NAMPT (nicotinamide phosphoribosyltransferase) - Rat Genome Database

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Gene: NAMPT (nicotinamide phosphoribosyltransferase) Homo sapiens
Analyze
Symbol: NAMPT
Name: nicotinamide phosphoribosyltransferase
RGD ID: 1351636
HGNC Page HGNC:30092
Description: Enables identical protein binding activity. Involved in positive regulation of nitric-oxide synthase biosynthetic process and positive regulation of transcription by RNA polymerase II. Located in cell junction and nuclear speck. Implicated in transient cerebral ischemia. Biomarker of carotid artery disease; coronary artery disease; obesity; pulmonary hypertension; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 1110035O14Rik; DKFZp666B131; MGC117256; NAmPRTase; PBEF; PBEF1; pre-B cell-enhancing factor; pre-B-cell colony enhancing factor 1; pre-B-cell colony-enhancing factor 1; VF; VISFATIN
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: NAMPTP1   NAMPTP2   NAMPTP3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387106,248,298 - 106,285,888 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7106,248,298 - 106,285,966 (-)EnsemblGRCh38hg38GRCh38
GRCh377105,888,744 - 105,925,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367105,675,967 - 105,712,874 (-)NCBINCBI36hg18NCBI36
Build 347105,495,899 - 105,519,318NCBI
Celera7100,694,260 - 100,731,169 (-)NCBI
Cytogenetic Map7q22.3NCBI
HuRef7100,248,062 - 100,285,253 (-)NCBIHuRef
CHM1_17105,822,212 - 105,859,137 (-)NCBICHM1_1
T2T-CHM13v2.07107,563,712 - 107,600,408 (-)NCBI
CRA_TCAGchr7v27105,249,752 - 105,286,646 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (EXP)
(-)-demecolcine  (EXP)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methylnicotinamide  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
acetic acid  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
alpha-phellandrene  (EXP)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (EXP)
antirheumatic drug  (EXP)
aristolochic acid  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
azoxystrobin  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzofurans  (ISO)
berberine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bromobenzene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
CHIR 99021  (EXP)
chlorendic acid  (ISO)
chloroacetaldehyde  (EXP)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
cidofovir anhydrous  (EXP)
cisplatin  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
diazoxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
divanadium pentaoxide  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
estriol  (ISO)
ethylbenzene  (EXP)
eugenol  (EXP)
fenofibrate  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
furan  (ISO)
gentamycin  (ISO)
glucose  (EXP)
hydralazine  (EXP)
hydroxyurea  (ISO)
ibuprofen  (EXP)
isotretinoin  (EXP)
ivermectin  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (EXP)
letrozole  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
metformin  (EXP,ISO)
methotrexate  (EXP,ISO)
methylmercury chloride  (ISO)
mitoxantrone  (EXP)
NAD zwitterion  (EXP,ISO)
NAD(+)  (EXP,ISO)
nefazodone  (ISO)
nevirapine  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nifedipine  (EXP)
nimesulide  (ISO)
NMN zwitterion  (EXP,ISO)
p-anisidine  (ISO)
paclitaxel  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
picoxystrobin  (EXP)
progesterone  (EXP,ISO)
quinoline  (EXP)
rac-lactic acid  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulindac  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
tanespimycin  (EXP)
temozolomide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thiram  (EXP)
Tolmetin glucuronide  (EXP)
toluene  (EXP)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
triphenylstannane  (EXP)
Triptolide  (ISO)
troglitazone  (EXP)
uranium atom  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (EXP)
vorinostat  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. NAMPT inhibitor protects ischemic neuronal injury in rat brain via anti-neuroinflammation. Chen CX, etal., Neuroscience. 2017 Jul 25;356:193-206. doi: 10.1016/j.neuroscience.2017.05.022. Epub 2017 May 19.
2. Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension. Chen J, etal., Circulation. 2017 Apr 18;135(16):1532-1546. doi: 10.1161/CIRCULATIONAHA.116.024557. Epub 2017 Feb 15.
3. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. Chen MP, etal., J Clin Endocrinol Metab. 2006 Jan;91(1):295-9. Epub 2005 Oct 18.
4. Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization. Dahl TB, etal., Circulation. 2007 Feb 27;115(8):972-80. Epub 2007 Feb 5.
5. Nampt/PBEF/visfatin exerts neuroprotective effects against ischemia/reperfusion injury via modulation of Bax/Bcl-2 ratio and prevention of caspase-3 activation. Erfani S, etal., J Mol Neurosci. 2015 May;56(1):237-43. doi: 10.1007/s12031-014-0486-1. Epub 2015 Jan 22.
6. Increased plasma levels of visfatin/pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome. Filippatos TD, etal., J Endocrinol Invest. 2007 Apr;30(4):323-6.
7. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
8. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Houtkooper RH, etal., Endocr Rev. 2010 Apr;31(2):194-223. doi: 10.1210/er.2009-0026. Epub 2009 Dec 9.
9. Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats. Hu Q, etal., Stroke. 2017 Jun;48(6):1655-1664. doi: 10.1161/STROKEAHA.116.015753. Epub 2017 May 11.
10. Visfatin: gene expression in isolated adipocytes and sequence analysis in obese WOKW rats compared with lean control rats. Kloting N and Kloting I, Biochem Biophys Res Commun. 2005 Jul 15;332(4):1070-2.
11. Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. Kowalska I, etal., Hum Reprod. 2007 Jul;22(7):1824-9.
12. Periodontitis contributes to aberrant metabolism in type 2 diabetes mellitus rats by stimulating the expression of adipokines. Luo S, etal., J Periodontal Res. 2016 Aug;51(4):453-61. doi: 10.1111/jre.12322. Epub 2015 Oct 12.
13. Protective effect of P7C3 on retinal ganglion cells from optic nerve injury. Oku H, etal., Jpn J Ophthalmol. 2017 Mar;61(2):195-203. doi: 10.1007/s10384-016-0493-6. Epub 2016 Dec 28.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study. Retnakaran R, etal., Clin Endocrinol (Oxf). 2008 Dec;69(6):885-93. Epub 2008 Apr 10.
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Sleep restriction induced energy, methylation and lipogenesis metabolic switches in rat liver. Sengupta A, etal., Int J Biochem Cell Biol. 2017 Dec;93:129-135. doi: 10.1016/j.biocel.2017.08.014. Epub 2017 Aug 30.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. The renoprotective effect of curcumin in cisplatin-induced nephrotoxicity. Ugur S, etal., Ren Fail. 2015 Mar;37(2):332-6. doi: 10.3109/0886022X.2014.986005. Epub 2015 Jan 16.
21. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Wen W, etal., Cell Discov. 2020 May 4;6:31. doi: 10.1038/s41421-020-0168-9. eCollection 2020.
22. Serum concentration of visfatin in obese women. Zahorska-Markiewicz B, etal., Metabolism. 2007 Aug;56(8):1131-4.
23. Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
Additional References at PubMed
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PMID:30483779   PMID:30514106   PMID:30541001   PMID:30563239   PMID:30575818   PMID:30799084   PMID:30833792   PMID:30856230   PMID:30892950   PMID:30948266   PMID:30952715   PMID:30963978  
PMID:31022738   PMID:31025138   PMID:31026096   PMID:31076892   PMID:31091453   PMID:31132798   PMID:31177228   PMID:31204283   PMID:31235138   PMID:31322259   PMID:31372850   PMID:31452406  
PMID:31487747   PMID:31588856   PMID:31710121   PMID:31717318   PMID:31771561   PMID:31900828   PMID:31940881   PMID:31957305   PMID:32060556   PMID:32087970   PMID:32098202   PMID:32107941  
PMID:32142369   PMID:32176739   PMID:32243098   PMID:32252104   PMID:32296183   PMID:32311618   PMID:32390008   PMID:32416067   PMID:32423001   PMID:32460545   PMID:32466159   PMID:32495871  
PMID:32503436   PMID:32597148   PMID:32618342   PMID:32681594   PMID:32694731   PMID:32807821   PMID:32807901   PMID:32994395   PMID:33029930   PMID:33045468   PMID:33122129   PMID:33247685  
PMID:33356858   PMID:33432364   PMID:33462405   PMID:33488923   PMID:33513808   PMID:33540574   PMID:33543238   PMID:33567341   PMID:33568815   PMID:33626391   PMID:33649309   PMID:33658012  
PMID:33742100   PMID:33816632   PMID:33823623   PMID:33901513   PMID:33916271   PMID:33944612   PMID:33961781   PMID:33975612   PMID:33976173   PMID:34070254   PMID:34079125   PMID:34101492  
PMID:34139379   PMID:34201564   PMID:34202251   PMID:34360874   PMID:34373451   PMID:34439776   PMID:34445345   PMID:34551033   PMID:34626279   PMID:34645483   PMID:34656559   PMID:34709727  
PMID:34711951   PMID:34717061   PMID:34748530   PMID:34780058   PMID:34967693   PMID:35013218   PMID:35111160   PMID:35120922   PMID:35227662   PMID:35241646   PMID:35271311   PMID:35466629  
PMID:35509820   PMID:35545034   PMID:35562734   PMID:35628596   PMID:35661560   PMID:35694583   PMID:35809287  


Genomics

Comparative Map Data
NAMPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387106,248,298 - 106,285,888 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7106,248,298 - 106,285,966 (-)EnsemblGRCh38hg38GRCh38
GRCh377105,888,744 - 105,925,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367105,675,967 - 105,712,874 (-)NCBINCBI36hg18NCBI36
Build 347105,495,899 - 105,519,318NCBI
Celera7100,694,260 - 100,731,169 (-)NCBI
Cytogenetic Map7q22.3NCBI
HuRef7100,248,062 - 100,285,253 (-)NCBIHuRef
CHM1_17105,822,212 - 105,859,137 (-)NCBICHM1_1
T2T-CHM13v2.07107,563,712 - 107,600,408 (-)NCBI
CRA_TCAGchr7v27105,249,752 - 105,286,646 (-)NCBI
Nampt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,870,334 - 32,903,368 (+)NCBIGRCm39mm39
GRCm39 Ensembl1232,869,544 - 32,903,348 (+)Ensembl
GRCm381232,820,335 - 32,853,369 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1232,819,545 - 32,853,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv371233,505,200 - 33,538,234 (+)NCBIGRCm37mm9NCBIm37
MGSCv361233,405,722 - 33,436,855 (+)NCBImm8
Celera1234,264,778 - 34,297,952 (+)NCBICelera
Cytogenetic Map12A3NCBI
Nampt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2649,425,316 - 49,462,109 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl649,424,332 - 49,462,100 (+)Ensembl
Rnor_6.0652,122,085 - 52,156,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl652,122,085 - 52,156,472 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,753,125 - 61,787,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4651,129,160 - 51,166,514 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1651,132,285 - 51,169,639 (+)NCBI
Celera648,619,485 - 48,654,540 (+)NCBICelera
Cytogenetic Map6q16NCBI
Nampt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541010,717,664 - 10,751,177 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541010,717,664 - 10,742,109 (-)NCBIChiLan1.0ChiLan1.0
NAMPT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17110,952,876 - 110,989,233 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7110,952,876 - 110,981,967 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0798,227,071 - 98,262,254 (-)NCBIMhudiblu_PPA_v0panPan3
NAMPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11814,110,045 - 14,211,268 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1813,993,022 - 14,208,657 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1813,815,825 - 13,860,578 (+)NCBI
ROS_Cfam_1.01814,441,923 - 14,486,695 (+)NCBI
ROS_Cfam_1.0 Ensembl1814,441,184 - 14,486,688 (+)Ensembl
UMICH_Zoey_3.11814,254,107 - 14,298,642 (+)NCBI
UNSW_CanFamBas_1.01814,175,231 - 14,219,981 (+)NCBI
UU_Cfam_GSD_1.01814,455,285 - 14,500,038 (+)NCBI
Nampt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511856,558,385 - 56,593,898 (+)NCBI
SpeTri2.0NW_00493647917,682,070 - 17,716,713 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAMPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9106,119,899 - 106,294,586 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19106,119,896 - 106,162,126 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29116,889,082 - 116,932,047 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NAMPT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12175,160,748 - 75,195,781 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2175,158,596 - 75,196,025 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604228,713,073 - 28,750,454 (+)NCBIVero_WHO_p1.0
Nampt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473923,411,488 - 23,442,359 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473923,411,478 - 23,444,590 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH36790  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371634,323,211 - 34,323,302UniSTSGRCh37
GRCh377105,888,854 - 105,888,945UniSTSGRCh37
Build 367105,676,090 - 105,676,181RGDNCBI36
Celera7100,694,383 - 100,694,474UniSTS
Celera666,708,204 - 66,708,295RGD
Cytogenetic Map7q22.3UniSTS
HuRef1631,077,256 - 31,077,347UniSTS
HuRef7100,248,185 - 100,248,276UniSTS
CRA_TCAGchr7v27105,249,875 - 105,249,966UniSTS
A002U17  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377105,888,884 - 105,889,023UniSTSGRCh37
