMID:19661458  
PMID:19666527   PMID:19727662   PMID:19751774   PMID:19913571   PMID:19929131   PMID:20456420   PMID:20458337   PMID:20658215   PMID:21246601   PMID:21664630   PMID:21841463   PMID:22113203  
PMID:23001182   PMID:23065734   PMID:23533145   PMID:23831038   PMID:23946338   PMID:24287278   PMID:24304571   PMID:24332931   PMID:24667915   PMID:25351242   PMID:25358398   PMID:25505128  
PMID:25645057   PMID:26051626   PMID:26694625   PMID:26857566   PMID:27083000   PMID:28478801   PMID:29663373   PMID:29772226   PMID:32466159   PMID:34029951   PMID:34434488   PMID:34952398  
PMID:34967693   PMID:35111160  


Genomics

Comparative Map Data
Nampt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2649,425,316 - 49,462,109 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl649,424,332 - 49,462,100 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx649,728,050 - 49,763,075 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0650,042,969 - 50,077,994 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0649,480,294 - 49,514,732 (+)NCBIRnor_WKY
Rnor_6.0652,122,085 - 52,156,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl652,122,085 - 52,156,472 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,753,125 - 61,787,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4651,129,160 - 51,166,514 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1651,132,285 - 51,169,639 (+)NCBI
Celera648,619,485 - 48,654,540 (+)NCBICelera
Cytogenetic Map6q16NCBI
NAMPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387106,248,298 - 106,285,888 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7106,248,298 - 106,285,966 (-)EnsemblGRCh38hg38GRCh38
GRCh377105,888,744 - 105,925,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367105,675,967 - 105,712,874 (-)NCBINCBI36Build 36hg18NCBI36
Build 347105,495,899 - 105,519,318NCBI
Celera7100,694,260 - 100,731,169 (-)NCBICelera
Cytogenetic Map7q22.3NCBI
HuRef7100,248,062 - 100,285,253 (-)NCBIHuRef
CHM1_17105,822,212 - 105,859,137 (-)NCBICHM1_1
T2T-CHM13v2.07107,563,712 - 107,600,408 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27105,249,752 - 105,286,646 (-)NCBI
Nampt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,870,334 - 32,903,368 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1232,869,544 - 32,903,348 (+)EnsemblGRCm39 Ensembl
GRCm381232,820,335 - 32,853,369 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1232,819,545 - 32,853,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv371233,505,200 - 33,538,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361233,405,722 - 33,436,855 (+)NCBIMGSCv36mm8
Celera1234,264,778 - 34,297,952 (+)NCBICelera
Cytogenetic Map12A3NCBI
Nampt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541010,717,664 - 10,751,177 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541010,717,664 - 10,742,109 (-)NCBIChiLan1.0ChiLan1.0
NAMPT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17110,952,876 - 110,989,233 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7110,952,876 - 110,981,967 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0798,227,071 - 98,262,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NAMPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11814,110,045 - 14,211,268 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1813,993,022 - 14,208,657 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1813,815,825 - 13,860,578 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01814,441,923 - 14,486,695 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1814,441,184 - 14,486,688 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11814,254,107 - 14,298,642 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01814,175,231 - 14,219,981 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01814,455,285 - 14,500,038 (+)NCBIUU_Cfam_GSD_1.0
Nampt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511856,558,385 - 56,593,898 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647917,682,201 - 17,716,661 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647917,682,070 - 17,716,713 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAMPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9106,119,899 - 106,294,586 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19106,119,896 - 106,162,126 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29116,889,082 - 116,932,047 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NAMPT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12175,160,748 - 75,195,781 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2175,158,596 - 75,196,025 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604228,713,073 - 28,750,454 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nampt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473923,411,488 - 23,442,359 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473923,411,478 - 23,444,590 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nampt
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:600
Count of miRNA genes:289
Interacting mature miRNAs:353
Transcripts:ENSRNOT00000013043
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat

