Gnal (G protein subunit alpha L) - Rat Genome Database

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Gene: Gnal (G protein subunit alpha L) Rattus norvegicus
Analyze
Symbol: Gnal
Name: G protein subunit alpha L
RGD ID: 2715
Description: Predicted to enable G protein activity; G protein-coupled receptor binding activity; and G-protein beta/gamma-subunit complex binding activity. Involved in cellular response to dopamine and regulation of long-term synaptic depression. Located in acrosomal vesicle; apical cytoplasm; and sperm midpiece. Part of ciliary necklace. Used to study dystonia. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in dystonia 25. Orthologous to human GNAL (G protein subunit alpha L); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate cyclase-stimulating G alpha protein, olfactory type; Golf; guanine nucleotide binding protein, alpha activating activity polypeptide, olfactory type; guanine nucleotide binding protein, alpha stimulating, olfactory type; guanine nucleotide-binding protein G(olf) subunit alpha; guanine nucleotide-binding protein G(olf), alpha subunit; LOC361343; Olf; Olf-alpha protein (olfactory neuron-specific G protein); RGD1305940; similar to RIKEN cDNA 9630020G10 gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Gnalem1Hpng ; Gnalem2Hpng ; Gnalem3Hpng
Genetic Models: SD-Gnalem1Hpng+/- ; SD-Gnalem3Hpng ; SD-Gnalem2Hpng ; SD-Gnalem1Hpng-/-
Is Marker For: Strains:   BB.SHR-(Gnal-D18Mit9)/K  
QTLs:   Iddm4   Bp48   Iddm15   Sprol1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81862,892,257 - 63,032,510 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1862,892,226 - 63,043,129 (+)EnsemblGRCr8
mRatBN7.21860,622,311 - 60,762,599 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1860,622,311 - 60,762,599 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1862,697,583 - 62,835,273 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,396,310 - 63,534,014 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,243,031 - 61,383,188 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,805,406 - 62,946,133 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,805,410 - 62,944,630 (+)Ensemblrn6Rnor6.0
Rnor_5.01861,991,738 - 62,131,420 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41863,595,606 - 63,735,803 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1858,730,137 - 58,870,361 (+)NCBICelera
RGSC_v3.11863,668,806 - 63,809,004 (+)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-amphetamine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbon nanotube  (ISO)
citronellal  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decanal  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
GSK-J4  (ISO)
heptan-2-one  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
nonanedioic acid  (ISO)
octanal  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
rifampicin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sunitinib  (ISO)
testosterone  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ga(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia. Alcacer C, etal., J Neurosci. 2012 Apr 25;32(17):5900-10. doi: 10.1523/JNEUROSCI.0837-12.2012.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. 'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus. Gonçalves I, etal., FEBS J. 2016 May;283(9):1748-66. doi: 10.1111/febs.13700. Epub 2016 Mar 30.
5. New genetic insights highlight 'old' ideas on motor dysfunction in dystonia. Goodchild RE, etal., Trends Neurosci. 2013 Dec;36(12):717-25. doi: 10.1016/j.tins.2013.09.003. Epub 2013 Oct 18.
6. Molecular analysis of the multiple Golf alpha subunit mRNAs in the rat brain. Herve D, etal., Brain Res Mol Brain Res 1995 Aug;32(1):125-34.
7. Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. Lelianova VG, etal., J Biol Chem 1997 Aug 22;272(34):21504-8.
8. Immunocytochemical Localization of Olfactory-signaling Molecules in Human and Rat Spermatozoa. Makeyeva Y, etal., J Histochem Cytochem. 2020 Jul;68(7):491-513. doi: 10.1369/0022155420939833. Epub 2020 Jun 30.
9. Developmental expression of G-proteins and adenylyl cyclase in peripheral olfactory systems. Light microscopic and freeze-substitution electron microscopic immunocytochemistry. Menco BP, etal., J Neurocytol. 1994 Nov;23(11):708-27. doi: 10.1007/BF01181645.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Quantitative Proteomic Study Reveals Up-Regulation of cAMP Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury. Song H, etal., J Proteome Res. 2018 Feb 2;17(2):858-869. doi: 10.1021/acs.jproteome.7b00618. Epub 2017 Dec 27.
20. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
21. Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia. Yu-Taeger L, etal., Neurobiol Dis. 2020 Feb;134:104634. doi: 10.1016/j.nbd.2019.104634. Epub 2019 Oct 31.
