CALCIUM SIGNALING PATHWAY VIA THE CALCIUM-SENSING RECEPTOR (PW:0001141)

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Description

Calcium (Ca2+) signaling via the calcium-sensing receptor (Casr) exerts important roles in calcium homeostasis; it inhibits the secretion of parathyroid hormone (PTH) in parathyroid glands and regulates calcium absorption and water balance in the kidney, the two tissues where the receptor is most abundantly expressed. The function of Casr is also important for the proper functioning of cells involved in bone remodeling and of many types of neural cells, among others. In addition to Ca2+, the re

Pathway Diagram:

Ariadne Genomics Inc. Arrb2 Arrb1 G protein mediated signaling pathway via Galphai family --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway DAG IP3 Flna Rhoa increased DAG/IP3 via PLC activation Arrb2 ---- Casr Arrb1 ---- Casr Casr ---| parathyroid hormone signaling pathway Casr ---| PTH secretion Ca absoprtion, water balance calcimimetics ---- Casr calcilytics ---- Casr calcimimetics --+> Casr calcilytics ---| Casr Ca2+ ---- Casr G protein mediated signaling pathway via Galphaq family ---> increased DAG/IP3 via PLC activation Casr ---- Casr binding partners Casr ---> Ca absoprtion, water balance Casr --+> G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphaq family --+> Rho/Rac/Cdc42 mediated signaling pathway G protein mediated signaling pathway via Galpha12/Galpha13 family --+> Rho/Rac/Cdc42 mediated signaling pathway inhibition of adenylyl cyclases/decreased cAMP G protein mediated signaling pathway via Galphai family ---> inhibition of adenylyl cyclases/decreased cAMP RGS proteins ---| G protein mediated signaling pathway via Galphai family Arrb1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Arrb2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Casr RGS proteins ---| G protein mediated signaling pathway via Galphaq family RGS proteins ---| G protein mediated signaling pathway via Galpha12/Galpha13 family Casr ---- Flna G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galpha12/Galpha13 family Rho/Rac/Cdc42 mediated signaling pathway protein kinase C (PKC) signaling pathway parathyroid hormone signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway Casr binding partners GRKs RGS proteins receptor desensitization PTH secretion calcimimetics calcilytics Ca2+ Casr --+> G protein mediated signaling pathway via Galphai family Casr --+> G protein mediated signaling pathway via Galpha12/Galpha13 family G protein mediated signaling pathway via Galphaq family --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway increased DAG/IP3 via PLC activation --+> protein kinase C (PKC) signaling pathway GRKs ---| Casr
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Genes in Pathway:

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calcium signaling pathway via the calcium-sensing receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:7207060
RGD:7207059
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:7207060
RGD:7207059
G Casr calcium-sensing receptor JBrowse link 11 67,188,204 67,262,261 RGD:7207059
RGD:7207227
RGD:7207060
G Flna filamin A JBrowse link X 156,460,785 156,487,245 RGD:7207227
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:7207060
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:7207060
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 14 81,261,708 81,339,516 RGD:7207060
G Rgs12 regulator of G-protein signaling 12 JBrowse link 14 80,975,239 81,069,519 RGD:7207227
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:7207227
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:7207227
G Rgs5 regulator of G-protein signaling 5 JBrowse link 13 87,966,820 88,002,831 RGD:7207228
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:7207227

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassGRKsG-protein coupled kinases
Gene GroupCasr binding partnersOther proteins interacting with Casr
Functional ClassRGS proteinsRegulators of G-protein signaling

