RGD Reference Report - Association of dystroglycan and laminin-2 coexpression with myelinogenesis in peripheral nerves. - Rat Genome Database

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Association of dystroglycan and laminin-2 coexpression with myelinogenesis in peripheral nerves.

Authors: Masaki, T  Matsumura, K  Saito, F  Yamada, H  Higuchi, S  Kamakura, K  Yorifuji, H  Shimizu, T 
Citation: Masaki T, etal., Med Electron Microsc. 2003 Dec;36(4):221-39.
RGD ID: 11537480
Pubmed: PMID:16228655   (View Abstract at PubMed)
DOI: DOI:10.1007/s00795-003-0231-2   (Journal Full-text)

To provide clues to the biological functions of dystroglycan-laminin-2 complex in peripheral nerves, we investigated the expressions of beta-dystroglycan and laminin-alpha(2) chain in rat sciatic nerve during axonal degeneration and regeneration and during development, as well as in rat dorsal root ganglia. In normal conditions, immunoreactivity of the cytoplasmic domain of beta-dystroglycan was associated with the Schwann cell abaxonal membrane. The immunoreactivities of both beta-dystroglycan and the laminin-alpha(2) chain decreased in Schwann cells losing axons during axonal degeneration and progressively increased in remyelinating Schwann cells during axonal regeneration. Interestingly, during axonal degeneration, the abaxonal membrane losing contact with the basal lamina lost the association with beta-dystroglycan immunoreactivity. During development, expression of both beta-dystroglycan and laminin-alpha(2) chain strikingly increased during postnatal 7 days, which is a critical period when basal lamina assembly and myelin formation rapidly progress. These results suggest that coexpression of dystroglycan and laminin-2 is associated with myelinogenesis in peripheral nerves. These two proteins may function as an anchorage between the abaxonal membrane and the basal lamina, enabling myelin forma-tion to progress. Beta-dystroglycan and laminin-2 were also coexpressed in satellite cells in dorsal root ganglia, suggesting that interaction of these two proteins plays some role in physiological functions of these cells.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Nerve Degeneration  ISODag1 (Rattus norvegicus)11537480; 11537480 RGD 
Nerve Degeneration  IEP 11537480 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axon regeneration  IEP 11537480 RGD 
nerve development  IEP 11537480 RGD 
Schwann cell differentiation  IEP 11537480 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dag1  (dystroglycan 1)

Genes (Mus musculus)
Dag1  (dystroglycan 1)

Genes (Homo sapiens)
DAG1  (dystroglycan 1)


Additional Information