JAK2 (Janus kinase 2) - Rat Genome Database

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Gene: JAK2 (Janus kinase 2) Pan paniscus
Analyze
Symbol: JAK2
Name: Janus kinase 2
RGD ID: 12041863
Description: ENCODES a protein that exhibits acetylcholine receptor binding (ortholog); growth hormone receptor binding (ortholog); insulin receptor substrate binding (ortholog); INVOLVED IN axon regeneration (ortholog); cell differentiation (ortholog); cellular response to dexamethasone stimulus (ortholog); PARTICIPATES IN aldosterone signaling pathway; altered Jak-Stat signaling pathway; angiotensin II signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); euchromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein kinase JAK2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.195,006,271 - 5,156,626 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl95,006,271 - 5,156,626 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v094,820,303 - 4,971,867 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lymphoblastic Leukemia, with Lymphomatous Features  (ISO)
acute myeloid leukemia  (ISO)
adrenocortical carcinoma  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
ankylosing spondylitis  (ISO)
bacterial gastritis  (ISO)
Brain Injuries  (ISO)
Budd-Chiari syndrome  (ISO)
Cachexia  (ISO)
calcinosis  (ISO)
Cancer Pain  (ISO)
chronic myeloid leukemia  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colorectal carcinoma  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
Diabetic Nephropathies  (ISO)
esophageal carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
essential thrombocythemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
familial erythrocytosis 1  (ISO)
familial erythrocytosis 2  (ISO)
fatty liver disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glucose intolerance  (ISO)
Growth Disorders  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hyperalgesia  (ISO)
hyperuricemia  (ISO)
Inflammation  (ISO)
Intestinal Reperfusion Injury  (ISO)
leukemia  (ISO)
limited scleroderma  (ISO)
liver cancer  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung carcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
mesenteric vascular occlusion  (ISO)
myelofibrosis  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
Niemann-Pick disease type C1  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
polycythemia  (ISO)
polycythemia vera  (ISO)
portal hypertension  (ISO)
Pregnancy Complications  (ISO)
primary biliary cholangitis  (ISO)
Primary Ovarian Failure  (ISO)
primary ovarian insufficiency  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Sepsis  (ISO)
Sepsis-Associated Encephalopathy  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
stomach cancer  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
Thrombocythemia 3  (ISO)
thrombocytosis  (ISO)
Thromboembolism  (ISO)
thrombosis  (ISO)
transient cerebral ischemia  (ISO)
ulcerative colitis  (ISO)
Uterine Cervical Neoplasms  (ISO)
Venous Thrombosis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (IEA)
activation of Janus kinase activity  (IEA)
adaptive immune response  (IEA)
axon regeneration  (ISO)
cell differentiation  (IEA,ISO)
cellular response to dexamethasone stimulus  (IEA,ISO)
cellular response to interleukin-3  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
chromatin organization  (IEA)
collagen-activated signaling pathway  (IEA)
cytokine-mediated signaling pathway  (IEA)
enzyme-linked receptor protein signaling pathway  (IEA,ISO)
erythrocyte differentiation  (IEA)
extrinsic apoptotic signaling pathway  (IEA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
granulocyte-macrophage colony-stimulating factor signaling pathway  (IEA)
growth hormone receptor signaling pathway  (IEA)
growth hormone receptor signaling pathway via JAK-STAT  (IEA,ISO)
histone H3-Y41 phosphorylation  (IEA)
hormone-mediated signaling pathway  (ISO)
interferon-gamma-mediated signaling pathway  (ISO)
interleukin-12-mediated signaling pathway  (IEA)
intracellular signal transduction  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISO)
mammary gland epithelium development  (IEA,ISO)
microglial cell activation  (IEA)
mineralocorticoid receptor signaling pathway  (ISO)
modulation of chemical synaptic transmission  (ISO)
myeloid cell differentiation  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of DNA binding  (IEA,ISO)
negative regulation of heart contraction  (ISO)
negative regulation of neuron apoptotic process  (ISO)
peptidyl-tyrosine phosphorylation  (IEA,ISO)
phosphorylation  (IEA)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of cell activation  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cell-substrate adhesion  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of epithelial cell apoptotic process  (ISO)
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  (ISO)
positive regulation of growth hormone receptor signaling pathway  (IEA)
positive regulation of inflammatory response  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of interferon-gamma production  (IEA)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of leukocyte proliferation  (IEA)
positive regulation of MAPK cascade  (ISO)
positive regulation of MHC class II biosynthetic process  (IEA)
positive regulation of natural killer cell proliferation  (IEA)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IEA)
positive regulation of NK T cell proliferation  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA)
positive regulation of phosphoprotein phosphatase activity  (ISO)
positive regulation of platelet activation  (IEA,ISO)
positive regulation of platelet aggregation  (IEA,ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IEA)
positive regulation of signaling receptor activity  (IEA)
positive regulation of SMAD protein signal transduction  (IEA,ISO)
positive regulation of T cell proliferation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
post-embryonic hemopoiesis  (IEA)
post-translational protein modification  (IEA)
postsynapse to nucleus signaling pathway  (ISO)
programmed cell death induced by symbiont  (IEA,ISO)
protein autophosphorylation  (IEA,ISO)
protein phosphorylation  (IEA)
receptor signaling pathway via JAK-STAT  (IEA,ISO)
regulation of cell adhesion  (IEA)
regulation of inflammatory response  (IEA)
regulation of multicellular organismal process  (IEA)
regulation of nitric oxide biosynthetic process  (ISO)
response to amine  (ISO)
response to antibiotic  (IEA,ISO)
response to hydroperoxide  (ISO)
response to interleukin-12  (IEA)
response to lipopolysaccharide  (IEA)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to tumor necrosis factor  (IEA)
signal transduction  (IEA)
transcription by RNA polymerase II  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (IEA)
tyrosine phosphorylation of STAT protein  (IEA,ISO)

