Tf (transferrin) - Rat Genome Database

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Gene: Tf (transferrin) Rattus norvegicus
Analyze
Symbol: Tf
Name: transferrin
RGD ID: 3845
Description: Enables ferric iron binding activity. Involved in several processes, including cellular response to cAMP; cellular response to follicle-stimulating hormone stimulus; and regulation of nervous system development. Located in several cellular components, including basement membrane; cell tip; and dendrite. Used to study hepatitis. Biomarker of anemia and obesity. Human ortholog(s) of this gene implicated in anemia (multiple); atransferrinemia; gastrointestinal system disease; glucose metabolism disease (multiple); and restless legs syndrome. Orthologous to human TF (transferrin); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; hypoxia inducible factor pathway; iron uptake pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-1 metal-binding globulin; liver regeneration-related protein LRRG03; MGC93500; serotransferrin; siderophilin; Tfn; Trf
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Hcar3
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88112,668,667 - 112,695,376 (-)NCBIGRCr8
mRatBN7.28103,789,780 - 103,816,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8103,767,995 - 103,816,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8109,449,188 - 109,475,891 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08107,648,350 - 107,675,056 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08105,491,027 - 105,517,729 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08111,694,570 - 111,721,275 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,673,547 - 111,721,333 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08111,085,984 - 111,112,688 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48108,217,774 - 108,244,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18108,237,229 - 108,263,942 (-)NCBI
Celera8103,167,171 - 103,194,045 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
TfRatAcute-Phase Reaction  IEP 1601529 RGD 
TfRatanemia treatmentISOTF (Homo sapiens)7244154associated with Heart FailureRGD 
TfRatanemia  IEP 7244377associated with Trypanosomiasis and protein:increased expression:serumRGD 
TfRatBrain Hypoxia-Ischemia treatmentISOTF (Homo sapiens)7244383 RGD 
TfRatBrain Injuries  IEP 7244386 RGD 
TfRatDiabetic Nephropathies  IDA 7244196 RGD 
TfRatExperimental Diabetes Mellitus  IEP 1601532 RGD 
TfRatExperimental Liver Cirrhosis  IEP 7244387 RGD 
TfRatgastrointestinal system disease  ISOTF (Homo sapiens)7244197associated with Anemia and Renal Insufficiency and ChronicRGD 
TfRatglomerulonephritis severityISOTF (Homo sapiens)7244194 RGD 
TfRathepatitis  IDA 1601541protein:decreased modification:serumRGD 
TfRathyperglycemia susceptibilityISOTF (Homo sapiens)1601518 RGD 
TfRathypertension  ISOTF (Homo sapiens)1601524protein:decreased expressionRGD 
TfRatInsulin Resistance  IEP 1601515protein:increased expression:plasmaRGD 
TfRatIntracranial Hemorrhages  IEP 1601537associated with Iron-Deficiency Anemia and protein:increased expression:basal gangliaRGD 
TfRatiron deficiency anemia susceptibilityISOTF (Homo sapiens)1601513DNA:missense mutation:exon:p.G277SRGD 
TfRatmembranous glomerulonephritis  ISOTF (Homo sapiens)7244198associated with Lupus Erythematosus and SystemicRGD 
TfRatMetabolic Syndrome susceptibilityISOTF (Homo sapiens)1601514protein:increased expression:serumRGD 
TfRatNerve Degeneration resistanceIDA 1601536 RGD 
TfRatobesity  IEP 1601520 RGD 
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TfRatalkaptonuria  ISOTF (Homo sapiens)8554872ClinVar Annotator: match by term: AlkaptonuriaClinVarPMID:12501223 more ...
TfRatAlzheimer's disease  ISOTF (Homo sapiens)8554872ClinVar Annotator: match by term: Transferrin variant C1/C2ClinVarPMID:15060098 more ...
TfRatatransferrinemia  ISOTF (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11110675 more ...
TfRatiron deficiency anemia  ISOTF (Homo sapiens)8554872ClinVar Annotator: match by term: Iron deficiency anemiaClinVarPMID:11703331 more ...
TfRatPrimary Lymphedema with Myelodysplasia  ISOTF (Homo sapiens)8554872ClinVar Annotator: match by term: Emberger syndromeClinVarPMID:22147895 and PMID:25741868
TfRatprostate cancer  ISOTF (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
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TfRatacute kidney failure  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28885000
TfRatalcohol use disorder  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11000917 and PMID:21792595
TfRatAlzheimer's disease  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15060098 and PMID:17192785
TfRatAnimal Mammary Neoplasms  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9879772 and PMID:16316942
TfRatatransferrinemia  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11110675 and PMID:12111369
TfRatautistic disorder  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15363659
TfRatcarcinoma  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9879772 and PMID:16316942
TfRatChemical and Drug Induced Liver Injury  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16099942
TfRatDrug-Related Side Effects and Adverse Reactions  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28885000
TfRatechinococcosis  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24270252
TfRatExperimental Liver Cirrhosis  ISOTrf (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15650968
TfRatExperimental Mammary Neoplasms  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9879772 and PMID:16316942
TfRathepatitis  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21907177
TfRathypochromic microcytic anemia  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11110675
TfRatInflammation  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20008134
TfRatIron Overload  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11110675
TfRatlung adenocarcinoma  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19381893
TfRatmalignant mesothelioma  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26818092
TfRatNeoplasm Invasiveness  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20390345
TfRatnephrotic syndrome  ISOTF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17178036
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TfRatatransferrinemia  ISSTrf (Mus musculus)13592920OMIM:209300MouseDO 
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TfRatatransferrinemia  ISOTF (Homo sapiens)7240710 OMIM 