Additional References at PubMed
PMID:2499043   PMID:9459443   PMID:11404425   PMID:12488442   PMID:12832082   PMID:15908736   PMID:16310044   PMID:17194762   PMID:21171433   PMID:23533145   PMID:38182074  


Genomics

Comparative Map Data
Gnal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81862,892,257 - 63,032,510 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1862,892,226 - 63,043,129 (+)EnsemblGRCr8
mRatBN7.21860,622,311 - 60,762,599 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1860,622,311 - 60,762,599 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1862,697,583 - 62,835,273 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,396,310 - 63,534,014 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,243,031 - 61,383,188 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,805,406 - 62,946,133 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,805,410 - 62,944,630 (+)Ensemblrn6Rnor6.0
Rnor_5.01861,991,738 - 62,131,420 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41863,595,606 - 63,735,803 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1858,730,137 - 58,870,361 (+)NCBICelera
RGSC_v3.11863,668,806 - 63,809,004 (+)NCBI
Cytogenetic Map18q12.1NCBI
GNAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381811,689,264 - 11,885,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1811,689,264 - 11,885,685 (+)Ensemblhg38GRCh38
GRCh371811,689,263 - 11,885,684 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361811,679,263 - 11,871,922 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341811,679,264 - 11,871,919NCBI
Celera1811,568,478 - 11,764,014 (+)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1811,644,058 - 11,840,338 (+)NCBIHuRef
CHM1_11811,688,387 - 11,885,176 (+)NCBICHM1_1
T2T-CHM13v2.01811,851,607 - 12,048,391 (+)NCBIT2T-CHM13v2.0
Gnal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391867,221,369 - 67,359,863 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1867,221,287 - 67,359,863 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381867,088,298 - 67,226,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1867,088,216 - 67,226,792 (+)Ensemblmm10GRCm38
MGSCv371867,247,990 - 67,386,446 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361867,213,705 - 67,349,624 (+)NCBIMGSCv36mm8
Celera1868,356,933 - 68,494,863 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.85NCBI
Gnal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554021,181,133 - 1,248,616 (-)Ensembl
ChiLan1.0NW_0049554021,182,515 - 1,249,301 (-)NCBIChiLan1.0ChiLan1.0
GNAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21726,138,789 - 26,334,162 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11811,835,143 - 12,026,963 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0182,420,578 - 2,615,947 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1184,684,622 - 4,818,026 (-)NCBIPanPan1.1PanPan1.1panPan2
GNAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1777,378,134 - 77,521,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl777,413,986 - 77,521,042 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha776,779,701 - 76,925,568 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0777,435,802 - 77,579,609 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl777,435,223 - 77,581,670 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1777,133,536 - 77,276,782 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0777,179,815 - 77,323,366 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0777,466,820 - 77,610,501 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gnal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049441,140,980 - 1,232,788 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936626373,433 - 460,788 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936626372,893 - 460,884 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl697,342,474 - 97,429,364 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1697,342,468 - 97,429,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2690,674,125 - 90,703,582 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNAL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11869,508,254 - 69,699,628 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1869,510,512 - 69,635,000 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605044,505,410 - 44,707,045 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnal
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477019,433,660 - 19,504,698 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477019,433,614 - 19,504,759 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gnal
