Activ1 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Activ1 (Activity QTL 1) Rattus norvegicus

Symbol: Activ1
Name: Activity QTL 1
RGD ID: 631217
Previously known as: Act1; Ma1; Motor activity QTL 1
Trait: voluntary movement trait   (VT:0003491)    
Measurement Type: number of photobeam interruptions in an experimental apparatus   (CMO:0001517)    
LOD Score: 15.9
P Value: Not Available
Variance: 35.0
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88111,249,511 - 117,802,327RGD_MAPPER_PIPELINE
mRatBN7.28102,370,617 - 108,923,645RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.08110,212,979 - 116,947,981RGD_MAPPER_PIPELINERnor6.0
Rnor_5.08109,621,234 - 116,312,980RGDRnor5.0
RGSC_v3.48106,733,287 - 113,364,148RGDRGSC3.4
RGSC_v3.18106,752,743 - 113,498,899RGD
Cross Type: intercross
Strains Crossed: WKY WKHA/N 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Activ1RatHyperkinesis  IDA 631170 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Activ1Rathyperactivity  QTM 631170 RGD 
Activ1Ratincreased exploration in new environment  QTM 631228 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Activ1Ratnumber of photobeam interruptions in an experimental apparatus  IDA 631228 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Activ1Ratcontrol condition  IDA 631228 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Activ1Ratnovel cage apparatus test utilizing automatic movement detection system  IDA 631228 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Activ1RatWKHA/N  IEA 631228 RGD 
Activ1RatWKY  IEA 631228 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Activ1Ratvoluntary movement trait  IDA 631228 RGD 


#
Reference Title
Reference Citation
1. Lineage is an epigenetic modifier of QTL influencing behavioral coping with stress. Ahmadiyeh N, etal., Behav Genet 2005 Mar;35(2):189-98.
2. Further dissection of a genomic locus associated with behavioral activity in the Wistar-Kyoto hyperactive rat, an animal model of hyperkinesis. Moisan MP, etal., Mol Psychiatry 2003 Mar;8(3):348-52.
3. A major quantitative trait locus influences hyperactivity in the WKHA rat. Moisan MP, etal., Nat Genet 1996 Dec;14(4):471-3.

Related QTL Description Reference
Stresp11 maps to same region RGD:1358767
Activ2 maps to same region RGD:631228



1 to 20 of 136 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
2556Ephb1Eph receptor B18102507549102944839Rat
1305407Kykyphoscoliosis peptidase8103086959103126305Rat
41111708Rpl27-ps3ribosomal protein L27, pseudogene 38103138302103138924Rat
1561183Cep63centrosomal protein 638103162639103214177Rat
1583270Anapc13anaphase promoting complex subunit 138103205520103213936Rat
70977Amotl2angiomotin like 28103303368103319161Rat
620549Rykreceptor-like tyrosine kinase8103419338103492083Rat
7621358LOC102549824uncharacterized LOC1025498248103578910103588660Rat
3051Slco2a1solute carrier organic anion transporter family, member 2a18103588916103672546Rat
41348082LOC120094519small nucleolar RNA SNORA178103607316103607440Rat
1309958Rab6bRAB6B, member RAS oncogene family8103695328103764023Rat
1304698SrprbSRP receptor subunit beta8103768685103782632Rat
3845Tftransferrin8103789780103816487Rat
41361285LOC120094247uncharacterized LOC1200942478103826885103829663Rat
1310507Inhcainhibitor of carbonic anhydrase8103836846103874980Rat
1562949Topbp1DNA topoisomerase II binding protein 18103887805103931662Rat
1359113Cdv3carnitine deficiency-associated gene expressed in ventricle 38103934006103947173Rat
7532272LOC102550226uncharacterized LOC1025502268103967818103978728Rat
1591927Bfsp2beaded filament structural protein 28104006226104063399Rat
1311530Tmem108transmembrane protein 1088104066081104360172Rat

