JAK2 (Janus kinase 2) - Rat Genome Database

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Gene: JAK2 (Janus kinase 2) Homo sapiens
Symbol: JAK2
Name: Janus kinase 2
RGD ID: 731748
HGNC Page HGNC:6192
Description: Enables several functions, including SH2 domain binding activity; heme binding activity; and protein kinase activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of lymphocyte proliferation; and protein modification process. Acts upstream of or within positive regulation of SMAD protein signal transduction; positive regulation of platelet activation; and response to antibiotic. Located in several cellular components, including focal adhesion; granulocyte macrophage colony-stimulating factor receptor complex; and nucleoplasm. Implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Biomarker of several diseases, including bacterial gastritis; gastrointestinal system cancer (multiple); limited scleroderma; liver cirrhosis (multiple); and obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: JAK-2; Janus kinase 2 (a protein tyrosine kinase); JTK10; THCYT3; tyrosine-protein kinase JAK2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3894,984,390 - 5,129,948 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl94,984,390 - 5,129,948 (+)EnsemblGRCh38hg38GRCh38
GRCh3794,984,390 - 5,129,948 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3694,975,245 - 5,117,995 (+)NCBINCBI36Build 36hg18NCBI36
Build 3494,975,244 - 5,117,995NCBI
Celera94,910,860 - 5,053,802 (+)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef94,940,783 - 5,083,727 (+)NCBIHuRef
CHM1_194,985,470 - 5,128,355 (+)NCBICHM1_1
T2T-CHM13v2.094,989,498 - 5,135,022 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lymphoblastic Leukemia, with Lymphomatous Features  (IAGP)
acute myeloid leukemia  (EXP,IAGP)
adrenocortical carcinoma  (IAGP)
alcoholic liver cirrhosis  (IEP)
Alzheimer's disease  (ISO)
anemia  (ISO)
ankylosing spondylitis  (IAGP)
bacterial gastritis  (IEP)
Brain Injuries  (ISO)
Budd-Chiari syndrome  (EXP,IAGP)
Cachexia  (ISO)
calcinosis  (EXP)
Cancer Pain  (ISO)
chromosome 9p deletion syndrome  (IAGP)
chronic myelogenous leukemia, BCR-ABL1 positive  (IAGP)
chronic myeloid leukemia  (IAGP)
colon adenocarcinoma  (IEP,IMP)
colon cancer  (ISO)
colorectal carcinoma  (ISO)
Crohn's disease  (IAGP)
Diabetic Nephropathies  (ISO)
esophageal carcinoma  (IDA)
esophagus squamous cell carcinoma  (IEP)
essential thrombocythemia  (EXP,IAGP)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (EXP,ISO)
Experimental Liver Neoplasms  (EXP)
familial erythrocytosis 1  (IAGP)
familial erythrocytosis 2  (ISO)
fatty liver disease  (ISO)
genetic disease  (IAGP)
Genetic Predisposition to Disease  (EXP)
glucose intolerance  (ISO)
Growth Disorders  (ISO)
heart disease  (ISO)
heart valve disease  (EXP)
hepatocellular carcinoma  (IEP,ISO)
hereditary breast ovarian cancer syndrome  (IAGP)
Hyperalgesia  (ISO)
hyperuricemia  (ISO)
Inflammation  (EXP)
Intestinal Reperfusion Injury  (ISO)
leukemia  (EXP,IAGP)
limited scleroderma  (IEP)
liver cancer  (IEP,IMP)
liver cirrhosis  (IEP)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (IMP)
lung carcinoma  (IEP)
lung non-small cell carcinoma  (IMP)
mesenteric vascular occlusion  (EXP)
myelofibrosis  (EXP,IAGP,IMP)
myeloid neoplasm  (EXP,IAGP)
myeloproliferative neoplasm  (ISS)
myocardial infarction  (ISO)
Myocardial Ischemia  (EXP)
Myocardial Reperfusion Injury  (ISO)
nasopharynx carcinoma  (IEP)
Neoplasm Metastasis  (IMP)
Neoplastic Cell Transformation  (EXP)
nephrotic syndrome  (ISO)
Niemann-Pick disease type C1  (ISO)
