RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: brain infarction
Accession: DOID:3454
browse the term
Definition: Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.
Synonyms: exact_synonym: Anterior Cerebral Circulation Infarction; Anterior Circulation Brain Infarction; Brain Infarctions; Brain Venous Infarction; Brain Venous Infarctions; Posterior Circulation Brain Infarction
primary_id: MESH:D020520 ; RDO:0005165
For additional species annotation, visit the
Alliance of Genome Resources .
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Adipoq
adiponectin, C1Q and collagen domain containing
IDA
RGD
PMID:19362080
RGD:5686830
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Adk
adenosine kinase
ISO IMP
RGD
PMID:16685255 PMID:9731623
RGD:6482657 , RGD:6482667
NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
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Adm
adrenomedullin
treatment
ISO
RGD
PMID:21695352
RGD:5508764
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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Adnp
activity-dependent neuroprotector homeobox
IDA
RGD
PMID:11935065
RGD:1358226
NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312
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Aif1
allograft inflammatory factor 1
IEP ISO
protein:increased expression:brain subventricular zone (rat) protein:increased expression:brain white matter (human)
RGD
PMID:19053043 PMID:10683518
RGD:2313025 , RGD:2313026
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Aldh2
aldehyde dehydrogenase 2 family member
susceptibility
ISO
RGD
PMID:17388993
RGD:1601161
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Alox5ap
arachidonate 5-lipoxygenase activating protein
ISO
associated with Metabolic Syndrome X; DNA:polymorphism:g.162A>C rs4769055 (human)
RGD
PMID:18506375
RGD:2311309
NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
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Becn1
beclin 1
IEP
protein:increased expression:brain
RGD
PMID:22227058
RGD:6483057
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Cfh
complement factor H
treatment
ISO
RGD
PMID:21695352
RGD:5508764
NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
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Ctsb
cathepsin B
IEP
protein:increased expression:cerebral cortical segment, cytoplasm (rat)
RGD
PMID:19941836
RGD:2315502
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Cybb
cytochrome b-245 beta chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19417757
NCBI chr X:13,360,583...13,392,517
Ensembl chr X:13,359,430...13,392,586
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Ece1
endothelin converting enzyme 1
ISO
RGD
PMID:15485550
RGD:1580908
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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Fgf2
fibroblast growth factor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17524524
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Gpr17
G protein-coupled receptor 17
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18974869
NCBI chr18:23,576,212...23,583,177
Ensembl chr18:23,577,242...23,582,966
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Hgf
hepatocyte growth factor
treatment
IDA
RGD
PMID:16421510
RGD:8548626
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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Hnmt
histamine N-methyltransferase
severity
IMP
RGD
PMID:21131122 PMID:16330002
RGD:5509772 , RGD:5509773
NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
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Icam1
intercellular adhesion molecule 1
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum
RGD
PMID:18692933
RGD:2313474
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Igf2
insulin-like growth factor 2
IEP
mRNA, protein:increased expression:brain
RGD
PMID:7770004
RGD:5509999
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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Il15
interleukin 15
ISO
associated with Hypertension;protein:increased expression:serum
RGD
PMID:16109314
RGD:1626610
NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
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Il1b
interleukin 1 beta
