Nampt (nicotinamide phosphoribosyltransferase) - Rat Genome Database

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Gene: Nampt (nicotinamide phosphoribosyltransferase) Mus musculus
Analyze
Symbol: Nampt
Name: nicotinamide phosphoribosyltransferase
RGD ID: 1332214
MGI Page MGI
Description: Enables identical protein binding activity and nicotinamide phosphoribosyltransferase activity. Involved in circadian regulation of gene expression. Acts upstream of or within NAD biosynthetic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110035O14Rik; AI314458; AI480535; expressed sequence AI480535; NAmPRTase; Pbef; Pbef1; pre-B-cell colony-enhancing factor 1 homolog; Vi; Visfatin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm14841  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,870,334 - 32,903,368 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1232,869,544 - 32,903,348 (+)EnsemblGRCm39 Ensembl
GRCm381232,820,335 - 32,853,369 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1232,819,545 - 32,853,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv371233,505,200 - 33,538,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361233,405,722 - 33,436,855 (+)NCBIMGSCv36mm8
Celera1234,264,778 - 34,297,952 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1213.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methylnicotinamide  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acetic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzofurans  (EXP)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carteolol  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorendic acid  (ISO)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazoxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP)
dichloromethane  (EXP)
dicrotophos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
estriol  (EXP)
ethylbenzene  (ISO)
eugenol  (ISO)
fenofibrate  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
furan  (ISO)
gentamycin  (ISO)
glucose  (ISO)
hydralazine  (ISO)
hydroxyurea  (EXP)
ibuprofen  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
letrozole  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
NAD zwitterion  (EXP,ISO)
NAD(+)  (EXP,ISO)
nefazodone  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nifedipine  (ISO)
nimesulide  (ISO)
NMN zwitterion  (EXP,ISO)
p-anisidine  (EXP)
paclitaxel  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
pentachlorophenol  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
progesterone  (EXP,ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tanespimycin  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
Tolmetin glucuronide  (ISO)
toluene  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
uranium atom  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. NAMPT inhibitor protects ischemic neuronal injury in rat brain via anti-neuroinflammation. Chen CX, etal., Neuroscience. 2017 Jul 25;356:193-206. doi: 10.1016/j.neuroscience.2017.05.022. Epub 2017 May 19.
2. Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension. Chen J, etal., Circulation. 2017 Apr 18;135(16):1532-1546. doi: 10.1161/CIRCULATIONAHA.116.024557. Epub 2017 Feb 15.
3. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. Chen MP, etal., J Clin Endocrinol Metab. 2006 Jan;91(1):295-9. Epub 2005 Oct 18.
4. Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization. Dahl TB, etal., Circulation. 2007 Feb 27;115(8):972-80. Epub 2007 Feb 5.
5. Nampt/PBEF/visfatin exerts neuroprotective effects against ischemia/reperfusion injury via modulation of Bax/Bcl-2 ratio and prevention of caspase-3 activation. Erfani S, etal., J Mol Neurosci. 2015 May;56(1):237-43. doi: 10.1007/s12031-014-0486-1. Epub 2015 Jan 22.
6. Increased plasma levels of visfatin/pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome. Filippatos TD, etal., J Endocrinol Invest. 2007 Apr;30(4):323-6.
7. Leptin, adiponectin, visfatin and retinol-binding protein-4 - mediators of comorbidities in patients with psoriasis? Gerdes S, etal., Exp Dermatol. 2012 Jan;21(1):43-7. doi: 10.1111/j.1600-0625.2011.01402.x.
8. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Houtkooper RH, etal., Endocr Rev. 2010 Apr;31(2):194-223. doi: 10.1210/er.2009-0026. Epub 2009 Dec 9.
9. Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats. Hu Q, etal., Stroke. 2017 Jun;48(6):1655-1664. doi: 10.1161/STROKEAHA.116.015753. Epub 2017 May 11.
10. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
11. Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor. Kitani T, etal., FEBS Lett 2003 Jun 5;544(1-3):74-8.
12. Visfatin: gene expression in isolated adipocytes and sequence analysis in obese WOKW rats compared with lean control rats. Kloting N and Kloting I, Biochem Biophys Res Commun. 2005 Jul 15;332(4):1070-2.
13. Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. Kowalska I, etal., Hum Reprod. 2007 Jul;22(7):1824-9.
14. Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease. Li C, etal., Acta Cir Bras. 2016 Nov;31(11):706-713. doi: 10.1590/S0102-865020160110000001.
