Jak2 (Janus kinase 2) - Rat Genome Database

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Gene: Jak2 (Janus kinase 2) Rattus norvegicus
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Symbol: Jak2
Name: Janus kinase 2
RGD ID: 2939
Description: Enables several functions, including insulin receptor substrate binding activity; protein C-terminus binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of protein transport; and regulation of apoptotic process. Located in several cellular components, including euchromatin; glutamatergic synapse; and nucleolus. Used to study several diseases, including hyperuricemia; liver disease (multiple); non-alcoholic fatty liver disease; retinal detachment; and thrombocytosis. Biomarker of gastrointestinal system cancer (multiple); heart disease; liver cirrhosis; and obesity. Human ortholog(s) of this gene implicated in several diseases, including familial erythrocytosis 1; gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); and inflammatory bowel disease (multiple). Orthologous to human JAK2 (Janus kinase 2); PARTICIPATES IN aldosterone signaling pathway; angiotensin II signaling pathway; angiotensin II signaling pathway via AT1 receptor; INTERACTS WITH (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid; (R)-mevalonic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: JAK-2; Janus kinase 2 (a protein tyrosine kinase); tyrosine-protein kinase JAK2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21226,995,334 - 227,054,381 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1247,398,598 - 247,458,509 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01247,398,667 - 247,457,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01254,646,160 - 254,706,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,915,995 - 232,974,763 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11233,080,017 - 233,138,786 (+)NCBI
Celera1224,147,256 - 224,206,104 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lymphoblastic Leukemia, with Lymphomatous Features  (ISO)
acute myeloid leukemia  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
ankylosing spondylitis  (ISO)
bacterial gastritis  (ISO)
Brain Injuries  (IMP)
Budd-Chiari syndrome  (ISO)
Cachexia  (ISO)
calcinosis  (ISO)
Cancer Pain  (IEP)
chronic myeloid leukemia  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (IEP)
colorectal carcinoma  (IEP)
COVID-19  (ISO)
Crohn's disease  (ISO)
Diabetic Nephropathies  (IDA)
esophageal carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
essential thrombocythemia  (ISO)
Experimental Arthritis  (IDA,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
familial erythrocytosis 1  (ISO)
familial erythrocytosis 2  (ISO)
fatty liver disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glucose intolerance  (ISO)
Growth Disorders  (IEP)
heart disease  (IEP)
heart valve disease  (ISO)
hepatocellular carcinoma  (IEP,ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hyperalgesia  (IMP,ISO)
hyperuricemia  (IDA)
Inflammation  (ISO)
Intestinal Reperfusion Injury  (IMP)
leukemia  (ISO)
limited scleroderma  (ISO)
liver cancer  (IEP,IMP)
liver cirrhosis  (IEP)
Liver Injury  (IDA)
Liver Reperfusion Injury  (IDA)
lung adenocarcinoma  (ISO)
lung carcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
mesenteric vascular occlusion  (ISO)
myelofibrosis  (ISO)
myeloid neoplasm  (ISO)
myeloproliferative neoplasm  (ISS)
myocardial infarction  (IMP)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IMP)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
Niemann-Pick disease type C1  (ISO)
non-alcoholic fatty liver disease  (IDA,ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (IEP,ISO)
polycythemia  (ISO)
polycythemia vera  (ISO)
portal hypertension  (IMP)
Pregnancy Complications  (ISO)
primary biliary cholangitis  (IMP)
primary ovarian insufficiency  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (IDA)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Sepsis  (IDA)
Sepsis-Associated Encephalopathy  (IDA)
Spinal Cord Injuries  (IMP)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
stomach cancer  (ISO)
Stroke  (IMP)
systemic lupus erythematosus  (ISO)
Thrombocythemia 3  (ISO)
thrombocytosis  (IAGP,ISO)
Thromboembolism  (ISO)
thrombosis  (IAGP)
transient cerebral ischemia  (IDA)
ulcerative colitis  (ISO)
Uterine Cervical Neoplasms  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(R)-mevalonic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
actinomycin D  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
all-trans-retinol  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
angiotensin II  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
auranofin  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chelerythrine  (EXP)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clomiphene  (ISO)
clothianidin  (ISO)
clozapine  (EXP)
cocaine  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
crocin-1  (ISO)
cucurbitacin I  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
erlotinib hydrochloride  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fraxetin  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
Goe 6976  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hesperetin  (EXP)
