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Strain: WKY

Symbol: WKY
Strain: WKY
RGD ID: 61103
RRID: RGD_61103
Ontology ID: RS:0000742
Alleles: Nos3;   Cd36
Type: inbred
Source: Medical College of Ohio, Toledo, Ohio
Origin: This strain was maintained at Medical College of Ohio, Toledo, Ohio
Last Known Status: Unknown

Mutant Strains
WKY/Kiha




Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
diastolic blood pressure
mean arterial blood pressure
body weight
heart weight
hematocrit
blood glucose level
blood urea nitrogen level
serum creatinine level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
right kidney wet weight
lung wet weight
plasma renin activity level
urine potassium level
urine sodium level
ejection fraction
heart posterior wall thickness
timed urine volume
serum triglyceride level
serum total cholesterol level
tibia length
blood glomerular filtration rate
serum potassium level
serum sodium level
heart left ventricle weight to body weight ratio
plasma creatinine level
plasma triglyceride level
serum albumin level
plasma aldosterone level
plasma angiotensin II level
plasma total cholesterol level
left ventricular end-systolic blood pressure
left ventricular end-diastolic blood pressure
single kidney wet weight to body weight ratio
single kidney wet weight as percentage of body weight
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
plasma very low density lipoprotein cholesterol level
heart left ventricle infarction size to total heart left ventricle size ratio
urine protein excretion rate
urine sodium excretion rate
urine potassium excretion rate
urine calcium excretion rate
heart left ventricle weight
heart left ventricular end-diastolic diameter
heart left ventricle end-systolic diameter
heart left ventricle fractional shortening
heart ventricle septal wall thickness
index of glomerular damage
plasma corticosterone level
heart weight to tibia length ratio
kidney fibrotic lesion area to total kidney area ratio
kidney sclerotic glomeruli count to total glomeruli count ratio
ethanol intake volume to total fluid intake volume ratio
liver cholesterol level
liver triglyceride level
ethanol drink intake rate to body weight ratio
maximum rate of positive change in left ventricular blood pressure
blood ethanol clearance rate
decrease in blood ethanol level to body weight ratio per unit time
renal vascular resistance
renal plasma flow
left kidney wet weight to body weight ratio
kidney renin level
kidney glomerulus volume
blood very low density lipoprotein triglyceride level
heart angiotensin I converting enzyme 2 activity level
heart angiotensin I converting enzyme activity level
kidney angiotensin I converting enzyme 2 activity level
kidney angiotensin I converting enzyme activity level
lung angiotensin I converting enzyme 2 activity level
lung angiotensin I converting enzyme activity level
renal plasma flow to body weight ratio
glomerular filtration rate to body weight ratio
kidney sclerotic glomerular volume to total kidney glomerular volume ratio
heart left ventricle weight to tibia length ratio
E/A wave ratio
artery tunica media width to artery inner diameter ratio
renal filtration fraction
single nephron glomerular filtration rate
single nephron filtration fraction
afferent arteriolar plasma flow rate
glomerular capillary hydraulic pressure
afferent arteriolar plasma protein concentration
afferent colloid osmotic pressure
efferent colloid osmotic pressure
glomerular capillary ultrafiltration coefficient
mean proximal tubular hydraulic pressure
efferent arteriolar hydraulic pressure
glomerular transcapillary hydraulic pressure gradient
kidney glomerular surface area
kidney glomerular tuft surface area
measurement of minimal mechanical stimulus needed to elicit evasive reaction

References

References - curated
1. Carswell HV, etal., Methods Mol Med 2005;104:49-74.
2. Cerutti C, etal., Physiol Genomics. 2006 Nov 27;27(3):295-308. doi: 10.1152/physiolgenomics.00318.2005. Epub 2006 Aug 1.
3. Chung WK, etal., Genomics 1997 May 1;41(3):332-44
4. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
5. Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
6. Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
7. Frantz SA, etal., Hypertension 1998 Oct;32(4):639-46
8. Friedman J, etal., Am J Hypertens 2003 Dec;16(12):1049-52.
9. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
10. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
11. Hilbert P, etal., Nature 1991 Oct 10;353(6344):521-9
12. Jacob HJ, etal., Cell 1991 Oct 4;67(1):213-24
13. Jeffs B, etal., Nat Genet 1997 Aug;16(4):364-7
14. Klett CP, etal., Clin Exp Pharmacol Physiol Suppl 1995 Dec;22(1):S265-7.
15. Lindpaintner K, etal., J Hypertens 1993 Jan;11(1):19-23
16. Ohashi H, etal., Jpn Circ J. 1986 Feb;50(2):140-6.
17. Rapp JP and Deng AY, Hypertension 1995 Jun;25(6):1121-8.
18. RGD Automated Pipelines
19. Saito H, etal., Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S257-9. doi: 10.1111/j.1440-1681.1995.tb02906.x.
20. Samani NJ, etal., Hypertension 1996 Dec;28(6):1118-22
21. Tachi Y, etal., Life Sci 2001 Jul 20;69(9):1039-47.
22. Togashi H, etal., Stroke 1996 Mar;27(3):520-5; discussion 525-6.
23. Zhang L, etal., Clin Exp Pharmacol Physiol 1997 Jun;24(6):442-4.