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11564,072,488 - 64,216,425 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gnal
1112 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:46
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000025172
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186198220476619168Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186160038472538878Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186289225779484461Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186289225779484461Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41863,737,839 - 63,737,956RGDRGSC3.4
RGSC_v3.41863,737,840 - 63,737,956UniSTSRGSC3.4
Celera1858,870,895 - 58,871,011UniSTS
RGSC_v3.11863,811,040 - 63,811,157RGD
RH 3.4 Map18616.3RGD
RH 2.0 Map18298.8RGD
D18Mit17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,763,132 - 60,763,249 (+)MAPPERmRatBN7.2
Rnor_6.01862,946,667 - 62,946,783NCBIRnor6.0
Rnor_5.01862,133,457 - 62,133,573UniSTSRnor5.0
RGSC_v3.41832,458,754 - 32,458,974RGDRGSC3.4
RGSC_v3.41863,737,840 - 63,737,956UniSTSRGSC3.4
Celera1858,870,895 - 58,871,011UniSTS
RGSC_v3.11863,811,040 - 63,811,157RGD
RH 3.4 Map18616.3UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map18q12.1-q12.2UniSTS
D18Rat89  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81862,992,208 - 62,992,419 (+)Marker Load Pipeline
mRatBN7.21860,722,286 - 60,722,497 (+)MAPPERmRatBN7.2
Rnor_6.01862,905,559 - 62,905,769NCBIRnor6.0
Rnor_5.01862,092,349 - 62,092,559UniSTSRnor5.0
RGSC_v3.41863,697,005 - 63,697,215UniSTSRGSC3.4
RGSC_v3.41863,697,004 - 63,697,215RGDRGSC3.4
Celera1858,830,032 - 58,830,242UniSTS
RGSC_v3.11863,770,206 - 63,770,416RGD
RH 3.4 Map18610.5RGD
RH 3.4 Map18610.5UniSTS
RH 2.0 Map18300.8RGD
SHRSP x BN Map1835.3999RGD
Cytogenetic Map18q12.1-q12.2UniSTS
D18Arb5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,763,053 - 60,763,320 (+)MAPPERmRatBN7.2
Rnor_6.01862,946,588 - 62,946,854NCBIRnor6.0
Rnor_5.01862,133,378 - 62,133,644UniSTSRnor5.0
RGSC_v3.41863,737,761 - 63,738,027UniSTSRGSC3.4
RGSC_v3.41863,737,760 - 63,738,027RGDRGSC3.4
Celera1858,870,816 - 58,871,082UniSTS
RGSC_v3.11863,810,961 - 63,811,228RGD
FHH x ACI Map1841.94RGD
FHH x ACI Map1841.94UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map18q12.1-q12.2UniSTS
RH129239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,741,670 - 60,741,886 (+)MAPPERmRatBN7.2
Rnor_6.01862,924,942 - 62,925,157NCBIRnor6.0
Rnor_5.01862,111,732 - 62,111,947UniSTSRnor5.0
RGSC_v3.41863,716,388 - 63,716,603UniSTSRGSC3.4
Celera1858,849,449 - 58,849,664UniSTS
RH 3.4 Map18615.3UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map18q12.1-q12.2UniSTS
RH129499  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,741,670 - 60,741,878 (+)MAPPERmRatBN7.2
Rnor_6.01862,924,942 - 62,925,149NCBIRnor6.0
Rnor_5.01862,111,732 - 62,111,939UniSTSRnor5.0
RGSC_v3.41863,716,388 - 63,716,595UniSTSRGSC3.4
Celera1858,849,449 - 58,849,656UniSTS
RH 3.4 Map18616.3UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map18q12.1-q12.2UniSTS
RH144614  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,737,983 - 60,738,174 (+)MAPPERmRatBN7.2
Rnor_6.01862,921,255 - 62,921,445NCBIRnor6.0
Rnor_5.01862,108,045 - 62,108,235UniSTSRnor5.0
RGSC_v3.41863,712,701 - 63,712,891UniSTSRGSC3.4
Celera1858,845,762 - 58,845,952UniSTS
RH 3.4 Map18614.4UniSTS
Cytogenetic Map18q12.1-q12.2UniSTS
BF417987  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,672,584 - 60,672,731 (+)MAPPERmRatBN7.2
Rnor_6.01862,855,889 - 62,856,035NCBIRnor6.0
Rnor_5.01862,042,184 - 62,042,330UniSTSRnor5.0
RGSC_v3.41863,646,962 - 63,647,108UniSTSRGSC3.4
Celera1858,780,404 - 58,780,550UniSTS
RH 3.4 Map18611.4UniSTS
Cytogenetic Map18q12.1-q12.2UniSTS
UniSTS:237833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,740,919 - 60,741,119 (+)MAPPERmRatBN7.2
Rnor_6.01862,924,191 - 62,924,390NCBIRnor6.0
Rnor_5.01862,110,981 - 62,111,180UniSTSRnor5.0
RGSC_v3.41863,715,637 - 63,715,836UniSTSRGSC3.4
Celera1858,848,698 - 58,848,897UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map18q12.1-q12.2UniSTS


Related Rat Strains
The following Strains have been annotated to Gnal
BB.SHR-(Gnal-D18Mit9)/K    


Genetic Models
This gene Gnal is modified in the following models/strains:
SD-Gnalem1Hpng+/-     SD-Gnalem3Hpng     SD-Gnalem2Hpng     SD-Gnalem1Hpng-/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 88 59 6 351 187 10 142 81 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025172   ⟹   ENSRNOP00000025172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1862,892,226 - 63,033,307 (+)Ensembl
mRatBN7.2 Ensembl1860,622,311 - 60,762,599 (+)Ensembl