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TfRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TF mRNA]CTDPMID:31150632
TfRat(1->4)-beta-D-glucan multiple interactionsISOTrf (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TRF mRNACTDPMID:36331819
TfRat(R)-pantothenic acid multiple interactionsISOTF (Homo sapiens)6480464[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA more ...CTDPMID:34323617
TfRat(R,R,R)-alpha-tocopherol multiple interactionsISOTF (Homo sapiens)6480464[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of TF proteinCTDPMID:36372912
TfRat(S)-nicotine multiple interactionsISOTF (Homo sapiens)6480464[Nicotine co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of TF proteinCTDPMID:36372912
TfRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of TF mRNACTDPMID:12655037 and PMID:17351261
TfRat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of TF mRNACTDPMID:17108234
TfRat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TF mRNACTDPMID:32741896
TfRat17beta-estradiol affects expressionISOTrf (Mus musculus)6480464Estradiol affects the expression of TRF mRNACTDPMID:39298647
TfRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of TF proteinCTDPMID:32145629
TfRat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TF mRNACTDPMID:32741896
TfRat2,3,7,8-tetrabromodibenzodioxine increases expressionISOTrf (Mus musculus)64804642 more ...CTDPMID:27604104
TfRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of TF mRNA and Tetrachlorodibenzodioxin results in increased expression of TF proteinCTDPMID:15644576 and PMID:16497791
TfRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of TF mRNACTDPMID:34747641
TfRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOTrf (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of TRF mRNA and Tetrachlorodibenzodioxin results in increased expression of TRF proteinCTDPMID:28213091 and PMID:29673856
TfRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTrf (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TRF mRNACTDPMID:21570461 and PMID:24680724
TfRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTF (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of TF mRNACTDPMID:21998131
TfRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTrf (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of TRF mRNACTDPMID:19770486 and PMID:28213091
TfRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TF mRNACTDPMID:16497791
TfRat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOTrf (Mus musculus)64804642 more ...CTDPMID:38648751