Pathway Gene Annotations

Disease Annotations Associated with Genes in the calcium signaling pathway via the calcium-sensing receptor
Disease TermsGene Symbols
Abnormalities, Drug-InducedRhoa
acute myeloid leukemiaRgs2
AlbuminuriaCasr
allergic contact dermatitisGrk2
amphetamine abuseArrb2
AneurysmFlna
Animal Disease ModelsRhoa
aortic aneurysmFlna
Arterial ThrombosisFlna
arterial tortuosity syndromeFlna
Arteriovenous FistulaArrb1 , Arrb2
asthmaRhoa
atherosclerosisCasr
autosomal dominant hypocalcemiaCasr
autosomal dominant hypocalcemia 1Casr
Autosomal Dominant Hypocalcemia, with Bartter SyndromeCasr
autosomal recessive limb-girdle muscular dystrophy type 2AFlna
bipolar disorderGrk3
bladder diseaseRgs2 , Rgs4
Brain InjuriesRhoa
breast cancerRhoa
Breast NeoplasmsFlna , Rgs2 , Rhoa
BurnsGrk2
carcinomaRhoa
Cardiac Valvular Dysplasia, X-LinkedFlna
CardiomegalyGrk2 , Grk3 , Rhoa
cardiomyopathyCasr , Grk2
cardiovascular system diseaseGrk2
Chemical and Drug Induced Liver InjuryGrk4
cleft palateFlna
colitisArrb1
colorectal cancerRhoa
Colorectal NeoplasmsRhoa
Congenital AbnormalitiesGrk2
Congenital Idiopathic Intestinal PseudoobstructionFlna
congestive heart failureArrb1 , Grk2 , Grk3
craniosynostosisFlna
cutaneous T cell lymphomaRhoa
Diabetic CardiomyopathiesCasr
Drug-Induced DyskinesiaRgs4
Ehlers-Danlos Syndrome Classic TypeFlna
Embryo LossGrk2
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsFlna
end stage renal failureCasr
endometriosisRgs4
epilepsyFlna , Rgs4
esophageal carcinomaRhoa
Esophageal NeoplasmsRhoa
essential hypertensionGrk4 , Rgs5
Experimental ArthritisArrb1 , Arrb2 , Grk2
Experimental Autoimmune EncephalomyelitisRhoa
Experimental Autoimmune NeuritisRhoa
Experimental Diabetes MellitusCasr , Rhoa
Experimental Liver CirrhosisArrb2 , Flna , Grk2 , Rgs2 , Rgs5 , Rhoa
Experimental SeizuresRgs4
familial hypocalciuric hypercalcemiaCasr
familial hypocalciuric hypercalcemia 1Casr
Familial Thoracic Aortic Aneurysm 2Flna
female stress incontinenceRgs2
FG syndromeFlna
FibrosisRhoa
Frontometaphyseal DysplasiaFlna
gastric adenocarcinomaRhoa
genetic diseaseCasr , Flna , Rhoa
Germ Cell and Embryonal NeoplasmsRhoa
glomerulosclerosisRgs2
head and neck squamous cell carcinomaRhoa
Hearing Loss, ConductiveFlna
Hernias, Diaphragmatic, CongenitalRhoa
HyperalgesiaGrk2 , Rgs4
hypercalcemiaCasr
HypercalciuriaCasr
Hypercalciuric HypercalcemiaCasr
hyperglycemiaGrk2
HyperparathyroidismCasr
Hyperparathyroidism, Neonatal Severe PrimaryCasr
hypertensionArrb2 , Grk2 , Grk3 , Rgs2 , Rgs4 , Rgs5 , Rhoa
Hypertrophy, Left VentricularGrk2 , Rhoa
HypocalcemiaCasr
hypoparathyroidismCasr
Hypoparathyroidism Familial IsolatedCasr
hypothyroidismGrk3
HypoxiaCasr
idiopathic generalized epilepsyCasr
Immunoblastic LymphadenopathyRhoa
Insulin ResistanceGrk2
intellectual disabilityCasr
intestinal pseudo-obstructionFlna
lesion of sciatic nerveRgs4
Limb IschemiaGrk2
liver cirrhosisArrb1 , Rgs2
Liver Neoplasms, ExperimentalArrb2
lung adenocarcinomaRhoa
Lymphatic MetastasisRhoa
major depressive disorderArrb1
Malformations of Cortical Development, Group IIFlna
Marfan syndromeFlna
membranous glomerulonephritisRhoa
mitral valve prolapseFlna
multiple sclerosisRhoa
myocardial infarctionCasr
Myocardial Reperfusion InjuryArrb2 , Casr , Grk2 , Rhoa
Neoplasm InvasivenessRhoa
Neoplasm MetastasisRhoa
nephrolithiasisCasr
Nephrolithiasis, Calcium OxalateCasr
Niemann-Pick disease type C1Flna
non-Hodgkin lymphomaRhoa
obesityRhoa
opioid abuseRgs2 , Rgs4
Optic Nerve InjuriesRhoa
osteochondrodysplasiaFlna
Oto-Palato-Digital Syndrome Type 1Flna
Oto-Palato-Digital Syndrome, Type 2Flna
Otopalatodigital Spectrum DisorderFlna
Ovarian NeoplasmsRhoa
parathyroid adenomaCasr
Parkinson's diseaseGrk2 , Grk3
