RGD Reference Report - Further dissection of a genomic locus associated with behavioral activity in the Wistar-Kyoto hyperactive rat, an animal model of hyperkinesis. - Rat Genome Database

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Further dissection of a genomic locus associated with behavioral activity in the Wistar-Kyoto hyperactive rat, an animal model of hyperkinesis.

Authors: Moisan, MP  Llamas, B  Cook, MN  Mormede, P 
Citation: Moisan MP, etal., Mol Psychiatry 2003 Mar;8(3):348-52.
RGD ID: 631228
Pubmed: (View Article at PubMed) PMID:12660808
DOI: Full-text: DOI:10.1038/sj.mp.4001234

Molecular genetic studies of attention-deficit hyperactivity disorder (ADHD) are a major focus of current research since this syndrome has been shown to be highly heritable.(1) Our approach has been to search for quantitative trait loci (QTL) in a genetic animal model of hyperkinesis, the Wistar-Kyoto hyperactive (WKHA) rat, by a whole-genome scan analysis. In a previous article, we reported the detection of a major QTL associated with behavioral activity in an F2 cross between WKHA and Wistar-Kyoto (WKY) rat strains.(2) Here, we extend our analysis of this cross by adding new genetic markers, now defining a 10 cM interval on rat chromosome 8 associated with ambulatory and exploratory activities. Then we present a replication of this QTL detection, at least for exploratory activity, by a new genetic mapping analysis of an activity QTL in an F2 cross between the WKHA and Brown Norway (BN) rat strains. Overall, the results provide compelling evidence for the presence of gene(s) influencing activity at this locus. The QTL interval has been refined such that the human orthologous region could be defined and tested in human populations for association with ADHD. Ultimately, the improved dissection of this genomic locus should allow the identification of the causal genes.Molecular Psychiatry (2003) 8, 348-352. doi:10.1038/sj.mp.4001234

Annotation

Disease Annotations    
Hyperkinesis  (QTM)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Activ1  (Activity QTL 1)
Activ2  (Activity QTL 2)


Additional Information