Gene: Dag1 (dystroglycan 1) Mus musculus
Analyze
Symbol:
Dag1
Name:
dystroglycan 1
Description:
This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. A complete lack of the encoded protein in mice results in embryonic lethality due to the disorganization of Reichert's membrane. Chimeric mice deficient in the encoded protein overcome embryonic lethality but develop a progressive muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
alpha-dystroglycan; beta-dystroglycan; D9Wsu13e; DG; Dp427; Dp71; dystroglycan; dystrophin associated glycoprotein 1; dystrophin-associated glycoprotein 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
DAG1 (dystroglycan 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Dag1 (dystroglycan 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Dag1 (dystroglycan 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
DAG1 (dystroglycan 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
DAG1 (dystroglycan 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Dag1 (dystroglycan 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
DAG1 (dystroglycan 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Dag1 (dystroglycan 1)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Homo sapiens (human):
DAG1 (dystroglycan 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
dag1 (dystroglycan 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
Dg
Alliance
DIOPT (Ensembl Compara, OrthoInspector, PANTHER, Roundup)
Caenorhabditis elegans (roundworm):
dgn-1
Alliance
DIOPT (Hieranoid, OrthoInspector, Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 108,204,861 - 108,263,977 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 108,108,289 - 108,166,067 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 108,064,059 - 108,121,837 (-) NCBI mm8 Celera 9 107,813,482 - 107,872,794 (-) NCBI Celera Cytogenetic Map 9 F1 NCBI cM Map 9 59.08 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by OMIM:613818 ClinVar PMID:25503980 autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by term: Limb-girdle muscular dystrophy-dystroglycanopathy, type C9 ClinVar PMID:25934851 , PMID:28492532 autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by term: Limb-girdle muscular dystrophy-dystroglycanopathy, type C9 ClinVar PMID:24052401 , PMID:28492532 autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by term: Limb-girdle muscular dystrophy-dystroglycanopathy, type C9 ClinVar PMID:14678799 , PMID:21388311 autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by term: Limb-girdle muscular dystrophy-dystroglycanopathy, type C9 ClinVar PMID:24033266 , PMID:25741868 autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by term: MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2P ClinVar PMID:24033266 more ... autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by term: MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2P ClinVar PMID:25503980 more ... autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by OMIM:613818 ClinVar autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by term: Limb-girdle muscular dystrophy-dystroglycanopathy, type C9 ClinVar PMID:26467025 , PMID:28492532 autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by term: MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2P ClinVar PMID:25741868 more ... autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by term: MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2P ClinVar PMID:25671699 more ... autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by term: MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2P ClinVar PMID:28492532 autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 8554872 ClinVar Annotator: match by term: MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2P ClinVar PMID:25741868 , PMID:28492532 congenital muscular dystrophy-dystroglycanopathy type A9 ISO RGD:1344302 8554872 ClinVar Annotator: match by term: Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 9 ClinVar PMID:25934851 congenital muscular dystrophy-dystroglycanopathy type A9 ISO RGD:1344302 8554872 ClinVar Annotator: match by term: Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 9 ClinVar PMID:24052401 muscular disease ISO RGD:1344302 8554872 ClinVar Annotator: match by term: Myopathy ClinVar PMID:25741868 , PMID:28492532 myopathy ISO RGD:1344302 8554872 ClinVar Annotator: match by term: Myopathy ClinVar PMID:25741868 , PMID:28492532
Imported Annotations - CTD
Lassa fever ISO RGD:1344302 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17287727 Prostatic Neoplasms ISO RGD:1344302 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17013881 Walker-Warburg syndrome ISO RGD:1344302 11554173 CTD Direct Evidence: marker/mechanism CTD Imported Annotations - MGI
autosomal recessive limb-girdle muscular dystrophy type 2P IEA 13592920 OMIM:613818 MouseDO dilated cardiomyopathy IEA 13592920 MouseDO lissencephaly IEA 13592920 OMIM:300067 more ... MouseDO Imported Annotations - OMIM
