Dag1 (dystroglycan 1) - Rat Genome Database

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Gene: Dag1 (dystroglycan 1) Rattus norvegicus
Analyze
Symbol: Dag1
Name: dystroglycan 1
RGD ID: 621890
Description: Enables laminin-1 binding activity. Involved in several processes, including calcium-dependent cell-matrix adhesion; nervous system development; and regulation of nervous system development. Located in several cellular components, including basolateral plasma membrane; costamere; and focal adhesion. Part of dystrophin-associated glycoprotein complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study myocardial infarction. Biomarker of muscular atrophy; primary biliary cholangitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia and myopathy (multiple). Orthologous to human DAG1 (dystroglycan 1); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; dilated cardiomyopathy pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-dystroglycan; beta-dystroglycan; dystroglycan; dystroglycan 1 (dystrophin-associated glycoprotein 1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,769,517 - 117,834,347 (-)NCBIGRCr8
mRatBN7.28108,890,926 - 108,955,611 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,890,929 - 108,952,325 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,517,133 - 114,529,813 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,716,461 - 112,729,141 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,559,095 - 110,571,775 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,980,501 - 116,993,182 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,980,497 - 116,993,193 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,334,176 - 116,346,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,470,871 - 113,483,433 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,492,696 - 113,493,023 (-)NCBI
Celera8108,195,279 - 108,207,962 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
LY294002  (ISO)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis involved in wound healing  (IEP)
axon guidance  (IBA)
axon regeneration  (IEP)
basement membrane organization  (IEA,ISO)
branching involved in salivary gland morphogenesis  (IEA,ISO)
calcium-dependent cell-matrix adhesion  (IMP)
cellular response to cholesterol  (IEP)
cellular response to mechanical stimulus  (IMP)
commissural neuron axon guidance  (IEA,ISO)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
heart development  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
membrane protein ectodomain proteolysis  (IEA,ISO)
microtubule anchoring  (IEA,ISO)
morphogenesis of an epithelial sheet  (IEA,ISO)
morphogenesis of an epithelium  (IBA)
muscle attachment  (IBA)
myelination in peripheral nervous system  (IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of MAPK cascade  (IEA,ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
nerve development  (IBA,IEP)
nerve maturation  (IEA,ISO)
positive regulation of cell-matrix adhesion  (IMP)
positive regulation of myelination  (IMP)
positive regulation of oligodendrocyte differentiation  (IMP)
positive regulation of protein kinase activity  (IMP)
protein transport  (IEA,ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IEA,ISO)
regulation of synapse organization  (IEA,ISO)
regulation of synaptic plasticity  (IEA,ISO)
response to denervation involved in regulation of muscle adaptation  (IEP)
response to muscle activity  (IEA,ISO)
response to peptide hormone  (IEP)
retrograde trans-synaptic signaling by trans-synaptic protein complex  (IEA,ISO)
Schwann cell development  (IEA,ISO)
Schwann cell differentiation  (IEP)
skeletal muscle tissue regeneration  (IEP)
symbiont entry into host cell  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of Dp71¿(78-79), a novel dystrophin mutant that stimulates PC12 cell differentiation. Aragón J, etal., J Neurochem. 2011 Nov;119(4):697-707. doi: 10.1111/j.1471-4159.2011.07347.x. Epub 2011 Sep 22.
2. Dystroglycan expression in hepatic stellate cells: role in liver fibrosis. Bedossa P, etal., Lab Invest. 2002 Aug;82(8):1053-61.
3. Localization of cranin (dystroglycan) at sites of cell-matrix and cell-cell contact: recruitment to focal adhesions is dependent upon extracellular ligands. Belkin AM and Smalheiser NR, Cell Adhes Commun. 1996 Nov;4(4-5):281-96.
4. Increased expression of dystrophin, beta-dystroglycan and adhalin in denervated rat muscles. Biral D, etal., J Muscle Res Cell Motil. 1996 Oct;17(5):523-32.
5. Stretch-induced activation of AMP kinase in the lung requires dystroglycan. Budinger GR, etal., Am J Respir Cell Mol Biol. 2008 Dec;39(6):666-72. doi: 10.1165/rcmb.2007-0432OC. Epub 2008 Jun 12.
6. Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy. Chockalingam PS, etal., Am J Physiol Cell Physiol 2002 Aug;283(2):C500-11.
