Acp3 (acid phosphatase 3) - Rat Genome Database
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Gene: Acp3 (acid phosphatase 3) Rattus norvegicus
Analyze
Symbol: Acp3
Name: acid phosphatase 3
RGD ID: 2023
Description: Exhibits acid phosphatase activity; choline binding activity; and protein homodimerization activity. Involved in dephosphorylation. Localizes to Golgi cisterna; apical part of cell; and cytoplasmic vesicle. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ACP3 (acid phosphatase 3); PARTICIPATES IN riboflavin metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5'-NT; 5'-nucleotidase; acid phosphatase prostate; acid phosphatase, prostate; Acpp; Acpp11; ecto-5'-nucleotidase; fluoride-resistant acid phosphatase; FRAP; pap; Ppal; prostatic acid phosphatase; prostatic acid phosphatase (rPAP); RNACPP11; thiamine monophosphatase; TMPase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28104,905,570 - 104,956,146 (-)NCBI
Rnor_6.0 Ensembl8112,834,707 - 112,884,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08112,838,574 - 112,884,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08112,224,707 - 112,272,400 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48109,354,381 - 109,400,296 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18109,382,705 - 109,419,751 (-)NCBI
Celera8104,274,154 - 104,317,190 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP)
carbon nanotube  (ISO)
carmustine  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
finasteride  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
indole-3-methanol  (EXP)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
methotrexate  (EXP)
methylseleninic acid  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
Swertiamarin  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
thioacetamide  (EXP)
tioguanine  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8132635   PMID:8334986   PMID:8407898   PMID:10639192   PMID:15280042   PMID:15578709   PMID:17638863   PMID:17658863   PMID:17897319   PMID:18083097   PMID:18940592   PMID:19056867  
PMID:20084276   PMID:21630459   PMID:22389722   PMID:23376485   PMID:23533145   PMID:24657436   PMID:25482440   PMID:25674224   PMID:27348306  


Genomics

Candidate Gene Status
Acp3 is a candidate Gene for QTL Coreg1
Comparative Map Data
Acp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28104,905,570 - 104,956,146 (-)NCBI
Rnor_6.0 Ensembl8112,834,707 - 112,884,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08112,838,574 - 112,884,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08112,224,707 - 112,272,400 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48109,354,381 - 109,400,296 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18109,382,705 - 109,419,751 (-)NCBI
Celera8104,274,154 - 104,317,190 (-)NCBICelera
Cytogenetic Map8q32NCBI
ACP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3132,317,369 - 132,368,298 (+)EnsemblGRCh38hg38GRCh38
GRCh383132,317,403 - 132,368,765 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373132,036,251 - 132,087,146 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363133,518,949 - 133,560,294 (+)NCBINCBI36hg18NCBI36
Build 343133,518,956 - 133,560,298NCBI
Celera3130,462,489 - 130,513,425 (+)NCBI
Cytogenetic Map3q22.1ENTREZGENE
HuRef3129,415,425 - 129,466,393 (+)NCBIHuRef
CHM1_13131,999,235 - 132,050,170 (+)NCBICHM1_1
Acpp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399104,165,439 - 104,214,921 (-)NCBIGRCm39mm39
GRCm39 Ensembl9104,165,450 - 104,214,947 (-)Ensembl
GRCm389104,288,240 - 104,337,722 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9104,288,251 - 104,337,748 (-)EnsemblGRCm38mm10GRCm38
MGSCv379104,190,570 - 104,240,052 (-)NCBIGRCm37mm9NCBIm37
MGSCv369104,146,585 - 104,196,067 (-)NCBImm8
Celera9103,840,497 - 103,890,048 (-)NCBICelera
Cytogenetic Map9F1NCBI
Acp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555016,164,152 - 6,218,967 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555016,168,083 - 6,218,934 (-)NCBIChiLan1.0ChiLan1.0
ACP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13136,713,816 - 136,764,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3136,713,816 - 136,764,655 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03129,392,396 - 129,465,962 (+)NCBIMhudiblu_PPA_v0panPan3
ACP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2329,294,843 - 29,343,499 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12329,294,641 - 29,353,970 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Acp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365295,661,772 - 5,723,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1373,471,881 - 73,571,052 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11373,471,837 - 73,530,778 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21381,003,170 - 81,028,400 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACP3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11557,887,528 - 57,934,851 (-)NCBI
ChlSab1.1 Ensembl1557,887,365 - 57,934,707 (-)Ensembl
Acp3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247308,375,429 - 8,441,375 (+)NCBI

