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Gene: Htr1a (5-hydroxytryptamine receptor 1A) Rattus norvegicus
Symbol: Htr1a
Name: 5-hydroxytryptamine receptor 1A
Description: Exhibits several functions, including G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding activity; and serotonin binding activity. Involved in several processes, including NMDA glutamate receptor clustering; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and regulation of neurotransmitter transport. Localizes to GABA-ergic synapse; axon hillock; and integral component of presynaptic membrane. Used to study Parkinson's disease and panic disorder. Human ortholog(s) of this gene implicated in anxiety disorder; mental depression; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1-(3-chlorophenyl)piperazine.
Type: protein-coding
Also known as: 5-HT-1A; 5-HT1A; 5-hydroxytryptamine (serotonin) receptor 1A; 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; 5HT1A; RAT5HT1A; serotonin 1A receptor; serotonin 5-HT1A receptor; serotonin receptor 1A
Homo sapiens (human) : HTR1A (5-hydroxytryptamine receptor 1A)  HGNC  Alliance
Mus musculus (house mouse) : Htr1a (5-hydroxytryptamine (serotonin) receptor 1A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htr1a (5-hydroxytryptamine receptor 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : HTR1A (5-hydroxytryptamine receptor 1A)
Canis lupus familiaris (dog) : HTR1A (5-hydroxytryptamine receptor 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htr1a (5-hydroxytryptamine receptor 1A)
Sus scrofa (pig) : HTR1A (5-hydroxytryptamine receptor 1A)
Chlorocebus sabaeus (African green monkey) : HTR1A (5-hydroxytryptamine receptor 1A)
Heterocephalus glaber (naked mole-rat) : Htr1a (5-hydroxytryptamine receptor 1A)
more info ...
Allele / Splice: Htr1am1Mcwi   Htr1am2Mcwi  
Genetic Models: FHH-Htr1am1Mcwi SS-Htr1am2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0236,246,628 - 36,247,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl236,246,628 - 36,247,896 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0255,362,662 - 55,363,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4236,434,518 - 36,435,786 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1236,354,886 - 36,356,155 (+)NCBI
Celera232,636,756 - 32,638,024 (+)NCBICelera
Cytogenetic Map2q13NCBI
RH 3.4 Map2156.5RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Htr1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2845
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.