Dock3 (dedicator of cyto-kinesis 3) - Rat Genome Database

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Gene: Dock3 (dedicator of cyto-kinesis 3) Rattus norvegicus
Analyze
Symbol: Dock3
Name: dedicator of cyto-kinesis 3
RGD ID: 1306677
Description: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human DOCK3 (dedicator of cytokinesis 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dedicator of cytokinesis protein 3; LOC315992
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28107,552,462 - 107,903,527 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,552,463 - 107,903,514 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,176,105 - 113,530,816 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08111,375,279 - 111,729,993 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08109,218,058 - 109,572,780 (-)NCBIRnor_WKY
Rnor_6.08115,627,282 - 115,982,260 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,629,583 - 115,981,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,986,112 - 115,343,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,114,186 - 112,469,166 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,136,122 - 112,488,623 (-)NCBI
Celera8106,864,355 - 107,214,223 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
plasma membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A novel mechanism for the regulation of amyloid precursor protein metabolism. Chen Q, etal., J Cell Biol 2002 Jul 8;158(1):79-89. Epub 2002 Jul 1.
2. Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype. de Silva MG, etal., J Med Genet 2003 Oct;40(10):733-40.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Isolation and characterization of novel presenilin binding protein. Kashiwa A, etal., J Neurochem 2000 Jul;75(1):109-16.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:15647471   PMID:22734669   PMID:26319681  


Genomics

Comparative Map Data
Dock3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28107,552,462 - 107,903,527 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,552,463 - 107,903,514 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,176,105 - 113,530,816 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08111,375,279 - 111,729,993 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08109,218,058 - 109,572,780 (-)NCBIRnor_WKY
Rnor_6.08115,627,282 - 115,982,260 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,629,583 - 115,981,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,986,112 - 115,343,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,114,186 - 112,469,166 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,136,122 - 112,488,623 (-)NCBI
Celera8106,864,355 - 107,214,223 (-)NCBICelera
Cytogenetic Map8q32NCBI
DOCK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,674,927 - 51,384,198 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl350,674,927 - 51,384,198 (+)EnsemblGRCh38hg38GRCh38
GRCh37350,712,358 - 51,421,629 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,687,676 - 51,396,669 (+)NCBINCBI36Build 36hg18NCBI36
Build 34350,687,675 - 51,396,669NCBI
Celera350,685,455 - 51,395,983 (+)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef350,872,126 - 51,478,856 (+)NCBIHuRef
CHM1_1350,664,865 - 51,373,537 (+)NCBICHM1_1
T2T-CHM13v2.0350,704,905 - 51,414,618 (+)NCBIT2T-CHM13v2.0
Dock3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,770,024 - 107,109,108 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,770,024 - 107,109,108 (-)EnsemblGRCm39 Ensembl
GRCm389106,892,825 - 107,232,330 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,892,825 - 107,231,909 (-)EnsemblGRCm38mm10GRCm38
MGSCv379106,795,156 - 107,134,240 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369106,753,481 - 107,089,960 (-)NCBIMGSCv36mm8
Celera9106,516,972 - 106,837,868 (-)NCBICelera
Cytogenetic Map9F1NCBI
Dock3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,615,939 - 3,073,971 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,616,700 - 3,073,926 (+)NCBIChiLan1.0ChiLan1.0
DOCK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,944,252 - 52,549,204 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,944,251 - 52,546,569 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0350,603,069 - 51,314,876 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DOCK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12038,200,938 - 38,707,310 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2038,203,520 - 38,707,254 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,180,469 - 38,625,554 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02038,549,777 - 39,060,437 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2038,550,598 - 39,060,757 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,913,166 - 38,428,401 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02038,317,483 - 38,831,992 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02038,607,120 - 39,111,912 (-)NCBIUU_Cfam_GSD_1.0
