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Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae.

Authors: Rambukkana, A  Yamada, H  Zanazzi, G  Mathus, T  Salzer, JL  Yurchenco, PD  Campbell, KP  Fischetti, VA 
Citation: Rambukkana A, etal., Science. 1998 Dec 11;282(5396):2076-9.
Pubmed: (View Article at PubMed) PMID:9851927

alpha-Dystroglycan (alpha-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies. Here, alpha-DG was shown to serve as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy. Mycobacterium leprae specifically bound to alpha-DG only in the presence of the G domain of the alpha2 chain of laminin-2. Native alpha-DG competitively inhibited the laminin-2-mediated M. leprae binding to primary Schwann cells. Thus, M. leprae may use linkage between the extracellular matrix and cytoskeleton through laminin-2 and alpha-DG for its interaction with Schwann cells.


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RGD Object Information
RGD ID: 2314897
Created: 2009-12-08
Species: All species
Last Modified: 2009-12-08
Status: ACTIVE


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