Rgs4 (regulator of G-protein signaling 4) - Rat Genome Database

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Gene: Rgs4 (regulator of G-protein signaling 4) Rattus norvegicus
Analyze
Symbol: Rgs4
Name: regulator of G-protein signaling 4
RGD ID: 3567
Description: Exhibits G-protein alpha-subunit binding activity and GTPase activator activity. Involved in several processes, including negative regulation of cation transmembrane transport; regulation of signal transduction; and response to alkaloid. Localizes to several cellular components, including cytosol; nucleus; and plasma membrane. Used to study epilepsy. Biomarker of bladder disease; hypertension; lesion of sciatic nerve; opioid abuse; and status epilepticus. Orthologous to human RGS4 (regulator of G protein signaling 4); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH (S)-amphetamine; 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: RGP4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21381,936,775 - 81,943,103 (-)NCBI
Rnor_6.0 Ensembl1388,054,817 - 88,061,108 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01388,054,817 - 88,061,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01392,682,956 - 92,689,247 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41385,533,882 - 85,540,173 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11385,548,069 - 85,554,361 (-)NCBI
Celera1381,602,391 - 81,608,682 (-)NCBICelera
RH 3.4 Map13510.9RGD
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (EXP)
(S)-timolol (anhydrous)  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
diazinon  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
diquat  (ISO)
doramapimod  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
formaldehyde  (ISO)
haloperidol  (EXP)
irinotecan  (EXP)
lipopolysaccharide  (EXP)
lithium chloride  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
morphine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
oxaliplatin  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
prednisolone  (EXP,ISO)
progesterone  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
reserpine  (EXP)
resveratrol  (EXP)
sarin  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
Soman  (EXP)
T-2 toxin  (EXP)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

References

References - curated
1. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
2. Blazer LL, etal., ACS Chem Neurosci. 2015 Jun 17;6(6):911-9. doi: 10.1021/acschemneuro.5b00063. Epub 2015 Apr 20.
3. Bodle CR, etal., Anal Biochem. 2017 Apr 1;522:10-17. doi: 10.1016/j.ab.2017.01.013. Epub 2017 Jan 20.
4. Carrasco GA, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):1012-9. Epub 2003 Oct 8.
5. Chen IS, etal., J Physiol. 2014 Mar 15;592(6):1237-48. doi: 10.1113/jphysiol.2013.269803. Epub 2014 Jan 13.
6. Costigan M, etal., Mol Cell Neurosci. 2003 Sep;24(1):106-16.
7. Ding J, etal., Nat Neurosci. 2006 Jun;9(6):832-42. doi: 10.1038/nn1700. Epub 2006 May 14.
8. Druey KM, etal., Nature 1996 Feb 22;379(6567):742-6.
9. GOA data from the GO Consortium
10. Gold SJ, etal., Eur J Neurosci. 2003 Mar;17(5):971-80.
11. Gold SJ, etal., J Neurochem. 2002 Aug;82(4):828-38.
12. Gu Z, etal., Mol Pharmacol. 2007 Apr;71(4):1030-9. doi: 10.1124/mol.106.032490. Epub 2007 Jan 12.
13. Ingi T and Aoki Y, Eur J Neurosci. 2002 Mar;15(5):929-36.
14. Ji M, etal., Brain Res. 2011 Sep 9;1411:1-8. doi: 10.1016/j.brainres.2011.07.008. Epub 2011 Jul 13.
15. Ko WK, etal., Neurobiol Dis. 2014 Oct;70:138-48. doi: 10.1016/j.nbd.2014.06.013. Epub 2014 Jun 24.
16. Koelle MR and Horvitz HR, Cell 1996 Jan 12;84(1):115-25.
17. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
18. Lan KL, etal., J Biol Chem. 2000 Oct 27;275(43):33497-503. doi: 10.1074/jbc.M005785200.
19. Lin TC, etal., Epilepsy Behav. 2009 Feb;14(2):316-23. doi: 10.1016/j.yebeh.2008.12.005. Epub 2009 Jan 4.
20. Luessen DJ, etal., Brain Res. 2017 Oct 1;1672:106-112. doi: 10.1016/j.brainres.2017.07.014. Epub 2017 Jul 21.
21. MGD data from the GO Consortium
22. Min C, etal., Pharmacol Res. 2012 Feb;65(2):213-20. doi: 10.1016/j.phrs.2011.08.008. Epub 2011 Aug 31.
23. Namvar S, etal., J Neurol Sci. 2017 Apr 15;375:450-459. doi: 10.1016/j.jns.2017.02.047. Epub 2017 Feb 22.
24. NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. OMIM Disease Annotation Pipeline
26. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
27. RGD automated data pipeline
28. RGD automated import pipeline for gene-chemical interactions
29. Rivero G, etal., Neuropharmacology. 2012 Feb;62(2):1044-51. doi: 10.1016/j.neuropharm.2011.10.015. Epub 2011 Oct 31.
30. Roman DL, etal., Mol Pharmacol. 2010 Sep;78(3):360-5. doi: 10.1124/mol.109.063388. Epub 2010 Jun 7.
31. Schwendt M, etal., Neuroreport. 2007 Aug 6;18(12):1261-5. doi: 10.1097/WNR.0b013e328240507a.
32. Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
33. Srinivasa SP, etal., J Biol Chem. 1998 Jan 16;273(3):1529-33.
34. Stewart A, etal., Front Physiol. 2012 Apr 13;3:95. doi: 10.3389/fphys.2012.00095. eCollection 2012.
35. Sun H, etal., Neuroscience. 2015 Oct 29;307:253-61. doi: 10.1016/j.neuroscience.2015.08.053. Epub 2015 Aug 28.
36. Taccola G, etal., Exp Neurol. 2016 Dec;286:1-11. doi: 10.1016/j.expneurol.2016.09.008. Epub 2016 Sep 15.
37. Tamirisa P, etal., Circulation. 1999 Jan 26;99(3):441-7.
38. Taymans JM, etal., J Neurochem 2003 Mar;84(5):1118-27.
39. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
40. Tesmer JJ, etal., Cell. 1997 Apr 18;89(2):251-61.
41. Wang L, etal., Proc Natl Acad Sci U S A 2001 Mar 13;98(6):3220-5.
42. Yono M, etal., BJU Int. 2010 Mar;105(6):877-83. doi: 10.1111/j.1464-410X.2009.08809.x. Epub 2009 Aug 18.
43. Zarzuelo MJ, etal., Hypertension. 2011 Oct;58(4):733-43. doi: 10.1161/HYPERTENSIONAHA.111.174490. Epub 2011 Aug 8.
Additional References at PubMed
PMID:9353196   PMID:10702309   PMID:10791963   PMID:12604710   PMID:15793568   PMID:16539683   PMID:17060050   PMID:18207159   PMID:19324084   PMID:20630860   PMID:21367864   PMID:22193724  
PMID:22970249   PMID:23977258   PMID:26119705   PMID:26478461  