Dock3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,421,764 - 66,010,610 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365292,182,255 - 2,774,346 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365292,182,261 - 2,771,107 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1333,152,428 - 33,657,131 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11333,152,138 - 33,657,133 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21336,385,270 - 36,847,528 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DOCK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12212,078,424 - 12,725,245 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2212,078,627 - 12,726,074 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041154,242,164 - 154,922,964 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dock3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,831,042 - 5,161,736 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,501,927 - 5,164,297 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dock3
1350 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:47
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000019867
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat

Markers in Region
D8Got175  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,779,518 - 107,779,754 (+)MAPPERmRatBN7.2
Rnor_6.08115,853,535 - 115,853,770NCBIRnor6.0
Rnor_5.08115,212,161 - 115,212,396UniSTSRnor5.0
RGSC_v3.48112,342,262 - 112,342,498RGDRGSC3.4
RGSC_v3.48112,342,263 - 112,342,498UniSTSRGSC3.4
RGSC_v3.18112,361,718 - 112,361,953RGD
Celera8107,089,971 - 107,090,206UniSTS
RH 3.4 Map81130.6UniSTS
RH 3.4 Map81130.6RGD
RH 2.0 Map8875.2RGD
Cytogenetic Map8q32UniSTS
D8Got173  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,680,423 - 107,680,674 (+)MAPPERmRatBN7.2
Rnor_6.08115,755,301 - 115,755,551NCBIRnor6.0
Rnor_5.08115,113,927 - 115,114,177UniSTSRnor5.0
RGSC_v3.48112,243,829 - 112,244,080RGDRGSC3.4
RGSC_v3.48112,243,830 - 112,244,080UniSTSRGSC3.4
RGSC_v3.18112,263,285 - 112,263,535RGD
Celera8106,991,819 - 106,992,069UniSTS
RH 3.4 Map81127.4UniSTS
RH 3.4 Map81127.4RGD
RH 2.0 Map8890.2RGD
Cytogenetic Map8q32UniSTS
D8Got312  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera8107,033,115 - 107,033,268UniSTS
Cytogenetic Map8q32UniSTS
RH138491  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,847,610 - 107,847,855 (+)MAPPERmRatBN7.2
mRatBN7.21061,814,371 - 61,814,616 (-)MAPPERmRatBN7.2
Rnor_6.01063,197,963 - 63,198,207NCBIRnor6.0
Rnor_6.08115,921,620 - 115,921,864NCBIRnor6.0
Rnor_5.01062,897,085 - 62,897,329UniSTSRnor5.0
Rnor_5.08115,280,823 - 115,281,067UniSTSRnor5.0
RGSC_v3.48112,410,634 - 112,410,878UniSTSRGSC3.4
RGSC_v3.41067,195,872 - 67,196,116UniSTSRGSC3.4
Celera1060,821,565 - 60,821,809UniSTS
Celera8107,157,761 - 107,158,005UniSTS
Cytogenetic Map8q32UniSTS
Cytogenetic Map10q26UniSTS
AI144800  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,552,421 - 107,552,528 (+)MAPPERmRatBN7.2
Rnor_6.08115,627,242 - 115,627,348NCBIRnor6.0
Rnor_5.08114,986,072 - 114,986,178UniSTSRnor5.0
RGSC_v3.48112,114,145 - 112,114,251UniSTSRGSC3.4
Celera8106,864,315 - 106,864,421UniSTS
RH 3.4 Map81138.0UniSTS
Cytogenetic Map8q32UniSTS
BE116557  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,599,289 - 107,599,439 (+)MAPPERmRatBN7.2
Rnor_6.08115,674,121 - 115,674,270NCBIRnor6.0
Rnor_5.08115,032,643 - 115,032,792UniSTSRnor5.0
RGSC_v3.48112,161,055 - 112,161,204UniSTSRGSC3.4
Celera8106,911,177 - 106,911,326UniSTS
RH 3.4 Map81135.3UniSTS
Cytogenetic Map8q32UniSTS
RH138011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,573,552 - 107,573,735 (+)MAPPERmRatBN7.2
Rnor_6.08115,648,373 - 115,648,555NCBIRnor6.0
Rnor_5.08115,007,203 - 115,007,385UniSTSRnor5.0
RGSC_v3.48112,135,276 - 112,135,458UniSTSRGSC3.4
Celera8106,885,446 - 106,885,628UniSTS
RH 3.4 Map81137.1UniSTS
Cytogenetic Map8q32UniSTS
AU048665  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,779,524 - 107,779,725 (+)MAPPERmRatBN7.2
Rnor_6.08115,853,541 - 115,853,741NCBIRnor6.0
Rnor_5.08115,212,167 - 115,212,367UniSTSRnor5.0
RGSC_v3.48112,342,269 - 112,342,469UniSTSRGSC3.4
Celera8107,089,977 - 107,090,177UniSTS
Cytogenetic Map8q32UniSTS
AU050008  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,680,423 - 107,680,679 (+)MAPPERmRatBN7.2
Rnor_6.08115,755,301 - 115,755,556NCBIRnor6.0
Rnor_5.08115,113,927 - 115,114,182UniSTSRnor5.0
RGSC_v3.48112,243,830 - 112,244,085UniSTSRGSC3.4
Celera8106,991,819 - 106,992,074UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64 17
Low 2 27 17 4 17 1 1 10 35 24 8 1
Below cutoff 3 40 26 20 13 20 7 7 3 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003750582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003754454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI070118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000019867   ⟹   ENSRNOP00000019867
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,552,463 - 107,903,514 (-)Ensembl
Rnor_6.0 Ensembl8115,629,583 - 115,981,910 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096313   ⟹   ENSRNOP00000079156
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,552,463 - 107,858,695 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109918   ⟹   ENSRNOP00000085218
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,552,463 - 107,903,514 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112624   ⟹   ENSRNOP00000095224
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,552,463 - 107,903,514 (-)Ensembl