Cellular Component

References

Genomics

Comparative Map Data
JAK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.195,006,271 - 5,156,626 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl95,006,271 - 5,156,626 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v094,820,303 - 4,971,867 (+)NCBIMhudiblu_PPA_v0panPan3
JAK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3894,984,390 - 5,129,948 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl94,984,390 - 5,129,948 (+)EnsemblGRCh38hg38GRCh38
GRCh3794,984,390 - 5,129,948 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3694,975,245 - 5,117,995 (+)NCBINCBI36hg18NCBI36
Build 3494,975,244 - 5,117,995NCBI
Celera94,910,860 - 5,053,802 (+)NCBI
Cytogenetic Map9p24.1NCBI
HuRef94,940,783 - 5,083,727 (+)NCBIHuRef
CHM1_194,985,470 - 5,128,355 (+)NCBICHM1_1
Jak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,229,006 - 29,290,495 (+)NCBIGRCm39mm39
GRCm39 Ensembl1929,229,228 - 29,290,480 (+)Ensembl
GRCm381929,251,803 - 29,313,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,251,828 - 29,313,080 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,326,318 - 29,387,570 (+)NCBIGRCm37mm9NCBIm37
MGSCv361929,318,452 - 29,377,979 (+)NCBImm8
Celera1930,028,576 - 30,089,642 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.73NCBI
Jak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21226,995,334 - 227,054,381 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1226,995,334 - 227,054,189 (+)Ensembl
Rnor_6.01247,398,667 - 247,457,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,398,598 - 247,458,509 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,646,160 - 254,706,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,915,995 - 232,974,763 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11233,080,017 - 233,138,786 (+)NCBI
Celera1224,147,256 - 224,206,104 (+)NCBICelera
Cytogenetic Map1q52NCBI
Jak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554349,227,595 - 9,341,208 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554349,227,897 - 9,341,208 (+)NCBIChiLan1.0ChiLan1.0
JAK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,321,055 - 93,438,898 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl193,142,635 - 93,435,997 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha193,730,062 - 93,844,204 (+)NCBI
ROS_Cfam_1.0193,940,875 - 93,989,640 (+)NCBI
ROS_Cfam_1.0 Ensembl193,877,224 - 93,990,814 (+)Ensembl
UMICH_Zoey_3.1193,507,891 - 93,622,032 (+)NCBI
UNSW_CanFamBas_1.0193,232,417 - 93,346,624 (+)NCBI
UU_Cfam_GSD_1.0193,996,654 - 94,110,963 (+)NCBI
Jak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947140,931,052 - 141,061,286 (+)NCBI
SpeTri2.0NW_004936503111,722 - 243,627 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,848,686 - 217,002,148 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,849,744 - 217,002,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,696,921 - 242,837,407 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JAK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11274,421,243 - 74,566,766 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1274,421,016 - 74,566,710 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603862,818,134 - 62,927,470 (-)NCBIVero_WHO_p1.0
Jak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247369,724,876 - 9,827,364 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000020897   ⟹   ENSPPAP00000004545
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl95,006,271 - 5,156,626 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000020932   ⟹   ENSPPAP00000004553
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl95,044,415 - 5,155,894 (+)Ensembl
RefSeq Acc Id: XM_003823367   ⟹   XP_003823415
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.195,006,271 - 5,156,626 (+)NCBI
Mhudiblu_PPA_v094,821,132 - 4,971,867 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024930144   ⟹   XP_024785912
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.195,006,271 - 5,156,626 (+)NCBI
Mhudiblu_PPA_v094,820,323 - 4,970,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034967096   ⟹   XP_034822987
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v094,820,323 - 4,971,286 (+)NCBI
RefSeq Acc Id: XM_034967097   ⟹   XP_034822988
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v094,820,322 - 4,970,760 (+)NCBI
RefSeq Acc Id: XM_034967098   ⟹   XP_034822989
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v094,820,303 - 4,954,035 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_003823415   ⟸   XM_003823367
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024785912   ⟸   XM_024930144
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034822989   ⟸   XM_034967098
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034822988   ⟸   XM_034967097
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034822987   ⟸   XM_034967096
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000004545   ⟸   ENSPPAT00000020897
RefSeq Acc Id: ENSPPAP00000004553   ⟸   ENSPPAT00000020932
Protein Domains
FERM   Protein kinase   SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000019000 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000004545 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000004553 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000020897 UniProtKB/TrEMBL
  ENSPPAT00000020932 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  Jak1_PHL_dom UniProtKB/TrEMBL
  JAK2_FERM_C-lobe UniProtKB/TrEMBL
  JAK2_SH2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  PTK_Jak2_rpt1 UniProtKB/TrEMBL
  PTKc_Jak2_rpt2 UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak2 UniProtKB/TrEMBL
KEGG Report pps:100979742 UniProtKB/TrEMBL
NCBI Gene JAK2 ENTREZGENE
Pfam FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  Jak1_Phl UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PIRSF TyrPK_Jak UniProtKB/TrEMBL
PRINTS JANUSKINASE UniProtKB/TrEMBL
  JANUSKINASE2 UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF47031 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R8ZHT5_PANPA UniProtKB/TrEMBL
  A0A2R8ZP32_PANPA UniProtKB/TrEMBL