Enables G protein-coupled serotonin receptor binding activity; GTPase activating protein binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of NAD(P)H oxidase activity; positive regulation of superoxide anion generation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in plasma membrane and zymogen granule. Biomarker of hypertension. Orthologous to human GNAI3 (G protein subunit alpha i3); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; endothelin signaling pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
diphenyleneiodonium affects the reaction [Glucose results in decreased expression of GNAI3 protein] and diphenyleneiodonium inhibits the reaction [Streptozocin results in decreased expression of GNAI3 protein]
Acetylcysteine inhibits the reaction [Glucose results in decreased expression of GNAI3 protein] and Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GNAI3 protein]
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein] and Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein]
CAV3 mutant form inhibits the reaction [Progesterone results in decreased expression of GNAI3 protein] and Cholesterol inhibits the reaction [Progesterone results in decreased expression of GNAI3 protein]
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein] more ...
Sirolimus inhibits the reaction [Dronabinol promotes the reaction [4-iodo-2 and 5-dimethoxyphenylisopropylamine results in increased activity of GNAI3 protein]]
Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GNAI3 protein] and diphenyleneiodonium inhibits the reaction [Streptozocin results in decreased expression of GNAI3 protein]
Knockdown of Inhibitory Guanine Nucleotide Binding Protein Gia-2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats.
PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8.
GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain.
Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins.
G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes.
