Gnaq (G protein subunit alpha q) - Rat Genome Database

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Gene: Gnaq (G protein subunit alpha q) Rattus norvegicus
Analyze
Symbol: Gnaq
Name: G protein subunit alpha q
RGD ID: 620770
Description: Enables alkylglycerophosphoethanolamine phosphodiesterase activity. Involved in several processes, including activation of phospholipase C activity; negative regulation of potassium ion transport; and positive regulation of smooth muscle cell proliferation. Located in caveola; cytosol; and synapse. Part of heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; congestive heart failure; and familial multiple nevi flammei. Orthologous to human GNAQ (G protein subunit alpha q); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Galphaq; guanine nucleotide binding protein (G protein), q polypeptide; guanine nucleotide binding protein alpha q subunit; guanine nucleotide binding protein, alpha q polypeptide; guanine nucleotide regulatory protein G alpha q; guanine nucleotide-binding protein alpha-q; guanine nucleotide-binding protein G(q) subunit alpha; heterotrimeric guanine nucleotide-binding protein alpha q subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21213,425,631 - 213,671,947 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1213,424,465 - 213,667,672 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1221,757,414 - 222,003,643 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01228,689,512 - 228,935,809 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01221,511,974 - 221,758,205 (+)NCBIRnor_WKY
Rnor_6.01233,382,778 - 233,622,584 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1233,382,708 - 233,622,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01240,497,178 - 240,736,860 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,520,998 - 219,764,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11219,685,020 - 219,928,420 (+)NCBI
Celera1210,763,138 - 211,002,668 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
2-nitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
apocynin  (EXP)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bromochloroacetic acid  (EXP)
caffeine  (EXP)
carbamazepine  (ISO)
cerium trichloride  (ISO)
chlorpyrifos  (ISO)
cicaprost  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
D-glucose  (EXP)
diazinon  (EXP)
diclofenac  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fingolimod hydrochloride  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fulvestrant  (EXP)
gadolinium atom  (ISO)
glucose  (EXP)
hexane  (EXP)
hydrogen cyanide  (ISO)
hydrogen sulfide  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel dichloride  (EXP)
omipalisib  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
potassium chromate  (ISO)
sodium fluoride  (ISO)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP)
strontium atom  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
theophylline  (EXP)
trametinib  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
UTP  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IBA,IEA,ISO)
activation of phospholipase C activity  (IMP)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IEA,ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IBA)
cranial skeletal system development  (IEA,ISO)
developmental pigmentation  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
endothelin receptor signaling pathway  (IEA,ISO)
forebrain neuron development  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
glutamate receptor signaling pathway  (IBA,IEA,ISO)
heart development  (IEA,ISO)
ion channel modulating, G protein-coupled receptor signaling pathway  (IEA,ISO)
ligand-gated ion channel signaling pathway  (IEA,ISO)
maternal behavior  (IEA,ISO)
multicellular organism aging  (IEA,ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of potassium ion transport  (IMP)
negative regulation of protein kinase activity  (ISO)
neuron remodeling  (IEA,ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IEA,ISO)
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IMP,ISO)
positive regulation of insulin secretion  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
post-embryonic development  (IEA,ISO)
protein stabilization  (ISO)
regulation of blood pressure  (IEA,ISO)
regulation of canonical Wnt signaling pathway  (ISO)
regulation of melanocyte differentiation  (IEA,ISO)
regulation of platelet activation  (IEA,ISO,ISS)
skeletal system development  (IEA,ISO)

Cellular Component
caveola  (IDA)
cell body  (IEA,ISO)
cytosol  (IDA)
dendrite  (IEA,ISO)
Golgi apparatus  (IEA)
heterotrimeric G-protein complex  (IBA,IDA)
membrane  (ISO)
nuclear membrane  (IEA)
plasma membrane  (IDA,IEA,ISO)
synapse  (IDA,IEA)