autosomal recessive limb-girdle muscular dystrophy type 2P ISO RGD:1344302 7240710 OMIM congenital muscular dystrophy-dystroglycanopathy type A9 ISO RGD:1344302 7240710 OMIM
(RS)-amphetamine decreases expression ISO RGD:621890 6480464 Amphetamine results in decreased expression of DAG1 mRNA CTD PMID:30779732 17beta-estradiol multiple interactions ISO RGD:1344302 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of DAG1 mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1344302 6480464 Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of DAG1 mRNA] CTD PMID:11007951 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of DAG1 mRNA CTD PMID:21570461 , PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:621890 6480464 Tetrachlorodibenzodioxin affects the expression of DAG1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of DAG1 mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of DAG1 mRNA CTD PMID:19465110 , PMID:25975270 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1344302 6480464 Tetrachlorodibenzodioxin results in decreased expression of DAG1 mRNA CTD PMID:11007951 2-methylcholine affects expression ISO RGD:1344302 6480464 beta-methylcholine affects the expression of DAG1 mRNA CTD PMID:21179406 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of DAG1 mRNA CTD PMID:26251327 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of DAG1 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:1344302 6480464 Aflatoxin B1 results in decreased methylation of DAG1 exon CTD PMID:30157460 aflatoxin B2 increases methylation ISO RGD:1344302 6480464 aflatoxin B2 results in increased methylation of DAG1 promoter CTD PMID:30157460 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of DAG1 mRNA CTD PMID:16236135 all-trans-retinoic acid decreases expression ISO RGD:1344302 6480464 Tretinoin results in decreased expression of DAG1 mRNA CTD PMID:15894607 , PMID:17045167 all-trans-retinoic acid multiple interactions ISO RGD:1344302 6480464 [Tretinoin co-treated with arsenic trioxide] results in decreased expression of DAG1 mRNA CTD PMID:15894607 ammonium chloride affects expression ISO RGD:621890 6480464 Ammonium Chloride affects the expression of DAG1 mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of DAG1 mRNA CTD PMID:19770486 benzo[a]pyrene affects methylation ISO RGD:1344302 6480464 Benzo(a)pyrene affects the methylation of DAG1 exon, Benzo(a)pyrene affects the methylation of DAG1 promoter CTD PMID:30157460 benzo[a]pyrene multiple interactions EXP 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of DAG1 mRNA] CTD PMID:22228805 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of DAG1 mRNA CTD PMID:22228805 benzo[e]pyrene increases methylation ISO RGD:1344302 6480464 benzo(e)pyrene results in increased methylation of DAG1 promoter CTD PMID:30157460 benzo[e]pyrene decreases methylation ISO RGD:1344302 6480464 benzo(e)pyrene results in decreased methylation of DAG1 exon CTD PMID:30157460 bisphenol A affects expression ISO RGD:621890 6480464 bisphenol A affects the expression of DAG1 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:621890 6480464 bisphenol A results in decreased expression of DAG1 mRNA CTD PMID:27697584 cadmium atom increases expression ISO RGD:1344302 6480464 Cadmium results in increased expression of DAG1 mRNA CTD PMID:24376830 carbamazepine affects expression ISO RGD:1344302 6480464 Carbamazepine affects the expression of DAG1 mRNA CTD PMID:25979313 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of DAG1 mRNA, Nanotubes, Carbon results in decreased expression of DAG1 mRNA CTD PMID:25554681 chloroprene increases expression ISO RGD:621890 6480464 Chloroprene results in increased expression of DAG1 mRNA CTD PMID:23125180 cobalt dichloride decreases expression ISO RGD:1344302 6480464 cobaltous chloride results in decreased expression of DAG1 mRNA CTD PMID:19376846 copper atom multiple interactions EXP 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of DAG1 mRNA CTD PMID:15467011 copper atom multiple interactions ISO RGD:1344302 6480464 [Disulfiram binds to Copper] which results in increased expression of DAG1 mRNA CTD PMID:24690739 copper(0) multiple interactions EXP 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of DAG1 mRNA CTD PMID:15467011 copper(0) multiple interactions ISO RGD:1344302 6480464 [Disulfiram binds to Copper] which results in increased expression of DAG1 mRNA CTD PMID:24690739 copper(2+) multiple interactions EXP 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of DAG1 mRNA CTD PMID:15467011 copper(2+) multiple interactions ISO RGD:1344302 6480464 [Disulfiram binds to Copper] which results in increased expression of DAG1 mRNA CTD PMID:24690739 cycloheximide multiple interactions ISO RGD:1344302 6480464 Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of DAG1 mRNA] CTD PMID:11007951 cyclosporin A decreases expression ISO RGD:1344302 6480464 Cyclosporine results in decreased expression of DAG1 mRNA CTD PMID:20106945 , PMID:25562108 dicrotophos increases expression ISO RGD:1344302 6480464 dicrotophos results in