Gnai3 (G protein subunit alpha i3) - Rat Genome Database

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Gene: Gnai3 (G protein subunit alpha i3) Rattus norvegicus
Analyze
Symbol: Gnai3
Name: G protein subunit alpha i3
RGD ID: 2714
Description: Enables G protein-coupled serotonin receptor binding activity; GTPase activating protein binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of NAD(P)H oxidase activity; positive regulation of superoxide anion generation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in membrane raft; plasma membrane; and zymogen granule. Biomarker of hypertension. Orthologous to human GNAI3 (G protein subunit alpha i3); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; endothelin signaling pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: g(i) alpha-3; GIP3A; guanine nucleotide binding protein (G protein), alpha inhibiting 3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide binding protein alpha inhibiting polypeptide 3; guanine nucleotide binding protein, alpha inhibiting 3; Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3; guanine nucleotide-binding protein G(i) subunit alpha; guanine nucleotide-binding protein G(i) subunit alpha-3; guanine nucleotide-binding protein G(k) subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22195,742,765 - 195,780,720 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,742,642 - 195,780,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,385,968 - 203,423,940 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02201,268,088 - 201,306,060 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02196,085,045 - 196,123,015 (-)NCBIRnor_WKY
Rnor_6.02210,896,779 - 210,934,733 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,896,656 - 210,934,749 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,366,027 - 230,403,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,668,275 - 203,706,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,631,028 - 203,668,983 (-)NCBI
Celera2188,388,024 - 188,425,978 (-)NCBICelera
RH 3.4 Map21390.8RGD
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-hydroxypropanoic acid  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8-Br-cAMP  (EXP)
aldehydo-D-glucose  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
calciol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
enniatin  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (EXP)
Guanabenz  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (EXP)
hypochlorous acid  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nitroprusside  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
peroxynitrous acid  (EXP)
phenobarbital  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (EXP)
rac-lactic acid  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 431542  (ISO)
sirolimus  (ISO)
Soman  (EXP)
streptozocin  (EXP)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Knockdown of Inhibitory Guanine Nucleotide Binding Protein Gia-2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats. Ali El-Basyuni Y, etal., J Am Heart Assoc. 2016 Oct 26;5(11). pii: JAHA.116.004594. doi: 10.1161/JAHA.116.004594.
2. Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Berg KA, etal., Neuroscience. 2007 Feb 9;144(3):889-97. Epub 2006 Dec 8.
3. PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8. Clement N, etal., J Cell Physiol. 2006 Sep;208(3):495-505.
4. GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. De Vries L, etal., Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11916-20.
5. GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. De Vries L, etal., Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15203-8.
6. GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Garcia-Marcos M, etal., Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3178-83. doi: 10.1073/pnas.0900294106. Epub 2009 Feb 11.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. GIV/Girdin activates Gαi and inhibits Gαs via the same motif. Gupta V, etal., Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5721-30. doi: 10.1073/pnas.1609502113. Epub 2016 Sep 12.
10. Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins. Hashim S and Anand-Srivastava MB, J Hypertens. 2004 Jan;22(1):181-90.
11. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
12. Opposing changes of trimeric G protein levels during ontogenetic development of rat brain. Ihnatovych I, etal., Brain Res Dev Brain Res. 2002 Jan 31;133(1):57-67.
13. Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. Itoh H, etal., J Biol Chem 1988 May 15;263(14):6656-64.
14. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. Jones DT and Reed RR, J Biol Chem 1987 Oct 15;262(29):14241-9.
15. RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. Kimple RJ, etal., J Biol Chem. 2001 Aug 3;276(31):29275-81. Epub 2001 May 31.
16. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
17. Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin. López-Sánchez I, etal., Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5510-5. doi: 10.1073/pnas.1303392110. Epub 2013 Mar 18.
18. Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain. Mannoury la Cour C, etal., Mol Pharmacol. 2006 Sep;70(3):1013-21. Epub 2006 Jun 13.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function. Padia SH and Carey RM, Pflugers Arch. 2013 Jan;465(1):99-110. doi: 10.1007/s00424-012-1146-3. Epub 2012 Sep 5.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. G(alpha)(i3) in pancreatic zymogen granules participates in vesicular fusion. Sattar AA, etal., J Biochem (Tokyo) 2002 Jun;131(6):815-20.
29. Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization. Shu FJ, etal., Cell Signal. 2007 Jan;19(1):163-76. Epub 2006 Jul 25.
30. Identification and characterization of a G-protein regulatory motif in WAVE1. Song KS, etal., FEBS Lett. 2006 Apr 3;580(8):1993-8. Epub 2006 Mar 6.
31. G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses. Straiker AJ, etal., J Neurosci 2002 Apr 1;22(7):2460-8.
32. Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction. Strakova Z and Soloff MS, Am J Physiol. 1997 May;272(5 Pt 1):E870-6.
33. Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. Tall GG, etal., J Biol Chem 2003 Mar 7;278(10):8356-62.
34. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
35. Lysophosphatidic acid rescues bone mesenchymal stem cells from hydrogen peroxide-induced apoptosis. Wang XY, etal., Apoptosis. 2015 Mar;20(3):273-84. doi: 10.1007/s10495-014-1074-0.
36. [Alterations of cardiac Gi protein alpha subunits during ischemia-reperfusion in rats]. Wang Y, etal., Sheng Li Xue Bao. 1998 Oct;50(5):514-8.
Additional References at PubMed
PMID:2159473   PMID:8192889   PMID:11121039   PMID:11158953   PMID:12642577   PMID:12719437   PMID:16009138   PMID:17635935   PMID:17897319   PMID:18441196   PMID:18952607   PMID:19056867  
PMID:19478087   PMID:19946888   PMID:20458337   PMID:22573829   PMID:24155894   PMID:27864364   PMID:28692698  


Genomics

Comparative Map Data
Gnai3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22195,742,765 - 195,780,720 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,742,642 - 195,780,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,385,968 - 203,423,940 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02201,268,088 - 201,306,060 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02196,085,045 - 196,123,015 (-)NCBIRnor_WKY
Rnor_6.02210,896,779 - 210,934,733 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,896,656 - 210,934,749 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,366,027 - 230,403,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,668,275 - 203,706,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,631,028 - 203,668,983 (-)NCBI
Celera2188,388,024 - 188,425,978 (-)NCBICelera
RH 3.4 Map21390.8RGD
Cytogenetic Map2q34NCBI
GNAI3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,548,615 - 109,600,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1109,548,615 - 109,600,195 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,091,237 - 110,142,817 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361109,892,824 - 109,938,498 (+)NCBINCBI36Build 36hg18NCBI36
Build 341109,803,342 - 109,849,017NCBI
Celera1108,360,485 - 108,407,751 (+)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1107,983,708 - 108,030,976 (+)NCBIHuRef
CHM1_11110,206,106 - 110,253,386 (+)NCBICHM1_1
T2T-CHM13v2.01109,581,338 - 109,632,911 (+)NCBIT2T-CHM13v2.0
Gnai3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393108,014,591 - 108,053,468 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3108,014,596 - 108,053,462 (-)EnsemblGRCm39 Ensembl
GRCm383108,107,275 - 108,146,152 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3108,107,280 - 108,146,146 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,910,217 - 107,949,032 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,235,355 - 108,274,170 (-)NCBIMGSCv36mm8
Celera3110,441,104 - 110,479,940 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
Gnai3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543512,965,006 - 13,005,614 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543512,965,006 - 13,005,614 (+)NCBIChiLan1.0ChiLan1.0
GNAI3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11111,154,060 - 111,198,771 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1111,154,060 - 111,198,768 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01111,925,668 - 111,971,941 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GNAI3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,275,060 - 42,315,545 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,276,998 - 42,315,533 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha645,050,635 - 45,090,449 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0642,606,591 - 42,646,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,605,654 - 42,646,132 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,339,208 - 42,379,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,297,245 - 42,336,814 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0642,732,429 - 42,771,713 (-)NCBIUU_Cfam_GSD_1.0
