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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2687
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ghr
Name: growth hormone receptor
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ghraffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of GHR mRNAPMID:22298810
Ghrdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of GHR mRNAPMID:18178546 PMID:18796159 PMID:20959002 PMID:21215274 PMID:27136898 PMID:32109520
Ghraffects expressionISOGhr (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of GHR mRNAPMID:26377647
Ghraffects expressionISOGHR (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of GHR mRNAPMID:22298810
Ghrdecreases expressionISOGhr (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of GHR mRNAPMID:18796159 PMID:19933214 PMID:22978700 PMID:29673856
Ghrdecreases expressionISOGHR (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of GHR mRNAPMID:19619570 PMID:20106945 PMID:26159488
Ghrmultiple interactionsISOGhr (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GHR mRNA; AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GHR mRNA]PMID:17942748 PMID:22978700
Ghrmultiple interactionsISOGHR (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GHR mRNA; Endosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GHR mRNA]PMID:19619570 PMID:26159488
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