7. Dystroglycan is present in rat thyroid and rat thyroid cells and responds to thyrotropin. Collins BJ, etal., Endocrinology 2001 Jul;142(7):3152-62.
8. Identification of dystroglycan as a second laminin receptor in oligodendrocytes, with a role in myelination. Colognato H, etal., Development. 2007 May;134(9):1723-36. Epub 2007 Mar 29.
9. Genetic analysis of the dystroglycan gene in bronchopulmonary dysplasia affected premature newborns. Concolino P, etal., Clin Chim Acta. 2007 Mar;378(1-2):164-7. Epub 2006 Nov 25.
10. Development of rabbit monoclonal antibodies for detection of alpha-dystroglycan in normal and dystrophic tissue. Fortunato MJ, etal., PLoS One. 2014 May 13;9(5):e97567. doi: 10.1371/journal.pone.0097567. eCollection 2014.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse. Grewal PK, etal., Nat Genet 2001 Jun;28(2):151-4.
13. Selective deficiency of alpha-dystroglycan in Fukuyama-type congenital muscular dystrophy. Hayashi YK, etal., Neurology. 2001 Jul 10;57(1):115-21.
14. The expression of dystrophin, alpha-sarcoglycan, and beta-dystroglycan during skeletal muscle regeneration: immunohistochemical and western blot studies. Hoshino S, etal., Acta Histochem. 2002;104(2):139-47.
15. Hypoglycosylation of alpha-dystroglycan in patients with hereditary IBM due to GNE mutations. Huizing M, etal., Mol Genet Metab. 2004 Mar;81(3):196-202.
16. Altered distribution of beta-dystroglycan in sarcolemma of human dystrophic muscles: an immunohistochemical study. Jimi T, etal., Muscle Nerve. 1995 Aug;18(8):910-3.
17. Axotomy of sympathetic neurons activates the metalloproteinase-2 enzymatic pathway. Leone L, etal., J Neuropathol Exp Neurol. 2005 Nov;64(11):1007-17.
18. Differential expression and subcellular distribution of dystrophin Dp71 isoforms during differentiation process. Marquez FG, etal., Neuroscience. 2003;118(4):957-66.
19. Expression of dystroglycan and the laminin-alpha 2 chain in the rat peripheral nerve during development. Masaki T, etal., Exp Neurol. 2002 Mar;174(1):109-17.
20. Association of dystroglycan and laminin-2 coexpression with myelinogenesis in peripheral nerves. Masaki T, etal., Med Electron Microsc. 2003 Dec;36(4):221-39.
21. A role of dystroglycan in schwannoma cell adhesion to laminin. Matsumura K, etal., J Biol Chem. 1997 May 23;272(21):13904-10.
22. Proteolysis of beta-dystroglycan in muscular diseases. Matsumura K, etal., Neuromuscul Disord. 2005 May;15(5):336-41.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty. Miyagawa S, etal., Circulation. 2002 May 28;105(21):2556-61.
25. Expression of the skeletal muscle dystrophin-dystroglycan complex and syntrophin-nitric oxide synthase complex is severely affected in the type 2 diabetic Goto-Kakizaki rat. Mulvey C, etal., Eur J Cell Biol. 2005 Nov;84(11):867-83.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. Loss of AQP4 polarized localization with loss of beta-dystroglycan immunoreactivity may induce brain edema following intracerebral hemorrhage. Qiu GP, etal., Neurosci Lett. 2015 Feb 19;588:42-8. doi: 10.1016/j.neulet.2014.12.053. Epub 2014 Dec 27.
30. Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. Rambukkana A, etal., Science. 1998 Dec 11;282(5396):2076-9.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Age-related dystrophin-glycoprotein complex structure and function in the rat extensor digitorum longus and soleus muscle. Rice KM, etal., J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1119-29.
35. Brain and eye malformations resembling Walker-Warburg syndrome are recapitulated in mice by dystroglycan deletion in the epiblast. Satz JS, etal., J Neurosci. 2008 Oct 15;28(42):10567-75. doi: 10.1523/JNEUROSCI.2457-08.2008.
36. Dystroglycan in the cerebellum is a laminin alpha 2-chain binding protein at the glial-vascular interface and is expressed in Purkinje cells. Tian M, etal., Eur J Neurosci. 1996 Dec;8(12):2739-47.