Gnai3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505819,038,470 - 19,085,429 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367041,032,708 - 1,074,384 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367041,031,476 - 1,075,662 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAI3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,525,546 - 110,579,053 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,527,363 - 110,579,331 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,990,186 - 121,037,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNAI3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,950,819 - 24,000,069 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2023,954,384 - 23,999,072 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603834,461,205 - 34,509,046 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnai3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247725,272,086 - 5,309,834 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gnai3
76 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:269
Count of miRNA genes:170
Interacting mature miRNAs:211
Transcripts:ENSRNOT00000026710
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat

Markers in Region
BF417859  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,743,349 - 195,743,528 (+)MAPPERmRatBN7.2
Rnor_6.02210,897,364 - 210,897,542NCBIRnor6.0
Rnor_5.02230,366,612 - 230,366,790UniSTSRnor5.0
RGSC_v3.42203,668,860 - 203,669,038UniSTSRGSC3.4
Celera2188,388,609 - 188,388,787UniSTS
RH 3.4 Map21389.0UniSTS
Cytogenetic Map2q34UniSTS
RH130562  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,742,821 - 195,743,038 (+)MAPPERmRatBN7.2
Rnor_6.02210,896,836 - 210,897,052NCBIRnor6.0
Rnor_5.02230,366,084 - 230,366,300UniSTSRnor5.0
RGSC_v3.42203,668,332 - 203,668,548UniSTSRGSC3.4
Celera2188,388,081 - 188,388,297UniSTS
RH 3.4 Map21386.5UniSTS
Cytogenetic Map2q34UniSTS
RH94416  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,744,472 - 195,744,659 (+)MAPPERmRatBN7.2
Rnor_6.02210,898,487 - 210,898,673NCBIRnor6.0
Rnor_5.02230,367,735 - 230,367,921UniSTSRnor5.0
RGSC_v3.42203,669,983 - 203,670,169UniSTSRGSC3.4
Celera2188,389,732 - 188,389,918UniSTS
RH 3.4 Map21390.8UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 6 7 74 35 41 11 6
Low 2 4 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026710   ⟹   ENSRNOP00000026710
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,742,642 - 195,780,742 (-)Ensembl
Rnor_6.0 Ensembl2210,896,656 - 210,934,749 (-)Ensembl
RefSeq Acc Id: NM_013106   ⟹   NP_037238
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22195,742,765 - 195,780,720 (-)NCBI
Rnor_6.02210,896,779 - 210,934,733 (-)NCBI
Rnor_5.02230,366,027 - 230,403,981 (-)NCBI
RGSC_v3.42203,668,275 - 203,706,229 (-)RGD
Celera2188,388,024 - 188,425,978 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037238   ⟸   NM_013106
- UniProtKB: P08753 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026710   ⟸   ENSRNOT00000026710
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08753-F1-model_v2 AlphaFold P08753 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691673
Promoter ID:EPDNEW_R2198
Type:initiation region
Name:Gnai3_1
Description:G protein subunit alpha i3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02210,934,755 - 210,934,815EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2714 AgrOrtholog
BioCyc Gene G2FUF-51633 BioCyc
Ensembl Genes ENSRNOG00000019465 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026710.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026710.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Gprotein_alpha_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25643 UniProtKB/Swiss-Prot
NCBI Gene 25643 ENTREZGENE
PANTHER PTHR10218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gnai3 PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPROTEINAI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART G_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229103
UniProt A0A8L2QEJ0_RAT UniProtKB/TrEMBL
  GNAI3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q45QM8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Gnai3  G protein subunit alpha i3  Gnai3  guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-05-03 Gnai3  guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3  Gnai3  guanine nucleotide binding protein (G protein), alpha inhibiting 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-20 Gnai3  guanine nucleotide binding protein (G protein), alpha inhibiting 3  Gnai3  guanine nucleotide binding protein, alpha inhibiting 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gnai3  Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA-abundant in hippocampus 625670
gene_process selectively interacts with different G-protein coupled receptors 625670
gene_process involved in presynaptic inhibition 625670