Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Dag1 (dystroglycan 1) Rattus norvegicus
Analyze
Symbol: Dag1
Name: dystroglycan 1
Description: Exhibits laminin-1 binding activity. Involved in several processes, including calcium-dependent cell-matrix adhesion; cellular response to cholesterol; and nervous system development. Localizes to several cellular components, including the costamere; focal adhesion; and postsynaptic cytosol. Used to study myocardial infarction. Biomarker of muscular atrophy; primary biliary cirrhosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; congenital muscular dystrophy-dystroglycanopathy type A9; and inclusion body myositis. Orthologous to human DAG1 (dystroglycan 1); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; dilated cardiomyopathy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-dystroglycan; beta-dystroglycan; dystroglycan; dystroglycan 1 (dystrophin-associated glycoprotein 1)
Orthologs:
Homo sapiens (human) : DAG1 (dystroglycan 1)  HGNC  Alliance
Mus musculus (house mouse) : Dag1 (dystroglycan 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dag1 (dystroglycan 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DAG1 (dystroglycan 1)
Canis lupus familiaris (dog) : DAG1 (dystroglycan 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dag1 (dystroglycan 1)
Sus scrofa (pig) : DAG1 (dystroglycan 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08116,980,501 - 116,993,182 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,980,497 - 116,993,193 (-)Ensembl
Rnor_5.08116,334,176 - 116,346,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,470,871 - 113,483,433 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18113,492,696 - 113,493,023 (-)NCBI
Celera8108,195,279 - 108,207,962 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Dag1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621890
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.