37. Beta-dystroglycan localization in the photoreceptor and Müller cells in the rat retina revealed by immunoelectron microscopy. Ueda H, etal., J Histochem Cytochem. 1998 Feb;46(2):185-91. doi: 10.1177/002215549804600207.
38. Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex. Ursitti JA, etal., J Biol Chem. 2004 Oct 1;279(40):41830-8. Epub 2004 Jul 6.
39. Cholesterol depletion uncouples beta-dystroglycans from discrete sarcolemmal domains, reducing the mechanical activity of skeletal muscle. Vega-Moreno J, etal., Cell Physiol Biochem. 2012;29(5-6):905-18. doi: 10.1159/000186933. Epub 2012 May 11.
40. Dynamics of dystroglycan complex proteins and laminin changes due to angiogenesis in rat cerebral hypoperfusion. Wappler EA, etal., Microvasc Res. 2011 Mar;81(2):153-9. doi: 10.1016/j.mvr.2010.12.005. Epub 2010 Dec 28.
41. Differential distribution of dystrophin and beta-spectrin at the sarcolemma of fast twitch skeletal muscle fibers. Williams MW and Bloch RJ, J Muscle Res Cell Motil. 1999 May;20(4):383-93.
42. Evidence that dystroglycan is associated with dynamin and regulates endocytosis. Zhan Y, etal., J Biol Chem. 2005 May 6;280(18):18015-24. Epub 2005 Feb 22.
Additional References at PubMed
PMID:8017170   PMID:9524190   PMID:10481911   PMID:10988290   PMID:11115849   PMID:11259414   PMID:11423118   PMID:11430802   PMID:11502221   PMID:11717465   PMID:11724572   PMID:11798066  
PMID:12797959   PMID:14622018   PMID:14627610   PMID:15210115   PMID:15284294   PMID:15578661   PMID:16254364   PMID:16502470   PMID:16935300   PMID:17628813   PMID:17993586   PMID:18188865  
PMID:18201566   PMID:18341635   PMID:18691338   PMID:18764929   PMID:19199708   PMID:19348877   PMID:19451651   PMID:19587235   PMID:19694806   PMID:19931597   PMID:19946898   PMID:20512930  
PMID:20857503   PMID:21423176   PMID:22117643   PMID:23217742   PMID:23376485   PMID:23533145   PMID:23793062   PMID:23940118   PMID:24006456   PMID:25157101   PMID:26583111   PMID:27068509  
PMID:27559042   PMID:27707967   PMID:34160889   PMID:35169214  


Genomics

Comparative Map Data
Dag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,769,517 - 117,834,347 (-)NCBIGRCr8
mRatBN7.28108,890,926 - 108,955,611 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,890,929 - 108,952,325 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,517,133 - 114,529,813 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,716,461 - 112,729,141 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,559,095 - 110,571,775 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,980,501 - 116,993,182 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,980,497 - 116,993,193 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,334,176 - 116,346,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,470,871 - 113,483,433 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,492,696 - 113,493,023 (-)NCBI
Celera8108,195,279 - 108,207,962 (-)NCBICelera
Cytogenetic Map8q32NCBI
DAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,468,948 - 49,535,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,468,713 - 49,535,618 (+)EnsemblGRCh38hg38GRCh38
GRCh37349,506,381 - 49,573,048 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,482,569 - 49,548,052 (+)NCBINCBI36Build 36hg18NCBI36
Build 34349,482,594 - 49,548,048NCBI
Celera349,470,589 - 49,537,675 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,565,602 - 49,632,289 (+)NCBIHuRef
CHM1_1349,458,558 - 49,525,426 (+)NCBICHM1_1
T2T-CHM13v2.0349,498,008 - 49,564,630 (+)NCBIT2T-CHM13v2.0
Dag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,082,060 - 108,141,176 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,081,833 - 108,141,157 (-)EnsemblGRCm39 Ensembl
GRCm389108,204,861 - 108,263,977 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,204,634 - 108,263,958 (-)EnsemblGRCm38mm10GRCm38
MGSCv379108,108,289 - 108,166,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,064,059 - 108,121,837 (-)NCBIMGSCv36mm8
Celera9107,814,579 - 107,872,572 (-)NCBICelera
Cytogenetic Map9F1- F2NCBI
cM Map959.08NCBI
Dag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,397,900 - 1,466,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,446,553 - 1,465,310 (+)NCBIChiLan1.0ChiLan1.0
DAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,450,093 - 49,519,011 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,454,874 - 49,523,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,396,180 - 49,464,689 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,637,707 - 50,703,852 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,640,615 - 50,703,852 (+)Ensemblpanpan1.1panPan2
DAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,707,672 - 39,779,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,708,053 - 39,778,550 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,627,718 - 39,697,490 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,064,114 - 40,135,683 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,064,115 - 40,135,215 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,432,635 - 39,502,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,836,035 - 39,906,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,115,684 - 40,185,987 (-)NCBIUU_Cfam_GSD_1.0
Dag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,339,013 - 64,411,089 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,099,647 - 1,173,124 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,099,510 - 1,171,587 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,029,522 - 32,092,450 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,028,019 - 32,092,450 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DAG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,864,058 - 10,934,179 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,865,724 - 10,934,200 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,068,731 - 156,143,284 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dag1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,417,347 - 3,488,879 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,417,356 - 3,488,300 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Dag1
275 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:68
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000026327
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
Dag1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,894,531 - 108,894,777 (+)MAPPERmRatBN7.2
Rnor_6.08116,984,107 - 116,984,352NCBIRnor6.0
Rnor_5.08116,337,782 - 116,338,027UniSTSRnor5.0
RGSC_v3.48113,474,477 - 113,474,722UniSTSRGSC3.4
Celera8108,198,886 - 108,199,131UniSTS
Cytogenetic Map8q32UniSTS
BG378140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,894,377 - 108,894,495 (+)MAPPERmRatBN7.2
Rnor_6.08116,983,953 - 116,984,070NCBIRnor6.0
Rnor_5.08116,337,628 - 116,337,745UniSTSRnor5.0
RGSC_v3.48113,474,323 - 113,474,440UniSTSRGSC3.4
Celera8108,198,731 - 108,198,849UniSTS
RH 3.4 Map81117.3UniSTS
Cytogenetic Map8q32UniSTS
RH135177  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,892,138 - 108,892,355 (+)MAPPERmRatBN7.2
Rnor_6.08116,981,714 - 116,981,930NCBIRnor6.0
Rnor_5.08116,335,389 - 116,335,605UniSTSRnor5.0
RGSC_v3.48113,472,084 - 113,472,300UniSTSRGSC3.4
Celera8108,196,492 - 108,196,708UniSTS
RH 3.4 Map81118.6UniSTS
Cytogenetic Map8q32UniSTS
RH125695  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,891,055 - 108,891,213 (+)MAPPERmRatBN7.2
Rnor_6.08116,980,631 - 116,980,788NCBIRnor6.0
Rnor_5.08116,334,306 - 116,334,463UniSTSRnor5.0
RGSC_v3.48113,471,001 - 113,471,158UniSTSRGSC3.4
Celera8108,195,409 - 108,195,566UniSTS
Cytogenetic Map8q32UniSTS
SSC24F05  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,892,012 - 108,892,172 (+)MAPPERmRatBN7.2
Rnor_6.08116,981,588 - 116,981,747NCBIRnor6.0
Rnor_5.08116,335,263 - 116,335,422UniSTSRnor5.0
RGSC_v3.48113,471,958 - 113,472,117UniSTSRGSC3.4
Celera8108,196,366 - 108,196,525UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026327   ⟹   ENSRNOP00000026327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,890,929 - 108,952,325 (-)Ensembl
Rnor_6.0 Ensembl8116,980,497 - 116,993,193 (-)Ensembl
RefSeq Acc Id: NM_053697   ⟹   NP_446149
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,769,517 - 117,782,199 (-)NCBI
mRatBN7.28108,890,926 - 108,903,609 (-)NCBI
Rnor_6.08116,980,501 - 116,993,182 (-)NCBI
Rnor_5.08116,334,176 - 116,346,857 (-)NCBI
Celera8108,195,279 - 108,207,962 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080664   ⟹   XP_038936592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,769,520 - 117,830,948 (-)NCBI
