Htr2c (5-hydroxytryptamine receptor 2C) - Rat Genome Database
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Gene: Htr2c (5-hydroxytryptamine receptor 2C) Rattus norvegicus
Analyze
Symbol: Htr2c
Name: 5-hydroxytryptamine receptor 2C
RGD ID: 2848
Description: Exhibits G protein-coupled serotonin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; behavioral response to nicotine; and positive regulation of amine transport. Localizes to external side of plasma membrane. Used to study anxiety disorder; major depressive disorder; and substance-related disorder. Human ortholog(s) of this gene implicated in bipolar disorder; obesity; and schizophrenia. Orthologous to human HTR2C (5-hydroxytryptamine receptor 2C); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-bromopropane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5-HT-1C; 5-HT1C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5HT-1C; serotonin 1c receptor; serotonin receptor 2C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X110,640,777 - 110,870,288 (+)NCBI
Rnor_6.0 EnsemblX118,084,890 - 118,318,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X118,084,520 - 118,318,040 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X118,226,113 - 118,460,830 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X31,012,921 - 31,244,127 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X31,069,048 - 31,185,684 (-)NCBI
CeleraX109,958,913 - 110,179,824 (+)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2-dichloroethane  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-chloro-6-(1-piperazinyl)pyrazine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
agomelatine  (ISO)
all-trans-retinoic acid  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
aripiprazole  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP)
calcitriol  (ISO)
carbamazepine  (EXP)
chlorpyrifos  (EXP)
citalopram  (ISO)
clomipramine  (EXP,ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
cyclosporin A  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
dioxygen  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenfluramine  (ISO)
fenvalerate  (EXP)
fluoxetine  (EXP,ISO)
fluphenazine  (ISO)
folic acid  (ISO)
genistein  (EXP)
haloperidol  (EXP)
imidacloprid  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
loxapine  (EXP)
mesulergine  (EXP,ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (EXP)
mianserin  (ISO)
mirtazapine  (ISO)
nefazodone  (ISO)
nitrates  (EXP)
nortriptyline  (ISO)
olanzapine  (ISO)
paroxetine  (ISO)
PCB138  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
risperidone  (ISO)
sarpogrelate  (ISO)
SB 206553  (EXP,ISO)
SB 243213  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
serotonin  (EXP,ISO)
sertraline  (EXP)
testosterone  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trazodone  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
behavioral fear response  (ISO,ISS)
behavioral response to nicotine  (IMP)
cellular calcium ion homeostasis  (ISO)
cGMP-mediated signaling  (ISO)
chemical synaptic transmission  (IBA)
feeding behavior  (IEA,IMP,ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA,TAS)
G protein-coupled serotonin receptor signaling pathway  (IEA,ISO)
inositol phosphate-mediated signaling  (IDA)
locomotory behavior  (IEA)
negative regulation of dopamine metabolic process  (IMP)
negative regulation of locomotion  (IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA)
phospholipase C-activating serotonin receptor signaling pathway  (IDA,ISO)
phospholipase D-activating G protein-coupled receptor signaling pathway  (IMP)
positive regulation of acetylcholine secretion, neurotransmission  (IMP)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gamma-aminobutyric acid secretion  (IMP)
positive regulation of phosphatidylinositol biosynthetic process  (ISO)
positive regulation of vasoconstriction  (IMP)
regulation of appetite  (ISO,ISS)
regulation of corticotropin-releasing hormone secretion  (ISO,ISS)
regulation of nervous system process  (ISO,ISS)
regulation of sensory perception of pain  (IMP)
release of sequestered calcium ion into cytosol  (IBA,ISO)
response to drug  (IBA,IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Berg KA, etal., J Pharmacol Exp Ther. 2006 Oct;319(1):260-8. Epub 2006 Jun 28.
2. Boothman L, etal., Br J Pharmacol. 2006 Dec;149(7):861-9. Epub 2006 Oct 16.
3. Burns CM, etal., Nature 1997 May 15;387(6630):303-8.
4. Calama E, etal., Pharmacology. 2004 Jun;71(2):66-72.
5. Canton H, etal., Mol Pharmacol 1996 Oct;50(4):799-807.
6. Dunlop J, etal., J Pharmacol Exp Ther. 2005 May;313(2):862-9. Epub 2005 Feb 10.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. GOA data from the GO Consortium