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Biological Process
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Original Reference(s)
TfRatactin filament organization involved_inISOTrf (Mus musculus)1624291 PMID:19252502RGDPMID:19252502
TfRatacute-phase response  IEP 1601529 RGD 
TfRatantibacterial humoral response involved_inIBAPANTHER:PTN002608129 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
TfRatapoptotic process involved_inISSUniProtKB:O887641600115GO_REF:0000024UniProtGO_REF:0000024
TfRatcell surface receptor signaling pathway involved_inISOTF (Homo sapiens)1624291 PMID:9465039RGDPMID:9465039
TfRatcellular response to cAMP involved_inIEP 8553441PMID:15831523UniProt 
TfRatcellular response to follicle-stimulating hormone stimulus involved_inIEP 8553441PMID:15831523UniProt 
TfRatcellular response to iron ion involved_inISOTF (Homo sapiens)1624291UniProtKB:Q07891 more ...RGDPMID:18353247
TfRatERK1 and ERK2 cascade involved_inISOTrf (Mus musculus)1624291 PMID:19252502RGDPMID:19252502
TfRatintracellular iron ion homeostasis  TAS 737676 RGD 
TfRatintracellular iron ion homeostasis involved_inIEAInterPro:IPR0306851600115GO_REF:0000002InterProGO_REF:0000002
TfRatintracellular iron ion homeostasis involved_inISOTF (Homo sapiens)1624291UniProtKB:Q9UP52 and PMID:18353247RGDPMID:18353247
TfRatiron ion transport  TAS 737676 RGD 
TfRatiron ion transport involved_inISOTF (Homo sapiens)1624291UniProtKB:Q9UP52 more ...RGDPMID:18353247 and PMID:9465039
TfRatiron ion transport involved_inIEAInterPro:IPR0306851600115GO_REF:0000002InterProGO_REF:0000002
TfRatiron ion transport acts_upstream_of_or_withinISOTrf (Mus musculus)1624291MGI:1856905 PMID:11230685RGDPMID:11230685
TfRatiron ion transport involved_inIBAMGI:98821 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
TfRatiron ion transport involved_inIEAUniProtKB-KW:KW-04101600115GO_REF:0000043UniProtGO_REF:0000043
TfRatiron ion transport  IDA 1601530 RGD 
TfRatmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component
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TfRatapical plasma membrane located_inISOTF (Homo sapiens)1624291 PMID:11208127RGDPMID:11208127
TfRatbasal part of cell located_inISOTF (Homo sapiens)1624291 PMID:15880641RGDPMID:15880641
TfRatbasal plasma membrane located_inISOTF (Homo sapiens)1624291 PMID:15880641RGDPMID:15880641
TfRatbasement membrane  IDA 1625719 RGD 
TfRatcell surface located_inISOTF (Homo sapiens)1624291 PMID:16195351RGDPMID:16195351
TfRatcell tip  IDA 1601530 RGD 
TfRatclathrin-coated pit located_inISOTF (Homo sapiens)1624291 PMID:12857860RGDPMID:12857860
TfRatclathrin-coated pit located_inISOTrf (Mus musculus)1624291 PMID:20427320RGDPMID:20427320
TfRatcytoplasmic vesicle located_inISOTF (Homo sapiens)1624291 PMID:12857860RGDPMID:12857860
TfRatdendrite  IDA 152995513MMO:0000686RGD 
TfRatdense body located_inISOTF (Homo sapiens)1624291 PMID:21266579RGDPMID:21266579
TfRatearly endosome located_inISOTF (Homo sapiens)1624291 PMID:15880641RGDPMID:15880641
TfRatearly endosome is_active_inIBAFB:FBgn0036299 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
TfRatearly endosome located_inISOTrf (Mus musculus)1624291 PMID:23416069 and PMID:24035762RGDPMID:23416069 and PMID:24035762
TfRatendocytic vesicle located_inISOTF (Homo sapiens)1624291 PMID:15229288 and PMID:15292400RGDPMID:15229288 and PMID:15292400
TfRatendocytic vesicle located_inISOTrf (Mus musculus)1624291 PMID:12121420RGDPMID:12121420
TfRatendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
TfRatendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
TfRatendosome located_inISOTrf (Mus musculus)1624291 PMID:15247266 more ...RGDPMID:15247266 more ...
TfRatextracellular region located_inIEAInterPro:IPR0181951600115GO_REF:0000002InterProGO_REF:0000002
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Molecular Function
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RGD Manual Annotations


  
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Original Reference(s)
TfRatiron uptake pathway  ISOTrf (Mus musculus)11554199 RGD 

Imported Annotations - PID (archival)

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Original Reference(s)
TfRatephrin - ephrin receptor bidirectional signaling axis  ISOTF (Homo sapiens)6484113 PIDPID:200052
TfRathypoxia inducible factor pathway   ISOTF (Homo sapiens)6484113 PIDPID:200202

