Hyal2 (hyaluronidase 2) - Rat Genome Database

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Gene: Hyal2 (hyaluronidase 2) Rattus norvegicus
Analyze
Symbol: Hyal2
Name: hyaluronidase 2
RGD ID: 620321
Description: Enables hyaluronoglucuronidase activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of urine volume; and renal water absorption. Located in Golgi membrane; membrane raft; and plasma membrane. Biomarker of pulmonary hypertension. Orthologous to human HYAL2 (hyaluronidase 2); PARTICIPATES IN glycosaminoglycan degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hyal-2; hyaluronidase-2; hyaluronoglucosaminidase 2; hyaluronoglucosaminidase-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,241,895 - 108,246,853 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,243,133 - 108,246,850 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,870,193 - 113,873,885 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08112,069,349 - 112,073,041 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08109,912,130 - 109,915,822 (+)NCBIRnor_WKY
Rnor_6.08116,324,062 - 116,328,978 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,324,040 - 116,328,978 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,680,309 - 115,685,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,817,001 - 112,820,693 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,836,484 - 112,840,147 (+)NCBI
Celera8107,549,728 - 107,586,609 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
carbohydrate metabolic process  (IEA)
cartilage development  (IEA,ISO,ISS)
cellular response to fibroblast growth factor stimulus  (IEA,ISO,ISS)
cellular response to interleukin-1  (IEA,ISO,ISS)
cellular response to transforming growth factor beta stimulus  (IEA,ISO,ISS)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to UV-B  (IEA,ISO,ISS)
defense response to virus  (IEA,ISO)
fusion of virus membrane with host plasma membrane  (IEA,ISO,ISS)
glycosaminoglycan catabolic process  (ISO,ISS)
hematopoietic progenitor cell differentiation  (IEA,ISO)
hyaluronan catabolic process  (IBA,IDA,IEA,ISO)
kidney development  (IEP)
monocyte activation  (IEA,ISO,ISS)
multicellular organism aging  (IEA,ISO)
multicellular organismal iron ion homeostasis  (IEA,ISO)
negative regulation of cell growth  (IEA,ISO,ISS)
negative regulation of fibroblast migration  (IEA,ISO,ISS)
negative regulation of MAP kinase activity  (IEA,ISO,ISS)
negative regulation of protein kinase B signaling  (IEA,ISO,ISS)
negative regulation of protein tyrosine kinase activity  (IEA,ISO,ISS)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of inflammatory response  (IEA,ISO,ISS)
positive regulation of interleukin-6 production  (IEA,ISO,ISS)
positive regulation of interleukin-8 production  (IEA,ISO,ISS)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of urine volume  (IEP)
renal water absorption  (IEP)
response to antibiotic  (IEA,ISO)
response to reactive oxygen species  (IEA,ISO,ISS)
response to virus  (ISO,ISS)
skeletal system morphogenesis  (IEA,ISO)
viral entry into host cell  (IDA,IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hyal2 is a glycosylphosphatidylinositol-anchored, lipid raft-associated hyaluronidase. Andre B, etal., Biochem Biophys Res Commun. 2011 Jul 22;411(1):175-9. doi: 10.1016/j.bbrc.2011.06.125. Epub 2011 Jun 25.
2. Synthesis and fragmentation of hyaluronan in renal ischaemia. Decleves AE, etal., Nephrol Dial Transplant. 2012 Oct;27(10):3771-81. doi: 10.1093/ndt/gfs098. Epub 2012 Apr 23.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins. Liu SL, etal., J Virol 2003 Mar;77(5):2850-8.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension. Ormiston ML, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L148-57. doi: 10.1152/ajplung.00097.2009. Epub 2009 Nov 13.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. The effect of hyaluronic acid size and concentration on branching morphogenesis and tubule differentiation in developing kidney culture systems: potential applications to engineering of renal tissues. Rosines E, etal., Biomaterials. 2007 Nov;28(32):4806-17. Epub 2007 Aug 15.