Rnor_6.0 Ensembl1862,850,588 - 62,944,627 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086679   ⟹   ENSRNOP00000073266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1862,892,226 - 62,994,004 (+)Ensembl
mRatBN7.2 Ensembl1860,622,311 - 60,724,082 (+)Ensembl
Rnor_6.0 Ensembl1862,805,410 - 62,944,630 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087673   ⟹   ENSRNOP00000074114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1862,936,398 - 63,033,307 (+)Ensembl
mRatBN7.2 Ensembl1860,666,501 - 60,762,599 (+)Ensembl
Rnor_6.0 Ensembl1862,852,303 - 62,944,627 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159899   ⟹   ENSRNOP00000109137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1862,936,398 - 63,043,129 (+)Ensembl
RefSeq Acc Id: NM_001191836   ⟹   NP_001178765
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81862,892,257 - 63,032,510 (+)NCBI
mRatBN7.21860,622,311 - 60,762,599 (+)NCBI
Rnor_6.01862,805,406 - 62,946,133 (+)NCBI
Rnor_5.01861,991,738 - 62,131,420 (+)NCBI
Celera1858,730,137 - 58,870,361 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178765 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP32222 (Get FASTA)   NCBI Sequence Viewer  
  AAP32223 (Get FASTA)   NCBI Sequence Viewer  
  EDM14716 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025172
GenBank Protein P38406 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001178765   ⟸   NM_001191836
- UniProtKB: Q64711 (UniProtKB/Swiss-Prot),   P38406 (UniProtKB/Swiss-Prot),   G3V8E8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074114   ⟸   ENSRNOT00000087673
Ensembl Acc Id: ENSRNOP00000073266   ⟸   ENSRNOT00000086679
Ensembl Acc Id: ENSRNOP00000025172   ⟸   ENSRNOT00000025172
Ensembl Acc Id: ENSRNOP00000109137   ⟸   ENSRNOT00000159899
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P38406-F1-model_v2 AlphaFold P38406 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700846
Promoter ID:EPDNEW_R11363
Type:single initiation site
Name:Gnal_1
Description:G protein subunit alpha L
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01862,850,564 - 62,850,624EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2715 AgrOrtholog
BioCyc Gene G2FUF-7160 BioCyc
Ensembl Genes ENSRNOG00000010440 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025172 ENTREZGENE
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro Gprotein_alpha_S UniProtKB/Swiss-Prot
  Gprotein_alpha_su UniProtKB/Swiss-Prot
  GproteinA_insert UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:24611 UniProtKB/Swiss-Prot
NCBI Gene 24611 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(OLF) SUBUNIT ALPHA UniProtKB/Swiss-Prot
  PTHR10218 UniProtKB/Swiss-Prot
Pfam G-alpha UniProtKB/Swiss-Prot
PhenoGen Gnal PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot
  GPROTEINAS UniProtKB/Swiss-Prot
PROSITE G_ALPHA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010440 RatGTEx
SMART G_alpha UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2K526_RAT UniProtKB/TrEMBL
  A0A0G2K795_RAT UniProtKB/TrEMBL
  A0ABK0LSX3_RAT UniProtKB/TrEMBL
  A6IXT5_RAT UniProtKB/TrEMBL
  G3V8E8 ENTREZGENE, UniProtKB/TrEMBL
  GNAL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64711 ENTREZGENE
UniProt Secondary Q64711 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Gnal  G protein subunit alpha L  Gnal  guanine nucleotide binding protein, alpha activating activity polypeptide, olfactory type  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-05-18 Gnal  guanine nucleotide binding protein, alpha activating activity polypeptide, olfactory type  Gnal  guanine nucleotide binding protein, alpha stimulating, olfactory type  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-01-07 Gnal  guanine nucleotide binding protein, alpha stimulating, olfactory type  RGD1305940  similar to RIKEN cDNA 9630020G10 gene   Data merged from RGD:1305940 737654 APPROVED
2008-04-30 RGD1305940  similar to RIKEN cDNA 9630020G10 gene   RGD1305940_predicted  similar to RIKEN cDNA 9630020G10 gene (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1305940_predicted  similar to RIKEN cDNA 9630020G10 gene (predicted)  LOC361343_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-20 Gnal  guanine nucleotide binding protein, alpha stimulating, olfactory type      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 LOC361343_predicted  similar to RIKEN cDNA 9630020G10 gene (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Gnal  guanine nucleotide binding protein, alpha stimulating, olfactory type      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed primarily in brain tissue, olfactory neurons but not in liver, eye, kidney or testis 61489
gene_process activates adenylate cyclase