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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2939
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jak2
Name: Janus kinase 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak2increases activityISOJak2 (Mus musculus)6480464CTD[Lipopolysaccharides results in increased activity of JAK2 protein] which results in increased activity of STAT3 protein; Lipopolysaccharides results in increased activity of JAK2 proteinPMID:24486434
Jak2increases phosphorylationISOJak2 (Mus musculus)6480464CTDLipopolysaccharides results in increased phosphorylation of JAK2 proteinPMID:25576658 PMID:29470957 PMID:30053449
Jak2increases phosphorylationISOJAK2 (Homo sapiens)6480464CTDLipopolysaccharides results in increased phosphorylation of JAK2 proteinPMID:37209277
Jak2multiple interactionsISOJak2 (Mus musculus)6480464CTDcirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]; kaempferol 7-O-glucoside inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]PMID:29470957 PMID:30053449
Jak2multiple interactionsISOJAK2 (Homo sapiens)6480464CTDalpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]]PMID:37209277
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