non-alcoholic fatty liver disease  (EXP,ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (IEP,ISO)
polycythemia  (EXP,IAGP,ISO)
polycythemia vera  (EXP,IAGP)
portal hypertension  (IMP)
Pregnancy Complications  (EXP)
primary biliary cholangitis  (ISO)
Primary Ovarian Failure  (IAGP)
primary ovarian insufficiency  (IAGP)
Prostatic Neoplasms  (EXP)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Sepsis  (ISO)
Sepsis-Associated Encephalopathy  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (IAGP)
Spontaneous Abortions  (EXP)
stomach cancer  (IAGP,IEP)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
Thrombocythemia 3  (IAGP)
thrombocytosis  (EXP,IAGP)
Thromboembolism  (EXP)
thrombosis  (IAGP)
transient cerebral ischemia  (ISO)
ulcerative colitis  (EXP,IAGP)
Uterine Cervical Neoplasms  (EXP)
Venous Thrombosis  (EXP,IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R)-mevalonic acid  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-ethoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (EXP)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
abamectin  (ISO)
acetamide  (ISO)
acetic acid  (ISO)
actinomycin D  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
amlodipine  (EXP)
ammonium chloride  (ISO)
angiotensin II  (EXP)
antirheumatic drug  (EXP)
apocynin  (EXP)
arecoline  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
auranofin  (EXP)
Bardoxolone methyl  (ISO)
baricitinib  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-Elemonic acid  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP)
ceruletide  (ISO)
chelerythrine  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
Cirsimarin  (ISO)
cisplatin  (EXP,ISO)
clomiphene  (EXP)
clothianidin  (EXP)
clozapine  (ISO)
cocaine  (ISO)
coniferyl aldehyde  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
coumermycin A1  (ISO)
crocin-1  (EXP)
cucurbitacin I  (EXP)
Cuprizon  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (ISO)
delphinidin  (EXP)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
divanadium pentaoxide  (EXP)
doxorubicin  (EXP,ISO)
emodin  (EXP)
eriocitrin  (EXP)
erlotinib hydrochloride  (EXP)
estrone  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
fraxetin  (EXP)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
galaxolide  (EXP)
Ganoderic acid A  (ISO)
genistein  (EXP)
Ginkgoic acid  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
Goe 6976  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
hesperetin  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (EXP)
hexestrol  (EXP)
hispidulin  (EXP)
hydrogen peroxide  (EXP,ISO)
ivermectin  (EXP)
kainic acid  (EXP,ISO)
ketamine  (ISO)
L-arginine  (ISO)
lapatinib  (EXP)
limonin  (ISO)
linagliptin  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
LY294002  (ISO)
melittin  (EXP)
melphalan  (EXP)
mercury atom  (EXP)
mercury dichloride  (EXP)
mercury(0)  (EXP)
mesalamine  (ISO)
mestranol  (EXP)
methyl methanesulfonate  (EXP)
methylmercury chloride  (ISO)
Methylthiouracil  (EXP)
mitoxantrone  (EXP)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
okadaic acid  (EXP)
olanzapine  (ISO)
oleic acid  (EXP)
ozone  (ISO)
pantoprazole  (ISO)
paracetamol  (ISO)
paroxetine  (EXP)
PD123319  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenylpropanolamine  (ISO)
phosphane  (ISO)
phosphatidic acid  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
ponatinib  (EXP)
Ponicidin  (EXP)
potassium chromate  (EXP)
progesterone  (EXP)
propofol  (EXP)
pterostilbene  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
Rhynchophylline  (ISO)
rotenone  (EXP)
rutin  (ISO)
