Ghr (growth hormone receptor) - Rat Genome Database
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Gene: Ghr (growth hormone receptor) Mus musculus
Analyze
Symbol: Ghr
Name: growth hormone receptor
RGD ID: 10644
MGI Page MGI
Description: Exhibits growth hormone receptor activity and peptide hormone binding activity. Involved in several processes, including growth hormone receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and taurine metabolic process. Localizes to extrinsic component of membrane; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Used to study Laron syndrome. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor); PARTICIPATES IN growth hormone signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA986417; GH receptor; GHB; GHBP; GHR/; GHR/BP; Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein); growth hormone receptor/binding protein; growth hormone receptor/binding protein, high molecular weight; growth hormone receptor/binding protein, low molecular weight; somatotropin receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,347,237 - 3,612,834 (-)NCBIGRCm39mm39
GRCm38153,317,755 - 3,583,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,317,760 - 3,583,492 (-)EnsemblGRCm38mm10GRCm38
MGSCv37153,267,760 - 3,533,230 (-)NCBIGRCm37mm9NCBIm37
MGSCv36153,267,774 - 3,533,231 (-)NCBImm8
Celera153,182,321 - 3,448,882 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-vinylcyclohexene dioxide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
bacitracin  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
buspirone  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
chlormequat chloride  (ISO)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
crocidolite asbestos  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
cytarabine  (ISO)
DDT  (ISO)
dexamethasone  (ISO)
dichlorine  (ISO)
diclofenac  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
L-methionine  (EXP)
menadione  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propiconazole  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulindac  (ISO)
sumatriptan  (ISO)
tamoxifen  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal artery morphology  (IAGP)
abnormal avoidance learning behavior  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal body weight  (IAGP)
abnormal bone ossification  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal circulating lipid level  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal epididymis weight  (IAGP)
abnormal fluid regulation  (IAGP)
abnormal food intake  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal metestrus  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovary physiology  (IAGP)
abnormal seminal vesicle weight  (IAGP)
abnormal skeleton development  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal testes secretion  (IAGP)
abnormal trabecular bone morphology  (IAGP)
decreased activity of thyroid gland  (IAGP)
decreased areal bone mineral density  (IAGP)
decreased birth weight  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased brain weight  (IAGP)
decreased circulating adiponectin level  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating estradiol level  (IAGP)
decreased circulating glucagon level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating LDL cholesterol level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating triiodothyronine level  (IAGP)
decreased circulating VLDL cholesterol level  (IAGP)
decreased corpora lutea number  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased epididymis weight  (IAGP)
decreased fetal size  (IAGP)
decreased fetal weight  (IAGP)
decreased heart weight  (IAGP)
decreased inguinal fat pad weight  (IAGP)
decreased insulin secretion  (IAGP)
decreased kidney weight  (IAGP)
decreased lean body mass  (IAGP)
decreased length of long bones  (IAGP)
decreased litter size  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased liver weight  (IAGP)
decreased ovulation rate  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell proliferation  (IAGP)
decreased pituitary gland weight  (IAGP)
decreased prostate gland weight  (IAGP)
decreased seminal vesicle weight  (IAGP)
decreased serotonin level  (IAGP)
decreased spleen weight  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased testis weight  (IAGP)
decreased triiodothyronine level  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed balanopreputial separation  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed female fertility  (IAGP)
delayed male fertility  (IAGP)
delayed sexual maturation  (IAGP)
delayed vaginal opening  (IAGP)
extended life span  (IAGP)
female infertility  (IAGP)
fetal growth retardation  (IAGP)
hepatic steatosis  (IAGP)
hyperglycemia  (IAGP)
hypoglycemia  (IAGP)
impaired embryo implantation  (IAGP)
impaired glucose tolerance  (IAGP)
impaired luteinization  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased abdominal fat pad weight  (IAGP)
increased body weight  (IAGP)
increased brain weight  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased circulating adiponectin level  (IAGP)
increased circulating chloride level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating creatine kinase level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating growth hormone level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating insulin-like growth factor I level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating prolactin level  (IAGP)
increased circulating serum albumin level  (IAGP)
increased food intake  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased insulin sensitivity  (IAGP)
increased interscapular fat pad weight  (IAGP)
increased kidney weight  (IAGP)
increased lean body mass  (IAGP)
increased liver weight  (IAGP)
increased mesenteric fat pad weight  (IAGP)
increased percent body fat/body weight  (IAGP)
increased placenta weight  (IAGP)
increased retroperitoneal fat pad weight  (IAGP)
increased soleus weight  (IAGP)
increased subcutaneous adipose tissue amount  (IAGP)
increased total body fat amount  (IAGP)
increased uterus weight  (IAGP)
increased white adipose tissue amount  (IAGP)
increased white fat cell size  (IAGP)
long gestation period  (IAGP)
obese  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
prolonged diestrus  (IAGP)
prolonged estrous cycle  (IAGP)
proportional dwarf  (IAGP)
reduced male fertility  (IAGP)
short femur  (IAGP)
short tibia  (IAGP)
small kidney  (IAGP)
small pancreatic islets  (IAGP)
small spleen  (IAGP)
References

References - curated
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2. Bellush LL, etal., Endocrinology. 2000 Jan;141(1):163-8.
