Rgs4 (regulator of G-protein signaling 4) - Rat Genome Database

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Gene: Rgs4 (regulator of G-protein signaling 4) Rattus norvegicus
Symbol: Rgs4
Name: regulator of G-protein signaling 4
RGD ID: 3567
Description: Enables G-protein alpha-subunit binding activity; GTPase activator activity; and protein kinase binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of transmembrane transport; and regulation of signal transduction. Part of protein-containing complex. Used to study epilepsy. Biomarker of bladder disease; hypertension; lesion of sciatic nerve; opioid abuse; and status epilepticus. Orthologous to human RGS4 (regulator of G protein signaling 4); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH (S)-amphetamine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: RGP4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81384,469,593 - 84,475,884 (-)NCBIGRCr8
mRatBN7.21381,936,775 - 81,943,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1381,936,775 - 81,943,068 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1384,564,610 - 84,570,879 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01385,857,386 - 85,863,677 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,089,853 - 83,096,122 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01388,054,817 - 88,061,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1388,054,817 - 88,061,108 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01392,682,956 - 92,689,247 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41385,533,882 - 85,540,173 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11385,548,069 - 85,554,361 (-)NCBI
Celera1381,602,391 - 81,608,682 (-)NCBICelera
RH 3.4 Map13510.9RGD
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (EXP)
(S)-timolol (anhydrous)  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
diazinon  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
diquat  (ISO)
doramapimod  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
eticlopride(1+)  (EXP)
flavonoids  (EXP)
formaldehyde  (ISO)
haloperidol  (EXP)
hydrogen cyanide  (ISO)
irinotecan  (EXP)
kenpaullone  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nitrofen  (EXP)
oxaliplatin  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
prednisolone  (EXP,ISO)
progesterone  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
reserpine  (EXP)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
Soman  (EXP)
T-2 toxin  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
thioacetamide  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)


References - curated
# Reference Title Reference Citation
1. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
2. Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors. Blazer LL, etal., ACS Chem Neurosci. 2015 Jun 17;6(6):911-9. doi: 10.1021/acschemneuro.5b00063. Epub 2015 Apr 20.
3. Development of a bimolecular luminescence complementation assay for RGS: G protein interactions in cells. Bodle CR, etal., Anal Biochem. 2017 Apr 1;522:10-17. doi: 10.1016/j.ab.2017.01.013. Epub 2017 Jan 20.
4. A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal. Carrasco GA, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):1012-9. Epub 2003 Oct 8.
5. RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents. Chen IS, etal., J Physiol. 2014 Mar 15;592(6):1237-48. doi: 10.1113/jphysiol.2013.269803. Epub 2014 Jan 13.
6. High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons. Costigan M, etal., Mol Cell Neurosci. 2003 Sep;24(1):106-16.
7. RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Ding J, etal., Nat Neurosci. 2006 Jun;9(6):832-42. doi: 10.1038/nn1700. Epub 2006 May 14.
8. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Druey KM, etal., Nature 1996 Feb 22;379(6567):742-6.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Regulation of RGS proteins by chronic morphine in rat locus coeruleus. Gold SJ, etal., Eur J Neurosci. 2003 Mar;17(5):971-80.
11. Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures. Gold SJ, etal., J Neurochem. 2002 Aug;82(4):828-38.
12. RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia. Gu Z, etal., Mol Pharmacol. 2007 Apr;71(4):1030-9. doi: 10.1124/mol.106.032490. Epub 2007 Jan 12.
13. CASK associates with glutamate receptor interacting protein and signaling molecules. Hong CJ and Hsueh YP, Biochem Biophys Res Commun. 2006 Dec 22;351(3):771-6. Epub 2006 Oct 30.
14. Expression of RGS2, RGS4 and RGS7 in the developing postnatal brain. Ingi T and Aoki Y, Eur J Neurosci. 2002 Mar;15(5):929-36.
15. RGS2 and RGS4 modulate melatonin-induced potentiation of glycine currents in rat retinal ganglion cells. Ji M, etal., Brain Res. 2011 Sep 9;1411:1-8. doi: 10.1016/j.brainres.2011.07.008. Epub 2011 Jul 13.
16. RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease. Ko WK, etal., Neurobiol Dis. 2014 Oct;70:138-48. doi: 10.1016/j.nbd.2014.06.013. Epub 2014 Jun 24.
17. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Koelle MR and Horvitz HR, Cell 1996 Jan 12;84(1):115-25.
18. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
19. Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7. Lan KL, etal., J Biol Chem. 2000 Oct 27;275(43):33497-503. doi: 10.1074/jbc.M005785200.
20. Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence. Lin TC, etal., Epilepsy Behav. 2009 Feb;14(2):316-23. doi: 10.1016/j.yebeh.2008.12.005. Epub 2009 Jan 4.
21. Chronic intermittent ethanol exposure selectively alters the expression of Ga subunit isoforms and RGS subtypes in rat prefrontal cortex. Luessen DJ, etal., Brain Res. 2017 Oct 1;1672:106-112. doi: 10.1016/j.brainres.2017.07.014. Epub 2017 Jul 21.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. RGS4 exerts inhibitory activities on the signaling of dopamine D2 receptor and D3 receptor through the N-terminal region. Min C, etal., Pharmacol Res. 2012 Feb;65(2):213-20. doi: 10.1016/j.phrs.2011.08.008. Epub 2011 Aug 31.
24. The antiepileptogenic effect of low-frequency stimulation on perforant path kindling involves changes in regulators of G-protein signaling in rat. Namvar S, etal., J Neurol Sci. 2017 Apr 15;375:450-459. doi: 10.1016/j.jns.2017.02.047. Epub 2017 Feb 22.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Differential regulation of RGS proteins in the prefrontal cortex of short- and long-term human opiate abusers. Rivero G, etal., Neuropharmacology. 2012 Feb;62(2):1044-51. doi: 10.1016/j.neuropharm.2011.10.015. Epub 2011 Oct 31.
31. Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986. Roman DL, etal., Mol Pharmacol. 2010 Sep;78(3):360-5. doi: 10.1124/mol.109.063388. Epub 2010 Jun 7.
32. Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum. Schwendt M, etal., Neuroreport. 2007 Aug 6;18(12):1261-5. doi: 10.1097/WNR.0b013e328240507a.
33. Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes. Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
34. Mechanism of RGS4, a GTPase-activating protein for G protein alpha subunits. Srinivasa SP, etal., J Biol Chem. 1998 Jan 16;273(3):1529-33.
35. RGS Proteins in Heart: Brakes on the Vagus. Stewart A, etal., Front Physiol. 2012 Apr 13;3:95. doi: 10.3389/fphys.2012.00095. eCollection 2012.
36. The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Sun H, etal., Neuroscience. 2015 Oct 29;307:253-61. doi: 10.1016/j.neuroscience.2015.08.053. Epub 2015 Aug 28.
37. A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity. Taccola G, etal., Exp Neurol. 2016 Dec;286:1-11. doi: 10.1016/j.expneurol.2016.09.008. Epub 2016 Sep 15.
38. RGS4 inhibits G-protein signaling in cardiomyocytes. Tamirisa P, etal., Circulation. 1999 Jan 26;99(3):441-7.
39. Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions. Taymans JM, etal., J Neurochem 2003 Mar;84(5):1118-27.
40. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
41. Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Tesmer JJ, etal., Cell. 1997 Apr 18;89(2):251-61.
42. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Wang L, etal., Proc Natl Acad Sci U S A 2001 Mar 13;98(6):3220-5.
43. Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. Yono M, etal., BJU Int. 2010 Mar;105(6):877-83. doi: 10.1111/j.1464-410X.2009.08809.x. Epub 2009 Aug 18.
44. Antihypertensive effects of peroxisome proliferator-activated receptor-beta activation in spontaneously hypertensive rats. Zarzuelo MJ, etal., Hypertension. 2011 Oct;58(4):733-43. doi: 10.1161/HYPERTENSIONAHA.111.174490. Epub 2011 Aug 8.
