Gnao1 (G protein subunit alpha o1) - Rat Genome Database

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Gene: Gnao1 (G protein subunit alpha o1) Rattus norvegicus
Analyze
Symbol: Gnao1
Name: G protein subunit alpha o1
RGD ID: 628732
Description: Enables several functions, including G protein-coupled receptor binding activity; GTP binding activity; and GTPase activating protein binding activity. Involved in several processes, including nervous system development; odontogenesis of dentin-containing tooth; and response to hydrogen peroxide. Located in myelin sheath. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1); PARTICIPATES IN G protein mediated signaling pathway; dopamine signaling pathway via D2 family of receptors; endothelin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gnao; GTP-binding protein; GTP-binding protein alpha o; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha O; guanine nucleotide binding protein, alpha O polypeptide 1; guanine nucleotide-binding protein G(o) subunit alpha; heterotrimeric guanine nucleotide-binding protein 1g; Hg1g; RATBPGTPC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,040,788 - 11,198,437 (-)NCBIGRCr8
mRatBN7.21911,034,874 - 11,192,531 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1911,035,956 - 11,192,493 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1911,003,977 - 11,161,720 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,769,148 - 11,926,880 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01911,056,156 - 11,213,897 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,513,201 - 11,669,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,513,201 - 11,669,578 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,487,578 - 11,643,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,472,083 - 11,623,600 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,476,908 - 11,628,426 (-)NCBI
Celera1910,919,521 - 11,074,052 (-)NCBICelera
Cytogenetic Map19p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dichlorine  (EXP)
diethyl malate  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
Ethylenethiourea  (EXP)
fenvalerate  (EXP)
flavonoids  (EXP)
genistein  (EXP,ISO)
glyphosate  (EXP)
Guanabenz  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
nickel atom  (ISO)
ozone  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
pentobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propanal  (ISO)
quercetin  (EXP)
reserpine  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
thapsigargin  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Developmental expression of G alpha o and G alpha s isoforms in PC12 cells: relationship to neurite outgrowth. Andreopoulos S, etal., Brain Res Dev Brain Res. 1995 Aug 28;88(1):30-6.
2. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology. Bangasser DA, etal., Mol Psychiatry. 2010 Sep;15(9):877, 896-904. Epub 2010 Jun 15.
3. Serotonin-mediated palmitoylation and depalmitoylation of G alpha proteins in rat brain cortical membranes. Bhamre S, etal., J Pharmacol Exp Ther. 1998 Sep;286(3):1482-9.
4. Reduced adenosine A1 receptor and G alpha protein coupling in rat ventricular myocardium during aging. Cai G, etal., Circ Res. 1997 Dec;81(6):1065-71.
5. Voltage-dependent calcium channel beta-subunits in combination with alpha 1 subunits, have a GTPase activating effect to promote the hydrolysis of GTP by G alpha o in rat frontal cortex. Campbell V, etal., FEBS Lett. 1995 Aug 14;370(1-2):135-40.
6. Muscarinic M-current inhibition via G alpha q/11 and alpha-adrenoceptor inhibition of Ca2+ current via G alpha o in rat sympathetic neurones. Caulfield MP, etal., J Physiol. 1994 Jun 15;477 ( Pt 3):415-22.
7. Light response of retinal ON bipolar cells requires a specific splice variant of Galpha(o). Dhingra A, etal., J Neurosci 2002 Jun 15;22(12):4878-84.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Compartmentalization of protein kinase A signaling by the heterotrimeric G protein Go. Ghil S, etal., Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19158-63. Epub 2006 Dec 5.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Itoh H, etal., Proc Natl Acad Sci U S A 1986 Jun;83(11):3776-80.
12. Multiple neurological abnormalities in mice deficient in the G protein Go. Jiang M, etal., Proc Natl Acad Sci U S A 1998 Mar 17;95(6):3269-74.
13. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. Jones DT and Reed RR, J Biol Chem 1987 Oct 15;262(29):14241-9.
14. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
15. Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in rats. Kim Y and Oh S, Neurochem Res. 2002 Jun;27(6):527-33.
16. Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. Kosloff M, etal., Nat Struct Mol Biol. 2011 Jun 19;18(7):846-53. doi: 10.1038/nsmb.2068.
17. Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. Lelianova VG, etal., J Biol Chem 1997 Aug 22;272(34):21504-8.
18. Effect of thyroid deficiency on Go alpha-subunit isoforms in developing rat cerebral cortex. Li PP, etal., Neurochem Res. 1995 Oct;20(10):1249-55.
19. Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain. Mannoury la Cour C, etal., Mol Pharmacol. 2006 Sep;70(3):1013-21. Epub 2006 Jun 13.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Functionally selective dopamine D(2), D(3) receptor partial agonists. Moller D, etal., J Med Chem. 2014 Jun 12;57(11):4861-75. doi: 10.1021/jm5004039. Epub 2014 May 23.
22. Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits. Mostany R, etal., Neuropharmacology. 2008 May;54(6):989-97. Epub 2008 Feb 16.
23. G alpha(i) and G alpha(o) are target proteins of reactive oxygen species. Nishida M, etal., Nature. 2000 Nov 23;408(6811):492-5.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. In situ hybridization reveals specific increases in G alpha s and G alpha o mRNA in discrete brain regions of morphine-tolerant rats. Parolaro D, etal., Eur J Pharmacol. 1993 Feb 15;244(3):211-22.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. In vivo IL-1beta-induced modulation of G-protein alphaO subunit subclass in the hypothalamic ventromedial nucleus: implications to IL-1beta-associated anorexia. Plata-Salaman CR, etal., Brain Res Mol Brain Res. 1998 Jul 15;58(1-2):188-94.
29. Norepinephrine exocytosis stimulated by alpha-latrotoxin requires both external and stored Ca2+ and is mediated by latrophilin, G proteins and phospholipase C. Rahman MA, etal., Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):379-86.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986. Roman DL, etal., Mol Pharmacol. 2010 Sep;78(3):360-5. doi: 10.1124/mol.109.063388. Epub 2010 Jun 7.
34. RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents. Saitoh O, etal., J Biol Chem 1999 Apr 2;274(14):9899-904.
35. RGS8 accelerates G-protein-mediated modulation of K+ currents. Saitoh O, etal., Nature 1997 Dec 4;390(6659):525-9.
36. G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses. Straiker AJ, etal., J Neurosci 2002 Apr 1;22(7):2460-8.
37. Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. Tall GG, etal., J Biol Chem 2003 Mar 7;278(10):8356-62.
38. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
39. RNA-Sequencing Analyses Demonstrate the Involvement of Canonical Transient Receptor Potential Channels in Rat Tooth Germ Development. Yang J, etal., Front Physiol. 2017 Jun 29;8:455. doi: 10.3389/fphys.2017.00455. eCollection 2017.
40. Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel. Zhao Y, etal., J Biol Chem. 2008 Feb 29;283(9):5306-16. Epub 2007 Dec 27.
