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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2939
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jak2
Name: Janus kinase 2
Acc ID: CHEBI:131968
Term: tyrphostin B42
Definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine.
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak2decreases expressionEXP 18337263RGDTurphostin B42 decreased expression of Jak2 mRNA in myofibroblasts 
Jak2multiple interactionsISOJak2 (Mus musculus)149735351RGDtyrphostin B42 inhibits the reaction [cisplatin increases expression of Jak2 mRNA in kidney] 
Jak2multiple interactionsISOJAK2 (Homo sapiens)127284886RGDtyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of JAK2 protein in stomach] 
Jak2multiple interactionsISOJAK2 (Homo sapiens)127285665RGDtyrphostin B42 decreases expression and phosphorylation of JAK2 protein in colonic epithelium 
Jak2multiple interactionsISOJAK2 (Homo sapiens)127285668RGDtyrphostin B42 inhibits the reaction [selumetinib increases phosphorylation of JAK2 protein in colonic epithelium] 
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