increased expression of DAG1 mRNA CTD PMID:28302478 dioxygen multiple interactions EXP 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of DAG1 mRNA CTD PMID:30529165 disulfiram multiple interactions ISO RGD:1344302 6480464 [Disulfiram binds to Copper] which results in increased expression of DAG1 mRNA CTD PMID:24690739 dorsomorphin multiple interactions ISO RGD:1344302 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin affects response to substance ISO RGD:1344302 6480464 DAG1 protein affects the susceptibility to Doxorubicin CTD PMID:16217747 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of DAG1 mRNA CTD PMID:19277126 endosulfan affects expression ISO RGD:621890 6480464 Endosulfan affects the expression of DAG1 mRNA CTD PMID:29391264 ethanol multiple interactions ISO RGD:1344302 6480464 [[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of DAG1 mRNA CTD PMID:29432896 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of DAG1 mRNA CTD PMID:30319688 ethanol increases expression EXP 6480464 Ethanol results in increased expression of DAG1 mRNA CTD PMID:30319688 finasteride increases expression ISO RGD:621890 6480464 Finasteride results in increased expression of DAG1 mRNA CTD PMID:24136188 flutamide decreases expression ISO RGD:621890 6480464 Flutamide results in decreased expression of DAG1 mRNA CTD PMID:24793618 isoprenaline decreases expression ISO RGD:621890 6480464 Isoproterenol results in decreased expression of DAG1 CTD PMID:18808529 LY294002 multiple interactions ISO RGD:1344302 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of DAG1 mRNA] CTD PMID:12710931 methapyrilene decreases methylation ISO RGD:1344302 6480464 Methapyrilene results in decreased methylation of DAG1 exon CTD PMID:30157460 methapyrilene increases methylation ISO RGD:1344302 6480464 Methapyrilene results in increased methylation of DAG1 promoter CTD PMID:30157460 methapyrilene decreases expression ISO RGD:621890 6480464 Methapyrilene results in decreased expression of DAG1 mRNA CTD PMID:30467583 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:1344302 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of DAG1 mRNA] CTD PMID:12710931 nefazodone decreases expression ISO RGD:621890 6480464 nefazodone results in decreased expression of DAG1 mRNA CTD PMID:24136188 nimesulide decreases expression ISO RGD:621890 6480464 nimesulide results in decreased expression of DAG1 mRNA CTD PMID:24136188 oxaliplatin increases expression ISO RGD:1344302 6480464 oxaliplatin results in increased expression of DAG1 mRNA CTD PMID:17762391 ozone decreases expression ISO RGD:621890 6480464 Ozone results in decreased expression of DAG1 mRNA CTD PMID:16716893 paracetamol increases expression ISO RGD:1344302 6480464 Acetaminophen results in increased expression of DAG1 mRNA CTD PMID:22230336 perfluorooctanoic acid decreases expression ISO RGD:1344302 6480464 perfluorooctanoic acid results in decreased expression of DAG1 protein CTD PMID:26879310 PhIP increases expression ISO RGD:621890 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of DAG1 mRNA CTD PMID:15215175 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of DAG1 mRNA CTD PMID:18301758 pirinixic acid increases expression ISO RGD:621890 6480464 pirinixic acid results in increased expression of DAG1 mRNA CTD PMID:22484513 potassium dichromate increases expression ISO RGD:1344302 6480464 Potassium Dichromate results in increased expression of DAG1 protein CTD PMID:23718831 raloxifene increases expression ISO RGD:1344302 6480464 Raloxifene Hydrochloride results in increased expression of DAG1 mRNA CTD PMID:16497877 reactive oxygen species multiple interactions ISO RGD:621890 6480464 Reactive Oxygen Species inhibits the reaction [DAG1 protein modified form binds to AGRN protein] CTD PMID:16672922 reactive oxygen species decreases glycosylation ISO RGD:621890 6480464 Reactive Oxygen Species results in decreased glycosylation of DAG1 protein CTD PMID:16672922 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of DAG1 mRNA CTD PMID:22610192 resveratrol decreases expression ISO RGD:1344302 6480464 resveratrol results in decreased expression of DAG1 protein CTD PMID:18089832 sarin decreases expression ISO RGD:1344302 6480464 Sarin results in decreased expression of DAG1 mRNA CTD PMID:19522546 SB 431542 multiple interactions ISO RGD:1344302 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:1344302 6480464 Silicon Dioxide results in decreased expression of DAG1 mRNA CTD PMID:25351596 silver atom decreases expression ISO RGD:1344302 6480464 Silver results in decreased expression of DAG1 mRNA CTD PMID:26551752 silver atom decreases expression EXP 6480464 Silver results in decreased expression of DAG1 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1344302 6480464 Silver results in decreased expression of DAG1 mRNA CTD PMID:26551752 silver(0) decreases expression EXP 6480464 Silver results in decreased expression of DAG1 mRNA CTD PMID:27131904 silver(1+) decreases expression EXP 6480464 Silver results in decreased