Additional References at PubMed
PMID:2158629   PMID:8484716   PMID:9050846   PMID:9990023   PMID:10570206   PMID:10926822   PMID:11248120   PMID:11685543   PMID:12383522   PMID:12454992   PMID:12524446   PMID:12880866  
PMID:12887697   PMID:12915235   PMID:16800795   PMID:17634366   PMID:18262754   PMID:18525017   PMID:22871113   PMID:24625528   PMID:26620557   PMID:29476059   PMID:31155309   PMID:31686426  
PMID:32357304   PMID:35839930  


Genomics

Comparative Map Data
Gnao1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,040,788 - 11,198,437 (-)NCBIGRCr8
mRatBN7.21911,034,874 - 11,192,531 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1911,035,956 - 11,192,493 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1911,003,977 - 11,161,720 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,769,148 - 11,926,880 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01911,056,156 - 11,213,897 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,513,201 - 11,669,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,513,201 - 11,669,578 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,487,578 - 11,643,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,472,083 - 11,623,600 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,476,908 - 11,628,426 (-)NCBI
Celera1910,919,521 - 11,074,052 (-)NCBICelera
Cytogenetic Map19p12NCBI
GNAO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,191,489 - 56,357,444 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,191,390 - 56,357,444 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,225,401 - 56,391,356 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,783,649 - 54,948,651 (+)NCBINCBI36Build 36hg18NCBI36
Build 341654,783,648 - 54,935,363NCBI
Celera1640,722,067 - 40,888,176 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,096,140 - 42,261,995 (+)NCBIHuRef
CHM1_11657,632,612 - 57,798,711 (+)NCBICHM1_1
T2T-CHM13v2.01661,986,534 - 62,152,480 (+)NCBIT2T-CHM13v2.0
Gnao1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,537,213 - 94,696,016 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,536,594 - 94,696,016 (+)EnsemblGRCm39 Ensembl
GRCm38893,810,153 - 93,969,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl893,809,966 - 93,969,388 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,334,738 - 96,493,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36896,700,050 - 96,858,087 (+)NCBIMGSCv36mm8
Celera898,140,645 - 98,299,435 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map845.94NCBI
Gnao1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,004,813 - 14,172,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543314,004,813 - 14,170,631 (+)NCBIChiLan1.0ChiLan1.0
GNAO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21865,669,503 - 65,839,209 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11671,588,239 - 71,758,365 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,473,852 - 36,643,789 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11655,606,920 - 55,776,619 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1655,606,920 - 55,776,619 (+)Ensemblpanpan1.1panPan2
GNAO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,805,675 - 59,980,782 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,806,689 - 59,980,398 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,439,284 - 56,614,525 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,350,680 - 60,525,810 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,350,811 - 60,526,437 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,180,704 - 57,353,192 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,189,791 - 58,364,758 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,082,779 - 59,255,395 (-)NCBIUU_Cfam_GSD_1.0
Gnao1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,907,469 - 50,975,262 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364758,565,889 - 8,690,673 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364758,610,123 - 8,681,606 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl629,416,708 - 29,592,516 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1629,416,574 - 29,592,874 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,756,513 - 26,788,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNAO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,105,295 - 42,272,573 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl542,105,334 - 42,273,059 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604734,092,746 - 34,260,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnao1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624757178,616 - 346,443 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gnao1