hexadecanoic acid  (ISO)
hexestrol  (ISO)
hispidulin  (ISO)
hydrogen peroxide  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP)
linagliptin  (ISO)
lipopolysaccharide  (ISO)
losartan  (ISO)
LY294002  (ISO)
melittin  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
mestranol  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
Methylthiouracil  (ISO)
mitoxantrone  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
oleic acid  (ISO)
ozone  (ISO)
pantoprazole  (ISO)
paracetamol  (ISO)
paroxetine  (ISO)
PD123319  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylpropanolamine  (EXP)
PhIP  (ISO)
phosphatidic acid  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
ponatinib  (ISO)
Ponicidin  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propofol  (ISO)
pterostilbene  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
Rhynchophylline  (EXP)
rotenone  (ISO)
rutin  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S3I-201  (ISO)
Salinomycin  (ISO)
selumetinib  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
Sinomenine  (EXP)
sodium arsenite  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (EXP)
stattic  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
theobromine  (EXP)
Tiron  (ISO)
tofacitinib  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tyrphostin B42  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
verteporfin  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
activation of Janus kinase activity  (ISO,ISS)
adaptive immune response  (IEA)
axon regeneration  (IMP)
cell differentiation  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to interleukin-3  (ISO)
cellular response to lipopolysaccharide  (ISO)
collagen-activated signaling pathway  (IEA,ISO)
cytokine-mediated signaling pathway  (IBA,ISO,ISS)
enzyme linked receptor protein signaling pathway  (ISO)
erythrocyte differentiation  (IBA,ISO,ISS)
extrinsic apoptotic signaling pathway  (ISO)
G protein-coupled receptor signaling pathway  (IMP)
growth hormone receptor signaling pathway  (ISO)
growth hormone receptor signaling pathway via JAK-STAT  (IDA,ISO,ISS)
histone H3-Y41 phosphorylation  (IBA,ISO,ISS)
hormone-mediated signaling pathway  (IDA)
interferon-gamma-mediated signaling pathway  (IDA)
interleukin-12-mediated signaling pathway  (ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IMP)
mammary gland epithelium development  (ISO)
microglial cell activation  (ISO)
mineralocorticoid receptor signaling pathway  (IMP)
modulation of chemical synaptic transmission  (IDA,IMP)
myeloid cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell death  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell-cell adhesion  (IMP)
negative regulation of DNA binding  (ISO)
negative regulation of heart contraction  (IMP)
negative regulation of neuron apoptotic process  (IMP)
peptidyl-tyrosine phosphorylation  (ISO)
platelet-derived growth factor receptor signaling pathway  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell activation  (IMP)
positive regulation of cell differentiation  (IMP)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of DNA binding  (IMP)
positive regulation of DNA-binding transcription factor activity  (IMP)
positive regulation of epithelial cell apoptotic process  (IMP)
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  (IMP)
positive regulation of growth hormone receptor signaling pathway  (ISO)
positive regulation of inflammatory response  (IMP)
positive regulation of insulin secretion  (IMP)
positive regulation of interleukin-1 beta production  (IMP,ISO)
positive regulation of MAPK cascade  (IMP)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of nitric-oxide synthase biosynthetic process  (IDA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of phosphoprotein phosphatase activity  (IMP)
positive regulation of platelet activation  (IEA,ISO)
positive regulation of platelet aggregation  (IEA,ISO)
positive regulation of protein import into nucleus  (IMP)
positive regulation of signaling receptor activity  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO,ISS)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
post-embryonic hemopoiesis  (ISO)
postsynapse to nucleus signaling pathway  (EXP,IDA)
programmed cell death induced by symbiont  (ISO)
protein autophosphorylation  (IMP,ISO,ISS)
receptor signaling pathway via JAK-STAT  (IDA,ISO)
regulation of apoptotic process  (IBA)
regulation of inflammatory response  (ISO)
regulation of nitric oxide biosynthetic process  (IGI)
response to amine  (IEP)
response to antibiotic  (ISO)
response to hydroperoxide  (IMP)
response to interleukin-12  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (IEP)
response to oxidative stress  (IMP)
response to tumor necrosis factor  (ISO)
signal transduction  (ISO,ISS)
tumor necrosis factor-mediated signaling pathway  (ISO)
tyrosine phosphorylation of STAT protein  (IBA,IMP,ISO)

Cellular Component
caveola  (ISO)
cytoplasm  (IDA,ISO)
cytoskeleton  (IEA)
cytosol  (IDA,TAS)
endomembrane system  (IEA)
euchromatin  (IDA)
focal adhesion  (IEA,ISO)
glutamatergic synapse  (EXP,IDA,IMP)
membrane raft  (ISO)
nucleolus  (IDA)
nucleoplasm  (IEA,ISO)
nucleus  (ISO,ISS)
plasma membrane  (ISO)
postsynapse  (IDA)

References

