DAG1 (dystroglycan 1) - Rat Genome Database

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Gene: DAG1 (dystroglycan 1) Canis lupus familiaris
Analyze
Symbol: DAG1
Name: dystroglycan 1
RGD ID: 12378318
Description: ENCODES a protein that exhibits laminin binding (ortholog); laminin-1 binding (ortholog); INVOLVED IN aging (ortholog); angiogenesis involved in wound healing (ortholog); axon regeneration (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 1 (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2D (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2P (ortholog); FOUND IN adherens junction (ortholog); basement membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dystroglycan; dystrophin-associated glycoprotein 1; glycine cleavage system T-protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,707,672 - 39,779,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,708,053 - 39,778,550 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,627,718 - 39,697,490 (-)NCBI
ROS_Cfam_1.02040,064,114 - 40,135,683 (-)NCBI
UMICH_Zoey_3.12039,432,635 - 39,502,839 (-)NCBI
UNSW_CanFamBas_1.02039,836,035 - 39,906,605 (-)NCBI
UU_Cfam_GSD_1.02040,115,684 - 40,185,987 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis involved in wound healing  (ISO)
axon guidance  (IBA)
axon regeneration  (ISO)
basement membrane organization  (IEA,ISO)
branching involved in salivary gland morphogenesis  (IEA,ISO)
calcium-dependent cell-matrix adhesion  (ISO)
cellular response to cholesterol  (ISO)
cellular response to mechanical stimulus  (ISO)
commissural neuron axon guidance  (IEA,ISO)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
membrane protein ectodomain proteolysis  (IEA)
microtubule anchoring  (IEA)
modulation by virus of host process  (IEA)
morphogenesis of an epithelial sheet  (IEA,ISO)
morphogenesis of an epithelium  (IBA)
muscle attachment  (IBA)
myelination in peripheral nervous system  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of MAPK cascade  (IEA)
negative regulation of protein kinase B signaling  (IEA)
nerve development  (IBA,ISO)
nerve maturation  (IEA)
positive regulation of basement membrane assembly involved in embryonic body morphogenesis  (IEA)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of myelination  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of protein kinase activity  (ISO)
regulation of epithelial to mesenchymal transition  (IEA)
regulation of gastrulation  (IEA)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IEA)
regulation of synapse organization  (IEA)
response to denervation involved in regulation of muscle adaptation  (ISO)
response to peptide hormone  (ISO)
retrograde trans-synaptic signaling by trans-synaptic protein complex  (IEA)
Schwann cell development  (ISO)
Schwann cell differentiation  (ISO)
skeletal muscle tissue regeneration  (ISO)
viral entry into host cell  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:10575237   PMID:10720570   PMID:10894947   PMID:11105220   PMID:12392556  


