Gnai2 (G protein subunit alpha i2) - Rat Genome Database

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Gene: Gnai2 (G protein subunit alpha i2) Chinchilla lanigera
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Symbol: Gnai2
Name: G protein subunit alpha i2
RGD ID: 9008339
Description: INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); cell division (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; angiotensin II signaling pathway via AT2 receptor; dopamine signaling pathway via D2 family of receptors; ASSOCIATED WITH Adrenal Cortex Neoplasms (ortholog); Aicardi-Goutieres Syndrome 1 (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cell body (ortholog); centrosome (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide-binding protein G(i) subunit alpha-2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,059,038 - 2,079,957 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,059,038 - 2,079,120 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
cell division  (ISO)
cell population proliferation  (ISO)
G protein-coupled acetylcholine receptor signaling pathway  (ISO)
G protein-coupled adenosine receptor signaling pathway  (ISO)
G protein-coupled glutamate receptor signaling pathway  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of calcium ion-dependent exocytosis  (ISO)
negative regulation of protein tyrosine phosphatase activity  (ISO)
negative regulation of synaptic transmission  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of NAD(P)H oxidase activity  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of urine volume  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of calcium ion transport  (ISO)
regulation of heart contraction  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gnai2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,059,038 - 2,079,957 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,059,038 - 2,079,120 (+)NCBIChiLan1.0ChiLan1.0
GNAI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,227,068 - 50,263,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,226,292 - 50,259,362 (+)EnsemblGRCh38hg38GRCh38
GRCh37350,264,500 - 50,296,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,248,651 - 50,271,790 (+)NCBINCBI36Build 36hg18NCBI36
Build 34350,248,650 - 50,271,790NCBI
Celera350,246,476 - 50,269,614 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,329,335 - 50,352,473 (+)NCBIHuRef
CHM1_1350,225,922 - 50,249,058 (+)NCBICHM1_1
T2T-CHM13v2.0350,256,406 - 50,288,697 (+)NCBIT2T-CHM13v2.0
Gnai2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,491,324 - 107,512,542 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,491,324 - 107,512,566 (-)EnsemblGRCm39 Ensembl
GRCm389107,614,125 - 107,635,391 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,614,125 - 107,635,367 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,516,469 - 107,537,673 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,472,714 - 107,493,430 (-)NCBIMGSCv36mm8
Celera9107,222,922 - 107,240,939 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.43NCBI
Gnai2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,167,045 - 117,187,652 (-)NCBIGRCr8
mRatBN7.28108,288,401 - 108,309,009 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,288,401 - 108,308,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,915,238 - 113,935,641 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,114,396 - 112,134,799 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,957,178 - 109,977,581 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,370,730 - 116,391,337 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,370,744 - 116,391,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,726,562 - 115,746,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,861,952 - 112,882,647 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,881,416 - 112,902,054 (-)NCBI
Celera8107,594,933 - 107,615,332 (-)NCBICelera
Cytogenetic Map8q32NCBI
GNAI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,209,618 - 50,242,401 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,224,024 - 50,247,178 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,154,731 - 50,187,948 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,398,981 - 51,422,000 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,398,981 - 51,421,988 (+)Ensemblpanpan1.1panPan2
GNAI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,075,085 - 39,094,697 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,075,085 - 39,094,697 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,996,147 - 39,015,757 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,431,154 - 39,450,979 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,430,574 - 39,451,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,798,956 - 38,818,559 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,202,455 - 39,222,063 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,482,556 - 39,502,160 (-)NCBIUU_Cfam_GSD_1.0
Gnai2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,019,103 - 65,040,746 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,779,571 - 1,801,255 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,779,582 - 1,801,251 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,705,321 - 32,733,794 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,705,326 - 32,733,804 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,891,199 - 35,912,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNAI2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,623,394 - 11,646,464 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,623,408 - 11,647,191 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041155,339,947 - 155,363,875 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnai2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,103,905 - 4,126,737 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,096,061 - 4,126,538 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000021941   ⟹   ENSCLAP00000021738
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555322,059,038 - 2,079,957 (+)Ensembl
RefSeq Acc Id: XM_005410250   ⟹   XP_005410307
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555322,059,038 - 2,079,120 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005410307 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021738
  ENSCLAP00000021738.1
RefSeq Acc Id: XP_005410307   ⟸   XM_005410250
- UniProtKB: A0A8C2YTA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021738   ⟸   ENSCLAT00000021941


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014883 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021941 ENTREZGENE
  ENSCLAT00000021941.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.400.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro Gprotein_alpha_I UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Gnai2 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-2 UniProtKB/TrEMBL
  PTHR10218 UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/TrEMBL
PRINTS GPROTEINA UniProtKB/TrEMBL
  GPROTEINAI UniProtKB/TrEMBL
PROSITE G_ALPHA UniProtKB/TrEMBL
SMART G_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8C2YTA9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Gnai2  G protein subunit alpha i2    guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2  Symbol and/or name change 5135510 APPROVED