Build 367105,676,120 - 105,676,259RGDNCBI36
Celera7100,694,413 - 100,694,552RGD
Cytogenetic Map7q22.3UniSTS
HuRef7100,248,215 - 100,248,354UniSTS
CRA_TCAGchr7v27105,249,905 - 105,250,044UniSTS
GeneMap99-GB4 RH Map7527.51UniSTS
D7S2650  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371634,323,204 - 34,323,325UniSTSGRCh37
GRCh377105,888,831 - 105,888,952UniSTSGRCh37
Build 367105,676,067 - 105,676,188RGDNCBI36
Celera7100,694,360 - 100,694,481UniSTS
Celera666,708,197 - 66,708,318RGD
Cytogenetic Map7q22.3UniSTS
HuRef1631,077,249 - 31,077,370UniSTS
HuRef7100,248,162 - 100,248,283UniSTS
CRA_TCAGchr7v27105,249,852 - 105,249,973UniSTS
SHGC-33252  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377105,900,355 - 105,900,482UniSTSGRCh37
Build 367105,687,591 - 105,687,718RGDNCBI36
Celera7100,705,884 - 100,706,011RGD
Cytogenetic Map7q22.3UniSTS
HuRef7100,259,669 - 100,259,796UniSTS
CRA_TCAGchr7v27105,261,359 - 105,261,486UniSTS
TNG Radiation Hybrid Map746144.0UniSTS
GeneMap99-GB4 RH Map7532.41UniSTS
Whitehead-RH Map7484.1UniSTS
GeneMap99-G3 RH Map75173.0UniSTS
RH16541  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377105,900,355 - 105,900,540UniSTSGRCh37
Build 367105,687,591 - 105,687,776RGDNCBI36
Celera7100,705,884 - 100,706,069RGD
Cytogenetic Map7q22.3UniSTS
HuRef7100,259,669 - 100,259,854UniSTS
CRA_TCAGchr7v27105,261,359 - 105,261,544UniSTS
GeneMap99-GB4 RH Map7525.81UniSTS
SHGC-33423  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377105,909,871 - 105,909,971UniSTSGRCh37
Build 367105,697,107 - 105,697,207RGDNCBI36
Celera7100,715,398 - 100,715,498RGD
Cytogenetic Map7q22.3UniSTS
HuRef7100,269,485 - 100,269,585UniSTS
CRA_TCAGchr7v27105,270,875 - 105,270,975UniSTS
TNG Radiation Hybrid Map746152.0UniSTS
Stanford-G3 RH Map75164.0UniSTS
NCBI RH Map71089.7UniSTS
GeneMap99-G3 RH Map75164.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1481
Count of miRNA genes:837
Interacting mature miRNAs:980
Transcripts:ENST00000222553, ENST00000354289, ENST00000393618, ENST00000417537, ENST00000424768, ENST00000441045, ENST00000463871, ENST00000467730, ENST00000484527, ENST00000486949, ENST00000489358, ENST00000489732, ENST00000491027
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3 171 168 6 2 2 4 6 5
Medium 2312 2673 1651 594 1747 436 4314 2010 2582 364 1241 1594 171 1198 2757 3
Low 123 147 75 29 36 29 37 185 1148 55 215 15 4 1 26 3 1
Below cutoff 3 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047419699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047419700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI299587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI859562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS463832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS545604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB775574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD117879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH762803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000222553   ⟹   ENSP00000222553
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,298 - 106,284,983 (-)Ensembl
RefSeq Acc Id: ENST00000354289   ⟹   ENSP00000346242
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,261,490 - 106,285,192 (-)Ensembl
RefSeq Acc Id: ENST00000393618
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,269,415 - 106,284,557 (-)Ensembl
RefSeq Acc Id: ENST00000417537   ⟹   ENSP00000390896
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,272,461 - 106,284,951 (-)Ensembl
RefSeq Acc Id: ENST00000424768   ⟹   ENSP00000390591
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,313 - 106,285,966 (-)Ensembl
RefSeq Acc Id: ENST00000441045
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,272,166 - 106,284,951 (-)Ensembl
RefSeq Acc Id: ENST00000463871
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,043 - 106,257,477 (-)Ensembl
RefSeq Acc Id: ENST00000467730
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,268,335 - 106,269,205 (-)Ensembl
RefSeq Acc Id: ENST00000484527
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,259,928 - 106,277,161 (-)Ensembl