Parkinsonian DisordersRgs4
peripheral T-cell lymphomaRhoa
periventricular nodular heterotopiaFlna
Periventricular Nodular Heterotopia 4Flna
Phyllodes TumorFlna
portal hypertensionArrb2 , Grk2
prostate cancerCasr
proteinuriaRhoa
PruritusGrk2
pulmonary hypertensionCasr , Rhoa
renal fibrosisArrb2
rheumatoid arthritisGrk2
ricketsCasr
schizophreniaRgs12 , Rgs4
schizophrenia 9Rgs4
scoliosisFlna
secondary hyperparathyroidismCasr
secondary Parkinson diseaseRgs2
SepsisGrk2
Stargardt diseaseFlna
Stargardt Disease 1Flna
status epilepticusRgs4
Stomach NeoplasmsRgs2 , Rhoa
T-Cell LymphomaRhoa
Terminal Osseous Dysplasia and Pigmentary DefectsFlna
Transplant RejectionArrb1 , Arrb2
tuberous sclerosisFlna
type 2 diabetes mellitusArrb2
urinary bladder cancerRhoa
Urologic NeoplasmsRhoa
Vascular System InjuriesGrk2
visual epilepsyFlna
Wolff-Parkinson-White syndromeFlna
Pathway Annotations Associated with Genes in the calcium signaling pathway via the calcium-sensing receptor
Pathway TermsGene Symbols
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2 , Rgs2 , Rgs4
angiotensin II signaling pathway via AT1 receptorArrb1 , Arrb2 , Grk2 , Grk3 , Rgs2
calcium signaling pathway via the calcium-sensing receptorArrb1 , Arrb2 , Casr , Flna , Grk2 , Grk3 , Grk4 , Rgs12 , Rgs2 , Rgs4 , Rgs5 , Rhoa
chemokine mediated signaling pathwayArrb1 , Arrb2 , Grk2 , Grk3 , Grk4 , Rhoa
colorectal cancer pathwayRhoa
corticotropin-releasing hormone signaling pathwayArrb1 , Arrb2 , Grk3
dopamine signaling pathway via D1 family of receptorsArrb1 , Arrb2 , Grk2 , Grk3 , Rgs2 , Rgs4
dopamine signaling pathway via D2 family of receptorsArrb1 , Arrb2 , Grk2 , Grk3 , Rgs2 , Rgs4
E-cadherin signaling pathwayCasr , Rhoa
eicosanoid signaling pathwayArrb2 , Grk2 , Grk3 , Rhoa
endocytosis pathwayArrb1 , Arrb2 , Grk2 , Grk3 , Grk4 , Rhoa
endothelin signaling pathwayRhoa
ephrin - ephrin receptor bidirectional signaling axisRhoa
epinephrine signaling pathway via adrenergic receptor betaArrb1 , Arrb2 , Grk2
G protein mediated signaling pathwayGrk2 , Grk3
G protein mediated signaling pathway via Galpha12/Galpha13 familyCasr , Rgs12
G protein mediated signaling pathway via Galphai familyCasr , Rgs2 , Rgs4 , Rgs5
G protein mediated signaling pathway via Galphaq familyCasr , Rgs2 , Rgs4 , Rgs5
G protein mediated signaling pathway via Galphas familyGrk2 , Grk3 , Rgs2 , Rgs4
glutamate signaling pathwayGrk2 , Grk3
Hedgehog signaling pathwayArrb2 , Grk2
integrin mediated signaling pathwayFlna
interleukin-2 signaling pathwayRhoa
kinin signaling pathwayArrb1 , Arrb2 , Grk4
mitogen activated protein kinase signaling pathwayArrb1 , Arrb2 , Flna
mTOR signaling pathwayRhoa
N-cadherin signaling pathwayRhoa
neurotrophic factor signaling pathwayRhoa
nuclear factor kappa B signaling pathwayArrb2
parathyroid hormone signaling pathwayArrb1 , Arrb2 , Grk2
phosphatidylinositol 3-kinase class I signaling pathwayRhoa
platelet-derived growth factor signaling pathwayRhoa
Rho/Rac/Cdc42 mediated signaling pathwayFlna , Rhoa
sphingosine 1-phosphate signaling pathwayRhoa
syndecan signaling pathwayRhoa
T cell receptor signaling pathwayRhoa
transforming growth factor-beta Smad dependent signaling pathwayArrb2 , Rhoa
transforming growth factor-beta superfamily mediated signaling pathwayRhoa
tuberculosis pathwayRhoa
vascular endothelial growth factor signaling pathwayRhoa
visual phototransduction pathwayArrb1 , Arrb2
Wnt signaling pathwayRhoa
Wnt signaling, non-canonical pathwayArrb2 , Flna , Rhoa
Wnt signaling, the planar cell polarity pathwayRhoa

References Associated with the calcium signaling pathway via the calcium-sensing receptor:

Ontology Path Diagram:

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