expression of DAG1 mRNA CTD PMID:27131904 silver(1+) decreases expression ISO RGD:1344302 6480464 Silver results in decreased expression of DAG1 mRNA CTD PMID:26551752 Soman increases expression ISO RGD:621890 6480464 Soman results in increased expression of DAG1 mRNA CTD PMID:19281266 Soman decreases expression ISO RGD:621890 6480464 Soman results in decreased expression of DAG1 mRNA CTD PMID:19281266 tamoxifen increases expression ISO RGD:1344302 6480464 Tamoxifen results in increased expression of DAG1 mRNA CTD PMID:15604281 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of DAG1 mRNA CTD PMID:17484886 trichostatin A increases expression ISO RGD:1344302 6480464 trichostatin A results in increased expression of DAG1 mRNA CTD PMID:26272509 trichostatin A multiple interactions ISO RGD:1344302 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DAG1 mRNA CTD PMID:27188386 tungsten decreases expression EXP 6480464 Tungsten results in decreased expression of DAG1 mRNA CTD PMID:30912803 tungsten(4+) decreases expression EXP 6480464 Tungsten results in decreased expression of DAG1 mRNA CTD PMID:30912803 valproic acid decreases expression ISO RGD:1344302 6480464 Valproic Acid results in decreased expression of DAG1 mRNA CTD PMID:29154799 valproic acid multiple interactions ISO RGD:1344302 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DAG1 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1344302 6480464 Valproic Acid results in increased expression of DAG1 mRNA CTD PMID:23179753 , PMID:26272509 valproic acid affects expression ISO RGD:1344302 6480464 Valproic Acid affects the expression of DAG1 mRNA CTD PMID:25979313 vinclozolin decreases expression ISO RGD:621890 6480464 vinclozolin results in decreased expression of DAG1 mRNA CTD PMID:18042343 vinclozolin affects expression ISO RGD:621890 6480464 vinclozolin affects the expression of DAG1 mRNA CTD PMID:19015723
Biological Process basement membrane organization IMP MGI:MGI:1934902 2290270 (MGI:MGI:5470500, PMID:23217742) MGI MGI:MGI:5470500 , PMID:23217742 branching involved in salivary gland morphogenesis IMP 2290270 (MGI:MGI:2156962, PMID:11798066) MGI MGI:MGI:2156962 , PMID:11798066 calcium-dependent cell-matrix adhesion ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cellular response to mechanical stimulus ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 commissural neuron axon guidance IMP MGI:MGI:1934902 2290270 (MGI:MGI:5470500, PMID:23217742) MGI MGI:MGI:5470500 , PMID:23217742 cytoskeletal anchoring at plasma membrane ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 epithelial tube branching involved in lung morphogenesis IMP 2290270 (MGI:MGI:2156962, PMID:11798066) MGI MGI:MGI:2156962 , PMID:11798066 membrane protein ectodomain proteolysis ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 microtubule anchoring ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 modulation by virus of host morphology or physiology ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 morphogenesis of an epithelial sheet IMP 2290270 (MGI:MGI:2156962, PMID:11798066) MGI MGI:MGI:2156962 , PMID:11798066 myelination in peripheral nervous system IMP 2290270 (MGI:MGI:2663553, PMID:12797959) UniProtKB MGI:MGI:2663553 , PMID:12797959 negative regulation of cell migration ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of MAPK cascade ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of protein kinase B signaling ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nerve maturation IMP 2290270 (MGI:MGI:2663553, PMID:12797959) UniProtKB MGI:MGI:2663553 , PMID:12797959 positive regulation of basement membrane assembly involved in embryonic body morphogenesis ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of cell-matrix adhesion ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of myelination ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of oligodendrocyte differentiation ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of protein kinase activity ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 regulation of epithelial to mesenchymal transition ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of gastrulation ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP 2290270 (MGI:MGI:5804030, PMID:27707967) MGI MGI:MGI:5804030 , PMID:27707967 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA 2290270 (MGI:MGI:5804030, PMID:27707967) MGI MGI:MGI:5804030 , PMID:27707967 regulation of synapse organization IMP 2290270 (MGI:MGI:5804030, PMID:27707967) MGI MGI:MGI:5804030 , PMID:27707967 regulation of synapse organization IDA 2290270 (MGI:MGI:5804030, PMID:27707967) MGI MGI:MGI:5804030 , PMID:27707967 retrograde trans-synaptic signaling by trans-synaptic protein complex IDA 2290270 (MGI:MGI:5804030, PMID:27707967) MGI MGI:MGI:5804030 , PMID:27707967 retrograde trans-synaptic signaling by trans-synaptic protein complex IMP 2290270 (MGI:MGI:5804030, PMID:27707967) SynGO MGI:MGI:5804030 , PMID:27707967 Schwann cell development IMP 2290270 (MGI:MGI:2663553, PMID:12797959) UniProtKB