IEP
protein:increased expression:cerebral cortex (rat)
RGD
PMID:17678971
RGD:1626644
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Mdk
midkine
IDA
RGD
PMID:15450683
RGD:1582478
NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130
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Mir223
microRNA 223
IEP
RNA:increased expression:brain,blood
RGD
PMID:31342956
RGD:25824952
NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996
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Mmp9
matrix metallopeptidase 9
ISO
RGD
PMID:16599837
RGD:1582617
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Msi1
musashi RNA-binding protein 1
IEP
RGD
PMID:15250238
RGD:1582664
NCBI chr12:41,158,301...41,251,134
Ensembl chr12:41,158,599...41,191,076
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Nes
nestin
IEP
associated with Hypertension
RGD
PMID:16321245
RGD:1642069
NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
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Parg
poly (ADP-ribose) glycohydrolase
IMP
associated with Reperfusion Injury
RGD
PMID:12834903
RGD:2316742
NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273
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Pdgfb
platelet derived growth factor subunit B
IMP
RGD
PMID:14980813
RGD:1581758
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16190367
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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RT1-Ba
RT1 class II, locus Ba
ISO
DNA:polymorphisms (human)
RGD
PMID:11798899
RGD:5147807
NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
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Sirt1
sirtuin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22878646
NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
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Tbxas1
thromboxane A synthase 1
IDA
RGD
PMID:14650360
RGD:1601455
NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
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Htra1
HtrA serine peptidase 1
ISO
ClinVar Annotator: match by term: CARASIL syndrome | ClinVar Annotator: match by term: Cerebrovascular disease with thin skin, alopecia, and disc disease | ClinVar Annotator: match by term: HTRA1-related cerebral small vessel disease
OMIM ClinVar
PMID:11889251 PMID:18316707 PMID:19387015 PMID:21115960 PMID:21482952 PMID:22900900 PMID:23963851 PMID:24500651 PMID:24535794 PMID:25741868 PMID:25770224 PMID:25772074 PMID:25957642 PMID:26063658 PMID:26467025 PMID:27164673 PMID:28492532 PMID:28782182 PMID:29561953 PMID:29895533 PMID:31316458 PMID:32101834 PMID:32581362 PMID:33268848 PMID:34220097 More...
NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379
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A2m
alpha-2-macroglobulin
disease_progression
ISO
RGD
PMID:28266892
RGD:13702087
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Ace
angiotensin I converting enzyme
ISO
DNA:deletion:intron:IVS16+1464-1751del (human) ClinVar Annotator: match by term: Ischemic stroke
ClinVar RGD
PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 PMID:2847529 PMID:2849100 PMID:7593601 PMID:7729604 PMID:7783416 PMID:7854377 PMID:7909524 PMID:8131299 PMID:8131300 PMID:8136829 PMID:8170965 PMID:8208911 PMID:8298638 PMID:8314010 PMID:8541160 PMID:8644984 PMID:8675669 PMID:9120002 PMID:9236417 PMID:9259580 PMID:9699903 PMID:9737775 PMID:9916793 PMID:10099885 PMID:10636736 PMID:10643899 PMID:10841123 PMID:11687636 PMID:11956052 PMID:12220450 PMID:12666117 PMID:14657821 PMID:14872014 PMID:15110771 PMID:15277638 PMID:15381116 PMID:15531537 PMID:15534175 PMID:15635071 PMID:19221299 PMID:11596779 More...
RGD:11038922
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Adora1
adenosine A1 receptor
IDA
RGD
PMID:17067559
RGD:1625229
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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Ager
advanced glycosylation end product-specific receptor
ISO
protein:increased expression:plasma
RGD
PMID:23288172
RGD:8696004
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Alox5ap
arachidonate 5-lipoxygenase activating protein
ISO
OMIM
NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
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Ang