Additional References at PubMed
PMID:9353196   PMID:10702309   PMID:10791963   PMID:12604710   PMID:15793568   PMID:16539683   PMID:17060050   PMID:18207159   PMID:19324084   PMID:20630860   PMID:21367864   PMID:22193724  
PMID:22970249   PMID:23977258   PMID:26119705   PMID:26478461   PMID:32779957   PMID:34450404   PMID:36793204  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81384,469,593 - 84,475,884 (-)NCBIGRCr8
mRatBN7.21381,936,775 - 81,943,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1381,936,775 - 81,943,068 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1384,564,610 - 84,570,879 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01385,857,386 - 85,863,677 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,089,853 - 83,096,122 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01388,054,817 - 88,061,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1388,054,817 - 88,061,108 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01392,682,956 - 92,689,247 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41385,533,882 - 85,540,173 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11385,548,069 - 85,554,361 (-)NCBI
Celera1381,602,391 - 81,608,682 (-)NCBICelera
RH 3.4 Map13510.9RGD
Cytogenetic Map13q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381163,068,871 - 163,076,802 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,068,775 - 163,076,802 (+)EnsemblGRCh38hg38GRCh38
GRCh371163,038,661 - 163,046,592 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,305,285 - 161,313,216 (+)NCBINCBI36Build 36hg18NCBI36
Build 341159,770,808 - 159,778,036NCBI
Celera1136,142,715 - 136,150,908 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1134,283,724 - 134,291,924 (+)NCBIHuRef
CHM1_11164,461,279 - 164,469,481 (+)NCBICHM1_1
T2T-CHM13v2.01162,413,422 - 162,421,357 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391169,569,046 - 169,575,211 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,569,046 - 169,575,211 (-)EnsemblGRCm39 Ensembl
GRCm381169,741,477 - 169,747,642 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,741,477 - 169,747,642 (-)EnsemblGRCm38mm10GRCm38
MGSCv371171,671,608 - 171,677,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361171,578,350 - 171,584,295 (-)NCBIMGSCv36mm8
Celera1172,167,498 - 172,173,650 (-)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map176.84NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495546213,338,960 - 13,347,610 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546213,340,812 - 13,347,598 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2186,701,675 - 86,709,417 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1186,370,272 - 86,378,015 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01138,488,317 - 138,496,497 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11142,284,040 - 142,292,225 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1142,284,040 - 142,292,225 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13819,771,454 - 19,778,917 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3819,771,441 - 19,779,190 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3819,826,659 - 19,834,129 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03819,854,868 - 19,862,329 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3819,824,617 - 19,862,433 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13819,830,174 - 19,837,642 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03820,181,940 - 20,189,434 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03820,473,021 - 20,480,491 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024409344103,671,010 - 103,678,611 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937238102,061 - 109,474 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937238101,948 - 109,513 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl487,383,345 - 87,390,893 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1487,383,336 - 87,390,478 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2495,096,206 - 95,103,332 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12565,729,344 - 65,735,278 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2565,726,394 - 65,735,381 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605567,526,009 - 67,532,206 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248261,569,854 - 1,579,627 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248261,570,143 - 1,577,300 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Rgs4
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:329
Count of miRNA genes:207
Interacting mature miRNAs:254
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,938,701 - 81,938,885 (+)MAPPERmRatBN7.2