13. Hyaluronan synthases and hyaluronidases in the kidney during changes in hydration status. Rugheimer L, etal., Matrix Biol. 2009 Sep;28(7):390-5. doi: 10.1016/j.matbio.2009.07.002. Epub 2009 Jul 25.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9712871   PMID:11296287   PMID:11944887   PMID:12676986   PMID:16191204   PMID:16600643   PMID:17170110   PMID:18390475   PMID:18725949   PMID:18772348   PMID:19366691   PMID:19443707  
PMID:19577615   PMID:19783662   PMID:20554532   PMID:21699545  


Genomics

Comparative Map Data
Hyal2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,241,895 - 108,246,853 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,243,133 - 108,246,850 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,870,193 - 113,873,885 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08112,069,349 - 112,073,041 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08109,912,130 - 109,915,822 (+)NCBIRnor_WKY
Rnor_6.08116,324,062 - 116,328,978 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,324,040 - 116,328,978 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,680,309 - 115,685,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,817,001 - 112,820,693 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,836,484 - 112,840,147 (+)NCBI
Celera8107,549,728 - 107,586,609 (+)NCBICelera
Cytogenetic Map8q32NCBI
HYAL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,317,808 - 50,322,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl350,317,790 - 50,322,782 (-)EnsemblGRCh38hg38GRCh38
GRCh37350,355,239 - 50,360,176 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,330,244 - 50,335,146 (-)NCBINCBI36Build 36hg18NCBI36
Build 34350,330,243 - 50,333,903NCBI
Celera350,328,056 - 50,333,116 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,410,935 - 50,415,994 (-)NCBIHuRef
CHM1_1350,307,488 - 50,312,547 (-)NCBICHM1_1
T2T-CHM13v2.0350,347,534 - 50,352,469 (-)NCBIT2T-CHM13v2.0
Hyal2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,445,085 - 107,449,977 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,445,144 - 107,449,978 (+)EnsemblGRCm39 Ensembl
GRCm389107,567,873 - 107,572,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,567,945 - 107,572,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,471,494 - 107,475,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,427,264 - 107,430,879 (+)NCBIMGSCv36mm8
Celera9107,177,912 - 107,181,527 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.12NCBI
Hyal2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,120,781 - 2,123,726 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,120,781 - 2,125,083 (-)NCBIChiLan1.0ChiLan1.0
HYAL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,479,020 - 51,484,638 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,479,020 - 51,482,551 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0350,243,926 - 50,248,972 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HYAL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,029,426 - 39,034,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,031,735 - 39,034,130 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,950,366 - 38,955,492 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,385,361 - 39,390,488 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,385,565 - 39,396,473 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,753,188 - 38,758,313 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,156,748 - 39,161,868 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,436,765 - 39,441,893 (+)NCBIUU_Cfam_GSD_1.0
Hyal2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,084,685 - 65,090,478 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,845,763 - 1,851,252 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365291,845,445 - 1,851,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HYAL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,805,227 - 32,815,333 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,805,220 - 32,813,684 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,983,753 - 35,988,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q21NCBI
HYAL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,704,422 - 11,710,013 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,703,790 - 11,709,454 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041155,277,024 - 155,282,088 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hyal2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,169,742 - 4,175,242 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,170,045 - 4,175,264 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hyal2
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:124
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000017461
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat

Markers in Region
RH139126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,254,313 - 108,254,497 (+)MAPPERmRatBN7.2
Rnor_6.08116,336,441 - 116,336,624NCBIRnor6.0
Rnor_5.08115,692,701 - 115,692,884UniSTSRnor5.0
RGSC_v3.48112,828,079 - 112,828,262UniSTSRGSC3.4
Celera8107,560,892 - 107,561,075UniSTS
RH 3.4 Map81116.6UniSTS
Cytogenetic Map8q32UniSTS
RH131906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,271,751 - 108,271,957 (+)MAPPERmRatBN7.2
Rnor_6.08116,353,880 - 116,354,085NCBIRnor6.0