15. Periodontitis contributes to aberrant metabolism in type 2 diabetes mellitus rats by stimulating the expression of adipokines. Luo S, etal., J Periodontal Res. 2016 Aug;51(4):453-61. doi: 10.1111/jre.12322. Epub 2015 Oct 12.
16. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. MGD IEA MGD IEA
19. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
20. Protective effect of P7C3 on retinal ganglion cells from optic nerve injury. Oku H, etal., Jpn J Ophthalmol. 2017 Mar;61(2):195-203. doi: 10.1007/s10384-016-0493-6. Epub 2016 Dec 28.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study. Retnakaran R, etal., Clin Endocrinol (Oxf). 2008 Dec;69(6):885-93. Epub 2008 Apr 10.
24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Sleep restriction induced energy, methylation and lipogenesis metabolic switches in rat liver. Sengupta A, etal., Int J Biochem Cell Biol. 2017 Dec;93:129-135. doi: 10.1016/j.biocel.2017.08.014. Epub 2017 Aug 30.
27. The renoprotective effect of curcumin in cisplatin-induced nephrotoxicity. Ugur S, etal., Ren Fail. 2015 Mar;37(2):332-6. doi: 10.3109/0886022X.2014.986005. Epub 2015 Jan 16.
28. Serum concentration of visfatin in obese women. Zahorska-Markiewicz B, etal., Metabolism. 2007 Aug;56(8):1131-4.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12555668   PMID:14610273   PMID:14681479   PMID:15381699  
PMID:15489334   PMID:15840001   PMID:15899942   PMID:16141072   PMID:16141073   PMID:16783373   PMID:16783377   PMID:16970912   PMID:17237424   PMID:17418807   PMID:17543285   PMID:17889652  
PMID:17967808   PMID:17983582   PMID:18287559   PMID:18477450   PMID:18658108   PMID:18799693   PMID:18802071   PMID:18945671   PMID:18952695   PMID:19026557   PMID:19286518   PMID:19299583  
PMID:19334288   PMID:19500503   PMID:19501082   PMID:19661458   PMID:19855187   PMID:19898975   PMID:19936064   PMID:20004694   PMID:20485294   PMID:20724478   PMID:21106760   PMID:21267068  
PMID:21278135   PMID:21388966   PMID:21677750   PMID:21812028   PMID:21871178   PMID:21873635   PMID:22137121   PMID:22399297   PMID:22425197   PMID:22452634   PMID:22542568   PMID:23203961  
PMID:23313810   PMID:23499548   PMID:23537654   PMID:23670349   PMID:23834033   PMID:23869429   PMID:23936124   PMID:23946398   PMID:23970286   PMID:24194600   PMID:24196571   PMID:24278099  
PMID:24429804   PMID:24479481   PMID:24554513   PMID:24588101   PMID:24760840   PMID:24811750   PMID:24821571   PMID:24930994   PMID:25005877   PMID:25168658   PMID:25341895   PMID:25411251  
PMID:25505128   PMID:25921090   PMID:26019302   PMID:26272519   PMID:26332085   PMID:26358657   PMID:26481044   PMID:26536203   PMID:27160897   PMID:27229177   PMID:27498863   PMID:27508874  
PMID:27569277   PMID:27576732   PMID:27626380   PMID:27681422   PMID:27760313   PMID:27855185   PMID:28159473   PMID:28333140   PMID:28356339   PMID:28416276   PMID:28435063   PMID:28854367  
PMID:29178516   PMID:29208611   PMID:29217642   PMID:29309612   PMID:29398136   PMID:29408602   PMID:29452569   PMID:29551635   PMID:29663373   PMID:29669786   PMID:29684358   PMID:29753648  
PMID:29921717   PMID:30060995   PMID:30121947   PMID:30182136   PMID:30223098   PMID:30227242   PMID:30457570   PMID:30537866   PMID:30777853   PMID:30778219   PMID:30794635   PMID:30833708  
PMID:30846716   PMID:30858618   PMID:30943401   PMID:31143985   PMID:31204283   PMID:31289307   PMID:31320478   PMID:31347918   PMID:31385664   PMID:31553812   PMID:31694884   PMID:31717318  
PMID:31791580   PMID:31900990   PMID:31919382   PMID:31942708   PMID:31988240   PMID:32098202   PMID:32290105   PMID:32325033   PMID:32369735   PMID:32533606   PMID:32618342   PMID:32629939  
PMID:32636388   PMID:32987128   PMID:32992122   PMID:33199924   PMID:33535169   PMID:33543238   PMID:33568815   PMID:33788980   PMID:33805532   PMID:33928788   PMID:34119711   PMID:34139379  
PMID:34662475   PMID:34762911   PMID:35012648   PMID:35063804   PMID:35167418   PMID:35218657   PMID:35909566   PMID:36114006   PMID:36146932   PMID:36262545   PMID:36417873   PMID:36441480  
PMID:36539418   PMID:36797299   PMID:36996103   PMID:38187761   PMID:38280463  


Genomics

Comparative Map Data
Nampt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,870,334 - 32,903,368 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1232,869,544 - 32,903,348 (+)EnsemblGRCm39 Ensembl
GRCm381232,820,335 - 32,853,369 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1232,819,545 - 32,853,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv371233,505,200 - 33,538,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361233,405,722 - 33,436,855 (+)NCBIMGSCv36mm8
Celera1234,264,778 - 34,297,952 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1213.74NCBI
NAMPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387106,248,298 - 106,285,888 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7106,248,298 - 106,285,966 (-)EnsemblGRCh38hg38GRCh38
GRCh377105,888,744 - 105,925,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367105,675,967 - 105,712,874 (-)NCBINCBI36Build 36hg18NCBI36
Build 347105,495,899 - 105,519,318NCBI
Celera7100,694,260 - 100,731,169 (-)NCBICelera
Cytogenetic Map7q22.3NCBI
HuRef7100,248,062 - 100,285,253 (-)NCBIHuRef
CHM1_17105,822,212 - 105,859,137 (-)NCBICHM1_1
T2T-CHM13v2.07107,563,712 - 107,602,631 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27105,249,752 - 105,286,646 (-)NCBI
Nampt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8655,152,756 - 55,189,547 (+)NCBIGRCr8
mRatBN7.2649,425,316 - 49,462,109 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl649,424,332 - 49,462,100 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx649,728,050 - 49,763,075 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0650,042,969 - 50,077,994 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0649,480,294 - 49,514,732 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0652,122,085 - 52,156,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl652,122,085 - 52,156,472 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,753,125 - 61,787,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4651,129,160 - 51,166,514 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1651,132,285 - 51,169,639 (+)NCBI
Celera648,619,485 - 48,654,540 (+)NCBICelera
Cytogenetic Map6q16NCBI
Nampt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541010,717,664 - 10,751,177 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541010,717,664 - 10,742,109 (-)NCBIChiLan1.0ChiLan1.0
NAMPT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26143,085,389 - 143,122,843 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17191,355,357 - 191,392,827 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0798,227,071 - 98,262,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17110,952,876 - 110,989,233 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7110,952,876 - 110,981,967 (-)Ensemblpanpan1.1panPan2
NAMPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11814,110,045 - 14,211,268 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1813,993,022 - 14,208,657 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1813,815,825 - 13,860,578 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01814,441,923 - 14,486,695 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1814,441,184 - 14,486,688 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11814,254,107 - 14,298,642 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01814,175,231 - 14,219,981 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01814,455,285 - 14,500,038 (+)NCBIUU_Cfam_GSD_1.0
Nampt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511856,558,385 - 56,593,898 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647917,682,201 - 17,716,661 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647917,682,070 - 17,716,713 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAMPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9106,119,899 - 106,294,586 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19106,119,896 - 106,162,126 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29116,889,082 - 116,932,047 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NAMPT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12175,160,748 - 75,195,781 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2175,158,596 - 75,196,025 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604228,713,073 - 28,750,454 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nampt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473923,411,488 - 23,442,359 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473923,411,478 - 23,444,590 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nampt
1303 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:743
Count of miRNA genes:487
Interacting mature miRNAs:558
Transcripts:ENSMUST00000020886
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12772315841723301Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12805000040049999Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12835244442352581Mouse
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12949100443491112Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
14746972Manh72_mmandible shape 72 (mouse)121061528144615281Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121062064244620809Mouse
13524843Ppiq8_mprepulse inhibition QTL 8 (mouse)121104319450945796Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
4141516slwr_mslowlearner (mouse)Not determined1239247546392614Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