RefSeq Acc Id: ENST00000486949
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,271,095 - 106,275,226 (-)Ensembl
RefSeq Acc Id: ENST00000489358
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,272,039 - 106,284,950 (-)Ensembl
RefSeq Acc Id: ENST00000489732
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,043 - 106,284,994 (-)Ensembl
RefSeq Acc Id: ENST00000491027
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,263,150 - 106,284,951 (-)Ensembl
RefSeq Acc Id: ENST00000679461
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,048 - 106,271,979 (-)Ensembl
RefSeq Acc Id: ENST00000679643   ⟹   ENSP00000504962
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,710 - 106,284,983 (-)Ensembl
RefSeq Acc Id: ENST00000679717
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,259,897 - 106,284,983 (-)Ensembl
RefSeq Acc Id: ENST00000679873   ⟹   ENSP00000506282
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,368 - 106,285,009 (-)Ensembl
RefSeq Acc Id: ENST00000679894
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,043 - 106,273,139 (-)Ensembl
RefSeq Acc Id: ENST00000679951   ⟹   ENSP00000505427
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,043 - 106,284,973 (-)Ensembl
RefSeq Acc Id: ENST00000680077   ⟹   ENSP00000506239
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,298 - 106,284,951 (-)Ensembl
RefSeq Acc Id: ENST00000680129   ⟹   ENSP00000504872
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,701 - 106,284,997 (-)Ensembl
RefSeq Acc Id: ENST00000680152   ⟹   ENSP00000505353
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,552 - 106,284,951 (-)Ensembl
RefSeq Acc Id: ENST00000680468   ⟹   ENSP00000505172
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,043 - 106,284,934 (-)Ensembl
RefSeq Acc Id: ENST00000680482
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,043 - 106,259,287 (-)Ensembl
RefSeq Acc Id: ENST00000680516
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,259,905 - 106,270,322 (-)Ensembl
RefSeq Acc Id: ENST00000680584   ⟹   ENSP00000505012
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,309 - 106,285,094 (-)Ensembl
RefSeq Acc Id: ENST00000680616
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,552 - 106,257,483 (-)Ensembl
RefSeq Acc Id: ENST00000680669
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,309 - 106,284,971 (-)Ensembl
RefSeq Acc Id: ENST00000680675   ⟹   ENSP00000506337
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,298 - 106,284,935 (-)Ensembl
RefSeq Acc Id: ENST00000680708   ⟹   ENSP00000506527
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,298 - 106,284,983 (-)Ensembl
RefSeq Acc Id: ENST00000680786   ⟹   ENSP00000505453
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,745 - 106,284,555 (-)Ensembl
RefSeq Acc Id: ENST00000680823   ⟹   ENSP00000506618
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,043 - 106,284,973 (-)Ensembl
RefSeq Acc Id: ENST00000680864   ⟹   ENSP00000505845
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,308 - 106,285,000 (-)Ensembl
RefSeq Acc Id: ENST00000680991   ⟹   ENSP00000506283
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,298 - 106,284,983 (-)Ensembl
RefSeq Acc Id: ENST00000681223   ⟹   ENSP00000505065
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,836 - 106,284,992 (-)Ensembl
RefSeq Acc Id: ENST00000681255   ⟹   ENSP00000506129
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,332 - 106,285,966 (-)Ensembl
RefSeq Acc Id: ENST00000681297
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,263,150 - 106,271,979 (-)Ensembl
RefSeq Acc Id: ENST00000681372
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,053 - 106,267,826 (-)Ensembl
RefSeq Acc Id: ENST00000681391   ⟹   ENSP00000505390
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,298 - 106,284,983 (-)Ensembl
RefSeq Acc Id: ENST00000681455
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,252,514 - 106,254,876 (-)Ensembl
RefSeq Acc Id: ENST00000681456   ⟹   ENSP00000505633
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,298 - 106,284,951 (-)Ensembl
