DAG1 (dystroglycan 1) - Rat Genome Database
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Gene: DAG1 (dystroglycan 1) Sus scrofa
Analyze
Symbol: DAG1
Name: dystroglycan 1
RGD ID: 14231339
Description: ENCODES a protein that exhibits dystroglycan binding (ortholog); laminin binding (ortholog); laminin-1 binding (ortholog); INVOLVED IN aging (ortholog); angiogenesis involved in wound healing (ortholog); axon regeneration (ortholog); ASSOCIATED WITH autosomal recessive limb-girdle muscular dystrophy type 2D (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2P (ortholog); Bronchopulmonary Dysplasia (ortholog); FOUND IN adherens junction (ortholog); basement membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: dystroglycan; dystroglycan 1 (dystrophin-associated glycoprotein 1); Dystrophin-associated glycoprotein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,029,329 - 32,092,453 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,028,019 - 32,092,450 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis involved in wound healing  (ISO)
axon guidance  (IBA)
axon regeneration  (ISO)
basement membrane organization  (IEA,ISO)
branching involved in salivary gland morphogenesis  (IEA,ISO)
calcium-dependent cell-matrix adhesion  (ISO)
cellular response to cholesterol  (ISO)
cellular response to mechanical stimulus  (ISO)
commissural neuron axon guidance  (IEA,ISO)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
membrane protein ectodomain proteolysis  (IEA)
microtubule anchoring  (IEA)
modulation by virus of host process  (IEA)
morphogenesis of an epithelial sheet  (IEA,ISO)
morphogenesis of an epithelium  (IBA)
muscle attachment  (IBA)
myelination in peripheral nervous system  (IEA,ISO)
negative regulation of cell migration  (IEA)
negative regulation of MAPK cascade  (IEA)
negative regulation of protein kinase B signaling  (IEA)
nerve development  (IBA,ISO)
nerve maturation  (IEA,ISO)
positive regulation of basement membrane assembly involved in embryonic body morphogenesis  (IEA)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of myelination  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of protein kinase activity  (ISO)
regulation of epithelial to mesenchymal transition  (IEA)
regulation of gastrulation  (IEA)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IEA,ISO)
regulation of synapse organization  (IEA,ISO)
response to denervation involved in regulation of muscle adaptation  (ISO)
response to peptide hormone  (ISO)
retrograde trans-synaptic signaling by trans-synaptic protein complex  (IEA,ISO)
Schwann cell development  (ISO)
Schwann cell differentiation  (ISO)
skeletal muscle tissue regeneration  (ISO)
viral entry into host cell  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
DAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,029,329 - 32,092,453 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,028,019 - 32,092,450 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,468,703 - 49,535,618 (+)EnsemblGRCh38hg38GRCh38
GRCh38349,468,703 - 49,535,618 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,506,136 - 49,573,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,482,569 - 49,548,052 (+)NCBINCBI36hg18NCBI36
Build 34349,482,594 - 49,548,048NCBI
Celera349,470,589 - 49,537,675 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,565,602 - 49,632,289 (+)NCBIHuRef
CHM1_1349,458,558 - 49,525,426 (+)NCBICHM1_1
Dag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,082,060 - 108,141,176 (-)NCBIGRCm39mm39
GRCm39 Ensembl9108,081,833 - 108,141,157 (-)Ensembl
GRCm389108,204,861 - 108,263,977 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,204,634 - 108,263,958 (-)EnsemblGRCm38mm10GRCm38
MGSCv379108,108,289 - 108,166,067 (-)NCBIGRCm37mm9NCBIm37
MGSCv369108,064,059 - 108,121,837 (-)NCBImm8
Celera9107,814,579 - 107,872,572 (-)NCBICelera
Cytogenetic Map9F1- F2NCBI
cM Map959.08NCBI
Dag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,890,926 - 108,955,611 (-)NCBI
Rnor_6.0 Ensembl8116,980,497 - 116,993,193 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08116,980,501 - 116,993,182 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08116,334,176 - 116,346,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,470,871 - 113,483,433 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18113,492,696 - 113,493,023 (-)NCBI
Celera8108,195,279 - 108,207,962 (-)NCBICelera
Cytogenetic Map8q32NCBI
Dag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,397,900 - 1,466,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,446,553 - 1,465,310 (+)NCBIChiLan1.0ChiLan1.0
DAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,637,707 - 50,703,852 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,640,615 - 50,703,852 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0349,396,180 - 49,464,689 (+)NCBIMhudiblu_PPA_v0panPan3
DAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,708,053 - 39,778,550 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,707,672 - 39,779,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,099,510 - 1,171,587 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAG1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,864,058 - 10,934,179 (+)NCBI
ChlSab1.1 Ensembl2210,865,724 - 10,934,200 (+)Ensembl
Dag1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,417,356 - 3,488,300 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 2 3 1 2 16 2 3
Low 7 2 4 7 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021068740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK240563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK352481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBZA01000165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01105460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000026336   ⟹   ENSSSCP00000021948