Rnor_5.08115,710,139 - 115,710,344UniSTSRnor5.0
RGSC_v3.48112,845,518 - 112,845,723UniSTSRGSC3.4
Celera8107,578,335 - 107,578,540UniSTS
RH 3.4 Map81118.6UniSTS
Cytogenetic Map8q32UniSTS
BF387601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,253,956 - 108,254,130 (+)MAPPERmRatBN7.2
Rnor_6.08116,336,084 - 116,336,257NCBIRnor6.0
Rnor_5.08115,692,344 - 115,692,517UniSTSRnor5.0
RGSC_v3.48112,827,722 - 112,827,895UniSTSRGSC3.4
Celera8107,560,535 - 107,560,708UniSTS
RH 3.4 Map81120.8UniSTS
Cytogenetic Map8q32UniSTS
BF407105  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,266,299 - 108,266,425 (+)MAPPERmRatBN7.2
Rnor_6.08116,348,427 - 116,348,552NCBIRnor6.0
Rnor_5.08115,704,686 - 115,704,811UniSTSRnor5.0
RGSC_v3.48112,840,065 - 112,840,190UniSTSRGSC3.4
Celera8107,572,878 - 107,573,003UniSTS
RH 3.4 Map81120.9UniSTS
Cytogenetic Map8q32UniSTS
AI838527  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,265,918 - 108,266,002 (+)MAPPERmRatBN7.2
Rnor_6.08116,348,046 - 116,348,129NCBIRnor6.0
Rnor_5.08115,704,306 - 115,704,389UniSTSRnor5.0
RGSC_v3.48112,839,684 - 112,839,767UniSTSRGSC3.4
Celera8107,572,497 - 107,572,580UniSTS
Cytogenetic Map8q32UniSTS
RH142073  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,271,226 - 108,271,420 (+)MAPPERmRatBN7.2
Rnor_6.08116,353,355 - 116,353,548NCBIRnor6.0
Rnor_5.08115,709,614 - 115,709,807UniSTSRnor5.0
RGSC_v3.48112,844,993 - 112,845,186UniSTSRGSC3.4
Celera8107,577,810 - 107,578,003UniSTS
RH 3.4 Map81118.6UniSTS
Cytogenetic Map8q32UniSTS
UniSTS:236246  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,246,387 - 108,246,543 (+)MAPPERmRatBN7.2
Rnor_6.08116,328,513 - 116,328,668NCBIRnor6.0
Rnor_5.08115,684,773 - 115,684,928UniSTSRnor5.0
RGSC_v3.48112,820,228 - 112,820,383UniSTSRGSC3.4
Celera8107,552,955 - 107,553,110UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 35 26 12 26 1 4 66 35 35 11 1
Low 7 22 15 7 15 7 7 8 6 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017461   ⟹   ENSRNOP00000017461
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,243,133 - 108,246,850 (+)Ensembl
Rnor_6.0 Ensembl8116,325,286 - 116,328,978 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081353   ⟹   ENSRNOP00000075204
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8116,324,040 - 116,328,978 (+)Ensembl
RefSeq Acc Id: NM_172040   ⟹   NP_742037
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28108,243,161 - 108,246,853 (+)NCBI
Rnor_6.08116,325,286 - 116,328,978 (+)NCBI
Rnor_5.08115,680,309 - 115,685,238 (+)NCBI
RGSC_v3.48112,817,001 - 112,820,693 (+)RGD
Celera8107,549,728 - 107,586,609 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243855   ⟹   XP_006243917
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28108,241,895 - 108,246,851 (+)NCBI
Rnor_6.08116,324,062 - 116,328,978 (+)NCBI
Rnor_5.08115,680,309 - 115,685,238 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_742037   ⟸   NM_172040
- Peptide Label: precursor
- UniProtKB: Q80ZC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243917   ⟸   XM_006243855
- Peptide Label: isoform X1
- UniProtKB: G3V7P9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075204   ⟸   ENSRNOT00000081353
RefSeq Acc Id: ENSRNOP00000017461   ⟸   ENSRNOT00000017461
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2Q3-F1-model_v2 AlphaFold Q9Z2Q3 1-473 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696285
Promoter ID:EPDNEW_R6797
Type:multiple initiation site
Name:Hyal2_2
Description:hyaluronoglucosaminidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6798  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,324,064 - 116,324,124EPDNEW
RGD ID:13696273
Promoter ID:EPDNEW_R6798
Type:initiation region
Name:Hyal2_1
Description:hyaluronoglucosaminidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6797  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,325,276 - 116,325,336EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620321 AgrOrtholog
BioCyc Gene G2FUF-29191 BioCyc
Ensembl Genes ENSRNOG00000031420 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017461 ENTREZGENE
  ENSRNOP00000017461.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017461 ENTREZGENE
  ENSRNOT00000017461.4 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623650 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hyaluronidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64468 UniProtKB/TrEMBL
MGC_CLONE MGC:72280 IMAGE-MGC_LOAD
NCBI Gene 64468 ENTREZGENE
PANTHER PTHR11769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_56 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hyal2 PhenoGen
PIRSF Hyaluronidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLHYDRLASE56 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V7P9 ENTREZGENE, UniProtKB/TrEMBL
  HYAL2_RAT UniProtKB/Swiss-Prot
  Q80ZC7 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z2Q3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-15 Hyal2  hyaluronidase 2  Hyal2  hyaluronoglucosaminidase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hyal2  hyaluronoglucosaminidase 2    hyaluronidase 2  Name updated 1299863 APPROVED
2005-01-20 Hyal2  hyaluronidase 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Hyal2  hyaluronidase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process can suppress transformation by the Env proteins 633153