9. Gutierrez B, etal., Neurosci Lett 1996 Jul 5;212(1):65-7.
10. Harada K, etal., Eur J Pharmacol. 2006 Dec 28;553(1-3):171-84. Epub 2006 Sep 28.
11. Iwamoto K, etal., Neurosci Res. 2005 Sep;53(1):69-76.
12. Ji SP, etal., Nat Med. 2006 Mar;12(3):324-9. Epub 2006 Feb 12.
13. Julius D, etal., Science 1988 Jul 29;241(4865):558-64.
14. Mackowiak M, etal., J Physiol Pharmacol 2002 Sep;53(3):395-407.
15. Matsuuchi L, etal., Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3404-8.
16. McGrew L, etal., Mol Pharmacol. 2002 Dec;62(6):1339-43.
17. MGD data from the GO Consortium
18. Mosher T, etal., Eur J Pharmacol. 2005 May 16;515(1-3):107-16.
19. Mulder H, etal., Pharmacogenomics J. 2006 Oct 3;.
20. Nair SG and Gudelsky GA, Synapse. 2004 Sep 15;53(4):202-7.
21. Navailles S, etal., J Neurochem. 2006 Nov;99(4):1311-9. Epub 2006 Oct 2.
22. NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Obata H, etal., Eur J Pharmacol. 2007 Mar 30;.
24. Pipeline to import KEGG annotations from KEGG into RGD
25. Pooley EC, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126(1):124-7.
26. Pyroja S, etal., J Neurol Sci. 2007 Mar 15;254(1-2):3-8. Epub 2007 Jan 26.
27. Quarta D, etal., Psychopharmacology (Berl). 2007 May 1;.
28. RGD automated data pipeline
29. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. RGD automated import pipeline for gene-chemical interactions
31. Richards JD, etal., J Biol Chem. 1996 Mar 15;271(11):6458-66.
32. Sodhi MS, etal., Neuroreport 1995 Dec 29;7(1):169-72.
33. Xie J, etal., J Neurochem 2005 Jan;92(2):375-87.
Additional References at PubMed
PMID:7582481   PMID:7700379   PMID:8889548   PMID:12429884   PMID:12682077   PMID:12795815   PMID:12970106   PMID:14499940   PMID:14535948   PMID:14689478   PMID:15193431   PMID:15518545  
PMID:15652696   PMID:15668911   PMID:15831837   PMID:16010984   PMID:16195233   PMID:16343451   PMID:17161544   PMID:17203017   PMID:17288998   PMID:17360519   PMID:17429406   PMID:17451451  
PMID:17467185   PMID:17588622   PMID:17596444   PMID:17617403   PMID:18046307   PMID:18067955   PMID:18363829   PMID:18400210   PMID:18439428   PMID:18442977   PMID:18445227   PMID:18582863  
PMID:18599541   PMID:18604238   PMID:18691333   PMID:18703043   PMID:18977370   PMID:19029064   PMID:19057895   PMID:19133244   PMID:19280877   PMID:19368306   PMID:19494808   PMID:19629447  
PMID:19702657   PMID:19782661   PMID:20447448   PMID:20624416   PMID:20719859   PMID:20850460   PMID:20948451   PMID:20980537   PMID:21048120   PMID:21391883   PMID:21556842   PMID:21687728  
PMID:21835345   PMID:21958863   PMID:22291020   PMID:22512261   PMID:23049953   PMID:23123772   PMID:23201361   PMID:23337537   PMID:23632436   PMID:23864045   PMID:23939424   PMID:24269295  
PMID:24531181   PMID:24618688   PMID:24935789   PMID:25134499   PMID:25141845   PMID:25609374   PMID:25727097   PMID:25770211   PMID:25818050   PMID:26031442   PMID:26120876   PMID:26371055  
PMID:26769798   PMID:26926963   PMID:27252352   PMID:28011743   PMID:28258217   PMID:29555337   PMID:30447306   PMID:30645940   PMID:31706992  


Genomics

Comparative Map Data
Htr2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X110,640,777 - 110,870,288 (+)NCBI
Rnor_6.0 EnsemblX118,084,890 - 118,318,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X118,084,520 - 118,318,040 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X118,226,113 - 118,460,830 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X31,012,921 - 31,244,127 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X31,069,048 - 31,185,684 (-)NCBI
CeleraX109,958,913 - 110,179,824 (+)NCBICelera
Cytogenetic MapXq34NCBI
HTR2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX114,584,078 - 114,910,061 (+)EnsemblGRCh38hg38GRCh38
GRCh38X114,584,086 - 114,910,061 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X113,818,551 - 114,144,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X113,724,807 - 114,050,880 (+)NCBINCBI36hg18NCBI36
Build 34X113,641,530 - 113,967,604NCBI
CeleraX114,253,715 - 114,579,778 (+)NCBI
Cytogenetic MapXq23NCBI
HuRefX103,403,272 - 103,731,741 (+)NCBIHuRef
CHM1_1X113,729,484 - 114,055,500 (+)NCBICHM1_1
Htr2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X145,745,509 - 145,980,273 (+)NCBIGRCm39mm39
GRCm39 EnsemblX145,745,509 - 145,980,273 (+)Ensembl
GRCm38X146,962,464 - 147,197,277 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX146,962,513 - 147,197,277 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X143,397,056 - 143,631,820 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X142,208,881 - 142,443,644 (+)NCBImm8
CeleraX130,902,904 - 131,136,225 (+)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX68.46NCBI
Htr2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955490910,415 - 1,126,373 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955490912,615 - 1,126,347 (-)NCBIChiLan1.0ChiLan1.0
HTR2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X114,169,823 - 114,503,179 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX114,199,485 - 114,503,201 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X103,673,172 - 103,999,133 (+)NCBIMhudiblu_PPA_v0panPan3