References - curated
1. Alblas J, etal., Mol Cell Biol. 2005 Aug;25(16):7181-92. doi: 10.1128/MCB.25.16.7181-7192.2005.
2. Ali MS, etal., J Biol Chem. 1997 Sep 12;272(37):23382-8.
3. Arena S, etal., Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4.
4. Baeyens L, etal., Cell Death Differ. 2006 Nov;13(11):1892-9. Epub 2006 Mar 3.
5. Baxter EJ, etal., Lancet. 2005 Mar 19-25;365(9464):1054-61.
6. Byun HJ, etal., Oncol Rep. 2017 Jun;37(6):3270-3278. doi: 10.3892/or.2017.5588. Epub 2017 Apr 19.
7. Chen C, etal., Clin Immunol. 2010 Sep;136(3):442-6. Epub 2010 Jun 2.
8. Chen SP, etal., Mol Pain. 2018 Jan-Dec;14:1744806918793232. doi: 10.1177/1744806918793232. Epub 2018 Jul 20.
9. Cheng JZ, etal., Cancer Cell Int. 2018 Aug 13;18:110. doi: 10.1186/s12935-018-0605-0. eCollection 2018.
10. Chiba T, etal., Mol Psychiatry. 2009 Feb;14(2):206-22. doi: 10.1038/mp.2008.105. Epub 2008 Sep 23.
11. Colaizzo D, etal., J Thromb Haemost. 2007 Jan;5(1):55-61. Epub 2006 Oct 20.
12. Corbit KC, etal., JCI Insight. 2019 Aug 8;5. pii: 131310. doi: 10.1172/jci.insight.131310.
13. Dell'Albani P, etal., J Neurosci Res. 2001 Sep 1;65(5):417-24.
14. Dominguez E, etal., J Neurochem. 2008 Oct;107(1):50-60. Epub 2008 Jul 12.
15. Du W, etal., J Cell Mol Med. 2012 Aug;16(8):1878-88. doi: 10.1111/j.1582-4934.2011.01483.x.
16. Duan C, etal., J Biol Chem. 2004 Oct 15;279(42):43684-91. Epub 2004 Aug 16.
17. Duhe RJ, etal., Gene 1995 Jun 9;158(2):281-5.
18. Ferrand A, etal., Exp Cell Res. 2004 Dec 10;301(2):128-38.
19. Frank GD, etal., Mol Endocrinol 2002 Feb;16(2):367-77.
20. Freitas MC, etal., Liver Transpl. 2010 May;16(5):600-10.
21. Gao SP, etal., Sci Signal. 2016 Mar 29;9(421):ra33. doi: 10.1126/scisignal.aac8460.
22. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
23. Gerland K, etal., Mol Cell Endocrinol. 2000 Oct 25;168(1-2):1-9.
24. GOA data from the GO Consortium
25. Gomez-Ambrosi J, etal., FASEB J. 2004 Jan;18(1):215-7. Epub 2003 Nov 20.
26. Gorina R, etal., J Neurochem. 2005 Feb;92(3):505-18.
27. Granzow M, etal., Hepatology. 2014 Jul;60(1):334-48. doi: 10.1002/hep.27117. Epub 2014 May 6.
28. Guo D, etal., Oncotarget. 2017 Jun 13;8(24):39640-39648. doi: 10.18632/oncotarget.17387.