mRatBN7.28108,890,928 - 108,952,177 (-)NCBI
RefSeq Acc Id: XM_039080665   ⟹   XP_038936593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,769,520 - 117,830,932 (-)NCBI
mRatBN7.28108,890,928 - 108,952,363 (-)NCBI
RefSeq Acc Id: XM_039080666   ⟹   XP_038936594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,769,520 - 117,834,347 (-)NCBI
mRatBN7.28108,890,928 - 108,955,611 (-)NCBI
RefSeq Acc Id: XM_039080667   ⟹   XP_038936595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,769,520 - 117,830,751 (-)NCBI
mRatBN7.28108,890,928 - 108,951,904 (-)NCBI
RefSeq Acc Id: XM_039080668   ⟹   XP_038936596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,769,520 - 117,830,751 (-)NCBI
mRatBN7.28108,890,928 - 108,952,177 (-)NCBI
RefSeq Acc Id: XM_039080669   ⟹   XP_038936597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,769,520 - 117,830,932 (-)NCBI
mRatBN7.28108,890,928 - 108,952,363 (-)NCBI
RefSeq Acc Id: XM_039080670   ⟹   XP_038936598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,769,520 - 117,834,206 (-)NCBI
mRatBN7.28108,890,928 - 108,955,545 (-)NCBI
RefSeq Acc Id: XM_039080672   ⟹   XP_038936600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,769,520 - 117,830,751 (-)NCBI
mRatBN7.28108,890,928 - 108,952,177 (-)NCBI
RefSeq Acc Id: NP_446149   ⟸   NM_053697
- Peptide Label: precursor
- UniProtKB: F1M8K0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026327   ⟸   ENSRNOT00000026327
RefSeq Acc Id: XP_038936594   ⟸   XM_039080666
- Peptide Label: isoform X1
- UniProtKB: F1M8K0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936598   ⟸   XM_039080670
- Peptide Label: isoform X1
- UniProtKB: F1M8K0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936597   ⟸   XM_039080669
- Peptide Label: isoform X1
- UniProtKB: F1M8K0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936593   ⟸   XM_039080665
- Peptide Label: isoform X1
- UniProtKB: F1M8K0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936600   ⟸   XM_039080672
- Peptide Label: isoform X1
- UniProtKB: F1M8K0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936596   ⟸   XM_039080668
- Peptide Label: isoform X1
- UniProtKB: F1M8K0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936592   ⟸   XM_039080664
- Peptide Label: isoform X1
- UniProtKB: F1M8K0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936595   ⟸   XM_039080667
- Peptide Label: isoform X1
- UniProtKB: F1M8K0 (UniProtKB/TrEMBL)
Protein Domains
Dystroglycan C-terminal   Dystroglycan-type cadherin-like   Peptidase S72

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8K0-F1-model_v2 AlphaFold F1M8K0 1-893 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621890 AgrOrtholog
BioCyc Gene G2FUF-29155 BioCyc
Ensembl Genes ENSRNOG00000019400 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026327 ENTREZGENE
  ENSRNOT00000026327.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.30.70.1040 UniProtKB/TrEMBL
InterPro Alpha-dystroglycan_domain_2 UniProtKB/TrEMBL
  Alpha_DG1_N2 UniProtKB/TrEMBL
  Cadg UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  DAG1 UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  SEA_DG_dom UniProtKB/TrEMBL
KEGG Report rno:114489 UniProtKB/TrEMBL
NCBI Gene 114489 ENTREZGENE
PANTHER DYSTROGLYCAN UniProtKB/TrEMBL
  DYSTROGLYCAN-RELATED UniProtKB/TrEMBL
Pfam a_DG1_N2 UniProtKB/TrEMBL
  DAG1 UniProtKB/TrEMBL
  He_PIG UniProtKB/TrEMBL
PhenoGen Dag1 PhenoGen
PRINTS PRICHEXTENSN UniProtKB/TrEMBL
PROSITE SEA_DG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019400 RatGTEx
SMART CADG UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
  SSF111006 UniProtKB/TrEMBL
UniProt A6I340_RAT UniProtKB/TrEMBL
  F1M8K0 ENTREZGENE, UniProtKB/TrEMBL
  Q91XP6_RAT UniProtKB/TrEMBL
  Q91XP7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Dag1  dystroglycan 1  Dag1  dystroglycan 1 (dystrophin-associated glycoprotein 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Dag1  dystroglycan 1 (dystrophin-associated glycoprotein 1)  Dag1  dystroglycan 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dag1  dystroglycan 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 dag1  dystroglycan 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is reduced by thyrotropin (TSH) 632564