Region

Strain QTL Data
Symbol Name Trait
Activ1 Activity QTL 1 voluntary movement trait   (VT:0003491)    
Activ2 Activity QTL 2 voluntary movement trait   (VT:0003491)    
Alc14 Alcohol consumption QTL 14 consumption behavior trait   (VT:0002069)    
Alc15 Alcohol consumption QTL 15 consumption behavior trait   (VT:0002069)    
Alc16 Alcohol consumption QTL 16 consumption behavior trait   (VT:0002069)    
Alc17 Alcohol consumption QTL 17 consumption behavior trait   (VT:0002069)    
Anxrr12 Anxiety related response QTL 12 locomotor behavior trait   (VT:0001392)    
Anxrr13 Anxiety related response QTL 13 locomotor behavior trait   (VT:0001392)    
Anxrr14 Anxiety related response QTL 14 locomotor behavior trait   (VT:0001392)    
Anxrr15 Anxiety related response QTL 15 locomotor behavior trait   (VT:0001392)    
Bp1 Blood pressure QTL 1 arterial blood pressure trait   (VT:2000000)    
Bp10 Blood pressure QTL 10 arterial blood pressure trait   (VT:2000000)    
Bp100 Blood pressure QTL 100 arterial blood pressure trait   (VT:2000000)    
Bp11 Blood pressure QTL 11 blood pressure trait   (VT:0000183)    
Bp16 Blood pressure QTL 16 arterial blood pressure trait   (VT:2000000)    
Bp2 Blood pressure QTL 2 arterial blood pressure trait   (VT:2000000)    
Bp28 Blood pressure QTL 28 arterial blood pressure trait   (VT:2000000)    
Bp3 Blood pressure QTL 3 arterial blood pressure trait   (VT:2000000)    
Bp31 Blood pressure QTL 31 arterial blood pressure trait   (VT:2000000)    
Bp4 Blood pressure QTL 4 arterial blood pressure trait   (VT:2000000)    
Bp49 Blood pressure QTL 49 cerebrum integrity trait   (VT:0010549)    
Bp55 Blood pressure QTL 55 arterial blood pressure trait   (VT:2000000)    
Bp63 Blood pressure QTL 63 arterial blood pressure trait   (VT:2000000)    
Bp83 Blood pressure QTL 83 arterial blood pressure trait   (VT:2000000)    
BpQTLCluster3 Blood pressure QTL cluster 3 arterial blood pressure trait   (VT:2000000)    
Bw120 Body weight QTL 120 body mass   (VT:0001259)    
Hc1 Hypercalciuria QTL 1 urine calcium amount   (VT:0002985)    
Hc2 Hypercalciuria QTL 2 urine calcium amount   (VT:0002985)    
Hc3 Hypercalciuria QTL 3 urine calcium amount   (VT:0002985)    
Hc4 Hypercalciuria QTL 4 urine calcium amount   (VT:0002985)    
Hc5 Hypercalciuria QTL 5 urine calcium amount   (VT:0002985)    
Hrtrt17 Heart rate QTL 17 heart pumping trait   (VT:2000009)    
Niddm4 Non-insulin dependent diabetes mellitus QTL 4 blood glucose amount   (VT:0000188)    
Niddm6 Non-insulin dependent diabetes mellitus QTL 6 blood glucose amount   (VT:0000188)    
Pancm1 Pancreatic morphology QTL 1 islet of Langerhans morphology trait   (VT:0005215)    
Rf51 Renal function QTL 51 kidney plasma flow trait   (VT:0005524)    
Sach4 Saccharine consumption QTL 4 consumption behavior trait   (VT:0002069)    
Sach5 Saccharine consumption QTL 5 consumption behavior trait   (VT:0002069)    
Stresp1 Stress response QTL 1 stress-related behavior trait   (VT:0010451)    
Stresp2 Stress response QTL 2 stress-related behavior trait   (VT:0010451)    
Stresp3 Stress response QTL 3 stress-related behavior trait   (VT:0010451)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics The hyperglycemic conditions in streptozotocin-induced diabetic Wistar rats reduced the intracellular glutathione content in the aortic tissue. 61037
strain_characteristics The hyperglycemic conditions in streptozotocin-induced diabetic Wistar rats reduced the intracellular glutathione content in the aortic tissue. 61050
strain_characteristics The hyperglycemic conditions in streptozotocin-induced diabetic Wistar rats reduced the intracellular glutathione content in the aortic tissue. 619649
strain_drgs_chems 24 hours after the streptozotocin injection the blood glucose level was increased. This resulted in the reduction of the intracellular glutathione content (GSH). 1004
strain_drgs_chems 24 hours after the streptozotocin injection the blood glucose level was increased. This resulted in the reduction of the intracellular glutathione content (GSH). 619649
strain_drgs_chems 24 hours after the streptozotocin injection the blood glucose level was increased. This resulted in the reduction of the intracellular glutathione content (GSH). 634612
strain_phys_biochem cultured cardiac fibroblasts express higher levels of angiotensin II (AII) receptors than SHR cultured cardiac fibroblasts 1358982