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4. Casse AH, etal., Endocrinology. 2003 Aug;144(8):3692-7.
5. Christophidis LJ, etal., Growth Horm IGF Res. 2009 Dec;19(6):497-506. Epub 2009 Jun 12.
6. Claessen KM, etal., Ann Rheum Dis. 2014 Feb;73(2):433-6. doi: 10.1136/annrheumdis-2012-202713. Epub 2013 Jun 5.
7. Enhamre E, etal., Neurosci Lett. 2012 Aug 8;523(1):82-6. doi: 10.1016/j.neulet.2012.06.050. Epub 2012 Jun 27.
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15. Landau D, etal., Growth Horm IGF Res. 1998 Feb;8(1):39-45.
16. Landau D, etal., Int J Exp Diabetes Res. 2000;1(1):9-18.
17. Li W, etal., Acta Pharmacol Sin. 2004 Apr;25(4):490-5.
18. Menon RK, etal., J Endocrinol. 1994 Sep;142(3):453-62.
19. MGD and Homologene mouse data transfer
20. MGD data from the GO Consortium
21. MGD IEA
22. O'Leary MJ, etal., Intensive Care Med. 2000 Oct;26(10):1547-52.
23. OMIM Disease Annotation Pipeline
24. Pazaitou-Panayiotou K, etal., Eur J Endocrinol. 2007 Feb;156(2):187-94.
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26. Pipeline to import KEGG annotations from KEGG into RGD
27. RGD automated import pipeline
28. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:1354638   PMID:1404614   PMID:1639029   PMID:1794046   PMID:2739661   PMID:2776481   PMID:2825030   PMID:3200842   PMID:3398846   PMID:6303755   PMID:7529079   PMID:7588264  
PMID:7664676   PMID:7721793   PMID:7733275   PMID:7789316   PMID:7835269   PMID:7894338   PMID:7910583   PMID:7959737   PMID:7988474   PMID:8014591   PMID:8016161   PMID:8276403  
PMID:8365377   PMID:8661743   PMID:8702683   PMID:8827514   PMID:8884266   PMID:8921876   PMID:8973143   PMID:9005979   PMID:9112397   PMID:9144201   PMID:9196007   PMID:9507023  
PMID:9521872   PMID:9657863   PMID:9716552   PMID:9756919   PMID:10067829   PMID:10342852   PMID:10349636   PMID:10425445   PMID:10448090   PMID:10503715   PMID:10556764   PMID:10556780  
PMID:10564535   PMID:10631109   PMID:10715538   PMID:10875265   PMID:10974652   PMID:11018762   PMID:11042159   PMID:11067862   PMID:11076861   PMID:11133160   PMID:11133161   PMID:11165047  
PMID:11181526   PMID:11217851   PMID:11336996   PMID:11376119   PMID:11395925   PMID:11416014   PMID:11459789   PMID:11473059   PMID:11517152   PMID:11574907   PMID:11834450   PMID:12163409  
PMID:12185100   PMID:12239122   PMID:12297526   PMID:12368809   PMID:12379490   PMID:12384824   PMID:12403853   PMID:12466851   PMID:12477932   PMID:12563029   PMID:12653250   PMID:12933651  
PMID:12953790   PMID:14615057   PMID:14691110   PMID:14698815   PMID:14698816   PMID:14759523   PMID:14765976   PMID:14984790   PMID:15010456   PMID:15070777   PMID:15090034   PMID:15138153  
PMID:15165994   PMID:15231300   PMID:15271059   PMID:15308683   PMID:15314086   PMID:15326565   PMID:15489334   PMID:15498882   PMID:15519255   PMID:15601831   PMID:15690087   PMID:15701676  
PMID:15731363   PMID:15743767   PMID:15769825   PMID:15867334   PMID:15882993   PMID:15930104   PMID:16054319   PMID:16107429   PMID:16141072   PMID:16141073   PMID:16141391   PMID:16166215  
PMID:16174655   PMID:16259960   PMID:16514195   PMID:16524678   PMID:16602821   PMID:16621895   PMID:16670201   PMID:16682650   PMID:16916863   PMID:17065393   PMID:17244725   PMID:17264226  
PMID:17452569   PMID:17544797   PMID:17601656   PMID:18323468   PMID:18640258   PMID:18648510   PMID:18675334   PMID:18722179   PMID:19001545   PMID:19007875   PMID:19228785   PMID:19234595  
PMID:19269870   PMID:19460757   PMID:19747233   PMID:19747867   PMID:19786089   PMID:19884384   PMID:19901018   PMID:20185763   PMID:20197085   PMID:20660068   PMID:20921627   PMID:20928887  
PMID:21048919   PMID:21233833   PMID:21267068   PMID:21391871   PMID:21540290   PMID:21555853   PMID:21566652   PMID:21659478   PMID:21677750   PMID:21755522   PMID:21873635   PMID:22034225  
PMID:22040032   PMID:22109889   PMID:22187377   PMID:22323595   PMID:22577861   PMID:22693205   PMID:22897932   PMID:22947377   PMID:22999939   PMID:23024761   PMID:23031221   PMID:23209615  
PMID:23349524   PMID:23417424   PMID:23456957   PMID:23563309   PMID:23595986   PMID:23861377   PMID:23941873   PMID:24006456   PMID:24080228   PMID:24194600   PMID:24280222   PMID:24517230  
PMID:24550353   PMID:24606898   PMID:25053427   PMID:25063774   PMID:25179284   PMID:25234161   PMID:25237935   PMID:25244225   PMID:25274507   PMID:25456069   PMID:25566190   PMID:25855408  