Rnor_6.01388,056,744 - 88,056,927NCBIRnor6.0
Rnor_5.01392,684,883 - 92,685,066UniSTSRnor5.0
RGSC_v3.41385,535,809 - 85,535,992UniSTSRGSC3.4
Celera1381,604,318 - 81,604,501UniSTS
RH 3.4 Map13516.8UniSTS
Cytogenetic Map13q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,937,024 - 81,937,191 (+)MAPPERmRatBN7.2
Rnor_6.01388,055,067 - 88,055,233NCBIRnor6.0
Rnor_5.01392,683,206 - 92,683,372UniSTSRnor5.0
RGSC_v3.41385,534,132 - 85,534,298UniSTSRGSC3.4
Celera1381,602,641 - 81,602,807UniSTS
RH 3.4 Map13510.9UniSTS
Cytogenetic Map13q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,937,579 - 81,937,708 (+)MAPPERmRatBN7.2
Rnor_6.01388,055,622 - 88,055,750NCBIRnor6.0
Rnor_5.01392,683,761 - 92,683,889UniSTSRnor5.0
RGSC_v3.41385,534,687 - 85,534,815UniSTSRGSC3.4
Celera1381,603,196 - 81,603,324UniSTS
RH 3.4 Map13510.9UniSTS
Cytogenetic Map13q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,937,094 - 81,937,295 (+)MAPPERmRatBN7.2
Rnor_6.01388,055,137 - 88,055,337NCBIRnor6.0
Rnor_5.01392,683,276 - 92,683,476UniSTSRnor5.0
RGSC_v3.41385,534,202 - 85,534,402UniSTSRGSC3.4
Celera1381,602,711 - 81,602,911UniSTS
RH 3.4 Map13513.5UniSTS
Cytogenetic Map13q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,939,015 - 81,939,116 (+)MAPPERmRatBN7.2
Rnor_6.01388,057,058 - 88,057,158NCBIRnor6.0
Rnor_5.01392,685,197 - 92,685,297UniSTSRnor5.0
RGSC_v3.41385,536,123 - 85,536,223UniSTSRGSC3.4
Celera1381,604,632 - 81,604,732UniSTS
Cytogenetic Map13q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,939,658 - 81,940,647 (+)MAPPERmRatBN7.2
Rnor_6.01388,057,701 - 88,058,687NCBIRnor6.0
Rnor_5.01392,685,840 - 92,686,826UniSTSRnor5.0
RGSC_v3.41385,536,766 - 85,537,752UniSTSRGSC3.4
Celera1381,605,275 - 81,606,261UniSTS
Cytogenetic Map13q24UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 35 16 8 6 6 62 7 21 4 6
Low 1 8 30 30 11 30 2 5 12 28 20 7 2
Below cutoff 11 11 11


RefSeq Acc Id: ENSRNOT00000003774   ⟹   ENSRNOP00000003774
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1381,936,775 - 81,943,068 (-)Ensembl
Rnor_6.0 Ensembl1388,054,817 - 88,061,108 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098564   ⟹   ENSRNOP00000076439
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1381,936,775 - 81,941,037 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117519   ⟹   ENSRNOP00000089881
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1381,939,135 - 81,943,068 (-)Ensembl
RefSeq Acc Id: NM_017214   ⟹   NP_058910
Rat AssemblyChrPosition (strand)Source
GRCr81384,469,593 - 84,475,884 (-)NCBI
mRatBN7.21381,936,775 - 81,943,068 (-)NCBI
Rnor_6.01388,054,817 - 88,061,108 (-)NCBI
Rnor_5.01392,682,956 - 92,689,247 (-)NCBI
RGSC_v3.41385,533,882 - 85,540,173 (-)RGD
Celera1381,602,391 - 81,608,682 (-)RGD
RefSeq Acc Id: NP_058910   ⟸   NM_017214
- UniProtKB: P49799 (UniProtKB/Swiss-Prot),   A6IDM9 (UniProtKB/TrEMBL),   A0A8I5Y8W6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003774   ⟸   ENSRNOT00000003774
RefSeq Acc Id: ENSRNOP00000076439   ⟸   ENSRNOT00000098564
RefSeq Acc Id: ENSRNOP00000089881   ⟸   ENSRNOT00000117519
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49799-F1-model_v2 AlphaFold P49799 1-205 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698980
Promoter ID:EPDNEW_R9505
Type:single initiation site
Description:regulator of G-protein signaling 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01388,061,119 - 88,061,179EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3567 AgrOrtholog
BioCyc Gene G2FUF-17491 BioCyc
Ensembl Genes ENSRNOG00000002773 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023189 UniProtKB/Swiss-Prot
  ENSRNOG00060021688 UniProtKB/Swiss-Prot
  ENSRNOG00065020135 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003774 ENTREZGENE
  ENSRNOT00000003774.3 UniProtKB/Swiss-Prot
  ENSRNOT00000098564.1 UniProtKB/TrEMBL
  ENSRNOT00000117519.1 UniProtKB/TrEMBL
  ENSRNOT00055039881 UniProtKB/Swiss-Prot
  ENSRNOT00060037671 UniProtKB/Swiss-Prot
  ENSRNOT00065033993 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_RGS4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10845:SF184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rgs4 PhenoGen
PROSITE RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002773 RatGTEx
  ENSRNOG00055023189 RatGTEx
  ENSRNOG00060021688 RatGTEx
  ENSRNOG00065020135 RatGTEx
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216573
  P49799 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rgs4  regulator of G-protein signaling 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function may interact with heterotrimeric G protein alpha subunits and function as a GAP 69961