HTR2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX87,342,792 - 87,638,579 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X87,342,800 - 87,641,224 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Htr2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364991,002,083 - 1,109,446 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX94,053,456 - 94,313,356 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X94,053,415 - 94,313,352 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X108,811,549 - 108,871,722 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2X108,566,657 - 108,733,261 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR2C
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X102,190,355 - 102,499,928 (+)NCBI
ChlSab1.1 EnsemblX102,325,731 - 102,497,278 (+)Ensembl
Htr2c
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249401,040,744 - 1,299,266 (-)NCBI

Position Markers
DXRat66  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X36,769,460 - 36,769,609NCBIRnor6.0
Rnor_6.0X118,083,215 - 118,083,362NCBIRnor6.0
Rnor_5.0X118,224,438 - 118,224,585UniSTSRnor5.0
RGSC_v3.4X31,245,654 - 31,245,802RGDRGSC3.4
RGSC_v3.4X31,245,655 - 31,245,802UniSTSRGSC3.4
RGSC_v3.1X31,299,123 - 31,299,271RGD
CeleraX109,957,262 - 109,957,405UniSTS
SHRSP x BN MapX31.99UniSTS
SHRSP x BN MapX31.99RGD
Cytogenetic MapXq34-q35.1UniSTS
RH94622  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X118,315,386 - 118,315,498NCBIRnor6.0
Rnor_5.0X118,458,176 - 118,458,288UniSTSRnor5.0
RGSC_v3.4X31,015,463 - 31,015,575UniSTSRGSC3.4
CeleraX110,177,170 - 110,177,282UniSTS
Cytogenetic MapXq34-q35.1UniSTS
BF399131  
Rat AssemblyChrPosition (strand)SourceJBrowse
CeleraX109,963,331 - 109,963,482UniSTS
Cytogenetic MapXq34-q35.1UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX44557974120045269Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X70352120127888215Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X82930791127930791Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X101333032146333032Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX107886746152409805Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X110957467155957467Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X110957467155957467Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:555
Count of miRNA genes:281
Interacting mature miRNAs:353
Transcripts:ENSRNOT00000065293
Prediction methods:Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 48
Low 20 6 4 6
Below cutoff 4 7 4 1 4 4 4 4 8 27 5 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000065293   ⟹   ENSRNOP00000060345
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX118,084,890 - 118,318,039 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090922   ⟹   ENSRNOP00000070471
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX118,197,217 - 118,315,381 (+)Ensembl
RefSeq Acc Id: NM_012765   ⟹   NP_036897
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X110,641,153 - 110,870,288 (+)NCBI
Rnor_6.0X118,084,890 - 118,318,040 (+)NCBI
Rnor_5.0X118,226,113 - 118,460,830 (+)NCBI
RGSC_v3.4X31,012,921 - 31,244,127 (-)RGD
CeleraX109,958,913 - 110,179,824 (+)RGD
Sequence:
RefSeq Acc Id: XM_017601920   ⟹   XP_017457409
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X118,084,520 - 118,318,040 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099497   ⟹   XP_038955425
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X110,640,777 - 110,870,288 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036897   ⟸   NM_012765
- UniProtKB: P08909 (UniProtKB/Swiss-Prot),   Q62842 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457409   ⟸   XM_017601920
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000060345   ⟸   ENSRNOT00000065293
RefSeq Acc Id: ENSRNOP00000070471   ⟸   ENSRNOT00000090922
RefSeq Acc Id: XP_038955425   ⟸   XM_039099497
- Peptide Label: isoform X1
Protein Domains
G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701971
Promoter ID:EPDNEW_R12494
Type:initiation region
Name:Htr2c_1
Description:5-hydroxytryptamine receptor 2C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X118,084,952 - 118,085,012EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2848 AgrOrtholog
Ensembl Genes ENSRNOG00000030877 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000060345 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000070471 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065293 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000090922 UniProtKB/TrEMBL
InterPro 5HT2C_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HT_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25187 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25187 ENTREZGENE
PANTHER PTHR24247:SF32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HTR2C RGD
PhenoGen Htr2c PhenoGen
PRINTS 5HT2CRECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HTRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 5HT2C_RAT UniProtKB/Swiss-Prot
  A0A0G2JY06_RAT UniProtKB/TrEMBL
  F1LPS1_RAT UniProtKB/TrEMBL
  P08909 ENTREZGENE
  Q62842 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr2c  5-hydroxytryptamine receptor 2C  Htr2c  5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr2c  5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled  Htr2c  5-hydroxytryptamine (serotonin) receptor 2C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Htr2c  5-hydroxytryptamine (serotonin) receptor 2C      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in choroid plexus, striatum, hippocampus, hypothalamus, olfactory tubercles, and spinal cord 729200
gene_pathway activates the cyclooxygenase metabolic pathway in the parietal cortex 729238