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Reference Title
Reference Citation
1. Transferrin is not involved in the entry of 67Ga into hepatocytes from regenerating liver of partially hepatectomized rats. Abe S, etal., Biol Pharm Bull 2001 Dec;24(12):1343-6.
2. Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin. Adamo AM, etal., Exp Neurol. 2006 Apr;198(2):519-29. Epub 2006 Feb 14.
3. Nerve degeneration is prevented by a single intraneural apotransferrin injection into colchicine-injured sciatic nerves in the rat. Aquino JB, etal., Brain Res. 2006 Oct 30;1117(1):80-91. Epub 2006 Sep 28.
4. Target identification of the novel antiobesity agent tungstate in adipose tissue from obese rats. Barcelo-Batllori S, etal., Proteomics. 2005 Dec;5(18):4927-35.
5. IRON-HF study: A randomized trial to assess the effects of iron in heart failure patients with anemia. Beck-da-Silva L, etal., Int J Cardiol. 2013 May 13. pii: S0167-5273(13)00848-6. doi: 10.1016/j.ijcard.2013.04.181.
6. Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis. Brunner HI, etal., Arthritis Rheum. 2012 Aug;64(8):2687-97. doi: 10.1002/art.34426.
7. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego Cymerys M, etal., Pol Merkur Lekarski. 2003 Oct;15(88):352-4; discussion 354-5.
8. Iron metabolism and its relationship to anemia and immune system in Trypanosoma evansi infected rats. da Silva CB, etal., Exp Parasitol. 2013 Mar;133(3):357-64. doi: 10.1016/j.exppara.2012.12.010. Epub 2012 Dec 25.
9. Rat mammary-gland transferrin: nucleotide sequence, phylogenetic analysis and glycan structure. Escriva H, etal., Biochem J 1995 Apr 1;307 ( Pt 1):47-55.
10. Ferritin and transferrin are both predictive of the onset of hyperglycemia in men and women over 3 years: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. Fumeron F, etal., Diabetes Care. 2006 Sep;29(9):2090-4.
11. Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade. Gainey MA, etal., Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3590-9. doi: 10.1073/pnas.1510754112. Epub 2015 Jun 24.
12. Differential effects of apotransferrin on two populations of oligodendroglial cells. Garcia CI, etal., Glia 2003 Jun;42(4):406-16.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Immunolocalization of some plasmatic proteins in basement membranes during earliest rat morphogenesis with special reference to the gonadal differentiation. Gelly JL, etal., Histochemistry. 1991;96(4):323-6.
15. Intranasal administration of aTf protects and repairs the neonatal white matter after a cerebral hypoxic-ischemic event. Guardia Clausi M, etal., Glia. 2012 Oct;60(10):1540-54. doi: 10.1002/glia.22374. Epub 2012 Jun 26.
16. Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats. Han J, etal., Nutr Neurosci 2003 Feb;6(1):1-10.
17. Decisive indicator for gastrointestinal workup in anemic patients with nondialysis chronic kidney disease. Hwang HS, etal., Int J Med Sci. 2012;9(8):634-41. doi: 10.7150/ijms.4969. Epub 2012 Sep 19.
18. Time-dependent plasma protein changes in streptozotocin-induced diabetic rats before and after fungal polysaccharide treatments. Kim SW, etal., J Proteome Res. 2006 Nov;5(11):2966-76.
19. Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human. Kolachala VL, etal., World J Gastroenterol. 2007 Feb 21;13(7):1042-52.
20. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
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PMID:500689   PMID:1791188   PMID:3023031   PMID:3046665   PMID:6236811   PMID:8829802   PMID:9420335   PMID:9546397   PMID:9990067   PMID:11208127   PMID:11230685   PMID:11739192  
PMID:12121420   PMID:12477932   PMID:12704209   PMID:12857860   PMID:14701678   PMID:15047867   PMID:15229288   PMID:15247266   PMID:15292400   PMID:15469901   PMID:15489334   PMID:15637325  
PMID:15880641   PMID:16195351   PMID:16227996   PMID:16497717   PMID:16502470   PMID:17628542   PMID:18353247   PMID:18353773   PMID:18459135   PMID:18477453   PMID:18511206   PMID:18708193  
PMID:19056867   PMID:19061864   PMID:19250966   PMID:19252502   PMID:19464997   PMID:20080761   PMID:20202662   PMID:20427320   PMID:21195069   PMID:22206666   PMID:22479482   PMID:22516433  
PMID:22664934   PMID:23012479   PMID:23303939   PMID:23376485   PMID:23416069   PMID:23533145   PMID:23580065   PMID:24035762   PMID:25595122   PMID:25649872   PMID:26316108   PMID:29248829  
PMID:29388418   PMID:29476059   PMID:30758712   PMID:36361544  