723 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:105
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000026373, ENSRNOT00000026429
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat

Markers in Region
RH143789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,036,121 - 11,036,261 (+)MAPPERmRatBN7.2
Rnor_6.01911,513,367 - 11,513,506NCBIRnor6.0
Rnor_5.01911,487,744 - 11,487,883UniSTSRnor5.0
RGSC_v3.41911,472,249 - 11,472,388UniSTSRGSC3.4
Celera1910,919,687 - 10,919,826UniSTS
RH 3.4 Map19112.2UniSTS
Cytogenetic Map19p12UniSTS
BE120174  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,164,661 - 11,164,833 (+)MAPPERmRatBN7.2
Rnor_6.01911,641,749 - 11,641,920NCBIRnor6.0
Rnor_5.01911,615,605 - 11,615,776UniSTSRnor5.0
RGSC_v3.41911,595,838 - 11,596,009UniSTSRGSC3.4
Celera1911,046,387 - 11,046,558UniSTS
RH 3.4 Map19129.98UniSTS
Cytogenetic Map19p12UniSTS
RH136803  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,043,397 - 11,043,551 (+)MAPPERmRatBN7.2
Rnor_6.01911,520,643 - 11,520,796NCBIRnor6.0
Rnor_5.01911,495,020 - 11,495,173UniSTSRnor5.0
RGSC_v3.41911,479,525 - 11,479,678UniSTSRGSC3.4
Celera1910,926,963 - 10,927,116UniSTS
RH 3.4 Map19111.8UniSTS
Cytogenetic Map19p12UniSTS
RH137474  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,036,163 - 11,036,373 (+)MAPPERmRatBN7.2
Rnor_6.01911,513,409 - 11,513,618NCBIRnor6.0
Rnor_5.01911,487,786 - 11,487,995UniSTSRnor5.0
RGSC_v3.41911,472,291 - 11,472,500UniSTSRGSC3.4
Celera1910,919,729 - 10,919,938UniSTS
Cytogenetic Map19p12UniSTS
RH139637  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,043,363 - 11,043,551 (+)MAPPERmRatBN7.2
Rnor_6.01911,520,609 - 11,520,796NCBIRnor6.0
Rnor_5.01911,494,986 - 11,495,173UniSTSRnor5.0
RGSC_v3.41911,479,491 - 11,479,678UniSTSRGSC3.4
Celera1910,926,929 - 10,927,116UniSTS
RH 3.4 Map19128.6UniSTS
Cytogenetic Map19p12UniSTS
BF414418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,062,213 - 11,062,332 (+)MAPPERmRatBN7.2
Rnor_6.01911,539,478 - 11,539,596NCBIRnor6.0
Rnor_5.01911,513,855 - 11,513,973UniSTSRnor5.0
RGSC_v3.41911,498,409 - 11,498,527UniSTSRGSC3.4
Celera1910,945,807 - 10,945,925UniSTS
RH 3.4 Map19105.2UniSTS
Cytogenetic Map19p12UniSTS
AI103680  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,152,156 - 11,152,267 (+)MAPPERmRatBN7.2
Rnor_6.01911,629,246 - 11,629,356NCBIRnor6.0
Rnor_5.01911,603,102 - 11,603,212UniSTSRnor5.0
RGSC_v3.41911,583,335 - 11,583,445UniSTSRGSC3.4
Celera1911,033,911 - 11,034,021UniSTS
RH 3.4 Map19129.8UniSTS
Cytogenetic Map19p12UniSTS
PMC19731P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,052,825 - 11,053,826 (+)MAPPERmRatBN7.2
Rnor_6.01911,530,071 - 11,531,071NCBIRnor6.0
Rnor_5.01911,504,448 - 11,505,448UniSTSRnor5.0
RGSC_v3.41911,488,953 - 11,489,953UniSTSRGSC3.4
Celera1910,936,391 - 10,937,391UniSTS
Cytogenetic Map19p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 33 74 9
Low 2 10 25 9 19 9 8 11 35 32 11 8
Below cutoff 31 31 31

Sequence


RefSeq Acc Id: ENSRNOT00000026373   ⟹   ENSRNOP00000026373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1911,035,956 - 11,192,493 (-)Ensembl
Rnor_6.0 Ensembl1911,513,201 - 11,669,578 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116733   ⟹   ENSRNOP00000080513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1911,043,326 - 11,192,493 (-)Ensembl
RefSeq Acc Id: NM_001414909   ⟹   NP_001401838
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,049,186 - 11,198,437 (-)NCBI
mRatBN7.21911,043,272 - 11,192,531 (-)NCBI
RefSeq Acc Id: NM_001414910   ⟹   NP_001401839
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,040,788 - 11,198,437 (-)NCBI
mRatBN7.21911,034,874 - 11,192,531 (-)NCBI
RefSeq Acc Id: NM_017327   ⟹   NP_059023
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,040,788 - 11,198,437 (-)NCBI
mRatBN7.21911,034,874 - 11,192,531 (-)NCBI
Rnor_6.01911,513,201 - 11,669,578 (-)NCBI
Rnor_5.01911,487,578 - 11,643,367 (-)NCBI
RGSC_v3.41911,472,083 - 11,623,600 (-)RGD