RefSeq Acc Id: ENST00000681491   ⟹   ENSP00000506540
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,298 - 106,285,436 (-)Ensembl
RefSeq Acc Id: ENST00000681494   ⟹   ENSP00000506450
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,298 - 106,284,983 (-)Ensembl
RefSeq Acc Id: ENST00000681550   ⟹   ENSP00000505112
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,298 - 106,284,632 (-)Ensembl
RefSeq Acc Id: ENST00000681631
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,259,879 - 106,265,590 (-)Ensembl
RefSeq Acc Id: ENST00000681653   ⟹   ENSP00000506565
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,248,298 - 106,284,983 (-)Ensembl
RefSeq Acc Id: ENST00000681878   ⟹   ENSP00000505577
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,039 - 106,284,971 (-)Ensembl
RefSeq Acc Id: ENST00000681887
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,672 - 106,284,686 (-)Ensembl
RefSeq Acc Id: ENST00000681936   ⟹   ENSP00000504973
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7106,250,431 - 106,284,544 (-)Ensembl
RefSeq Acc Id: NM_005746   ⟹   NP_005737
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387106,248,298 - 106,284,983 (-)NCBI
GRCh377105,888,731 - 105,926,373 (-)NCBI
Build 367105,675,967 - 105,712,874 (-)NCBI Archive
HuRef7100,248,062 - 100,285,253 (-)ENTREZGENE
CHM1_17105,822,212 - 105,859,137 (-)NCBI
T2T-CHM13v2.07107,563,712 - 107,600,408 (-)NCBI
CRA_TCAGchr7v27105,249,752 - 105,286,646 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_047419699   ⟹   XP_047275655
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387106,248,298 - 106,285,888 (-)NCBI
RefSeq Acc Id: XM_047419700   ⟹   XP_047275656
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387106,263,666 - 106,284,983 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_005737   ⟸   NM_005746
- Peptide Label: precursor
- UniProtKB: Q8WW95 (UniProtKB/Swiss-Prot),   P43490 (UniProtKB/Swiss-Prot),   A0A024R718 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000390591   ⟸   ENST00000424768
RefSeq Acc Id: ENSP00000390896   ⟸   ENST00000417537
RefSeq Acc Id: ENSP00000346242   ⟸   ENST00000354289
RefSeq Acc Id: ENSP00000222553   ⟸   ENST00000222553
RefSeq Acc Id: ENSP00000506239   ⟸   ENST00000680077
RefSeq Acc Id: ENSP00000505172   ⟸   ENST00000680468
RefSeq Acc Id: ENSP00000506565   ⟸   ENST00000681653
RefSeq Acc Id: ENSP00000505633   ⟸   ENST00000681456
RefSeq Acc Id: ENSP00000506618   ⟸   ENST00000680823
RefSeq Acc Id: ENSP00000506283   ⟸   ENST00000680991
RefSeq Acc Id: ENSP00000505577   ⟸   ENST00000681878
RefSeq Acc Id: ENSP00000506129   ⟸   ENST00000681255
RefSeq Acc Id: ENSP00000504962   ⟸   ENST00000679643
RefSeq Acc Id: ENSP00000506540   ⟸   ENST00000681491
RefSeq Acc Id: ENSP00000506450   ⟸   ENST00000681494
RefSeq Acc Id: ENSP00000504872   ⟸   ENST00000680129
RefSeq Acc Id: ENSP00000505065   ⟸   ENST00000681223
RefSeq Acc Id: ENSP00000505427   ⟸   ENST00000679951
RefSeq Acc Id: ENSP00000505353   ⟸   ENST00000680152
RefSeq Acc Id: ENSP00000506282   ⟸   ENST00000679873
RefSeq Acc Id: ENSP00000505390   ⟸   ENST00000681391
RefSeq Acc Id: ENSP00000505453   ⟸   ENST00000680786
RefSeq Acc Id: ENSP00000505845   ⟸   ENST00000680864
RefSeq Acc Id: ENSP00000504973   ⟸   ENST00000681936
RefSeq Acc Id: ENSP00000505012   ⟸   ENST00000680584
RefSeq Acc Id: ENSP00000505112   ⟸   ENST00000681550
RefSeq Acc Id: ENSP00000506337   ⟸   ENST00000680675
RefSeq Acc Id: ENSP00000506527   ⟸   ENST00000680708
RefSeq Acc Id: XP_047275655   ⟸   XM_047419699
- Peptide Label: isoform X1
- UniProtKB: Q8WW95 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047275656   ⟸   XM_047419700
- Peptide Label: isoform X2
Protein Domains
NAMPT_N   NAPRTase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43490-F1-model_v2 AlphaFold P43490 1-491 view protein structure

Promoters
RGD ID:6805946
Promoter ID:HG_KWN:59199
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Lymphoblastoid
Transcripts:OTTHUMT00000316773
Position:
Human AssemblyChrPosition (strand)Source
Build 367105,681,176 - 105,682,127 (-)MPROMDB
RGD ID:6805945
Promoter ID:HG_KWN:59200