Tf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88112,668,667 - 112,695,376 (-)NCBIGRCr8
mRatBN7.28103,789,780 - 103,816,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8103,767,995 - 103,816,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8109,449,188 - 109,475,891 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08107,648,350 - 107,675,056 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08105,491,027 - 105,517,729 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08111,694,570 - 111,721,275 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,673,547 - 111,721,333 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08111,085,984 - 111,112,688 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48108,217,774 - 108,244,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18108,237,229 - 108,263,942 (-)NCBI
Celera8103,167,171 - 103,194,045 (-)NCBICelera
Cytogenetic Map8q32NCBI
TF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383133,661,998 - 133,796,641 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3133,746,040 - 133,796,641 (+)EnsemblGRCh38hg38GRCh38
GRCh373133,380,842 - 133,515,485 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363134,947,925 - 134,980,325 (+)NCBINCBI36Build 36hg18NCBI36
Build 343134,947,932 - 134,980,333NCBI
Celera3131,892,092 - 131,924,970 (+)NCBICelera
Cytogenetic Map3q22.1NCBI
HuRef3130,844,635 - 130,877,514 (+)NCBIHuRef
CHM1_13133,428,386 - 133,461,264 (+)NCBICHM1_1
T2T-CHM13v2.03136,407,161 - 136,541,840 (+)NCBIT2T-CHM13v2.0
Trf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399103,086,075 - 103,107,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9103,081,200 - 103,107,643 (-)EnsemblGRCm39 Ensembl
GRCm389103,208,876 - 103,230,286 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9103,204,001 - 103,230,444 (-)EnsemblGRCm38mm10GRCm38
MGSCv379103,111,206 - 103,132,616 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369103,067,026 - 103,088,436 (-)NCBIMGSCv36mm8
Celera9102,759,422 - 102,780,824 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map955.03NCBI
LOC102027549
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555014,801,885 - 4,831,910 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555014,801,710 - 4,832,025 (-)NCBIChiLan1.0ChiLan1.0
TF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22131,677,472 - 131,709,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13131,682,201 - 131,713,860 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03130,799,063 - 130,830,227 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13138,274,159 - 138,305,481 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3138,274,159 - 138,305,476 (+)Ensemblpanpan1.1panPan2
LOC477072
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12330,658,250 - 30,683,816 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2330,595,704 - 30,683,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2330,637,375 - 30,662,940 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02331,178,649 - 31,204,226 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12330,872,448 - 30,898,034 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02330,930,277 - 30,955,845 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02331,177,861 - 31,203,421 (+)NCBIUU_Cfam_GSD_1.0
LOC101970551
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560270,095,470 - 70,135,492 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365296,856,042 - 6,895,989 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1374,930,655 - 74,972,763 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11374,930,655 - 74,970,599 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21382,429,021 - 82,469,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q31NCBI
TF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11556,586,311 - 56,618,304 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1556,586,104 - 56,618,149 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604129,568,907 - 29,601,746 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101719398
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473010,078,165 - 10,109,349 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tf
109 total Variants

Predicted Target Of
Summary Value
Count of predictions:210
Count of miRNA genes:95
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000012725, ENSRNOT00000012946, ENSRNOT00000045628
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)888612425107550209Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat

1 to 10 of 26 rows
Trf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28103,816,628 - 103,816,847 (+)MAPPERmRatBN7.2
Rnor_6.08111,721,417 - 111,721,635NCBIRnor6.0
Rnor_5.08111,112,830 - 111,113,048UniSTSRnor5.0
RGSC_v3.48108,244,629 - 108,244,847UniSTSRGSC3.4
Celera8103,194,187 - 103,194,402UniSTS
Cytogenetic Map8q32UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 30 of 37 rows
RefSeq Transcripts NM_001013110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC119318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF468455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF476964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY327504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 37 rows