PMID:25950084   PMID:26015548   PMID:26219867   PMID:26233957   PMID:26372907   PMID:26436954   PMID:26450967   PMID:26481310   PMID:26493931   PMID:26703468   PMID:26774398   PMID:26876170  
PMID:26950202   PMID:27035649   PMID:27585733   PMID:27618784   PMID:27626380   PMID:27732088   PMID:28323915   PMID:28591635   PMID:28700664   PMID:29339473   PMID:29378959   PMID:29555426  
PMID:30295789   PMID:30443216   PMID:30462209   PMID:30728323   PMID:30737388   PMID:30779881   PMID:31002310   PMID:31366244   PMID:31806625  


Genomics

Comparative Map Data
Ghr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,347,237 - 3,612,834 (-)NCBIGRCm39mm39
GRCm38153,317,755 - 3,583,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,317,760 - 3,583,492 (-)EnsemblGRCm38mm10GRCm38
MGSCv37153,267,760 - 3,533,230 (-)NCBIGRCm37mm9NCBIm37
MGSCv36153,267,774 - 3,533,231 (-)NCBImm8
Celera153,182,321 - 3,448,882 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.84NCBI
GHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl542,423,439 - 42,721,878 (+)EnsemblGRCh38hg38GRCh38
GRCh38542,423,439 - 42,721,878 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37542,423,577 - 42,721,980 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36542,459,783 - 42,757,683 (+)NCBINCBI36hg18NCBI36
Build 34542,459,782 - 42,757,682NCBI
Celera542,314,115 - 42,611,474 (+)NCBI
Cytogenetic Map5p13.1-p12NCBI
HuRef542,375,464 - 42,673,429 (+)NCBIHuRef
CHM1_1542,425,901 - 42,723,964 (+)NCBICHM1_1
Ghr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0253,149,225 - 53,413,954 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl253,150,370 - 53,413,638 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0272,182,692 - 72,218,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0272,265,571 - 72,346,118 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4252,496,517 - 52,658,066 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1252,424,749 - 52,586,299 (-)NCBI
Celera248,257,266 - 48,408,640 (-)NCBICelera
Cytogenetic Map2q16NCBI
RH 3.4 Map2332.2RGD
Ghr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542626,689,581 - 26,871,684 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542626,553,509 - 26,873,619 (+)NCBIChiLan1.0ChiLan1.0
GHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1572,700,150 - 72,997,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl572,700,150 - 72,871,278 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0567,654,326 - 67,953,140 (-)NCBIMhudiblu_PPA_v0panPan3
GHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl467,022,252 - 67,290,473 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1467,021,821 - 67,245,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ghr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936518235,996 - 380,225 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1627,126,286 - 27,422,268 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11627,126,300 - 27,422,618 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21628,691,739 - 28,855,136 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GHR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl441,285,712 - 41,464,666 (+)Ensembl
ChlSab1.1441,171,038 - 41,464,474 (+)NCBI
Ghr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475912,282,295 - 12,570,106 (-)NCBI

Position Markers
D15Mit13  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38153,460,212 - 3,460,347UniSTSGRCm38
MGSCv37153,410,212 - 3,410,347UniSTSGRCm37
Celera153,326,148 - 3,326,267UniSTS
Cytogenetic Map15A1UniSTS
cM Map156.7UniSTS
Whitehead Genetic150.0UniSTS
Whitehead/MRC_RH158.12UniSTS
Whitehead_YAC15 UniSTS
AA986417  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38153,318,040 - 3,318,208UniSTSGRCm38
MGSCv37153,268,040 - 3,268,208UniSTSGRCm37
Celera153,182,601 - 3,182,769UniSTS
Cytogenetic Map15A1UniSTS
cM Map154.6UniSTS
Whitehead/MRC_RH155.9UniSTS
D15Mit174  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38153,444,907 - 3,445,032UniSTSGRCm38
MGSCv37153,394,907 - 3,395,032UniSTSGRCm37
Celera153,310,847 - 3,310,972UniSTS
Cytogenetic Map15A1UniSTS
cM Map156.7UniSTS
Whitehead Genetic150.0UniSTS
Whitehead/MRC_RH158.12UniSTS
Whitehead_YAC15 UniSTS
Ghr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38153,327,654 - 3,328,041UniSTSGRCm38
