GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Jak2 | decreases expression | ISO | JAK2 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of JAK2 mRNA | PMID:26537877 PMID:28940058 PMID:29803840 | Jak2 | increases phosphorylation | ISO | Jak2 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of JAK2 protein | PMID:34605108 | Jak2 | multiple interactions | ISO | Jak2 (Mus musculus) | 6480464 | CTD | Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of JAK2 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of JAK2 protein] | PMID:34605108 | | ||||||||||||||||||||||
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