29. Ha JS, etal., Ann Lab Med. 2012 Nov;32(6):385-91. doi: 10.3343/alm.2012.32.6.385. Epub 2012 Oct 17.
30. Hellgren G, etal., Growth Horm IGF Res. 1999 Jun;9(3):212-8.
31. Hellgren G, etal., J Interferon Cytokine Res. 2001 Feb;21(2):75-83.
32. Hou J, etal., Hepatology. 2013 Feb;57(2):678-88. doi: 10.1002/hep.25980. Epub 2012 Oct 30.
33. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
34. Hua Y, etal., Drug Des Devel Ther. 2020 Feb 24;14:745-755. doi: 10.2147/DDDT.S203048. eCollection 2020.
35. James C, etal., Nature. 2005 Apr 28;434(7037):1144-8.
36. Ji Y, etal., Cell Physiol Biochem. 2012;29(5-6):863-74. doi: 10.1159/000171034. Epub 2012 May 11.
37. Jia Y, etal., PLoS One. 2011;6(10):e27006. Epub 2011 Oct 31.
38. Jin J, etal., Pathol Oncol Res. 2019 Apr;25(2):769-775. doi: 10.1007/s12253-019-00592-6. Epub 2019 Jan 31.
39. Johansen T, etal., Growth Horm IGF Res. 2005 Feb;15(1):55-63. Epub 2005 Jan 22.
40. Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
41. Kang JW and Lee SM, J Pineal Res. 2012 Aug;53(1):67-76. doi: 10.1111/j.1600-079X.2012.00972.x. Epub 2012 Jan 31.
42. KEGG
43. Kirabo A, etal., Am J Pathol. 2012 Sep;181(3):858-65. doi: 10.1016/j.ajpath.2012.05.033. Epub 2012 Jul 13.
44. Klein S, etal., Gut. 2017 Jan;66(1):145-155. doi: 10.1136/gutjnl-2015-309600. Epub 2015 Sep 17.
45. Kondegowda NG, etal., Diabetologia. 2012 Jun;55(6):1721-32. doi: 10.1007/s00125-012-2501-9. Epub 2012 Mar 3.
46. Kou ZZ, etal., Pain Physician. 2013 Mar-Apr;16(2):E71-83.
47. Kralovics R, etal., N Engl J Med. 2005 Apr 28;352(17):1779-90.
48. Kurdi M and Booz GW, J Cell Physiol. 2007 Aug;212(2):424-31.
49. Kurosaka M and Machida S, Cell Prolif. 2013 Aug;46(4):365-73. doi: 10.1111/cpr.12045.
50. Lee S and Duhe RJ, J Biomed Sci. 2006 Nov;13(6):773-86. Epub 2006 Sep 14.
51. Li R, etal., Am J Nephrol. 2007;27(6):580-9. Epub 2007 Sep 6.
52. Li R, etal., Int Immunopharmacol. 2012 Oct;14(2):157-63. doi: 10.1016/j.intimp.2012.07.001. Epub 2012 Jul 15.
53. Liang B and Dong T, Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Mar 28;45(3):290-296. doi: 10.11817/j.issn.1672-7347.2020.180704.
54. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
55. Liang L, etal., J Exp Clin Cancer Res. 2019 Feb 12;38(1):71. doi: 10.1186/s13046-019-1093-3.
56. Lima Nda S, etal., Eur J Nutr. 2014 Feb;53(1):73-82. doi: 10.1007/s00394-013-0500-3. Epub 2013 Feb 9.
57. Liu JR, etal., Pathol Res Pract. 2015 Jun;211(6):426-34. doi: 10.1016/j.prp.2015.01.007. Epub 2015 Jan 24.
58. Liu K, etal., Cancer Sci. 2018 May;109(5):1369-1381. doi: 10.1111/cas.13575. Epub 2018 Apr 17.
59. Liu YF, etal., Int J Mol Sci. 2015 Jan 12;16(1):1576-89. doi: 10.3390/ijms16011576.
60. Lobie PE, etal., Endocrinology. 1996 Sep;137(9):4037-45.
61. Lu LD, etal., J Immunol. 2011 Oct 1;187(7):3840-53. Epub 2011 Aug 31.
62. Maegawa H, etal., Biochem Biophys Res Commun. 1996 Nov 1;228(1):122-7.
63. Marty C, etal., Blood. 2014 Feb 27;123(9):1372-83. doi: 10.1182/blood-2013-05-504555. Epub 2014 Jan 7.
64. Masamune A, etal., World J Gastroenterol. 2005 Jun 14;11(22):3385-91.
65. Mascareno E, etal., Vascul Pharmacol. 2005 Nov;43(5):327-35. Epub 2005 Nov 2.
66. Mathur A, etal., Biochem Pharmacol. 2009 Aug 15;78(4):382-9. doi: 10.1016/j.bcp.2009.04.025. Epub 2009 May 3.
67. MGD data from the GO Consortium
68. Miao L, etal., Cancer Immunol Immunother. 2014 Jul;63(7):699-711. doi: 10.1007/s00262-014-1550-y. Epub 2014 Apr 10.
69. Morales O, etal., J Biol Chem 2002 Sep 20;277(38):34879-84.
70. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
71. Na YJ, etal., J Neurochem. 2007 Oct;103(2):637-49.
72. NCBI rat LocusLink and RefSeq merged data July 26, 2002
73. Neeli I, etal., J Biol Chem. 2004 Oct 29;279(44):46122-8. Epub 2004 Aug 22.
74. Neubauer H, etal., Cell 1998 May 1;93(3):397-409.
75. Nicolas CS, etal., Neuron. 2012 Jan 26;73(2):374-90. doi: 10.1016/j.neuron.2011.11.024.
76. OMIM Disease Annotation Pipeline
77. Pan J, etal., Circ Res. 1997 Oct;81(4):611-7.
78. Parganas E, etal., Cell 1998 May 1;93(3):385-95.
79. Park EJ, etal., J Biol Chem 2003 Apr 25;278(17):14747-52. Epub 2003 Feb 12.
80. Peeters P, etal., Blood. 1997 Oct 1;90(7):2535-40.
81. Pendergrass SA, etal., PLoS One. 2010 Aug 17;5(8):e12106.
82. Pipeline to import KEGG annotations from KEGG into RGD
83. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
84. Polgar N, etal., Int J Immunogenet. 2012 Jan 23. doi: 10.1111/j.1744-313X.2012.01084.x.
85. Qiu J, etal., J Neurosci. 2005 Feb 16;25(7):1645-53.
86. Rai A, etal., Pharmacol Res. 2018 Jun;132:188-203. doi: 10.1016/j.phrs.2017.12.010. Epub 2017 Dec 8.
87. Rane SG and Reddy EP, Oncogene 2002 May 13;21(21):3334-58.
88. Ren DY, etal., Am J Chin Med. 2013;41(3):601-14. doi: 10.1142/S0192415X13500420.
89. Ren S, etal., Int J Biochem Cell Biol. 2020 Aug;125:105777. doi: 10.1016/j.biocel.2020.105777. Epub 2020 Jun 3.
90. RGD automated data pipeline
91. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
92. RGD automated import pipeline for gene-chemical interactions
93. Russell RC, etal., Nat Med. 2011 Jun 19;17(7):845-53. doi: 10.1038/nm.2370.
94. Seo Y, etal., Cell Transplant. 2011;20(7):1033-47. doi: 10.3727/096368910X545086. Epub 2010 Dec 22.
95. Shaw S, etal., J Biol Chem 2002 Nov 22;277(47):44920-4.
96. Shi SY, etal., Diabetologia. 2016 Jan;59(1):187-96. doi: 10.1007/s00125-015-3786-2. Epub 2015 Oct 29.
97. Shi SY, etal., J Biol Chem. 2012 Mar 23;287(13):10277-88. Epub 2012 Jan 24.
98. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
99. Shojaei-Zarghani S, etal., Biomed Pharmacother. 2021 Feb;134:111140. doi: 10.1016/j.biopha.2020.111140. Epub 2020 Dec 24.
100. Shyu WC, etal., J Clin Invest. 2008 Jan;118(1):133-48.
101. Singh AK, etal., Life Sci. 2018 May 15;201:161-172. doi: 10.1016/j.lfs.2018.02.029. Epub 2018 Feb 24.
102. Song Y, etal., Neurochem Res. 2013 Mar;38(3):610-9. doi: 10.1007/s11064-012-0959-y. Epub 2012 Dec 29.
103. Sonohara F, etal., Oncol Rep. 2015 Feb;33(2):767-73. doi: 10.3892/or.2014.3621. Epub 2014 Nov 25.
104. Stump KL, etal., Arthritis Res Ther. 2011 Apr 21;13(2):R68.
105. Sugiyama T, etal., Endocrinology. 2005 Sep;146(9):3900-6. Epub 2005 Jun 2.
106. Sun Q, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):164-170. doi: 10.1016/j.bbrc.2018.02.009. Epub 2018 Mar 5.