Markers in Region
AI314458  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2649,459,958 - 49,460,084 (+)MAPPERmRatBN7.2
Rnor_6.0652,156,088 - 52,156,213NCBIRnor6.0
Rnor_5.0661,787,190 - 61,787,315UniSTSRnor5.0
RGSC_v3.4651,166,129 - 51,166,254UniSTSRGSC3.4
Celera648,654,155 - 48,654,280UniSTS
Cytogenetic Map6q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 36 11 8
Low 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013043   ⟹   ENSRNOP00000013043
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl649,425,279 - 49,462,098 (+)Ensembl
Rnor_6.0 Ensembl652,122,085 - 52,156,472 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086432   ⟹   ENSRNOP00000071458
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl649,425,539 - 49,462,098 (+)Ensembl
Rnor_6.0 Ensembl652,122,318 - 52,155,611 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095339   ⟹   ENSRNOP00000097021
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl649,424,332 - 49,462,100 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110613   ⟹   ENSRNOP00000096815
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl649,434,626 - 49,462,098 (+)Ensembl
RefSeq Acc Id: NM_177928   ⟹   NP_808789
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2649,425,316 - 49,460,344 (+)NCBI
Rnor_6.0652,122,085 - 52,156,473 (+)NCBI
Rnor_5.0661,753,125 - 61,787,575 (+)NCBI
RGSC_v3.4651,129,160 - 51,166,514 (+)RGD
Celera648,619,485 - 48,654,540 (+)RGD
Sequence:
RefSeq Acc Id: XM_039111890   ⟹   XP_038967818
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2649,425,543 - 49,462,109 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_808789   ⟸   NM_177928
- UniProtKB: Q2VT47 (UniProtKB/Swiss-Prot),   Q80Z29 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071458   ⟸   ENSRNOT00000086432
RefSeq Acc Id: ENSRNOP00000013043   ⟸   ENSRNOT00000013043
RefSeq Acc Id: XP_038967818   ⟸   XM_039111890
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000097021   ⟸   ENSRNOT00000095339
RefSeq Acc Id: ENSRNOP00000096815   ⟸   ENSRNOT00000110613
Protein Domains
NAMPT_N   NAPRTase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80Z29-F1-model_v2 AlphaFold Q80Z29 1-491 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694548
Promoter ID:EPDNEW_R5073
Type:initiation region
Name:Nampt_1
Description:nicotinamide phosphoribosyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0652,122,055 - 52,122,115EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631365 AgrOrtholog
BioCyc Gene G2FUF-37882 BioCyc
Ensembl Genes ENSRNOG00000009754 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013043 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071458 ENTREZGENE
  ENSRNOP00000071458.1 UniProtKB/TrEMBL
  ENSRNOP00000096815.1 UniProtKB/TrEMBL
  ENSRNOP00000097021.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013043 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000086432 ENTREZGENE
  ENSRNOT00000086432.2 UniProtKB/TrEMBL
  ENSRNOT00000095339.1 UniProtKB/TrEMBL
  ENSRNOT00000110613.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192109 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF5598 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  N/Namide_PRibTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinamide_PRibTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinate_pribotase-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:297508 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93053 IMAGE-MGC_LOAD
NCBI Gene 297508 ENTREZGENE
PANTHER PTHR43816 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF5598 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAPRTase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NAMPT RGD
PhenoGen Nampt PhenoGen
PIRSF NMPRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0I3_RAT UniProtKB/TrEMBL
  A0A8I6ARB9_RAT UniProtKB/TrEMBL
  A0A8I6GMC5_RAT UniProtKB/TrEMBL
  NAMPT_RAT UniProtKB/Swiss-Prot
  Q2VT47 ENTREZGENE
  Q80Z29 ENTREZGENE
UniProt Secondary Q2VT47 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-25 Nampt  nicotinamide phosphoribosyltransferase  Pbef1  pre-B-cell colony enhancing factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pbef1  pre-B-cell colony enhancing factor 1  Pbef  pre-B-cell colony-enhancing factor  Symbol and Name updated 1299863 APPROVED