MGSCv37153,277,654 - 3,278,041UniSTSGRCm37
Celera153,192,215 - 3,192,599UniSTS
Cytogenetic Map15A1UniSTS
cM Map154.6UniSTS
Ghr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38153,319,806 - 3,319,937UniSTSGRCm38
MGSCv37153,269,806 - 3,269,937UniSTSGRCm37
Celera153,184,367 - 3,184,498UniSTS
Cytogenetic Map15A1UniSTS
cM Map154.6UniSTS
D2Chm149  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38153,460,130 - 3,460,330UniSTSGRCm38
MGSCv37153,410,130 - 3,410,330UniSTSGRCm37
Celera153,326,066 - 3,326,250UniSTS
Cytogenetic Map15A1UniSTS
cM Map154.6UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300953Bdt5_mbone density traits 5 (mouse)Not determined15120460347Mouse
1301023Sluc24_msusceptibility to lung cancer 24 (mouse)Not determined15120460347Mouse
1302121Cliff_mcliff drop aversion (mouse)Not determined15120460347Mouse
1301662Faq8_mfluctuating asymmetry QTL 8 (mouse)Not determined15120460347Mouse
5491193Mobq4_mmultigenic obesity QTL 4 (mouse)Not determined15120460347Mouse
4141541Tglq3_mtriglyceride QTL 3 (mouse)Not determined15120460347Mouse
1357459Nhdlq7_mnon-HDL QTL 7 (mouse)Not determined15120460347Mouse
11062069Bpq31_mblood pressure QTL 31 (mouse)15126273109Mouse
4141446Ffaq4_mfree fatty acid QTL 4 (mouse)Not determined127101304Mouse
1300594Eae2_msusceptibility to experimental allergic encephalomyelitis 2 (mouse)Not determined15131218650Mouse
1301136Pgia8_mproteoglycan induced arthritis 8 (mouse)Not determined15321068524388090Mouse
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15344490771325689Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined346021278717086Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined346021278717086Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined346021278717086Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15346021278717086Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15346021278717086Mouse
4141358Ath22_matherosclerosis 22 (mouse)Not determined346456637464566Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1389
Count of miRNA genes:686
Interacting mature miRNAs:841
Transcripts:ENSMUST00000069451, ENSMUST00000110697, ENSMUST00000110698, ENSMUST00000159508, ENSMUST00000159912, ENSMUST00000160343, ENSMUST00000161180, ENSMUST00000161561, ENSMUST00000161770, ENSMUST00000162993
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001048178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA106517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA289909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC113323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC121307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02129572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI194700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY271378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE625087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY754177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S65034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000069451   ⟹   ENSMUSP00000069457
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl153,317,760 - 3,583,230 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110697   ⟹   ENSMUSP00000106325
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl153,327,539 - 3,471,644 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110698   ⟹   ENSMUSP00000106326
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl153,327,525 - 3,583,188 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159508
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl153,346,509 - 3,583,211 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159912
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl153,543,837 - 3,583,187 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160343
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl153,341,029 - 3,583,188 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161180
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl153,384,309 - 3,583,492 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161561   ⟹   ENSMUSP00000124064
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl153,319,009 - 3,581,842 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161770   ⟹   ENSMUSP00000125044
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl153,333,439 - 3,582,596 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162993