Genomics

Comparative Map Data
Rgs4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21381,936,775 - 81,943,103 (-)NCBI
Rnor_6.0 Ensembl1388,054,817 - 88,061,108 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01388,054,817 - 88,061,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01392,682,956 - 92,689,247 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41385,533,882 - 85,540,173 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11385,548,069 - 85,554,361 (-)NCBI
Celera1381,602,391 - 81,608,682 (-)NCBICelera
RH 3.4 Map13510.9RGD
Cytogenetic Map13q24NCBI
RGS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1163,068,775 - 163,076,802 (+)EnsemblGRCh38hg38GRCh38
GRCh381163,068,871 - 163,076,802 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371163,038,661 - 163,046,592 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,305,285 - 161,313,216 (+)NCBINCBI36hg18NCBI36
Build 341159,770,808 - 159,778,036NCBI
Celera1136,142,715 - 136,150,908 (+)NCBI
Cytogenetic Map1q23.3NCBI
HuRef1134,283,724 - 134,291,924 (+)NCBIHuRef
CHM1_11164,461,279 - 164,469,481 (+)NCBICHM1_1
Rgs4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,569,046 - 169,575,211 (-)NCBIGRCm39mm39
GRCm39 Ensembl1169,569,046 - 169,575,211 (-)Ensembl
GRCm381169,741,477 - 169,747,642 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,741,477 - 169,747,642 (-)EnsemblGRCm38mm10GRCm38
MGSCv371171,671,608 - 171,677,773 (-)NCBIGRCm37mm9NCBIm37
MGSCv361171,578,350 - 171,584,295 (-)NCBImm8
Celera1172,167,498 - 172,173,650 (-)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map176.84NCBI
Rgs4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546213,338,960 - 13,347,610 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546213,340,812 - 13,347,598 (-)NCBIChiLan1.0ChiLan1.0
RGS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11142,284,040 - 142,292,225 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1142,284,040 - 142,292,225 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01138,488,317 - 138,496,497 (+)NCBIMhudiblu_PPA_v0panPan3
RGS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13819,771,454 - 19,778,917 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3819,771,441 - 19,779,190 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3819,826,659 - 19,834,129 (-)NCBI
ROS_Cfam_1.03819,854,868 - 19,862,329 (-)NCBI
UMICH_Zoey_3.13819,830,174 - 19,837,642 (-)NCBI
UNSW_CanFamBas_1.03820,181,940 - 20,189,434 (-)NCBI
UU_Cfam_GSD_1.03820,473,021 - 20,480,491 (-)NCBI
Rgs4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344103,671,010 - 103,678,611 (-)NCBI
SpeTri2.0NW_004937238101,948 - 109,513 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl487,381,386 - 87,390,467 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1487,383,336 - 87,390,478 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2495,096,206 - 95,103,332 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGS4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12565,729,344 - 65,735,278 (-)NCBI
ChlSab1.1 Ensembl2565,726,394 - 65,735,381 (-)Ensembl
Rgs4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248261,570,143 - 1,577,300 (+)NCBI

