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Gene: Jak2 (Janus kinase 2) Rattus norvegicus
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Symbol: Jak2
Name: Janus kinase 2
Description: Exhibits several functions, including insulin receptor substrate binding activity; protein C-terminus binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of nitrogen compound metabolic process; and regulation of apoptotic process. Localizes to several cellular components, including the cytosol; glutamatergic synapse; and nuclear matrix. Used to study several diseases, including hyperuricemia; nonalcoholic fatty liver disease; primary biliary cirrhosis; retinal detachment; and transient cerebral ischemia. Biomarker of heart disease and obesity. Human ortholog(s) of this gene implicated in several diseases, including Budd-Chiari syndrome; ankylosing spondylitis; familial erythrocytosis 1; hematologic cancer (multiple); and inflammatory bowel disease (multiple). Orthologous to human JAK2 (Janus kinase 2); PARTICIPATES IN aldosterone signaling pathway; angiotensin II signaling pathway; angiotensin II signaling pathway via AT1 receptor; INTERACTS WITH (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid; (R)-mevalonic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: JAK-2; Janus kinase 2 (a protein tyrosine kinase); tyrosine-protein kinase JAK2
Orthologs:
Homo sapiens (human) : JAK2 (Janus kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Jak2 (Janus kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jak2 (Janus kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : JAK2 (Janus kinase 2)
Canis lupus familiaris (dog) : JAK2 (Janus kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jak2 (Janus kinase 2)
Sus scrofa (pig) : JAK2 (Janus kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01247,398,667 - 247,457,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01254,646,160 - 254,706,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,915,995 - 232,974,763 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11233,080,017 - 233,138,786 (+)NCBI
Celera1224,147,256 - 224,206,104 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Jak2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2939
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.