RefSeq Acc Id: NM_001108184   ⟹   NP_001101654
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28107,552,462 - 107,903,514 (-)NCBI
RefSeq Acc Id: XM_006243865   ⟹   XP_006243927
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28107,552,462 - 107,903,527 (-)NCBI
Rnor_6.08115,627,282 - 115,982,260 (-)NCBI
Rnor_5.08114,986,112 - 115,343,879 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006243867   ⟹   XP_006243929
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28107,552,462 - 107,903,527 (-)NCBI
Rnor_6.08115,627,282 - 115,982,260 (-)NCBI
Rnor_5.08114,986,112 - 115,343,879 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081580   ⟹   XP_038937508
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28107,552,462 - 107,903,527 (-)NCBI
RefSeq Acc Id: XM_039081581   ⟹   XP_038937509
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28107,552,462 - 107,903,527 (-)NCBI
RefSeq Acc Id: XM_039081582   ⟹   XP_038937510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28107,552,462 - 107,903,527 (-)NCBI
RefSeq Acc Id: XM_039081583   ⟹   XP_038937511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28107,552,462 - 107,903,527 (-)NCBI
RefSeq Acc Id: XM_039081584   ⟹   XP_038937512
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28107,552,462 - 107,903,527 (-)NCBI
RefSeq Acc Id: XM_039081585   ⟹   XP_038937513
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28107,552,462 - 107,834,496 (-)NCBI
RefSeq Acc Id: XM_039081586   ⟹   XP_038937514
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28107,552,462 - 107,858,008 (-)NCBI
RefSeq Acc Id: XM_039081587   ⟹   XP_038937515
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28107,552,462 - 107,629,297 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_006243929   ⟸   XM_006243867
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZZP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243927   ⟸   XM_006243865
- Peptide Label: isoform X2
- UniProtKB: F1M4N6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019867   ⟸   ENSRNOT00000019867
RefSeq Acc Id: XP_038937511   ⟸   XM_039081583
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038937510   ⟸   XM_039081582
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038937509   ⟸   XM_039081581
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038937512   ⟸   XM_039081584
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038937508   ⟸   XM_039081580
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001101654   ⟸   NM_001108184
- UniProtKB: A0A8I6GLI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937514   ⟸   XM_039081586
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038937513   ⟸   XM_039081585
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038937515   ⟸   XM_039081587
- Peptide Label: isoform X8
RefSeq Acc Id: ENSRNOP00000085218   ⟸   ENSRNOT00000109918
RefSeq Acc Id: ENSRNOP00000095224   ⟸   ENSRNOT00000112624
RefSeq Acc Id: ENSRNOP00000079156   ⟸   ENSRNOT00000096313
Protein Domains
C2 DOCK-type   DOCKER   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M4N6-F1-model_v2 AlphaFold F1M4N6 1-2071 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306677 AgrOrtholog
BioCyc Gene G2FUF-29219 BioCyc
Ensembl Genes ENSRNOG00000014576 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019867 ENTREZGENE
  ENSRNOP00000019867.7 UniProtKB/TrEMBL
  ENSRNOP00000079156.1 UniProtKB/TrEMBL
  ENSRNOP00000085218 ENTREZGENE
  ENSRNOP00000085218.1 UniProtKB/TrEMBL
  ENSRNOP00000095224 ENTREZGENE
  ENSRNOP00000095224.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019867 ENTREZGENE
  ENSRNOT00000019867.8 UniProtKB/TrEMBL
  ENSRNOT00000096313.1 UniProtKB/TrEMBL
  ENSRNOT00000109918 ENTREZGENE
  ENSRNOT00000109918.1 UniProtKB/TrEMBL
  ENSRNOT00000112624 ENTREZGENE
  ENSRNOT00000112624.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.350 UniProtKB/TrEMBL
  1.20.58.740 UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_Dock-B UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DHR-2 UniProtKB/TrEMBL
  DOCK UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DOCK3 UniProtKB/TrEMBL
  DOCK3_SH3 UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
  DOCK_N_sub1 UniProtKB/TrEMBL
  DOCKER_Lobe_A UniProtKB/TrEMBL
  DOCKER_Lobe_B UniProtKB/TrEMBL
  DOCKER_Lobe_C UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene 315992 ENTREZGENE
PANTHER PTHR45653 UniProtKB/TrEMBL
  PTHR45653:SF4 UniProtKB/TrEMBL
Pfam Ded_cyto UniProtKB/TrEMBL
  DHR-2_Lobe_B UniProtKB/TrEMBL
  DHR-2_Lobe_C UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PhenoGen Dock3 PhenoGen
PROSITE DHR_1 UniProtKB/TrEMBL
  DHR_2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP SH3 UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
UniProt A0A8I5ZM58_RAT UniProtKB/TrEMBL
  A0A8I5ZZP1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLI7 ENTREZGENE, UniProtKB/TrEMBL
  F1M4N6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Dock3  dedicator of cyto-kinesis 3   Dock3_predicted  dedicator of cyto-kinesis 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dock3_predicted  dedicator of cyto-kinesis 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED