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Gene: Nprl2 (NPR2-like, GATOR1 complex subunit) Rattus norvegicus
Symbol: Nprl2
Name: NPR2-like, GATOR1 complex subunit
Description: Predicted to contribute to GTPase activator activity. Predicted to be involved in several processes, including cellular response to starvation; negative regulation of TOR signaling; and regulation of autophagy. Predicted to localize to the GATOR1 complex and lysosomal membrane. Human ortholog(s) of this gene implicated in focal epilepsy. Orthologous to human NPRL2 (NPR2 like, GATOR1 complex subunit); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC363138; MGC114378; nitrogen permease regulator-like 2; nitrogen permease regulator-like 2 (S. cerevisiae); tumor suppressor candidate 4; Tusc4
Homo sapiens (human) : NPRL2 (NPR2 like, GATOR1 complex subunit)  HGNC  Alliance
Mus musculus (house mouse) : Nprl2 (NPR2 like, GATOR1 complex subunit)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nprl2 (NPR2 like, GATOR1 complex subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : NPRL2 (NPR2 like, GATOR1 complex subunit)
Canis lupus familiaris (dog) : NPRL2 (NPR2 like, GATOR1 complex subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nprl2 (NPR2 like, GATOR1 complex subunit)
Sus scrofa (pig) : NPRL2 (NPR2 like, GATOR1 complex subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.08116,297,950 - 116,301,123 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,297,950 - 116,301,122 (+)Ensembl
Rnor_5.08115,654,210 - 115,657,383 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,789,664 - 112,792,837 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18112,809,139 - 112,812,182 (+)NCBI
Celera8107,522,243 - 107,525,416 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Nprl2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308927
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.