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Gene: Dag1 (dystroglycan 1) Mus musculus
Symbol: Dag1
Name: dystroglycan 1
Description: This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. A complete lack of the encoded protein in mice results in embryonic lethality due to the disorganization of Reichert's membrane. Chimeric mice deficient in the encoded protein overcome embryonic lethality but develop a progressive muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-dystroglycan; beta-dystroglycan; D9Wsu13e; DG; Dp427; Dp71; dystroglycan; dystrophin associated glycoprotein 1; dystrophin-associated glycoprotein 1
Homo sapiens (human) : DAG1 (dystroglycan 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dag1 (dystroglycan 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dag1 (dystroglycan 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DAG1 (dystroglycan 1)
Canis lupus familiaris (dog) : DAG1 (dystroglycan 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dag1 (dystroglycan 1)
Sus scrofa (pig) : DAG1 (dystroglycan 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm389108,204,861 - 108,263,977 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379108,108,289 - 108,166,067 (-)NCBIGRCm37mm9NCBIm37
MGSCv369108,064,059 - 108,121,837 (-)NCBImm8
Celera9107,813,482 - 107,872,794 (-)NCBICelera
Cytogenetic Map9 F1NCBI
cM Map959.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dag1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552006
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.