angiogenin
severity
ISO
protein:increased expression:serum
RGD
PMID:17823536
RGD:6892714
NCBI chr15:24,317,733...24,323,361
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Anxa1
annexin A1
treatment
IEP
associated with Ischemic Attack, Transient
RGD
PMID:22617647
RGD:7483559
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Apoa5
apolipoprotein A5
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :-1131T>C (human)
RGD
PMID:19107359
RGD:2313314
NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
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Apob
apolipoprotein B
ISO
protein:increased expression:serum
RGD
PMID:2352345
RGD:2313973
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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Apoe
apolipoprotein E
susceptibility
ISO
DNA:polymorphism: :3932T>C (human)
RGD
PMID:17016617
RGD:1601237
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Brinp3
BMP/retinoic acid inducible neural specific 3
ISO
associated with diabetes mellitus;mRNA:protein:increased expression:blood mononuclear cell:
RGD
PMID:26717922
RGD:14398486
NCBI chr13:58,413,883...58,846,828
Ensembl chr13:58,413,883...58,846,770
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Ccr5
C-C motif chemokine receptor 5
ISO
RGD
PMID:23602964
RGD:8552262
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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Cd36
CD36 molecule
ISO
associated with Hyperlipidemias
RGD
PMID:22718544
RGD:6893487
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Ephx2
epoxide hydrolase 2
IDA
RGD
PMID:16306811
RGD:1580986
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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F2
coagulation factor II
ISO
ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
OMIM ClinVar
PMID:2222810 PMID:2429850 PMID:6305407 PMID:8696333 PMID:8896550 PMID:8916933 PMID:9106528 PMID:9292507 PMID:9462220 PMID:9493607 PMID:9531249 PMID:9569177 PMID:9694698 PMID:9869612 PMID:10027711 PMID:10233438 PMID:10233439 PMID:10336270 PMID:10348710 PMID:10348711 PMID:10348712 PMID:10406905 PMID:10477778 PMID:10544935 PMID:11358905 PMID:11443298 PMID:11506076 PMID:11796466 PMID:11874997 PMID:11904676 PMID:15059842 PMID:15534175 PMID:16493002 PMID:19159930 PMID:19289024 PMID:19531787 PMID:19554541 PMID:19560233 PMID:19652888 PMID:20301327 PMID:21243428 PMID:21349849 PMID:23429074 PMID:24033266 PMID:25741868 PMID:27031503 PMID:28492532 PMID:34355501 More...
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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F5
coagulation factor V
ISO
ClinVar Annotator: match by term: Ischemic stroke
OMIM ClinVar
PMID:7586244 PMID:7803250 PMID:7877648 PMID:7910348 PMID:7911872 PMID:8049422 PMID:8164730 PMID:8164741 PMID:8566967 PMID:8616100 PMID:8822583 PMID:9245936 PMID:9339109 PMID:9372726 PMID:9415695 PMID:9454741 PMID:9459326 PMID:9518910 PMID:9734642 PMID:10328130 PMID:10348711 PMID:10477778 PMID:10494770 PMID:10507841 PMID:10666427 PMID:11018168 PMID:11110695 PMID:11686338 PMID:12070000 PMID:12421138 PMID:14996674 PMID:15534175 PMID:15638861 PMID:16493002 PMID:16931580 PMID:19652888 PMID:20051284 PMID:21116184 PMID:21774968 PMID:23382263 PMID:23677252 PMID:23900608 PMID:24033266 PMID:25741868 PMID:25977387 PMID:26251307 PMID:26990548 PMID:28492532 PMID:34355501 More...
NCBI chr13:76,513,463...76,583,106
Ensembl chr13:76,513,255...76,582,317
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F7
coagulation factor VII
treatment
ISO
protein:increased expression, increased activity:plasma (human) human protein in a mouse model
RGD
PMID:14733777 PMID:21998055
RGD:11049518 , RGD:11049520
NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
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Fbn1
fibrillin 1
ISO
ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
ClinVar
PMID:7611299 PMID:8894692 PMID:9401003 PMID:9536098 PMID:10533071 PMID:10874320 PMID:11700157 PMID:12402346 PMID:12938084 PMID:14695540 PMID:16220557 PMID:16222657 PMID:16835936 PMID:17253931 PMID:17576681 PMID:17657824 PMID:17663468 PMID:19159394 PMID:19293843 PMID:21542060 PMID:24033266 PMID:24161884 PMID:25741868 PMID:26133393 PMID:28492532 More...
NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
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Grin1
glutamate ionotropic receptor NMDA type subunit 1
severity
ISO
RGD
PMID:23723305
RGD:13792693
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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Grn
granulin precursor
ISO
ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
ClinVar
PMID:18723524 PMID:28492532
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
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Hba-a2
hemoglobin alpha, adult chain 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1634355
NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
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Hmgb1
high mobility group box 1
ISO
protein:increased expression:plasma
RGD
PMID:23288172
RGD:8696004
NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
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Hmox1
heme oxygenase 1
ISO
RGD
PMID:23311871
RGD:10755574
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Icam1
intercellular adhesion molecule 1
IEP
mRNA, protein:increased expression:cerebral cortex
RGD
PMID:20083630
RGD:8547724
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il18
interleukin 18
treatment
IEP
RGD
PMID:20584315
RGD:8655991
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Itga9
integrin subunit alpha 9
susceptibility
ISO
DNA:SNPs,haplotype:rs189897,rs2212020(human)
RGD
PMID:21764681
RGD:13602007
NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754
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Lipg
lipase G, endothelial type
susceptibility
ISO
DNA:polymorphism: :584C>T (human)
RGD
PMID:17016617
RGD:1601237
NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
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Lta
lymphotoxin alpha
ISO
RGD
PMID:14593215
RGD:1580416
NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
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Map2
microtubule-associated protein 2
IDA
RGD
PMID:22444278
RGD:6483079
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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Map3k5
mitogen-activated protein kinase kinase kinase 5
treatment
IMP
RGD
PMID:23968852
RGD:10412642
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Mir21
microRNA 21
IEP
RNA:increased expression:brain
RGD
PMID:20840605
RGD:41410884
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Mir223
microRNA 223
treatment
IEP
RGD
PMID:28469772
RGD:35668865
NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996
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Mir30a
microRNA 30a
treatment
IEP
RGD
PMID:28469772
RGD:35668865
NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670
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Mir383
microRNA 383
treatment
IEP
RGD
PMID:28469772
RGD:35668865
NCBI chr16:54,040,340...54,040,413
Ensembl chr16:54,040,340...54,040,413
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Mmp2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16846501
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16846501
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mt-co2
mitochondrially encoded cytochrome c oxidase II
ISO
ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
ClinVar
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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Mt-cyb
mitochondrially encoded cytochrome b
ISO
ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
ClinVar
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
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Mthfr
methylenetetrahydrofolate reductase
ISO
DNA:transition:cds:g.677C>T (human)
RGD
PMID:10929044
RGD:1580590
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Nos3
nitric oxide synthase 3
ISO
ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
OMIM ClinVar
PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 PMID:11026457 PMID:11354626 PMID:11394896 PMID:11745998 PMID:15007011 PMID:16059745 PMID:16813604 PMID:17165044 PMID:24033266 More...
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Notch3
notch receptor 3
ISO
ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
ClinVar
PMID:9388399 PMID:10371548 PMID:10802804 PMID:10854111 PMID:11102981 PMID:11755616 PMID:15364702 PMID:16009764 PMID:16193256 PMID:17729386 PMID:20301673 PMID:24844136 PMID:25578324 PMID:25623805 PMID:25741868 PMID:25973016 PMID:26308724 PMID:26467025 PMID:26715087 PMID:26843489 PMID:26912635 PMID:27206574 PMID:27890607 PMID:28710804 PMID:31915071 PMID:32457593 PMID:32581362 More...
NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
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Npy
neuropeptide Y
IEP ISO
protein:increased expression:cerebral cortex CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:11821007 PMID:17123484
RGD:10448931
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Park7
Parkinsonism associated deglycase
treatment
ISO
RGD
PMID:18003894 PMID:18003894
RGD:13462069 , RGD:13462069
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
G
Pdx1
pancreatic and duodenal homeobox 1
ISO
associated with Metabolic Syndrome; DNA:duplication:5' utr:-108 3G>4G (human)
RGD
PMID:18506375
RGD:2311309
NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
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Pla2g7
phospholipase A2 group VII
ISO
RGD
PMID:18201705
RGD:6482775
NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
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Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:1579960 PMID:1899364 PMID:9183334 PMID:16148626 PMID:18195371 PMID:18544249 More...