Position Markers
D8Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.08112,847,165 - 112,847,329NCBIRnor6.0
Rnor_5.08112,233,298 - 112,233,462UniSTSRnor5.0
RGSC_v3.48109,362,917 - 109,363,081UniSTSRGSC3.4
Celera8104,282,671 - 104,282,821UniSTS
Cytogenetic Map8q32UniSTS
BI283253  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.08112,846,788 - 112,846,905NCBIRnor6.0
Rnor_5.08112,232,921 - 112,233,038UniSTSRnor5.0
RGSC_v3.48109,362,540 - 109,362,657UniSTSRGSC3.4
Celera8104,282,295 - 104,282,411UniSTS
RH 3.4 Map81155.3UniSTS
Cytogenetic Map8q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)833558764113580387Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)844458129118087517Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)855435004115812386Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)865717449128033050Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)872849686117849686Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight as a percentage of body weight (CMO:0000654)874917593121080545Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)876103982127182642Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)878805083123805083Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)878805083123805083Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)878805083123805083Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)878805083123805083Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)880697934125697934Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)883894304128894304Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)889058229132243842Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)895319530115625029Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)895963141122354314Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102051964133307652Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8104682575133307652Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)8104682575133307652Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8107769005129956433Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8110212979116947981Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:52
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000016222
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 2 7 3
Low 3 3 41 25 19 25 2 2 23 31 32 8 2
Below cutoff 39 14 14 14 6 8 41 2 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016222   ⟹   ENSRNOP00000016222
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8112,847,499 - 112,884,062 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085585   ⟹   ENSRNOP00000072975
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8112,834,707 - 112,884,077 (-)Ensembl
RefSeq Acc Id: NM_001134901   ⟹   NP_001128373
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28104,908,971 - 104,954,196 (-)NCBI
Rnor_6.08112,838,629 - 112,884,022 (-)NCBI
Rnor_5.08112,224,707 - 112,272,400 (-)NCBI
RGSC_v3.48109,354,381 - 109,400,296 (-)RGD
Celera8104,274,154 - 104,317,150 (-)NCBI
Sequence:
RefSeq Acc Id: NM_020072   ⟹   NP_064457
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28104,917,841 - 104,954,236 (-)NCBI
Rnor_6.08112,847,499 - 112,884,062 (-)NCBI
Rnor_5.08112,224,707 - 112,272,400 (-)NCBI
RGSC_v3.48109,354,381 - 109,400,296 (-)RGD
Celera8104,282,991 - 104,317,190 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595869   ⟹   XP_017451358
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28104,905,570 - 104,956,146 (-)NCBI
Rnor_6.08112,838,574 - 112,883,989 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595870   ⟹   XP_017451359
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08112,838,574 - 112,883,993 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595871   ⟹   XP_017451360
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08112,838,574 - 112,881,173 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082022   ⟹   XP_038937950
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28104,905,570 - 104,954,207 (-)NCBI
RefSeq Acc Id: XM_039082023   ⟹   XP_038937951
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28104,905,570 - 104,949,213 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_064457   ⟸   NM_020072
- Peptide Label: short isoform precursor
- Sequence:
RefSeq Acc Id: NP_001128373   ⟸   NM_001134901
- Peptide Label: long isoform precursor
- UniProtKB: P20646 (UniProtKB/Swiss-Prot),   A0A0G2K4B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451359   ⟸   XM_017595870
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017451358   ⟸   XM_017595869
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017451360   ⟸   XM_017595871
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000016222   ⟸   ENSRNOT00000016222
RefSeq Acc Id: ENSRNOP00000072975   ⟸   ENSRNOT00000085585
RefSeq Acc Id: XP_038937950   ⟸   XM_039082022
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038937951   ⟸   XM_039082023
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696238
Promoter ID:EPDNEW_R6762
Type:multiple initiation site
Name:Acpp_1
Description:acid phosphatase, prostate
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08112,884,071 - 112,884,131EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2023 AgrOrtholog
Ensembl Genes ENSRNOG00000011820 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016222 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072975 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016222 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000085585 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Acid_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_Pase_clade-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56780 UniProtKB/Swiss-Prot
NCBI Gene 56780 ENTREZGENE
Pfam His_Phos_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acp3 PhenoGen
PROSITE HIS_ACID_PHOSPHAT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIS_ACID_PHOSPHAT_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53254 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4B4 ENTREZGENE, UniProtKB/TrEMBL
  P20646 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0G2JSL5 UniProtKB/Swiss-Prot
  A6XJQ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-30 Acp3  acid phosphatase 3  Acpp  acid phosphatase, prostate  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Acpp  acid phosphatase, prostate      Symbol and Name updated 629477 APPROVED
2003-03-06 Acpp  acid phosphatase, prostate  Ppal  prostatic acid phosphatase (rPAP)  Data Merged 628472 PROVISIONAL
2002-08-07 Ppal  prostatic acid phosphatase (rPAP)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Acpp  acid phosphatase, prostate      Symbol and Name status set to approved 70586 APPROVED
2001-06-12 Acpp  acid phosphatase, prostate      Symbol and Name updated to reflect Human and Mouse nomenclature 62408 APPROVED
2001-06-12 Acpp11  Prostatic acid phosphatase      Symbol and Name withdrawn 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression synthesized in prostate epithelial cells, released into prostatic fluid 69941
gene_expression synthesized in prostate epithelial cells, released into prostatic fluid 70323
gene_function hydrolyzes phosphomonoesters under acidic condition 69941
gene_function hydrolyzes phosphomonoesters under acidic condition 70323
gene_physical_interaction androgen receptor binds to two conserved regions, one in the proximal promoter and another in intron 1 69941
gene_physical_interaction androgen receptor binds to two conserved regions, one in the proximal promoter and another in intron 1 70323
gene_product cDNA 1626 nt long 69941
gene_product cDNA 1626 nt long 70323
gene_product contains 11 exons 69941
gene_product contains 11 exons 70323
gene_regulation regulated by androgen 69941
gene_regulation regulated by androgen 70323
gene_transcript three mRNA species (4.9, 2.3 and 1.5 kb) in prostate 69941
gene_transcript three mRNA species (4.9, 2.3 and 1.5 kb) in prostate 70323