10043977Obq34_mobesity QTL 34 (mouse)Not determined121514733149147331Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
26884413Bzwq9_mbi-zygomatic width QTL 9, 10 week (mouse)121615000147746783Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
15039339Nmrs29_mNAFLD-associated magnetic resonance shift 29 (mouse)121782585251825852Mouse
10043848Hdlq90_mHDL QTL 90 (mouse)Not determined121783993951840081Mouse
1300870Ath18_matherosclerosis 18 (mouse)Not determined121825996652260067Mouse
12904956Edlmmq10_mextensor digitorum longus muscle mass QTL 10 (mouse)121973983353739833Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse

Markers in Region
AI480535  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814108,769,942 - 108,770,060UniSTSGRCm38
GRCm381232,852,986 - 32,853,104UniSTSGRCm38
MGSCv3714109,169,159 - 109,169,277UniSTSGRCm37
MGSCv371233,537,851 - 33,537,969UniSTSGRCm37
Celera14107,319,113 - 107,319,231UniSTS
Celera1234,297,572 - 34,297,690UniSTS
Cytogenetic Map12B1UniSTS
Whitehead/MRC_RH12311.37UniSTS
AI314458  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381232,851,224 - 32,851,348UniSTSGRCm38
MGSCv371233,536,089 - 33,536,213UniSTSGRCm37
Celera1234,295,810 - 34,295,934UniSTS
Cytogenetic Map12B1UniSTS
Whitehead/MRC_RH12311.37UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000020886   ⟹   ENSMUSP00000020886
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1232,870,334 - 32,903,348 (+)Ensembl
GRCm38.p6 Ensembl1232,820,335 - 32,853,349 (+)Ensembl
RefSeq Acc Id: ENSMUST00000218491
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1232,870,800 - 32,885,011 (+)Ensembl
GRCm38.p6 Ensembl1232,820,801 - 32,835,012 (+)Ensembl
RefSeq Acc Id: ENSMUST00000220200   ⟹   ENSMUSP00000152015
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1232,869,544 - 32,889,206 (+)Ensembl
GRCm38.p6 Ensembl1232,819,545 - 32,839,207 (+)Ensembl
RefSeq Acc Id: NM_021524   ⟹   NP_067499
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391232,870,334 - 32,903,368 (+)NCBI
GRCm381232,820,335 - 32,853,369 (+)ENTREZGENE
MGSCv371233,505,200 - 33,538,234 (+)RGD
Celera1234,264,778 - 34,297,952 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_067499   ⟸   NM_021524
- UniProtKB: Q8C3B5 (UniProtKB/Swiss-Prot),   Q9JKM0 (UniProtKB/Swiss-Prot),   Q99KQ4 (UniProtKB/Swiss-Prot),   Q3TLX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000020886   ⟸   ENSMUST00000020886
RefSeq Acc Id: ENSMUSP00000152015   ⟸   ENSMUST00000220200
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99KQ4-F1-model_v2 AlphaFold Q99KQ4 1-491 view protein structure

Promoters
RGD ID:8678108
Promoter ID:EPDNEW_M17085
Type:initiation region
Name:Nampt_2
Description:Mus musculus nicotinamide phosphoribosyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17086  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381232,820,357 - 32,820,417EPDNEW
RGD ID:8678110
Promoter ID:EPDNEW_M17086
Type:initiation region
Name:Nampt_1
Description:Mus musculus nicotinamide phosphoribosyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17085  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381232,820,513 - 32,820,573EPDNEW
RGD ID:6823219
Promoter ID:MM_KWN:11457
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_021524
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361233,504,431 - 33,505,697 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929865 AgrOrtholog
Ensembl Genes ENSMUSG00000020572 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020886 ENTREZGENE
  ENSMUST00000020886.9 UniProtKB/Swiss-Prot
  ENSMUST00000220200.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF5598 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  N/Namide_PRibTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinamide_PRibTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinate_pribotase-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:59027 UniProtKB/Swiss-Prot
MGD MGI:1929865 ENTREZGENE
NCBI Gene 59027 ENTREZGENE
PANTHER NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43816 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF5598 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAPRTase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NAMPT RGD
PhenoGen Nampt PhenoGen
PIRSF NMPRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2P8A9_MOUSE UniProtKB/TrEMBL
  NAMPT_MOUSE UniProtKB/Swiss-Prot
  Q3TLX1 ENTREZGENE, UniProtKB/TrEMBL
  Q8C3B5 ENTREZGENE
  Q99KQ4 ENTREZGENE
  Q9JKM0 ENTREZGENE
UniProt Secondary Q8C3B5 UniProtKB/Swiss-Prot
  Q9JKM0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Nampt  nicotinamide phosphoribosyltransferase  AI480535  expressed sequence AI480535  Data merged from RGD:1609524 737654 PROVISIONAL