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GENE - TERM ANNOTATION REPORT

RGD ID: 621890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dag1
Name: dystroglycan 1
Acc ID: GO:0016011
Term: dystroglycan complex
Definition: A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.
Definition Source(s): PMID:15117830, PMID:16710609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IEAUniProtKB:Q62165, ensembl:ENSMUSP000001421091600115EnsemblGO_REF:0000107

GO_REF:0000107
 ISORGD:15520061624291RGD (MGI:MGI:2156962, PMID:11798066), (MGI:MGI:5882904, PMID:14622018)

MGI:MGI:2156962, MGI:MGI:5882904, PMID:11798066, PMID:14622018
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.