107. Sun Y, etal., J Thorac Oncol. 2011 Apr;6(4):699-706. doi: 10.1097/JTO.0b013e31820d9d11.
108. Thirone AC, etal., Diabetes. 2006 Apr;55(4):942-51.
109. Troib A, etal., Kidney Int. 2013 Nov;84(5):940-9. doi: 10.1038/ki.2013.196. Epub 2013 May 29.
110. Wang G, etal., Int J Biochem Cell Biol. 2008;40(3):461-70. Epub 2007 Aug 30.
111. Wang K, etal., Am J Chin Med. 2012;40(3):521-36.
112. Wang T, etal., Free Radic Biol Med. 2013 Oct;63:291-303. doi: 10.1016/j.freeradbiomed.2013.05.043. Epub 2013 Jun 6.
113. Wang XY, etal., Zhongguo Zhong Yao Za Zhi. 2013 Aug;38(16):2696-700.
114. Watanabe S, etal., Am J Nephrol. 2004 Jul-Aug;24(4):387-92. Epub 2004 Jul 9.
115. Wen SH, etal., Shock. 2012 Oct;38(4):411-9. doi: 10.1097/SHK.0b013e3182662266.
116. Westbrook RH, etal., Liver Transpl. 2012 Jul;18(7):819-27. doi: 10.1002/lt.23443.
117. William AD, etal., J Med Chem. 2012 Mar 22;55(6):2623-40. doi: 10.1021/jm201454n. Epub 2012 Mar 6.
118. Wold LE, etal., Hypertension 2002 Jan;39(1):69-74.
119. Wu L, etal., J Ethnopharmacol. 2013 Dec 12;150(3):960-6. doi: 10.1016/j.jep.2013.09.051. Epub 2013 Oct 24.
120. Wu L, etal., Oncol Rep. 2015 Dec;34(6):3311-7. doi: 10.3892/or.2015.4279. Epub 2015 Sep 16.
121. Wu X, etal., Oncotarget. 2017 Mar 28;8(13):20741-20750. doi: 10.18632/oncotarget.15119.
122. Xie Z, etal., Curr Eye Res. 2012 Feb;37(2):138-44. doi: 10.3109/02713683.2011.647225.
123. Xu Y and Lv SX, Biomed Pharmacother. 2016 Dec;84:1202-1212. doi: 10.1016/j.biopha.2016.09.040. Epub 2016 Oct 24.
124. Yan L, etal., J Surg Res. 2012 Dec;178(2):578-85. doi: 10.1016/j.jss.2012.06.007. Epub 2012 Jun 21.
125. Yang L, etal., PLoS One. 2013 May 24;8(5):e64628. doi: 10.1371/journal.pone.0064628. Print 2013.
126. Yang Y, etal., J Pineal Res. 2013 Oct;55(3):275-86. doi: 10.1111/jpi.12070. Epub 2013 Jun 25.
127. Yeh YT, etal., World J Surg. 2012 May;36(5):1128-35. doi: 10.1007/s00268-012-1505-4.
128. Yu JH, etal., Biochem Pharmacol. 2006 Nov 30;72(11):1555-62. Epub 2006 Aug 24.
129. Yu X, etal., J Biol Chem. 2003 May 2;278(18):16304-9. Epub 2003 Feb 20.
130. Zerjavic K, etal., Thromb Res. 2013 Aug;132(2):e86-93. doi: 10.1016/j.thromres.2013.06.021. Epub 2013 Jul 9.
131. Zhang DM, etal., Food Chem. 2012 Oct 15;134(4):2184-93. doi: 10.1016/j.foodchem.2012.04.026. Epub 2012 Apr 17.
132. Zhang F, etal., Am J Physiol Cell Physiol. 2006 Sep;291(3):C466-75. Epub 2006 Apr 5.
133. Zhang FQ, etal., Oncotarget. 2015 Jun 10;6(16):14329-43. doi: 10.18632/oncotarget.3685.
134. Zhang L, etal., Inflamm Res. 2019 Sep;68(9):751-760. doi: 10.1007/s00011-019-01258-4. Epub 2019 Jun 26.
135. Zhang M, etal., Mol Med Rep. 2013 Apr;7(4):1293-9. doi: 10.3892/mmr.2013.1315. Epub 2013 Feb 8.
136. Zhang Y, etal., Diabetes. 2013 Apr;62(4):1159-66. doi: 10.2337/db12-0670. Epub 2012 Dec 6.
137. Zhao J, etal., PLoS One. 2013;8(3):e58730. doi: 10.1371/journal.pone.0058730. Epub 2013 Mar 14.
138. Zhao JB, etal., Neurosci Lett. 2011 Jul 8;498(2):147-52. Epub 2011 May 10.
139. Zheng PY, etal., Zhong Xi Yi Jie He Xue Bao. 2008 Sep;6(9):921-7.
140. Zhou TF and Yu JG, J Surg Res. 2013 Jul;183(1):304-12. doi: 10.1016/j.jss.2012.11.035. Epub 2012 Dec 6.
141. Zhu H, etal., Eur J Pharmacol. 2013 Aug 15;714(1-3):23-31. doi: 10.1016/j.ejphar.2013.05.043. Epub 2013 Jun 11.
Additional References at PubMed
PMID:7527668   PMID:7528775   PMID:7538110   PMID:7782332   PMID:7961995   PMID:8022486   PMID:8378315   PMID:8400282   PMID:8609418   PMID:8923468   PMID:9111318   PMID:9727029  
PMID:10600756   PMID:10822380   PMID:10872802   PMID:10925297   PMID:11201744   PMID:11489994   PMID:11493922   PMID:11821424   PMID:12040017   PMID:12147240   PMID:12388746   PMID:12426001  
PMID:12538627   PMID:12777386   PMID:12941779   PMID:12960006   PMID:14522994   PMID:14678947   PMID:15012602   PMID:15065871   PMID:15143187   PMID:15156153   PMID:15159394   PMID:15354294  
PMID:15591245   PMID:15746188   PMID:15958724   PMID:16025117   PMID:16280321   PMID:16297319   PMID:17332060   PMID:17496209   PMID:17519522   PMID:17526654   PMID:17565041   PMID:17607690  
PMID:17726028   PMID:17728251   PMID:17761766   PMID:18006272   PMID:18499741   PMID:18582595   PMID:18611343   PMID:18798867   PMID:19063868   PMID:19276765   PMID:19350281   PMID:19435852  
PMID:19625377   PMID:19665053   PMID:19748527   PMID:19781194   PMID:19783980   PMID:19888448   PMID:20122990   PMID:20304997   PMID:20492356   PMID:20530874   PMID:20724918   PMID:20817061  
PMID:20848345   PMID:20976841   PMID:20979831   PMID:21036157   PMID:21470923   PMID:21502705   PMID:21509626   PMID:21536676   PMID:21606371   PMID:21808064   PMID:21813872   PMID:21841788  
PMID:21929289   PMID:22125600   PMID:22466958   PMID:22561747   PMID:22697788   PMID:22820988   PMID:22948409   PMID:23061660   PMID:23449887   PMID:23544085   PMID:24013029   PMID:24018979  
PMID:24463190   PMID:24965138   PMID:25129435   PMID:25380525   PMID:25500624   PMID:25537973   PMID:25559502   PMID:25731682   PMID:25986861   PMID:26227742   PMID:26261556   PMID:26527061  
PMID:26802935   PMID:26884823   PMID:27003918   PMID:27057278   PMID:27301615   PMID:27337676   PMID:27450794   PMID:27573711   PMID:27717845   PMID:28334068   PMID:28385490   PMID:28782583  
PMID:28782829   PMID:29032602   PMID:29061394   PMID:29174854   PMID:29210652   PMID:29550470   PMID:29580751   PMID:30552029   PMID:31264277   PMID:31406138   PMID:31454541   PMID:31545485  
PMID:31564534   PMID:31703282   PMID:31746349   PMID:31841394   PMID:31982878   PMID:32016456   PMID:32647179  


Genomics

Comparative Map Data
