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Gene: GNAO1 (G protein subunit alpha o1) Homo sapiens
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Symbol: GNAO1
Name: G protein subunit alpha o1
Description: Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and dopamine receptor signaling pathway. Predicted to localize to the heterotrimeric G-protein complex. Implicated in early infantile epileptic encephalopathy 17.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686O0962; EIEE17; G-ALPHA-o; GNAO; GO2-q chimeric G-protein; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha activating polypeptide O; guanine nucleotide-binding protein G(o) subunit alpha; guanine nucleotide-binding regulatory protein 2; HLA-DQB1; NEDIM
Orthologs:
Mus musculus (house mouse) : Gnao1 (guanine nucleotide binding protein, alpha O)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gnao1 (G protein subunit alpha o1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gnao1 (G protein subunit alpha o1)
Pan paniscus (bonobo/pygmy chimpanzee) : GNAO1 (G protein subunit alpha o1)
Canis lupus familiaris (dog) : GNAO1 (G protein subunit alpha o1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnao1 (G protein subunit alpha o1)
Sus scrofa (pig) : GNAO1 (G protein subunit alpha o1)
Chlorocebus sabaeus (green monkey) : GNAO1 (G protein subunit alpha o1)
Heterocephalus glaber (naked mole-rat) : Gnao1 (G protein subunit alpha o1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1656,191,489 - 56,357,444 (+)Ensembl
GRCh381656,191,489 - 56,357,444 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371656,225,251 - 56,391,356 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,783,649 - 54,948,651 (+)NCBINCBI36hg18NCBI36
Build 341654,783,648 - 54,935,363NCBI
Celera1640,722,067 - 40,888,176 (+)NCBI
Cytogenetic Map16q13NCBI
HuRef1642,096,140 - 42,261,995 (+)NCBIHuRef
CHM1_11657,632,612 - 57,798,711 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GNAO1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731076
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.