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1332,029,522 - 32,090,051 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000036961   ⟹   ENSSSCP00000048891
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1332,029,525 - 32,092,450 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000042010   ⟹   ENSSSCP00000053965
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1332,029,498 - 32,092,401 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000048888   ⟹   ENSSSCP00000036552
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1332,029,329 - 32,092,453 (+)Ensembl
RefSeq Acc Id: XM_021068740   ⟹   XP_020924399
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,028,019 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068741   ⟹   XP_020924400
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,504 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068742   ⟹   XP_020924401
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,355 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068743   ⟹   XP_020924402
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,028,019 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068744   ⟹   XP_020924403
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,028,019 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068746   ⟹   XP_020924405
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,320 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068747   ⟹   XP_020924406
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,277 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068748   ⟹   XP_020924407
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,516 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068749   ⟹   XP_020924408
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,646 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068750   ⟹   XP_020924409
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,338 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068751   ⟹   XP_020924410
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,487 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068752   ⟹   XP_020924411
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,487 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068753   ⟹   XP_020924412
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,291 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068754   ⟹   XP_020924413
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,484 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068755   ⟹   XP_020924414
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,447 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068757   ⟹   XP_020924416
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,334 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068758   ⟹   XP_020924417
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,355 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068759   ⟹   XP_020924418
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,289 - 32,092,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068760   ⟹   XP_020924419
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11332,029,295 - 32,092,450 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020924399   ⟸   XM_021068740
- Sequence:
RefSeq Acc Id: XP_020924402   ⟸   XM_021068743
- Sequence:
RefSeq Acc Id: XP_020924403   ⟸   XM_021068744
- Sequence:
RefSeq Acc Id: XP_020924406   ⟸   XM_021068747
- Sequence:
RefSeq Acc Id: XP_020924418   ⟸   XM_021068759
- Sequence:
RefSeq Acc Id: XP_020924412   ⟸   XM_021068753
- Sequence:
RefSeq Acc Id: XP_020924419   ⟸   XM_021068760
- Sequence:
RefSeq Acc Id: XP_020924405   ⟸   XM_021068746
- Sequence:
RefSeq Acc Id: XP_020924416   ⟸   XM_021068757
- Sequence:
RefSeq Acc Id: XP_020924409   ⟸   XM_021068750
- Sequence:
RefSeq Acc Id: XP_020924417   ⟸   XM_021068758
- Sequence:
RefSeq Acc Id: XP_020924401   ⟸   XM_021068742
- Sequence:
RefSeq Acc Id: XP_020924414   ⟸   XM_021068755
- Sequence:
RefSeq Acc Id: XP_020924413   ⟸   XM_021068754
- Sequence:
RefSeq Acc Id: XP_020924411   ⟸   XM_021068752
- Sequence:
RefSeq Acc Id: XP_020924410   ⟸   XM_021068751
- Sequence:
RefSeq Acc Id: XP_020924400   ⟸   XM_021068741
- Sequence:
RefSeq Acc Id: XP_020924407   ⟸   XM_021068748
- Sequence:
RefSeq Acc Id: XP_020924408   ⟸   XM_021068749
- Sequence:
RefSeq Acc Id: ENSSSCP00000036552   ⟸   ENSSSCT00000048888
RefSeq Acc Id: ENSSSCP00000021948   ⟸   ENSSSCT00000026336
RefSeq Acc Id: ENSSSCP00000048891   ⟸   ENSSSCT00000036961
RefSeq Acc Id: ENSSSCP00000053965   ⟸   ENSSSCT00000042010
Protein Domains
Peptidase S72


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034357 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000021948 UniProtKB/TrEMBL
  ENSSSCP00000036552 UniProtKB/TrEMBL
  ENSSSCP00000048891 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000053965 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000026336 UniProtKB/TrEMBL
  ENSSSCT00000036961 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000042010 UniProtKB/TrEMBL
  ENSSSCT00000048888 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.1040 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Alpha-dystroglycan_domain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha_DG1_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_DG_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene DAG1 ENTREZGENE
Pfam a_DG1_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SEA_DG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CADG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111006 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZY59_PIG UniProtKB/TrEMBL
  A0A287BAM0_PIG UniProtKB/TrEMBL
  A0A287BBR1_PIG UniProtKB/TrEMBL
  A0A2C9F3F8_PIG UniProtKB/TrEMBL
  DAG1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary I3LD20 UniProtKB/Swiss-Prot
VGNC ID VGNC:87151 ENTREZGENE