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Gene: Gnai2 (G protein subunit alpha i2) Rattus norvegicus
Symbol: Gnai2
Name: G protein subunit alpha i2
Description: Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of cell population proliferation; and regulation of signal transduction. Localizes to several cellular components, including cytosol; membrane raft; and nucleus. Used to study hypertension. Biomarker of hypertension. Orthologous to human GNAI2 (G protein subunit alpha i2); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; angiotensin II signaling pathway via AT2 receptor; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH (+)-alpha-tocopherol; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adenylate cyclase-inhibiting G alpha protein; G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); Galphai2; GTP-binding protein (G-alpha-i2); guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein, alpha inhibiting 2; guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-2 subunit
Homo sapiens (human) : GNAI2 (G protein subunit alpha i2)  HGNC  Alliance
Mus musculus (house mouse) : Gnai2 (guanine nucleotide binding protein (G protein), alpha inhibiting 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gnai2 (G protein subunit alpha i2)
Pan paniscus (bonobo/pygmy chimpanzee) : GNAI2 (G protein subunit alpha i2)
Canis lupus familiaris (dog) : GNAI2 (G protein subunit alpha i2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnai2 (G protein subunit alpha i2)
Sus scrofa (pig) : GNAI2 (G protein subunit alpha i2)
Chlorocebus sabaeus (African green monkey) : GNAI2 (G protein subunit alpha i2)
Heterocephalus glaber (naked mole-rat) : Gnai2 (G protein subunit alpha i2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.08116,370,730 - 116,391,337 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,370,744 - 116,391,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,726,562 - 115,746,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,861,952 - 112,882,647 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18112,881,416 - 112,902,054 (-)NCBI
Celera8107,594,933 - 107,615,332 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gnai2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620243
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.