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Gene: Gnai2 (guanine nucleotide binding protein (G protein), alpha inhibiting 2) Mus musculus
Symbol: Gnai2
Name: guanine nucleotide binding protein (G protein), alpha inhibiting 2
RGD ID: 730994
Description: Predicted to have several functions, including G-protein beta/gamma-subunit complex binding activity; GTP binding activity; and GTPase activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and cell population proliferation. Localizes to cell body and dendrite. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study inflammatory bowel disease 12. Orthologous to human GNAI2 (G protein subunit alpha i2); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; angiotensin II signaling pathway via AT2 receptor; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adenylate cyclase-inhibiting G alpha protein; C76432; G; Gal; Galphai2; Gia; Gna; Gnai-2; guanine nucleotide binding protein, alpha inhibiting 2; guanine nucleotide-binding protein G(i) subunit alpha-2
Homo sapiens (human) : GNAI2 (G protein subunit alpha i2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gnai2 (G protein subunit alpha i2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gnai2 (G protein subunit alpha i2)
Pan paniscus (bonobo/pygmy chimpanzee) : GNAI2 (G protein subunit alpha i2)
Canis lupus familiaris (dog) : GNAI2 (G protein subunit alpha i2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnai2 (G protein subunit alpha i2)
Sus scrofa (pig) : GNAI2 (G protein subunit alpha i2)
Chlorocebus sabaeus (African green monkey) : GNAI2 (G protein subunit alpha i2)
Heterocephalus glaber (naked mole-rat) : Gnai2 (G protein subunit alpha i2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm399107,491,324 - 107,512,617 (-)NCBI
GRCm389107,614,125 - 107,635,391 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,614,125 - 107,635,367 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,516,469 - 107,537,673 (-)NCBIGRCm37mm9NCBIm37
MGSCv369107,472,714 - 107,493,430 (-)NCBImm8
Celera9107,222,922 - 107,240,939 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gnai2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730994
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.