Celera1910,919,521 - 11,074,052 (-)RGD
Sequence:
RefSeq Acc Id: NP_059023   ⟸   NM_017327
- Peptide Label: isoform B
- UniProtKB: P30033 (UniProtKB/Swiss-Prot),   P59215 (UniProtKB/Swiss-Prot),   A6JY81 (UniProtKB/TrEMBL),   A6JY82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026373   ⟸   ENSRNOT00000026373
RefSeq Acc Id: ENSRNOP00000080513   ⟸   ENSRNOT00000116733
RefSeq Acc Id: NP_001401839   ⟸   NM_001414910
- Peptide Label: isoform B
- UniProtKB: P59215 (UniProtKB/Swiss-Prot),   P30033 (UniProtKB/Swiss-Prot),   A6JY81 (UniProtKB/TrEMBL),   A6JY82 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001401838   ⟸   NM_001414909
- Peptide Label: isoform A
- UniProtKB: A0A8I5ZT81 (UniProtKB/TrEMBL),   A6JY82 (UniProtKB/TrEMBL)
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59215-F1-model_v2 AlphaFold P59215 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700956
Promoter ID:EPDNEW_R11479
Type:initiation region
Name:Gnao1_1
Description:G protein subunit alpha o1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01911,669,578 - 11,669,638EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628732 AgrOrtholog
BioCyc Gene G2FUF-6466 BioCyc
Ensembl Genes ENSRNOG00000019482 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055021570 UniProtKB/Swiss-Prot
  ENSRNOG00060015601 UniProtKB/Swiss-Prot
  ENSRNOG00065004094 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026373 ENTREZGENE
  ENSRNOT00000026373.6 UniProtKB/Swiss-Prot
  ENSRNOT00000116733 ENTREZGENE
  ENSRNOT00000116733.1 UniProtKB/TrEMBL
  ENSRNOT00055036870 UniProtKB/Swiss-Prot
  ENSRNOT00060026724 UniProtKB/Swiss-Prot
  ENSRNOT00065005977 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Gprotein_alpha_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50664 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 50664 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(O) SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gnao1 PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPROTEINAI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019482 RatGTEx
  ENSRNOG00055021570 RatGTEx
  ENSRNOG00060015601 RatGTEx
  ENSRNOG00065004094 RatGTEx
SMART G_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZT81 ENTREZGENE, UniProtKB/TrEMBL
  A6JY81 ENTREZGENE, UniProtKB/TrEMBL
  A6JY82 ENTREZGENE, UniProtKB/TrEMBL
  GNAO_RAT UniProtKB/Swiss-Prot
  P30033 ENTREZGENE
  P59215 ENTREZGENE
UniProt Secondary P04900 UniProtKB/Swiss-Prot
  P30033 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Gnao1  G protein subunit alpha o1  Gnao1  guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-12 Gnao1  guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O  Gnao1  guanine nucleotide binding protein, alpha O polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Gnao1  guanine nucleotide binding protein, alpha O polypeptide 1  Gnao1  guanine nucleotide binding protein, alpha O  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Gnao1  guanine nucleotide binding protein, alpha O  Gnao  guanine nucleotide binding protein, alpha o  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gnao  guanine nucleotide binding protein, alpha o      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Gnao  guanine nucleotide binding protein, alpha o      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in rod bipolar cells and outer nuclear [ON] cone bipolar cells of retina 625670
gene_physical_interaction interacts with cannabinoid CB1 receptor,GABAB receptor and somatostatin (SSTR) receptor in hippocampal synapses 625670
gene_process involved in the olfactory signal transduction cascade 632848
gene_process a01 splice variant is crucial for cell light response 625670
gene_process involved in presynaptic inhibition 625670
gene_process involved in signaling of non-specific cation channel in retina  
gene_process alphao1 splice variant is crucial for cell light response 625670
gene_process a02 splice variant may regulate the metabotropic glutamate receptor [mGluR6] cascade pathway in ON bipolar cells 625670
gene_process interacts selectively with different G-protein coupled receptors 625670
gene_protein 310 amino acids 632849
gene_transcript transcribed into two splice variants alpha 01 and alpha 02 that differ at GTPase domains near C terminus 625670