References

References - curated
# Reference Title Reference Citation
1. The heterotrimeric G protein subunits Galpha(q) and Gbeta(1) have lysophospholipase D activity. Aoyama C, etal., Biochem J. 2011 Dec 1;440(2):241-50. doi: 10.1042/BJ20110545.
2. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology. Bangasser DA, etal., Mol Psychiatry. 2010 Sep;15(9):877, 896-904. Epub 2010 Jun 15.
3. A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal. Carrasco GA, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):1012-9. Epub 2003 Oct 8.
4. Short-term cocaine treatment causes neuroadaptive changes in Galphaq and Galpha11 proteins in rats undergoing withdrawal. Carrasco GA, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):349-55. Epub 2004 Jun 2.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Molecular properties of muscarinic acetylcholine receptors. Haga T Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(6):226-56.
8. The alpha subunit of Gq contributes to muscarinic inhibition of the M-type potassium current in sympathetic neurons. Haley JE, etal., J Neurosci. 1998 Jun 15;18(12):4521-31.
9. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
10. Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. Howes AL, etal., J Biol Chem 2003 Oct 10;278(41):40343-51. Epub 2003 Aug 4.
11. Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy. Howes AL, etal., J Mol Cell Cardiol. 2006 May;40(5):597-604. Epub 2006 Feb 8.
12. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
13. A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. Liggett SB, etal., Hum Mol Genet. 2007 Nov 15;16(22):2740-50. doi: 10.1093/hmg/ddm229. Epub 2007 Aug 24.
14. An immunocapture/scintillation proximity analysis of G alpha q/11 activation by native serotonin (5-HT)2A receptors in rat cortex: blockade by clozapine and mirtazapine. Mannoury La Cour C, etal., Synapse. 2009 Feb;63(2):95-105.
15. Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Mende U, etal., Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13893-8.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Alpha1-adrenergic receptor signaling is localized to caveolae in neonatal rat cardiomyocytes. Morris JB, etal., J Mol Cell Cardiol. 2006 Jul;41(1):17-25. Epub 2006 May 30.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Discovery of new membrane-associated proteins overexpressed in small-cell lung cancer. Ocak S, etal., J Thorac Oncol. 2014 Mar;9(3):324-36. doi: 10.1097/JTO.0000000000000090.
20. Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. Offermanns S, etal., EMBO J 1998 Aug 3;17(15):4304-12.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. Norepinephrine exocytosis stimulated by alpha-latrotoxin requires both external and stored Ca2+ and is mediated by latrophilin, G proteins and phospholipase C. Rahman MA, etal., Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):379-86.
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
29. Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling. Saitoh O, etal., Proc Natl Acad Sci U S A 2002 Jul 23;99(15):10138-43.
30. Gq/11-induced intracellular calcium mobilization mediates Per2 acute induction in Rat-1 fibroblasts. Takashima N, etal., Genes Cells. 2006 Sep;11(9):1039-49.
31. Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. Tall GG, etal., J Biol Chem 2003 Mar 7;278(10):8356-62.
32. Role of Galphaq in smooth muscle cell proliferation. Tanski WJ, etal., J Vasc Surg. 2004 Mar;39(3):639-44.
33. Temporal dispersion of activation of phospholipase C-beta1 and -gamma isoforms by angiotensin II in vascular smooth muscle cells. Role of alphaq/11, alpha12, and beta gamma G protein subunits. Ushio-Fukai M, etal., J Biol Chem. 1998 Jul 31;273(31):19772-7.
34. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu Y, etal., J Pharmacol Sci. 2003 Jul;92(3):259-66.
Additional References at PubMed
PMID:1299289   PMID:1333286   PMID:9016340   PMID:9391157   PMID:10481072   PMID:10818132   PMID:11438569   PMID:11567049   PMID:11685543   PMID:12077299   PMID:15322542   PMID:15340067  
PMID:15574748   PMID:15611106   PMID:15716410   PMID:16380388   PMID:17166350   PMID:17194762   PMID:17296805   PMID:17897319   PMID:18208547   PMID:18378685   PMID:18401763   PMID:18480127  
PMID:18518877   PMID:18525017   PMID:18665079   PMID:18712054   PMID:18820027   PMID:18952607   PMID:18987636   PMID:19056867   PMID:19095737   PMID:19199708   PMID:19879871   PMID:20036247  
PMID:20393598   PMID:20399743   PMID:20691780   PMID:21124736   PMID:21463572   PMID:21464134   PMID:21700703   PMID:22672634   PMID:22871113   PMID:23161540   PMID:23376485   PMID:23472081  
PMID:23533145   PMID:23696743   PMID:24687992   PMID:24760983   PMID:25595485   PMID:25822412   PMID:26747500   PMID:27379421   PMID:29476059   PMID:31011763   PMID:31825720   PMID:32247043  
PMID:32253686  