1 to 20 of 136 rows
1 to 20 of 190 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10074D8Wox151658104917506104917671Ratregion
33919D8Mit151018102370617102370718Ratregion
34062D8Mgh22608105647037105647297Ratregion
34068D8Mgh111648105647049105647213Ratregion
35405D8Rat601628104790881104791045Ratregion
35537D8Rat121968104215934104216130Ratregion
37130D8Rat1071888103897218103897433Ratregion
37736D8Rat652278105406630105406857Ratregion
34949D8Rat131678102387671102387838Ratregion
40480D8Rat1751238103687536103687659Ratregion
40308D8Rat1671748102620359102620533Ratregion
38956D8Rat671888108836661108836849Ratregion
39134D8Rat762268107269825107270051Ratregion
39328D8Rat1032328106538675106538907Ratregion
42230D8Arb182838103671211103671496Ratregion
42232D8Arb192218107183772107183995Ratregion
42234D8Arb204058108776825108777230Ratregion
42240D8Arb28608105495002105495062Ratregion
41082D8Rat1232108104073095104073311Ratregion
44510D8Got1611548102866210102866364Ratregion
1 to 20 of 190 rows

Flank 1: (D8Mit15)
Rat AssemblyChrPosition (strand)Source
GRCr88111,249,511 - 111,249,612 (+)Marker Load Pipeline
mRatBN7.28102,370,617 - 102,370,718 (+)MAPPER
Rnor_6.08110,212,979 - 110,213,079NCBI
Rnor_5.08109,621,234 - 109,621,334UniSTS
RGSC_v3.48106,733,287 - 106,733,388RGD
RGSC_v3.48106,733,288 - 106,733,388UniSTS
RGSC_v3.18106,752,743 - 106,752,843RGD
Celera8101,755,196 - 101,755,296UniSTS
RH 3.4 Map81170.9RGD
RH 3.4 Map81170.9UniSTS
RH 2.0 Map8858.6RGD
Peak: (D8Mgh11)
Rat AssemblyChrPosition (strand)Source
GRCr88114,525,837 - 114,526,001 (+)Marker Load Pipeline
mRatBN7.28105,647,049 - 105,647,213 (+)MAPPER
Rnor_6.08113,580,399 - 113,580,562NCBI
Rnor_5.08112,967,026 - 112,967,189UniSTS
RGSC_v3.48110,106,284 - 110,106,448RGD
RGSC_v3.48110,106,285 - 110,106,448UniSTS
RGSC_v3.18110,125,739 - 110,125,903RGD
Celera8105,003,697 - 105,003,860UniSTS
RH 3.4 Map81145.3UniSTS
RH 3.4 Map81145.3RGD
RH 2.0 Map8871.2RGD
Cytogenetic Map8q32UniSTS
Flank 2: (D8Wox11)
Rat AssemblyChrPosition (strand)Source
RGSC_v3.48113,364,040 - 113,364,148UniSTS
Celera8108,088,893 - 108,089,001UniSTS
RH 3.4 Map81120.8UniSTS
RH 3.4 Map81120.8RGD
RH 2.0 Map8873.1RGD
Cytogenetic Map8q32UniSTS


1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)888612425107550209Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat

1 to 10 of 26 rows


Database
Acc Id
Source(s)
NCBI Gene Activ1


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-14 Activ1  Activity QTL 1  Act1    Symbol updated 1299863 APPROVED
2003-10-17 Act1  Activity QTL 1  Ma1  Motor activity QTL 1  Symbol and Name updated 632217 PROVISIONAL

Note Type Note Reference
qtl_cross_type intercross  
qtl_disease model for hyperactivity 631170
qtl_gene D8Rat44 was used for linkage analysis with D2 dopamine receptor gene 631228
qtl_general also shows significance for rearings in an open field (lod=~6.4) and spontaneous activity (lod=4.4) 631170
qtl_general has strong influence on the hyperactivity phenotypes that are related to motor activity 631170
qtl_general highest LOD was observed for ambulatory activity at age 8 and 16 weeks over an hour period in activity cages which narrowed this QTL to approximately 10 cM 631228
qtl_general this QTL is weak in exploratory activity and not for ambulatory activity in the BNxWKHA cross as compared to the WKYxWKHA cross 631228