ruxolitinib  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S3I-201  (EXP)
Salinomycin  (EXP)
selumetinib  (EXP)
silibinin  (EXP)
silicon dioxide  (EXP)
simvastatin  (ISO)
Sinomenine  (ISO)
sodium arsenite  (EXP)
sphingosine 1-phosphate  (EXP)
spironolactone  (ISO)
stattic  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
theobromine  (ISO)
thymoquinone  (EXP,ISO)
Tiron  (EXP)
tofacitinib  (EXP)
trichostatin A  (EXP)
triptonide  (ISO)
tyrphostin B42  (EXP,ISO)
urethane  (EXP,ISO)
valproic acid  (EXP)
valsartan  (EXP)
verteporfin  (ISO)
vinclozolin  (ISO)
zidovudine  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament polymerization  (NAS)
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISS)
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (IEA,ISS)
activation of Janus kinase activity  (IEA,ISS)
adaptive immune response  (IEA)
apoptotic process  (ISS)
apoptotic process  (ISS)
axon regeneration  (IEA,ISO)
cell differentiation  (IEA,ISO,ISS)
cellular response to dexamethasone stimulus  (IEA,ISO)
cellular response to interleukin-3  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to virus  (NAS)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
collagen-activated signaling pathway  (IMP)
cytokine-mediated signaling pathway  (IBA,IDA,IEA,ISS,TAS)
enzyme-linked receptor protein signaling pathway  (IEA,ISO,ISS)
erythrocyte differentiation  (IBA)
erythrocyte differentiation  (IBA)
erythrocyte differentiation  (IEA)
erythrocyte differentiation  (ISS)
erythrocyte differentiation  (ISS)
extrinsic apoptotic signaling pathway  (IEA,ISO,ISS)
G protein-coupled receptor signaling pathway  (IEA,ISO)
granulocyte-macrophage colony-stimulating factor signaling pathway  (IDA)
growth hormone receptor signaling pathway  (IDA)
growth hormone receptor signaling pathway via JAK-STAT  (IEA,ISO,ISS)
hormone-mediated signaling pathway  (IEA,ISO)
immune response  (NAS)
immune system process  (IEA)
innate immune response  (IEA)
interleukin-12-mediated signaling pathway  (IDA)
interleukin-3-mediated signaling pathway  (IDA)
interleukin-35-mediated signaling pathway  (TAS)
interleukin-5-mediated signaling pathway  (IDA)
interleukin-6-mediated signaling pathway  (TAS)
intracellular signal transduction  (IBA,IEA,ISO,ISS,TAS)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO)
mammary gland epithelium development  (IEA,ISO,ISS)
mesoderm development  (TAS)
microglial cell activation  (IEA,ISS)
mineralocorticoid receptor signaling pathway  (IEA,ISO)
modulation of chemical synaptic transmission  (IEA)
myeloid cell differentiation  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of cell death  (IEA)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of cell-cell adhesion  (IEA,ISO)
negative regulation of DNA binding  (IEA,ISO,ISS)
negative regulation of heart contraction  (IEA)
negative regulation of heart contraction  (IEA)
negative regulation of heart contraction  (ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
obsolete histone H3-Y41 phosphorylation  (IBA,IDA)
peptidyl-tyrosine phosphorylation  (IEA,ISO,ISS)
phosphorylation  (IEA)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of cell activation  (IEA,ISO)
positive regulation of cell differentiation  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cell-substrate adhesion  (IDA)
positive regulation of cold-induced thermogenesis  (IEA,ISS)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of DNA binding  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO)
positive regulation of epithelial cell apoptotic process  (IEA,ISO)