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Lymphoblastoid
Transcripts:OTTHUMT00000316772
Position:
Human AssemblyChrPosition (strand)Source
Build 367105,697,206 - 105,697,706 (-)MPROMDB
RGD ID:6805506
Promoter ID:HG_KWN:59201
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000393617,   ENST00000393618,   OTTHUMT00000277146,   OTTHUMT00000316767,   OTTHUMT00000316768,   OTTHUMT00000316769,   OTTHUMT00000316770,   OTTHUMT00000316771,   OTTHUMT00000316776,   UC003VDR.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367105,712,066 - 105,713,942 (-)MPROMDB
RGD ID:6851342
Promoter ID:EP73469
Type:multiple initiation site
Name:HS_PBEF
Description:Pre-B-cell colony-enhancing factor.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 367105,712,633 - 105,712,693EPD
RGD ID:7211605
Promoter ID:EPDNEW_H11548
Type:initiation region
Name:NAMPT_1
Description:nicotinamide phosphoribosyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11549  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387106,284,983 - 106,285,043EPDNEW
RGD ID:7211607
Promoter ID:EPDNEW_H11549
Type:initiation region
Name:NAMPT_2
Description:nicotinamide phosphoribosyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11548  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387106,285,118 - 106,285,178EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q22.1-31.1(chr7:101807149-112414850)x1 copy number loss See cases [RCV000050924] Chr7:101807149..112414850 [GRCh38]
Chr7:101450429..112054905 [GRCh37]
Chr7:101237149..111842141 [NCBI36]
Chr7:7q22.1-31.1
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q22.3-31.1(chr7:106261939-111228036)x1 copy number loss See cases [RCV000054158] Chr7:106261939..111228036 [GRCh38]
Chr7:105902385..110868092 [GRCh37]
Chr7:105689621..110655328 [NCBI36]
Chr7:7q22.3-31.1
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q22.1-31.31(chr7:102196924-121278641)x1 copy number loss See cases [RCV000137522] Chr7:102196924..121278641 [GRCh38]
Chr7:101912320..120918695 [GRCh37]
Chr7:101626924..120705931 [NCBI36]
Chr7:7q22.1-31.31
pathogenic
GRCh38/hg38 7q22.3-31.1(chr7:105575647-107949294)x1 copy number loss See cases [RCV000142628] Chr7:105575647..107949294 [GRCh38]
Chr7:105216094..107589739 [GRCh37]
Chr7:105003330..107376975 [NCBI36]
Chr7:7q22.3-31.1
uncertain significance
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
NM_005746.3(NAMPT):c.1002T>C (p.Val334=) single nucleotide variant not provided [RCV000964133] Chr7:106261675 [GRCh38]
Chr7:105902121 [GRCh37]
Chr7:7q22.3
benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
NM_005746.3(NAMPT):c.1366-8T>C single nucleotide variant not provided [RCV000892510] Chr7:106251201 [GRCh38]
Chr7:105891647 [GRCh37]
Chr7:7q22.3
benign
NM_005746.3(NAMPT):c.201T>C (p.Asn67=) single nucleotide variant not provided [RCV000879166] Chr7:106277036 [GRCh38]
Chr7:105917482 [GRCh37]
Chr7:7q22.3
benign
GRCh37/hg19 7q22.3-31.1(chr7:104506008-107408857) copy number loss See cases [RCV000993745] Chr7:104506008..107408857 [GRCh37]
Chr7:7q22.3-31.1
pathogenic
NM_005746.3(NAMPT):c.999T>C (p.Pro333=) single nucleotide variant not provided [RCV000954683] Chr7:106261678 [GRCh38]
Chr7:105902124 [GRCh37]
Chr7:7q22.3
benign
GRCh37/hg19 7q22.1-31.1(chr7:99417471-111586308) copy number loss not specified [RCV002053711] Chr7:99417471..111586308 [GRCh37]
Chr7:7q22.1-31.1
pathogenic
GRCh37/hg19 7q22.1-31.31(chr7:100676872-119156160) copy number loss not specified [RCV002053712] Chr7:100676872..119156160 [GRCh37]
Chr7:7q22.1-31.31
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:30092 AgrOrtholog
COSMIC NAMPT COSMIC
Ensembl Genes ENSG00000105835 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000222553 ENTREZGENE
  ENSP00000222553.3 UniProtKB/Swiss-Prot
  ENSP00000346242.4 UniProtKB/TrEMBL
  ENSP00000390591 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000390591.2 UniProtKB/Swiss-Prot
  ENSP00000390896.2 UniProtKB/TrEMBL
  ENSP00000504872.1 UniProtKB/TrEMBL
  ENSP00000504962.1 UniProtKB/TrEMBL
  ENSP00000504973.1 UniProtKB/TrEMBL
  ENSP00000505012.1 UniProtKB/TrEMBL