Jak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21226,995,334 - 227,054,381 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1247,398,598 - 247,458,509 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01247,398,667 - 247,457,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01254,646,160 - 254,706,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,915,995 - 232,974,763 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11233,080,017 - 233,138,786 (+)NCBI
Celera1224,147,256 - 224,206,104 (+)NCBICelera
Cytogenetic Map1q52NCBI
JAK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl94,984,390 - 5,129,948 (+)EnsemblGRCh38hg38GRCh38
GRCh3894,984,390 - 5,129,948 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3794,984,390 - 5,129,948 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3694,975,245 - 5,117,995 (+)NCBINCBI36hg18NCBI36
Build 3494,975,244 - 5,117,995NCBI
Celera94,910,860 - 5,053,802 (+)NCBI
Cytogenetic Map9p24.1NCBI
HuRef94,940,783 - 5,083,727 (+)NCBIHuRef
CHM1_194,985,470 - 5,128,355 (+)NCBICHM1_1
Jak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,229,006 - 29,290,495 (+)NCBIGRCm39mm39
GRCm39 Ensembl1929,229,228 - 29,290,480 (+)Ensembl
GRCm381929,251,803 - 29,313,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,251,828 - 29,313,080 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,326,318 - 29,387,570 (+)NCBIGRCm37mm9NCBIm37
MGSCv361929,318,452 - 29,377,979 (+)NCBImm8
Celera1930,028,576 - 30,089,642 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.73NCBI
Jak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554349,227,595 - 9,341,208 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554349,227,897 - 9,341,208 (+)NCBIChiLan1.0ChiLan1.0
JAK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.195,006,271 - 5,156,626 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl95,006,271 - 5,156,626 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v094,820,303 - 4,971,867 (+)NCBIMhudiblu_PPA_v0panPan3
JAK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,321,055 - 93,438,898 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl193,142,635 - 93,435,997 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha193,730,062 - 93,844,204 (+)NCBI
ROS_Cfam_1.0193,940,875 - 93,989,640 (+)NCBI
UMICH_Zoey_3.1193,507,891 - 93,622,032 (+)NCBI
UNSW_CanFamBas_1.0193,232,417 - 93,346,624 (+)NCBI
UU_Cfam_GSD_1.0193,996,654 - 94,110,963 (+)NCBI
Jak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947140,931,052 - 141,061,286 (+)NCBI
SpeTri2.0NW_004936503111,722 - 243,627 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,848,686 - 217,002,148 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,849,744 - 217,002,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,696,921 - 242,837,407 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JAK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11274,421,243 - 74,566,766 (-)NCBI
ChlSab1.1 Ensembl1274,421,016 - 74,566,710 (-)Ensembl
Vero_WHO_p1.0NW_02366603862,818,134 - 62,927,470 (-)NCBI
Jak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247369,724,876 - 9,827,364 (+)NCBI

Position Markers
D1Bda61  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21227,053,939 - 227,054,173 (+)MAPPERmRatBN7.2
Rnor_6.01247,457,272 - 247,457,505NCBIRnor6.0
Rnor_5.01254,705,185 - 254,705,418UniSTSRnor5.0
RGSC_v3.41232,974,514 - 232,974,747UniSTSRGSC3.4
Celera1224,205,855 - 224,206,088UniSTS
Cytogenetic Map1q51-q53UniSTS
RH141418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21227,054,207 - 227,054,407 (+)MAPPERmRatBN7.2
Rnor_6.01247,457,540 - 247,457,739NCBIRnor6.0
Rnor_5.01254,705,453 - 254,705,652UniSTSRnor5.0
RGSC_v3.41232,974,782 - 232,974,981UniSTSRGSC3.4
Celera1224,206,123 - 224,206,322UniSTS
Cytogenetic Map1q51-q53UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1233490105264802994Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1236795785281795785Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1245529606282763074Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1236265430281265430Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1215711860260711860Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1236763415258766873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1161321152273792054Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1238830534278228767Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1233663100273792054Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1243272341282763074Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1244401175282365384Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1235850810280850810Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1244992467282365384Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1215828102260828102Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1216324817261324817Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1167394665278228889Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1241482188281795785Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1191825895279986079Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1227107736249206417Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1215711860258765521Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1238824734279986079Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1221901238266901238Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1221901238266901238Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1221901238266901238Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1221901238266901238Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1244401175264636028Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1244401175264636028Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1205195290250195290Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1244401175282365384Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