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  (IEA,ISO)
positive regulation of growth hormone receptor signaling pathway  (IEA,ISS)
positive regulation of inflammatory response  (IEA)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of insulin secretion  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO,ISS)
positive regulation of interleukin-17 production  (NAS)
positive regulation of leukocyte proliferation  (IDA)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of MHC class II biosynthetic process  (IEA,ISS)
positive regulation of natural killer cell proliferation  (IDA)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IEA,ISS)
positive regulation of NK T cell proliferation  (IDA,NAS)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISS)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA,ISS,TAS)
positive regulation of phosphoprotein phosphatase activity  (IEA,ISO)
positive regulation of platelet activation  (IDA)
positive regulation of platelet aggregation  (IDA)
positive regulation of platelet aggregation  (IDA)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IDA)
positive regulation of signaling receptor activity  (IEA,ISS)
positive regulation of SMAD protein signal transduction  (IGI)
positive regulation of T cell proliferation  (IDA,IEA)
positive regulation of T-helper 17 type immune response  (NAS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISS)
positive regulation of type II interferon production  (IDA)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISS)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
post-embryonic hemopoiesis  (IEA)
post-translational protein modification  (IDA)
postsynapse to nucleus signaling pathway  (IEA)
programmed cell death induced by symbiont  (IEA,ISO)
protein autophosphorylation  (IEA,ISO,ISS)
protein phosphorylation  (IDA,IEA,TAS)
receptor signaling pathway via JAK-STAT  (IBA,IDA,IEA,ISO,ISS,TAS)
regulation of apoptotic process  (IBA)
regulation of cell adhesion  (IEA)
regulation of inflammatory response  (IDA)
regulation of inflammatory response  (IDA)
regulation of multicellular organismal process  (IEA)
regulation of nitric oxide biosynthetic process  (IEA,ISS)
regulation of postsynapse to nucleus signaling pathway  (IEA)
regulation of receptor signaling pathway via JAK-STAT  (ISS)
response to amine  (IEA,ISO)
response to antibiotic  (IDA)
response to antibiotic  (IDA)
response to hydroperoxide  (IEA,ISO)
response to interleukin-12  (IDA)
response to lipopolysaccharide  (IEA,ISS)
response to organic cyclic compound  (IEA,ISO)
response to oxidative stress  (IEA,ISO)
response to tumor necrosis factor  (IDA)
signal transduction  (IEA)
signal transduction  (ISS)
signal transduction  (ISS)
transcription by RNA polymerase II  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (IDA)
type II interferon-mediated signaling pathway  (IEA,NAS,TAS)
tyrosine phosphorylation of STAT protein  (IBA,IEA,ISO,ISS)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abdominal pain  (IAGP)
Abnormal bleeding  (IAGP)
Abnormal megakaryocyte morphology  (IAGP)
Abnormal platelet morphology  (IAGP)
Abnormal thrombosis  (IAGP)
Acute hepatic failure  (IAGP)
Acute leukemia  (IAGP)
Acute myeloid leukemia  (IAGP)
Adrenocortical carcinoma  (IAGP)
Adult onset  (IAGP)
Amaurosis fugax  (IAGP)
Anemia  (IAGP)
Angina pectoris  (IAGP)
Anorexia  (IAGP)
Arterial thrombosis  (IAGP)
Arthralgia  (IAGP)
Ascites  (IAGP)
Autosomal dominant inheritance  (IAGP)
Autosomal recessive inheritance  (IAGP)
Back pain  (IAGP)
Bone marrow hypercellularity  (IAGP)
Bruising susceptibility  (IAGP)
Budd-Chiari syndrome  (IAGP)
