Strain Report - Rat Genome Database

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Strain: WKHA/N

Symbol: WKHA/N
Strain: WKHA
Substrain: N
RGD ID: 68186
RRID: RGD_68186
Ontology ID: RS:0001021
Also known as: RRRC:00188
Type: inbred
Source: Unavailable
Origin: From a cross between SHR and WKY with selection for high spontaneous activity and low systolic blood pressure.
Genetic Markers: .c.
Coat Color: Albino.
Inbred Generations: F36 (2000)
Last Known Status: Extinct





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
hyperactivity  (IAGP)

References


Region

Strain QTL Data
Symbol Name Trait
Activ1 Activity QTL 1 voluntary movement trait   (VT:0003491)    
Activ2 Activity QTL 2 voluntary movement trait   (VT:0003491)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Studies of this strain suggest that the exaggerated sympathetic-adrenal medullary response toacute stress found in SHR is associated with hyperactivity found also in WKHA rather thanhypertension (Hendley et al 1988, Knardahl and Hendley 1990, Hendley and Fan, 1992). BothSHR and WKHA show increased reactivity to stimuli, with WKHA reacting particularly to novelaversive stimuli (Sagvolden et al, 1992). See also Fan et al, (1995). 1004
strain_characteristics Studies of this strain suggest that the exaggerated sympathetic-adrenal medullary response toacute stress found in SHR is associated with hyperactivity found also in WKHA rather thanhypertension (Hendley et al 1988, Knardahl and Hendley 1990, Hendley and Fan, 1992). BothSHR and WKHA show increased reactivity to stimuli, with WKHA reacting particularly to novelaversive stimuli (Sagvolden et al, 1992). See also Fan et al, (1995). 634612

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-03 WKHA/N    WKHA/N    Name updated 68913 APPROVED
2013-04-15 WKHA/N    WKHA/N    Name updated 68913 APPROVED
2012-04-19 WKHA/N    WKHA/N    Name updated 68913 APPROVED
2012-04-19 WKHA/N    WKHA/N    Name updated 68913 APPROVED