1217054291281795785Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1193968438261264776Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1215828102260828102Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1225689973270689973Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1225689973270689973Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1195598053265002735Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1215684498260684498Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1244087148282763074Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1213476630278978026Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1226706329271706329Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1161321256273791893Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1196395041282763074Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1161321256273791893Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1192639698278228889Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1192639698278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1236795785281795785Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1210360774264802828Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1174905700264802994Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1201358068252480016Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1230420627282645769Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1208517798266948272Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1230420627262031693Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1216324817261324817Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1236265430281265430Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1215828102260828102Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238830408266793958Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1225689973247836969Rat
6480786Bw97Body weight QTL 975.03body mass (VT:0001259)body weight (CMO:0000012)1245529606248013094Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1227509470249252048Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1227509470249252048Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1202571665264802994Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1227509470255131140Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1210652654255652654Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221901238266901238Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1244148899282763074Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1202571665264802994Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1242302911282763074Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1222492538267492538Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210990171255990171Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:88
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000021217
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 31 45 29 19 29 6 6 74 33 36 11 6
Low 12 12 12 12 2 5 2 5 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087011   ⟹   ENSRNOP00000071877
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1247,398,598 - 247,458,509 (+)Ensembl
RefSeq Acc Id: NM_031514   ⟹   NP_113702
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21226,995,334 - 227,054,189 (+)NCBI
Rnor_6.01247,398,667 - 247,457,521 (+)NCBI
Rnor_5.01254,646,160 - 254,706,478 (+)NCBI
RGSC_v3.41232,915,995 - 232,974,763 (+)RGD
Celera1224,147,256 - 224,206,104 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097306   ⟹   XP_038953234
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21227,007,923 - 227,054,381 (+)NCBI
RefSeq Acc Id: XM_039097313   ⟹   XP_038953241
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21227,030,176 - 227,054,381 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_113702   ⟸   NM_031514
- UniProtKB: Q62689 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071877   ⟸   ENSRNOT00000087011
RefSeq Acc Id: XP_038953234   ⟸   XM_039097306
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953241   ⟸   XM_039097313
- Peptide Label: isoform X2
Protein Domains
FERM   Protein kinase   SH2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2939 AgrOrtholog
Ensembl Genes ENSRNOG00000059968 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000071877 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087011 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_F1 UniProtKB/Swiss-Prot
  FERM_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jak1_PHL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JAK2_FERM_C-lobe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JAK2_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  PTK_Jak2_rpt1 UniProtKB/Swiss-Prot
  PTKc_Jak2_rpt2 UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24514 UniProtKB/Swiss-Prot
NCBI Gene 24514 ENTREZGENE
Pfam FERM_F1 UniProtKB/Swiss-Prot
  FERM_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jak1_Phl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB JAK2 RGD
PhenoGen Jak2 PhenoGen
PIRSF TyrPK_Jak UniProtKB/Swiss-Prot
PRINTS JANUSKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JANUSKINASE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt JAK2_RAT UniProtKB/Swiss-Prot
  O35804_RAT UniProtKB/TrEMBL
  Q62689 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Jak2  Janus kinase 2 (a protein tyrosine kinase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two tandem protein kinase related domain 633059
gene_expression mRNA expressed in brain and spleen 633059
gene_homology 93.4% nucleotide and 97.1% amino acid homology with murine Jak2 633059
gene_product member of Janus family; non receptor protein tyrosine kinase 633059