MGI:MGI:2663553 , PMID:12797959 viral process IEA UniProtKB-KW:KW-0945 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Cellular Component basement membrane ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 basement membrane IDA 2290270 (MGI:MGI:1202096 more ... MGI MGI:MGI:1202096 more ... basolateral plasma membrane ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cell junction IEA UniProtKB-KW:KW-0965 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cell-cell adherens junction ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cell-cell junction IDA 2290270 (MGI:MGI:5544872, PMID:23793062) MGI MGI:MGI:5544872 , PMID:23793062 contractile ring ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 costamere ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cytoplasm ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cytoplasm ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cytoskeleton IEA UniProtKB-KW:KW-0206 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 dystroglycan complex IDA 2290270 (MGI:MGI:2156962, PMID:11798066) MGI MGI:MGI:2156962 , PMID:11798066 dystroglycan complex IMP 2290270 (MGI:MGI:5882904, PMID:14622018) CAFA MGI:MGI:5882904 , PMID:14622018 dystrophin-associated glycoprotein complex ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 dystrophin-associated glycoprotein complex ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 external side of plasma membrane IDA 2290270 (MGI:MGI:2663553, PMID:12797959) UniProtKB MGI:MGI:2663553 , PMID:12797959 extracellular region IEA UniProtKB-KW:KW-0964 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 extracellular space ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 extracellular space HDA 2290270 (MGI:MGI:5640941, PMID:24006456) BHF-UCL MGI:MGI:5640941 , PMID:24006456 extracellular space ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 filopodium ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 focal adhesion colocalizes_with ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 focal adhesion ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 GABA-ergic synapse IDA 2290270 (MGI:MGI:5804030, PMID:27707967) MGI MGI:MGI:5804030 , PMID:27707967 GABA-ergic synapse IMP 2290270 (MGI:MGI:5804030, PMID:27707967) SynGO MGI:MGI:5804030 , PMID:27707967 glutamatergic synapse ISO RGD:621890 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 integral component of membrane ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 lamellipodium ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 membrane IDA 2290270 (MGI:MGI:5470500, PMID:23217742) MGI MGI:MGI:5470500 , PMID:23217742 membrane raft IDA 2290270 (MGI:MGI:2135840, PMID:11259414) MGI MGI:MGI:2135840 , PMID:11259414 node of Ranvier IMP 2290270 (MGI:MGI:2663553, PMID:12797959) UniProtKB MGI:MGI:2663553 , PMID:12797959 nuclear periphery ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleoplasm ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane IDA 2290270 (MGI:MGI:1343715 more ... MGI MGI:MGI:1343715 more ... plasma membrane ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 plasma membrane raft ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 postsynaptic cytosol ISO RGD:621890 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 postsynaptic membrane IEA UniProtKB-KW:KW-0628 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 sarcolemma ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 sarcolemma IDA 2290270 (MGI:MGI:1202096 more ... MGI MGI:MGI:1202096 more ... synapse ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Molecular Function actin binding ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 alpha-actinin binding ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 calcium ion binding IEA InterPro:IPR015919 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 dystroglycan binding IPI UniProtKB:Q62165 2290270 (MGI:MGI:5882904, PMID:14622018) CAFA MGI:MGI:5882904 , PMID:14622018 laminin binding ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 laminin-1 binding ISO RGD:621890 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein binding IPI UniProtKB:P19137 2290270 (MGI:MGI:2156962, PMID:11798066) MGI MGI:MGI:2156962 , PMID:11798066 protein binding IPI UniProtKB:Q9R1B9 2290270 (MGI:MGI:5470500, PMID:23217742) MGI MGI:MGI:5470500 , PMID:23217742 protein binding IPI UniProtKB:P11532 2290270 (MGI:MGI:3511446, PMID:10355629) MGI MGI:MGI:3511446 , PMID:10355629 protein binding IPI UniProtKB:Q62165 2290270 (MGI:MGI:1927714, PMID:10988290) MGI MGI:MGI:1927714 , PMID:10988290 protein binding IPI UniProtKB:Q61095 2290270 (MGI:MGI:2181307, PMID:11430802) MGI MGI:MGI:2181307 , PMID:11430802 SH2 domain binding ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 structural constituent of muscle ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 tubulin binding ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 vinculin binding ISO UniProtKB:Q14118 2290270 MGI GO_REF:0000096, MGI:MGI:4834177
Gene-Chemical Interaction Annotations
