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Gene: Ghr (growth hormone receptor) Rattus norvegicus
Symbol: Ghr
Name: growth hormone receptor
RGD ID: 2687
Description: Exhibits SH2 domain binding activity; enzyme binding activity; and growth hormone receptor activity. Involved in several processes, including activation of protein kinase activity; cellular response to hormone stimulus; and receptor signaling pathway via JAK-STAT. Localizes to several cellular components, including extracellular space; mitochondrion; and neuronal cell body. Biomarker of congenital hypothyroidism; muscular atrophy; osteopetrosis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor); PARTICIPATES IN growth hormone signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: GH receptor; GHR/BP; growth hormone receptor precursor splice variant D56; growth hormone receptor variant d5-6; growth hormone receptor/binding protein; MGC124963; MGC156665; somatotropin receptor
Homo sapiens (human) : GHR (growth hormone receptor)  HGNC  Alliance
Mus musculus (house mouse) : Ghr (growth hormone receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ghr (growth hormone receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : GHR (growth hormone receptor)
Canis lupus familiaris (dog) : GHR (growth hormone receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ghr (growth hormone receptor)
Sus scrofa (pig) : GHR (growth hormone receptor)
Chlorocebus sabaeus (African green monkey) : GHR (growth hormone receptor)
Heterocephalus glaber (naked mole-rat) : Ghr (growth hormone receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0253,149,225 - 53,413,954 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl253,150,370 - 53,413,638 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0272,182,692 - 72,218,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0272,265,571 - 72,346,118 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4252,496,517 - 52,658,066 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1252,424,749 - 52,586,299 (-)NCBI
Celera248,257,266 - 48,408,640 (-)NCBICelera
Cytogenetic Map2q16NCBI
RH 3.4 Map2332.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Ghr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2687
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.