Ensembl Acc Id: ENSRNOT00000012725   ⟹   ENSRNOP00000012725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8103,767,995 - 103,816,511 (-)Ensembl
Rnor_6.0 Ensembl8111,673,547 - 111,721,333 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000045628   ⟹   ENSRNOP00000045637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8103,789,784 - 103,816,511 (-)Ensembl
Rnor_6.0 Ensembl8111,694,566 - 111,721,303 (-)Ensembl
RefSeq Acc Id: NM_001013110   ⟹   NP_001013128
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,668,667 - 112,695,376 (-)NCBI
mRatBN7.28103,789,780 - 103,816,487 (-)NCBI
Rnor_6.08111,694,570 - 111,721,275 (-)NCBI
Rnor_5.08111,085,984 - 111,112,688 (-)NCBI
RGSC_v3.48108,217,774 - 108,244,487 (-)RGD
Celera8103,167,171 - 103,194,045 (-)RGD
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_001013128 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42266 (Get FASTA)   NCBI Sequence Viewer  
  AAA42267 (Get FASTA)   NCBI Sequence Viewer  
  AAH87021 (Get FASTA)   NCBI Sequence Viewer  
  AAP97736 (Get FASTA)   NCBI Sequence Viewer  
  BAA07458 (Get FASTA)   NCBI Sequence Viewer  
  CAA54403 (Get FASTA)   NCBI Sequence Viewer  
  EDL77387 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045637
  ENSRNOP00000045637.2
GenBank Protein P12346 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_001013128   ⟸   NM_001013110
- Peptide Label: precursor
- UniProtKB: Q64630 (UniProtKB/Swiss-Prot),   Q64628 (UniProtKB/Swiss-Prot),   Q63602 (UniProtKB/Swiss-Prot),   Q7TNX0 (UniProtKB/Swiss-Prot),   P12346 (UniProtKB/Swiss-Prot),   A6I2I8 (UniProtKB/TrEMBL),   A6I2I9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045637   ⟸   ENSRNOT00000045628
Ensembl Acc Id: ENSRNOP00000012725   ⟸   ENSRNOT00000012725
Transferrin-like

Name Modeler Protein Id AA Range Protein Structure
AF-P12346-F1-model_v2 AlphaFold P12346 1-698 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696228
Promoter ID:EPDNEW_R6753
Type:multiple initiation site
Name:Tf_1
Description:transferrin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08111,721,296 - 111,721,356EPDNEW


1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-29332 BioCyc
Ensembl Genes ENSRNOG00000030625 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045628 ENTREZGENE
  ENSRNOT00000045628.6 UniProtKB/Swiss-Prot
Gene3D-CATH Periplasmic binding protein-like II UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132382 IMAGE-MGC_LOAD
InterPro Serotransferrin_mammal UniProtKB/Swiss-Prot
  Transferrin UniProtKB/Swiss-Prot
  Transferrin-like_dom UniProtKB/Swiss-Prot
  Transferrin_Fe_BS UniProtKB/Swiss-Prot
KEGG Report rno:24825 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93500 IMAGE-MGC_LOAD
NCBI Gene 24825 ENTREZGENE
PANTHER SEROTRANSFERRIN UniProtKB/Swiss-Prot
  TRANSFERRIN UniProtKB/Swiss-Prot
Pfam Transferrin UniProtKB/Swiss-Prot
PhenoGen Tf PhenoGen
PIRSF Serotransferrin UniProtKB/Swiss-Prot
  Transferrin UniProtKB/Swiss-Prot
PRINTS TRANSFERRIN UniProtKB/Swiss-Prot
PROSITE TRANSFERRIN_LIKE_1 UniProtKB/Swiss-Prot
  TRANSFERRIN_LIKE_2 UniProtKB/Swiss-Prot
  TRANSFERRIN_LIKE_3 UniProtKB/Swiss-Prot
  TRANSFERRIN_LIKE_4 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030625 RatGTEx
SMART TR_FER UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
UniProt A6I2I8 ENTREZGENE, UniProtKB/TrEMBL
  A6I2I9 ENTREZGENE, UniProtKB/TrEMBL
  P12346 ENTREZGENE
  Q63602 ENTREZGENE
  Q64628 ENTREZGENE
  Q64630 ENTREZGENE
  Q7TMC7_RAT UniProtKB/TrEMBL
  Q7TNX0 ENTREZGENE
  TRFE_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63602 UniProtKB/Swiss-Prot
  Q64628 UniProtKB/Swiss-Prot
  Q64630 UniProtKB/Swiss-Prot
  Q7TNX0 UniProtKB/Swiss-Prot
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tf  transferrin  Trf  transferrin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Trf  transferrin  Tf  transferrin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tf  Transferrin      Symbol and Name status set to approved 70586 APPROVED