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl153,345,227 - 3,583,212 (-)Ensembl
RefSeq Acc Id: NM_001048178   ⟹   NP_001041643
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39153,357,007 - 3,612,834 (-)NCBI
GRCm38153,327,525 - 3,583,352 (-)NCBI
MGSCv37153,267,760 - 3,533,230 (-)RGD
Celera153,182,316 - 3,449,004 (-)NCBI
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001286370   ⟹   NP_001273299
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39153,347,237 - 3,611,324 (-)NCBI
GRCm38153,317,755 - 3,581,842 (-)NCBI
Celera153,182,316 - 3,449,004 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010284   ⟹   NP_034414
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39153,347,237 - 3,612,834 (-)NCBI
GRCm38153,317,755 - 3,583,352 (-)NCBI
MGSCv37153,267,760 - 3,533,230 (-)RGD
Celera153,182,316 - 3,449,004 (-)NCBI
cM Map15 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034414   ⟸   NM_010284
- Peptide Label: isoform 1 precursor
- UniProtKB: P16882 (UniProtKB/Swiss-Prot),   Q3UNY8 (UniProtKB/TrEMBL),   Q3UP14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001041643   ⟸   NM_001048178
- Peptide Label: isoform 2 precursor
- UniProtKB: P16882 (UniProtKB/Swiss-Prot),   Q3UNY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273299   ⟸   NM_001286370
- Peptide Label: isoform 1 precursor
- UniProtKB: P16882 (UniProtKB/Swiss-Prot),   Q3UP14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000106325   ⟸   ENSMUST00000110697
RefSeq Acc Id: ENSMUSP00000106326   ⟸   ENSMUST00000110698
RefSeq Acc Id: ENSMUSP00000069457   ⟸   ENSMUST00000069451
RefSeq Acc Id: ENSMUSP00000124064   ⟸   ENSMUST00000161561
RefSeq Acc Id: ENSMUSP00000125044   ⟸   ENSMUST00000161770
Protein Domains
EpoR_lig-bind   Fibronectin type-III

Promoters
RGD ID:6826028
Promoter ID:MM_KWN:17907
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   Liver
Transcripts:OTTMUST00000075784
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36153,421,094 - 3,421,594 (-)MPROMDB
RGD ID:6826026
Promoter ID:MM_KWN:17908
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:NM_001048178,   NM_010284,   OTTMUST00000075777,   OTTMUST00000075778,   OTTMUST00000075780,   OTTMUST00000075781,   OTTMUST00000075782,   OTTMUST00000075783,   UC007VCB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36153,532,126 - 3,534,327 (-)MPROMDB
RGD ID:8683304
Promoter ID:EPDNEW_M19682
Type:initiation region
Name:Ghr_1
Description:Mus musculus growth hormone receptor , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38153,583,212 - 3,583,272EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95708 AgrOrtholog
Ensembl Genes ENSMUSG00000055737 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000069457 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000106325 UniProtKB/Swiss-Prot
  ENSMUSP00000106326 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000124064 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000125044 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000069451 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000110697 UniProtKB/Swiss-Prot
  ENSMUST00000110698 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000161561 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000161770 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GHBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth/epo_recpt_lig-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Long_hematopoietin_rcpt_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14600 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95708 ENTREZGENE
NCBI Gene 14600 ENTREZGENE
Pfam EpoR_lig-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GHBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GHR RGD
PhenoGen Ghr PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_L_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.3986 ENTREZGENE
UniProt E0CXS6_MOUSE UniProtKB/TrEMBL
  GHR_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UNY8 ENTREZGENE, UniProtKB/TrEMBL
  Q3UP14 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P16590 UniProtKB/Swiss-Prot
  Q61653 UniProtKB/Swiss-Prot
  Q6DI66 UniProtKB/Swiss-Prot
  Q80W86 UniProtKB/Swiss-Prot
  Q8R1M5 UniProtKB/Swiss-Prot
  Q920Z3 UniProtKB/Swiss-Prot
  Q9R264 UniProtKB/Swiss-Prot