Position Markers
RH133702  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01388,056,744 - 88,056,927NCBIRnor6.0
Rnor_5.01392,684,883 - 92,685,066UniSTSRnor5.0
RGSC_v3.41385,535,809 - 85,535,992UniSTSRGSC3.4
Celera1381,604,318 - 81,604,501UniSTS
RH 3.4 Map13516.8UniSTS
Cytogenetic Map13q24UniSTS
RH142220  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01388,055,067 - 88,055,233NCBIRnor6.0
Rnor_5.01392,683,206 - 92,683,372UniSTSRnor5.0
RGSC_v3.41385,534,132 - 85,534,298UniSTSRGSC3.4
Celera1381,602,641 - 81,602,807UniSTS
RH 3.4 Map13510.9UniSTS
Cytogenetic Map13q24UniSTS
RH140719  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01388,055,622 - 88,055,750NCBIRnor6.0
Rnor_5.01392,683,761 - 92,683,889UniSTSRnor5.0
RGSC_v3.41385,534,687 - 85,534,815UniSTSRGSC3.4
Celera1381,603,196 - 81,603,324UniSTS
RH 3.4 Map13510.9UniSTS
Cytogenetic Map13q24UniSTS
RH141357  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01388,055,137 - 88,055,337NCBIRnor6.0
Rnor_5.01392,683,276 - 92,683,476UniSTSRnor5.0
RGSC_v3.41385,534,202 - 85,534,402UniSTSRGSC3.4
Celera1381,602,711 - 81,602,911UniSTS
RH 3.4 Map13513.5UniSTS
Cytogenetic Map13q24UniSTS
AA004315  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01388,057,058 - 88,057,158NCBIRnor6.0
Rnor_5.01392,685,197 - 92,685,297UniSTSRnor5.0
RGSC_v3.41385,536,123 - 85,536,223UniSTSRGSC3.4
Celera1381,604,632 - 81,604,732UniSTS
Cytogenetic Map13q24UniSTS
MARC_16101-16102:1018026133:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01388,057,701 - 88,058,687NCBIRnor6.0
Rnor_5.01392,685,840 - 92,686,826UniSTSRnor5.0
RGSC_v3.41385,536,766 - 85,537,752UniSTSRGSC3.4
Celera1381,605,275 - 81,606,261UniSTS
Cytogenetic Map13q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135108098996080989Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135156924896569248Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)135157782490675199Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1357903612102903612Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1362975663107975663Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136500824591629354Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1366971778111971778Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137456837892916783Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137456837892916783Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137456837892916783Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1379567081103613733Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)138040355991629354Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1380403559108770687Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1386833393114033958Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:329
Count of miRNA genes:207
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000003774
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 35 16 8 6 6 62 7 21 4 6
Low 1 8 30 30 11 30 2 5 12 28 20 7 2
Below cutoff 11 11 11

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003774   ⟹   ENSRNOP00000003774
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1388,054,817 - 88,061,108 (-)Ensembl
RefSeq Acc Id: NM_017214   ⟹   NP_058910
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21381,936,775 - 81,943,068 (-)NCBI
Rnor_6.01388,054,817 - 88,061,108 (-)NCBI
Rnor_5.01392,682,956 - 92,689,247 (-)NCBI
RGSC_v3.41385,533,882 - 85,540,173 (-)RGD
Celera1381,602,391 - 81,608,682 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090639   ⟹   XP_038946567
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21381,939,034 - 81,943,103 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058910   ⟸   NM_017214
- UniProtKB: P49799 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003774   ⟸   ENSRNOT00000003774
RefSeq Acc Id: XP_038946567   ⟸   XM_039090639
- Peptide Label: isoform X1
Protein Domains
RGS

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698980
Promoter ID:EPDNEW_R9505
Type:single initiation site
Name:Rgs4_1
Description:regulator of G-protein signaling 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01388,061,119 - 88,061,179EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3567 AgrOrtholog
Ensembl Genes ENSRNOG00000002773 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000003774 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003774 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.196.10 UniProtKB/Swiss-Prot
InterPro RGS UniProtKB/Swiss-Prot
  RGS4 UniProtKB/Swiss-Prot
  RGS_RGS4 UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdom1/3 UniProtKB/Swiss-Prot
KEGG Report rno:29480 UniProtKB/Swiss-Prot
NCBI Gene 29480 ENTREZGENE
PANTHER PTHR10845:SF184 UniProtKB/Swiss-Prot
Pfam RGS UniProtKB/Swiss-Prot
PhenoGen Rgs4 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot
PROSITE RGS UniProtKB/Swiss-Prot
SMART RGS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot
TIGR TC216573
UniProt P49799 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rgs4  regulator of G-protein signaling 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function may interact with heterotrimeric G protein alpha subunits and function as a GAP 69961