Cachexia  (IAGP)
Cerebral hemorrhage  (IAGP)
Cerebral ischemia  (IAGP)
Chest pain  (IAGP)
Cholecystitis  (IAGP)
Chronic myelogenous leukemia  (IAGP)
Cirrhosis  (IAGP)
Dysarthria  (IAGP)
Easy fatigability  (IAGP)
Ecchymosis  (IAGP)
Elevated hepatic transaminase  (IAGP)
Epistaxis  (IAGP)
Esophageal varix  (IAGP)
Exertional dyspnea  (IAGP)
Extramedullary hematopoiesis  (IAGP)
Fatigue  (IAGP)
Fever  (IAGP)
Flank pain  (IAGP)
Gastrointestinal hemorrhage  (IAGP)
Gastrointestinal infarctions  (IAGP)
Gingival bleeding  (IAGP)
Headache  (IAGP)
Hemangioma  (IAGP)
Hematological neoplasm  (IAGP)
Hepatocellular carcinoma  (IAGP)
Hepatomegaly  (IAGP)
Hepatosplenomegaly  (IAGP)
Hyperhidrosis  (IAGP)
Hypertension  (IAGP)
Increased circulating lactate dehydrogenase concentration  (IAGP)
Increased hematocrit  (IAGP)
Increased hemoglobin  (IAGP)
Increased megakaryocyte count  (IAGP)
Increased micromegakaryocyte count  (IAGP)
Increased red blood cell mass  (IAGP)
Intermediate young adult onset  (IAGP)
Intermittent claudication  (IAGP)
Intestinal obstruction  (IAGP)
Ischemic stroke  (IAGP)
Jaundice  (IAGP)
Late onset  (IAGP)
Leukocytosis  (IAGP)
Low-grade fever  (IAGP)
Lymphadenopathy  (IAGP)
Malabsorption  (IAGP)
Middle age onset  (IAGP)
Miscarriage  (IAGP)
Myelodysplasia  (IAGP)
Myelofibrosis  (IAGP)
Myeloproliferative disorder  (IAGP)
Myocardial infarction  (IAGP)
Pallor  (IAGP)
Pancytopenia  (IAGP)
Paresthesia  (IAGP)
Peripheral arterial stenosis  (IAGP)
Peripheral thrombosis  (IAGP)
Peritonitis  (IAGP)
Petechiae  (IAGP)
Plethora  (IAGP)
Poikilocytosis  (IAGP)
Polycythemia  (IAGP)
Portal hypertension  (IAGP)
Portal vein thrombosis  (IAGP)
Premature ovarian insufficiency  (IAGP)
Prolonged bleeding time  (IAGP)
Pruritus  (IAGP)
Pulmonary arterial hypertension  (IAGP)
Pulmonary embolism  (IAGP)
Purpura  (IAGP)
Respiratory insufficiency  (IAGP)
Sacroiliac arthritis  (IAGP)
Seizure  (IAGP)
Somatic mutation  (IAGP)
Splenomegaly  (IAGP)
Sporadic  (IAGP)
Stroke  (IAGP)
Syncope  (IAGP)
Thrombocytopenia  (IAGP)
Thrombocytosis  (IAGP)
Thromboembolism  (IAGP)
Tinnitus  (IAGP)
Transient ischemic attack  (IAGP)
Venous thrombosis  (IAGP)
Vertigo  (IAGP)
Visual field defect  (IAGP)
Weight loss  (IAGP)

References - curated
# Reference Title Reference Citation
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60. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
61. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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67. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
68. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
69. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
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79. A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis. Stump KL, etal., Arthritis Res Ther. 2011 Apr 21;13(2):R68.
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90. Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18. 3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthritis. William AD, etal., J Med Chem. 2012 Mar 22;55(6):2623-40. doi: 10.1021/jm201454n. Epub 2012 Mar 6.
91. Da-Huang-Fu-Zi-Tang attenuates liver injury in rats with severe acute pancreatitis. Wu L, etal., J Ethnopharmacol. 2013 Dec 12;150(3):960-6. doi: 10.1016/j.jep.2013.09.051. Epub 2013 Oct 24.
92. Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway. Wu L, etal., Oncol Rep. 2015 Dec;34(6):3311-7. doi: 10.3892/or.2015.4279. Epub 2015 Sep 16.
93. IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway. Wu X, etal., Oncotarget. 2017 Mar 28;8(13):20741-20750. doi: 10.18632/oncotarget.15119.
