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Gene: GHR (growth hormone receptor) Homo sapiens
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Symbol: GHR
Name: growth hormone receptor
Description: Exhibits growth factor binding activity; peptide hormone binding activity; and protein homodimerization activity. Involved in several processes, including response to cycloheximide; response to estradiol; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to several cellular components, including cell surface; cytoplasmic ribonucleoprotein granule; and growth hormone receptor complex. Implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Biomarker of Laron syndrome; breast cancer; and type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GH receptor; GHBP; GHIP; growth hormone binding protein; serum binding protein; somatotropin receptor
Orthologs:
Mus musculus (house mouse) : Ghr (growth hormone receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ghr (growth hormone receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ghr (growth hormone receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : GHR (growth hormone receptor)
Canis lupus familiaris (dog) : GHR (growth hormone receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ghr (growth hormone receptor)
Sus scrofa (pig) : GHR (growth hormone receptor)
Chlorocebus sabaeus (African green monkey) : GHR (growth hormone receptor)
Heterocephalus glaber (naked mole-rat) : Ghr (growth hormone receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl542,423,439 - 42,721,878 (+)EnsemblGRCh38hg38GRCh38
GRCh38542,423,439 - 42,721,878 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37542,423,577 - 42,721,980 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36542,459,783 - 42,757,683 (+)NCBINCBI36hg18NCBI36
Build 34542,459,782 - 42,757,682NCBI
Celera542,314,115 - 42,611,474 (+)NCBI
Cytogenetic Map5p13.1-p12NCBI
HuRef542,375,464 - 42,673,429 (+)NCBIHuRef
CHM1_1542,425,901 - 42,723,964 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on GHR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69149
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.