  ENSP00000505065.1 UniProtKB/TrEMBL
  ENSP00000505112.1 UniProtKB/TrEMBL
  ENSP00000505172.1 UniProtKB/TrEMBL
  ENSP00000505245.1 UniProtKB/TrEMBL
  ENSP00000505320.1 UniProtKB/TrEMBL
  ENSP00000505353.1 UniProtKB/TrEMBL
  ENSP00000505390 ENTREZGENE
  ENSP00000505390.1 UniProtKB/TrEMBL
  ENSP00000505427.1 UniProtKB/TrEMBL
  ENSP00000505453.1 UniProtKB/TrEMBL
  ENSP00000505577.1 UniProtKB/TrEMBL
  ENSP00000505633.1 UniProtKB/TrEMBL
  ENSP00000505845.1 UniProtKB/TrEMBL
  ENSP00000506129.1 UniProtKB/Swiss-Prot
  ENSP00000506239.1 UniProtKB/TrEMBL
  ENSP00000506282.1 UniProtKB/TrEMBL
  ENSP00000506283.1 UniProtKB/TrEMBL
  ENSP00000506337.1 UniProtKB/TrEMBL
  ENSP00000506343.1 UniProtKB/TrEMBL
  ENSP00000506450.1 UniProtKB/TrEMBL
  ENSP00000506527.1 UniProtKB/TrEMBL
  ENSP00000506540.1 UniProtKB/Swiss-Prot
  ENSP00000506565.1 UniProtKB/TrEMBL
  ENSP00000506618.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000222553 ENTREZGENE
  ENST00000222553.8 UniProtKB/Swiss-Prot
  ENST00000354289.9 UniProtKB/TrEMBL
  ENST00000417537.2 UniProtKB/TrEMBL
  ENST00000424768 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000424768.2 UniProtKB/Swiss-Prot
  ENST00000441045.6 UniProtKB/TrEMBL
  ENST00000489358.5 UniProtKB/TrEMBL
  ENST00000491027.6 UniProtKB/TrEMBL
  ENST00000679643.1 UniProtKB/TrEMBL
  ENST00000679873.1 UniProtKB/TrEMBL
  ENST00000679951.1 UniProtKB/TrEMBL
  ENST00000680077.1 UniProtKB/TrEMBL
  ENST00000680129.1 UniProtKB/TrEMBL
  ENST00000680152.1 UniProtKB/TrEMBL
  ENST00000680468.1 UniProtKB/TrEMBL
  ENST00000680584.1 UniProtKB/TrEMBL
  ENST00000680675.1 UniProtKB/TrEMBL
  ENST00000680708.1 UniProtKB/TrEMBL
  ENST00000680786.1 UniProtKB/TrEMBL
  ENST00000680823.1 UniProtKB/TrEMBL
  ENST00000680864.1 UniProtKB/TrEMBL
  ENST00000680991.1 UniProtKB/TrEMBL
  ENST00000681223.1 UniProtKB/TrEMBL
  ENST00000681255.1 UniProtKB/Swiss-Prot
  ENST00000681391 ENTREZGENE
  ENST00000681391.1 UniProtKB/TrEMBL
  ENST00000681456.1 UniProtKB/TrEMBL
  ENST00000681491.1 UniProtKB/Swiss-Prot
  ENST00000681494.1 UniProtKB/TrEMBL
  ENST00000681550.1 UniProtKB/TrEMBL
  ENST00000681653.1 UniProtKB/TrEMBL
  ENST00000681878.1 UniProtKB/TrEMBL
  ENST00000681936.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000105835 GTEx
HGNC ID HGNC:30092 ENTREZGENE
Human Proteome Map NAMPT Human Proteome Map
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF5598 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  N/Namide_PRibTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinamide_PRibTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinate_pribotase-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 10135 ENTREZGENE
OMIM 608764 OMIM
PANTHER PTHR43816 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF5598 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAPRTase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NAMPT RGD, PharmGKB
PIRSF NMPRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R718 ENTREZGENE, UniProtKB/TrEMBL
  A0A0C4DFS8_HUMAN UniProtKB/TrEMBL
  A0A7P0T862_HUMAN UniProtKB/TrEMBL
  A0A7P0T895_HUMAN UniProtKB/TrEMBL
  A0A7P0T8D2_HUMAN UniProtKB/TrEMBL
  A0A7P0T8L3_HUMAN UniProtKB/TrEMBL
  A0A7P0T8R4_HUMAN UniProtKB/TrEMBL
  A0A7P0T8Z3_HUMAN UniProtKB/TrEMBL
  A0A7P0T931_HUMAN UniProtKB/TrEMBL
  A0A7P0T941_HUMAN UniProtKB/TrEMBL
  A0A7P0T973_HUMAN UniProtKB/TrEMBL
  A0A7P0T9F0_HUMAN UniProtKB/TrEMBL
  A0A7P0T9I9_HUMAN UniProtKB/TrEMBL
  A0A7P0TA73_HUMAN UniProtKB/TrEMBL
  A0A7P0TAI8_HUMAN UniProtKB/TrEMBL
  A0A7P0TAS5_HUMAN UniProtKB/TrEMBL
  A0A7P0TAZ2_HUMAN UniProtKB/TrEMBL
  A0A7P0TB17_HUMAN UniProtKB/TrEMBL
  A0A7P0TBB7_HUMAN UniProtKB/TrEMBL
  A0A7P0Z437_HUMAN UniProtKB/TrEMBL
  A0A7P0Z466_HUMAN UniProtKB/TrEMBL
  A0A7P0Z4L4_HUMAN UniProtKB/TrEMBL
  A0A7P0Z4N0_HUMAN UniProtKB/TrEMBL
  B7Z8W6_HUMAN UniProtKB/TrEMBL
  C9JF35_HUMAN UniProtKB/TrEMBL
  C9JG65_HUMAN UniProtKB/TrEMBL
  NAMPT_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q8WW95 ENTREZGENE
UniProt Secondary A4D0Q9 UniProtKB/Swiss-Prot
  A4D0R0 UniProtKB/Swiss-Prot
  Q3KQV0 UniProtKB/Swiss-Prot
  Q8WW95 UniProtKB/Swiss-Prot