94. Effects of supplemental erythropoietin on its receptor expression and signal transduction pathways in rat model of retinal detachment. Xie Z, etal., Curr Eye Res. 2012 Feb;37(2):138-44. doi: 10.3109/02713683.2011.647225.
95. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
96. The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K/AKT signaling pathways. Xu Y and Lv SX, Biomed Pharmacother. 2016 Dec;84:1202-1212. doi: 10.1016/j.biopha.2016.09.040. Epub 2016 Oct 24.
97. Emulsified isoflurane induces postconditioning against myocardial infarction via JAK-STAT pathway. Yan L, etal., J Surg Res. 2012 Dec;178(2):578-85. doi: 10.1016/j.jss.2012.06.007. Epub 2012 Jun 21.
98. Janus kinase 2 polymorphisms are associated with risk in patients with gastric cancer in a Chinese population. Yang L, etal., PLoS One. 2013 May 24;8(5):e64628. doi: 10.1371/journal.pone.0064628. Print 2013.
99. JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury. Yang Y, etal., J Pineal Res. 2013 Oct;55(3):275-86. doi: 10.1111/jpi.12070. Epub 2013 Jun 25.
100. Prolactin promotes hepatocellular carcinoma through Janus kinase 2. Yeh YT, etal., World J Surg. 2012 May;36(5):1128-35. doi: 10.1007/s00268-012-1505-4.
101. The association of the JAK2 46/1 haplotype with non-splanchnic venous thrombosis. Zerjavic K, etal., Thromb Res. 2013 Aug;132(2):e86-93. doi: 10.1016/j.thromres.2013.06.021. Epub 2013 Jul 9.
102. Protection of curcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signalling in rats. Zhang DM, etal., Food Chem. 2012 Oct 15;134(4):2184-93. doi: 10.1016/j.foodchem.2012.04.026. Epub 2012 Apr 17.
103. JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small cell lung carcinoma cells with mutated EGF receptor. Zhang FQ, etal., Oncotarget. 2015 Jun 10;6(16):14329-43. doi: 10.18632/oncotarget.3685.
104. Inhibition of JAK2/STAT3 signaling pathway protects mice from the DDP-induced acute kidney injury in lung cancer. Zhang L, etal., Inflamm Res. 2019 Sep;68(9):751-760. doi: 10.1007/s00011-019-01258-4. Epub 2019 Jun 26.
105. Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock. Zhang M, etal., Mol Med Rep. 2013 Apr;7(4):1293-9. doi: 10.3892/mmr.2013.1315. Epub 2013 Feb 8.
106. Amyloid-beta induces hepatic insulin resistance in vivo via JAK2. Zhang Y, etal., Diabetes. 2013 Apr;62(4):1159-66. doi: 10.2337/db12-0670. Epub 2012 Dec 6.
107. Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats. Zhao JB, etal., Neurosci Lett. 2011 Jul 8;498(2):147-52. Epub 2011 May 10.
108. [Effects of puerarin on expressions of leptin receptor mRNA, phosphorylated Janus kinase 2/phosphorylated signal transducers and activators of transcription 3 proteins in the liver of rats with non-alcoholic fatty liver]. Zheng PY, etal., Zhong Xi Yi Jie He Xue Bao. 2008 Sep;6(9):921-7.
109. Recombinant human erythropoietin attenuates neuronal apoptosis and cognitive defects via JAK2/STAT3 signaling in experimental endotoxemia. Zhou TF and Yu JG, J Surg Res. 2013 Jul;183(1):304-12. doi: 10.1016/j.jss.2012.11.035. Epub 2012 Dec 6.
110. SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. Zhu H, etal., Eur J Pharmacol. 2013 Aug 15;714(1-3):23-31. doi: 10.1016/j.ejphar.2013.05.043. Epub 2013 Jun 11.
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