Genomics

Comparative Map Data
Gnaq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21213,425,631 - 213,671,947 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1213,424,465 - 213,667,672 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1221,757,414 - 222,003,643 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01228,689,512 - 228,935,809 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01221,511,974 - 221,758,205 (+)NCBIRnor_WKY
Rnor_6.01233,382,778 - 233,622,584 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1233,382,708 - 233,622,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01240,497,178 - 240,736,860 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,520,998 - 219,764,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11219,685,020 - 219,928,420 (+)NCBI
Celera1210,763,138 - 211,002,668 (+)NCBICelera
Cytogenetic Map1q43NCBI
GNAQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38977,716,097 - 78,031,811 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl977,716,097 - 78,031,811 (-)EnsemblGRCh38hg38GRCh38
GRCh37980,331,013 - 80,646,727 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36979,525,009 - 79,836,012 (-)NCBINCBI36Build 36hg18NCBI36
Build 34977,564,746 - 77,875,746NCBI
Celera950,912,294 - 51,223,287 (-)NCBICelera
Cytogenetic Map9q21.2NCBI
HuRef950,167,421 - 50,477,535 (-)NCBIHuRef
CHM1_1980,482,435 - 80,793,672 (-)NCBICHM1_1
T2T-CHM13v2.0989,873,050 - 90,188,930 (-)NCBIT2T-CHM13v2.0
Gnaq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391916,110,048 - 16,365,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1916,110,195 - 16,364,827 (+)EnsemblGRCm39 Ensembl
GRCm381916,132,684 - 16,388,520 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1916,132,831 - 16,387,463 (+)EnsemblGRCm38mm10GRCm38
MGSCv371916,207,321 - 16,461,943 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361916,199,850 - 16,454,472 (+)NCBIMGSCv36mm8
MGSCv361915,738,354 - 16,003,046 (+)NCBIMGSCv36mm8
Celera1916,873,630 - 17,041,492 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map1911.01NCBI
Gnaq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555121,381,159 - 1,658,409 (+)NCBIChiLan1.0ChiLan1.0
GNAQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1976,570,773 - 76,773,847 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl976,575,815 - 76,773,849 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0946,816,409 - 47,129,116 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GNAQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1180,733,530 - 80,928,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl180,715,366 - 80,928,065 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha181,197,285 - 81,391,732 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0181,038,541 - 81,345,574 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl181,038,966 - 81,343,028 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1180,931,602 - 81,126,112 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0180,652,980 - 80,847,487 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0181,383,410 - 81,578,003 (+)NCBIUU_Cfam_GSD_1.0
LOC101971998
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947127,896,936 - 128,074,513 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650313,099,558 - 13,276,152 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493650313,098,517 - 13,276,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1230,605,265 - 230,907,674 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11230,607,469 - 230,906,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21257,372,859 - 257,378,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNAQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11288,666,375 - 88,988,989 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1288,670,424 - 88,871,154 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603876,997,006 - 77,320,682 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnaq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248115,163,793 - 5,486,140 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248115,158,665 - 5,485,812 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gnaq
722 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:34
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000019174
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1206329708222745518Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1207702246228581766Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat

Markers in Region
D1Rat117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21213,533,809 - 213,533,942 (+)MAPPERmRatBN7.2
Rnor_6.01233,490,105 - 233,490,237NCBIRnor6.0
Rnor_5.01240,604,381 - 240,604,513UniSTSRnor5.0
RGSC_v3.41219,629,755 - 219,629,888RGDRGSC3.4
RGSC_v3.41219,629,756 - 219,629,888UniSTSRGSC3.4
RGSC_v3.11219,793,778 - 219,793,911RGD
RH 2.0 Map11163.3RGD
FHH x ACI Map1102.12RGD
Cytogenetic Map1q43UniSTS
BM387879  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21213,439,805 - 213,439,966 (+)MAPPERmRatBN7.2
Rnor_6.01233,396,852 - 233,397,012NCBIRnor6.0
Rnor_5.01240,511,128 - 240,511,288UniSTSRnor5.0
RGSC_v3.41219,535,797 - 219,535,957UniSTSRGSC3.4
Celera1210,777,096 - 210,777,256UniSTS
RH 3.4 Map9758.49UniSTS
Cytogenetic Map1q43UniSTS
UniSTS:496675  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21213,666,842 - 213,667,164 (+)MAPPERmRatBN7.2
Rnor_6.01233,622,565 - 233,622,886NCBIRnor6.0
Rnor_5.01240,736,841 - 240,737,162UniSTSRnor5.0
RGSC_v3.41219,764,378 - 219,764,699UniSTSRGSC3.4
Celera1211,002,649 - 211,002,970UniSTS
Cytogenetic Map1q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 32 16 19 16 7 7 74 35 34 11 7
Low 5 25 25 25 1 4 7 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019174   ⟹   ENSRNOP00000019174
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1213,425,249 - 213,667,672 (+)Ensembl
Rnor_6.0 Ensembl1233,382,708 - 233,622,786 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117969   ⟹   ENSRNOP00000093162
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1213,424,465 - 213,667,672 (+)Ensembl
RefSeq Acc Id: NM_031036   ⟹   NP_112298
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21213,425,631 - 213,671,947 (+)NCBI
Rnor_6.01233,382,778 - 233,622,584 (+)NCBI
Rnor_5.01240,497,178 - 240,736,860 (+)NCBI
RGSC_v3.41219,520,998 - 219,764,401 (+)RGD
Celera1210,763,138 - 211,002,668 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112298   ⟸   NM_031036
- UniProtKB: A0A8I6AJ23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019174   ⟸   ENSRNOT00000019174
RefSeq Acc Id: ENSRNOP00000093162   ⟸   ENSRNOT00000117969
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P82471-F1-model_v2 AlphaFold P82471 1-359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620770 AgrOrtholog
BioCyc Gene G2FUF-56221 BioCyc
Ensembl Genes ENSRNOG00000014183 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019174.5 UniProtKB/TrEMBL
  ENSRNOP00000093162 ENTREZGENE
  ENSRNOP00000093162.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019174.6 UniProtKB/TrEMBL
  ENSRNOT00000117969 ENTREZGENE
  ENSRNOT00000117969.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Gprotein_alpha_Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81666 UniProtKB/Swiss-Prot
NCBI Gene 81666 ENTREZGENE
PANTHER PTHR10218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gnaq PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPROTEINAQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART G_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AJ23 ENTREZGENE, UniProtKB/TrEMBL
  D4AE68_RAT UniProtKB/TrEMBL
  GNAQ_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q45QM4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Gnaq  G protein subunit alpha q  Gnaq  guanine nucleotide binding protein (G protein), q polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-29 Gnaq  guanine nucleotide binding protein (G protein), q polypeptide  Gnaq  guanine nucleotide binding protein, alpha q polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gnaq  guanine nucleotide binding protein, alpha q polypeptide    heterotrimeric guanine nucleotide-binding protein alpha q subunit  Name updated 1299863 APPROVED
2002-08-07 Gnaq  heterotrimeric guanine nucleotide-binding protein alpha q subunit      Symbol and Name status set to provisional 70820 PROVISIONAL