Genomics

Comparative Map Data
DAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,707,672 - 39,779,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,708,053 - 39,778,550 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,627,718 - 39,697,490 (-)NCBI
ROS_Cfam_1.02040,064,114 - 40,135,683 (-)NCBI
UMICH_Zoey_3.12039,432,635 - 39,502,839 (-)NCBI
UNSW_CanFamBas_1.02039,836,035 - 39,906,605 (-)NCBI
UU_Cfam_GSD_1.02040,115,684 - 40,185,987 (-)NCBI
DAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,468,703 - 49,535,618 (+)EnsemblGRCh38hg38GRCh38
GRCh38349,468,703 - 49,535,618 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,506,136 - 49,573,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,482,569 - 49,548,052 (+)NCBINCBI36hg18NCBI36
Build 34349,482,594 - 49,548,048NCBI
Celera349,470,589 - 49,537,675 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,565,602 - 49,632,289 (+)NCBIHuRef
CHM1_1349,458,558 - 49,525,426 (+)NCBICHM1_1
Dag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,082,060 - 108,141,176 (-)NCBIGRCm39mm39
GRCm39 Ensembl9108,081,833 - 108,141,157 (-)Ensembl
GRCm389108,204,861 - 108,263,977 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,204,634 - 108,263,958 (-)EnsemblGRCm38mm10GRCm38
MGSCv379108,108,289 - 108,166,067 (-)NCBIGRCm37mm9NCBIm37
MGSCv369108,064,059 - 108,121,837 (-)NCBImm8
Celera9107,814,579 - 107,872,572 (-)NCBICelera
Cytogenetic Map9F1- F2NCBI
cM Map959.08NCBI
Dag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,890,926 - 108,955,611 (-)NCBI
Rnor_6.0 Ensembl8116,980,497 - 116,993,193 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08116,980,501 - 116,993,182 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08116,334,176 - 116,346,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,470,871 - 113,483,433 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18113,492,696 - 113,493,023 (-)NCBI
Celera8108,195,279 - 108,207,962 (-)NCBICelera
Cytogenetic Map8q32NCBI
Dag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,397,900 - 1,466,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,446,553 - 1,465,310 (+)NCBIChiLan1.0ChiLan1.0
DAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,637,707 - 50,703,852 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,640,615 - 50,703,852 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0349,396,180 - 49,464,689 (+)NCBIMhudiblu_PPA_v0panPan3
Dag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,339,013 - 64,411,089 (+)NCBI
SpeTri2.0NW_0049365291,099,510 - 1,171,587 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,029,329 - 32,092,453 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,028,019 - 32,092,450 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DAG1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,864,058 - 10,934,179 (+)NCBI
ChlSab1.1 Ensembl2210,865,724 - 10,934,200 (+)Ensembl
Vero_WHO_p1.0NW_023666041156,068,731 - 156,143,284 (-)NCBI
Dag1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,417,356 - 3,488,300 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 19 3 6 3 6 6 12 8 10 6
Low 3 3 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005632318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005632319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ012166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000017810   ⟹   ENSCAFP00000016488
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2039,708,053 - 39,778,550 (-)Ensembl
RefSeq Acc Id: NM_001033992   ⟹   NP_001029164
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,708,043 - 39,778,550 (-)NCBI
Dog10K_Boxer_Tasha2039,627,718 - 39,697,490 (-)NCBI
ROS_Cfam_1.02040,064,483 - 40,135,147 (-)NCBI
UMICH_Zoey_3.12039,432,635 - 39,502,839 (-)NCBI
UNSW_CanFamBas_1.02039,836,035 - 39,906,605 (-)NCBI
UU_Cfam_GSD_1.02040,115,684 - 40,185,987 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005632318   ⟹   XP_005632375
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,707,672 - 39,778,361 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005632319   ⟹   XP_005632376
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,707,672 - 39,778,190 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022406228   ⟹   XP_022261936
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,707,672 - 39,779,094 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022406229   ⟹   XP_022261937
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,707,672 - 39,729,541 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022406230   ⟹   XP_022261938
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,707,672 - 39,747,393 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022406231   ⟹   XP_022261939
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,707,672 - 39,714,230 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038426428   ⟹   XP_038282356
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02040,064,114 - 40,134,955 (-)NCBI
RefSeq Acc Id: XM_038426429   ⟹   XP_038282357
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02040,064,114 - 40,135,683 (-)NCBI
RefSeq Acc Id: XM_038426430   ⟹   XP_038282358
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02040,064,114 - 40,086,147 (-)NCBI
RefSeq Acc Id: XM_038426431   ⟹   XP_038282359
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02040,064,114 - 40,134,723 (-)NCBI
RefSeq Acc Id: XM_038426432   ⟹   XP_038282360
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02040,064,114 - 40,103,800 (-)NCBI
RefSeq Acc Id: XM_038426433   ⟹   XP_038282361
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02040,064,114 - 40,070,678 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005632375   ⟸   XM_005632318
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005632376   ⟸   XM_005632319
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001029164   ⟸   NM_001033992
- Peptide Label: precursor
- UniProtKB: Q9TSZ6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_022261936   ⟸   XM_022406228
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022261938   ⟸   XM_022406230
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022261937   ⟸   XM_022406229
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022261939   ⟸   XM_022406231
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000016488   ⟸   ENSCAFT00000017810
RefSeq Acc Id: XP_038282357   ⟸   XM_038426429
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038282356   ⟸   XM_038426428
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038282359   ⟸   XM_038426431
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038282360   ⟸   XM_038426432
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038282358   ⟸   XM_038426430
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038282361   ⟸   XM_038426433
- Peptide Label: isoform X2
Protein Domains
Peptidase S72

Promoters
RGD ID:13686870
Promoter ID:EPDNEW_C4940
Type:initiation region
Name:DAG1_1
Description:dystroglycan 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,778,437 - 39,778,497EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011207 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSCAFG00030013738 UniProtKB/Swiss-Prot
Ensembl Protein ENSCAFP00000016488 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSCAFP00030022207 UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000017810 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSCAFT00030025431 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.30.70.1040 UniProtKB/Swiss-Prot
InterPro Alpha-dystroglycan_domain_2 UniProtKB/Swiss-Prot
  Alpha_DG1_N2 UniProtKB/Swiss-Prot
  Cadg UniProtKB/Swiss-Prot
  Cadherin-like_sf UniProtKB/Swiss-Prot
  DAG1_C UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  SEA_DG_dom UniProtKB/Swiss-Prot
KEGG Report cfa:476623 UniProtKB/Swiss-Prot
NCBI Gene DAG1 ENTREZGENE
Pfam a_DG1_N2 UniProtKB/Swiss-Prot
  DAG1 UniProtKB/Swiss-Prot
PROSITE SEA_DG UniProtKB/Swiss-Prot
SMART CADG UniProtKB/Swiss-Prot
Superfamily-SCOP SSF111006 UniProtKB/Swiss-Prot
  SSF49313 UniProtKB/Swiss-Prot
UniProt DAG1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:39763 ENTREZGENE