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Plau
plasminogen activator, urokinase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12133459 PMID:16773802
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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Plaur
plasminogen activator, urokinase receptor
ISO
RGD
PMID:20138161
RGD:6483804
NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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Pon1
paraoxonase 1
susceptibility
ISO
DNA:missense mutation:cds:p.Q192R (human)
RGD
PMID:10729395
RGD:1580196
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Prkch
protein kinase C, eta
ISO
ClinVar Annotator: match by term: Cerebral infarction, susceptibility to | ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
OMIM ClinVar
PMID:12958323 PMID:17206144 PMID:25741868
NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33761690
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Pros1
protein S
ISO
DNA:missense mutation:exon:p.R355C (1063C>T) (human)
RGD
PMID:21172841
RGD:11250416
NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286
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Serpine1
serpin family E member 1
treatment
IDA
RGD
PMID:25702149
RGD:11075081
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serping1
serpin family G member 1
treatment
ISO
associated with Venous Thrombosis
RGD
PMID:10446335
RGD:8661653
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
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Slc6a1
solute carrier family 6 member 1
IEP
mRNA:increased expression:cerebral cortex, neuron
RGD
PMID:15349978
RGD:1643205
NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293
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Tbxas1
thromboxane A synthase 1
susceptibility
ISO
DNA:polymorphisms: :
RGD
PMID:19403042
RGD:11059536
NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
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Thbd
thrombomodulin
susceptibility
ISO
DNA:missense mutation:cds:p.A455V (human)
RGD
PMID:15574195
RGD:5685021
NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
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Tnf
tumor necrosis factor
ISO
RGD
PMID:16173529
RGD:1580315
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf11b
TNF receptor superfamily member 11B
disease_progression
ISO
RGD
PMID:19895657
RGD:7205492
NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
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Tomm40
translocase of outer mitochondrial membrane 40
ISO
DNA:SNP: :rs2075650 (human)
RGD
PMID:26171154
RGD:13464126
NCBI chr 1:79,358,781...79,370,976
Ensembl chr 1:79,358,786...79,370,915
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Vim
vimentin
IEP
RGD
PMID:18802758
RGD:6480442
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Fshb
follicle stimulating hormone subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17344003
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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Abcc8
ATP binding cassette subfamily C member 8
treatment
IMP
RGD
PMID:23149556 PMID:24602692
RGD:12790979 , RGD:12791996
NCBI chr 1:96,598,663...96,679,495
Ensembl chr 1:96,598,647...96,679,510
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Ace
angiotensin I converting enzyme
treatment
IMP
RGD
PMID:24471927
RGD:11039026
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ace2
angiotensin I converting enzyme 2
IEP
mRNA, protein:increased expression:brain
RGD
PMID:24090950
RGD:9685436
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Adora1
adenosine A1 receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:23437309
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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Ager
advanced glycosylation end product-specific receptor
IEP ISO
associated with Diabetes Mellitus, Experimental CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:25446913 PMID:24211797
RGD:8696008
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Agt
angiotensinogen
IEP
protein:increased expression:brain, serum
RGD
PMID:24090950
RGD:9685436
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Aifm1
apoptosis inducing factor, mitochondria associated 1
IEP
protein:altered localization: :
RGD
PMID:15181376
RGD:10047403
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Ak1
adenylate kinase 1
IEP
protein:decreased expression:cerebral cortex (rat)
RGD
PMID:16468349
RGD:5508760
NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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Alb
albumin
treatment
ISO
RGD
PMID:22227456
RGD:11036100
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Alox5
arachidonate 5-lipoxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19309543
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Ap2b1
adaptor related protein complex 2 subunit beta 1
IEP
protein:increased degradation:brain
RGD
PMID:19240038
RGD:13461853
NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
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Apaf1
apoptotic peptidase activating factor 1
treatment
IEP
RGD
PMID:24012531
RGD:13703113
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Apoe
apolipoprotein E
IDA
RGD
PMID:19623195
RGD:6903926
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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App
amyloid beta precursor protein
treatment
IEP
RGD
PMID:28963051
RGD:13782054
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Aqp4
aquaporin 4
treatment
IEP
RGD
PMID:20815926
RGD:8695955
NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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Arc
activity-regulated cytoskeleton-associated protein
IEP
RGD
PMID:22645329
RGD:10395314
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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Atf3
activating transcription factor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Bad
BCL2-associated agonist of cell death
treatment
IDA
RGD
PMID:22200499 PMID:21891976
RGD:10053665 , RGD:10053704
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Bax
BCL2 associated X, apoptosis regulator
treatment
IEP
RGD
PMID:23143152
RGD:10054501
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcan
brevican
IEP
RGD
PMID:15869933
RGD:9590118
NCBI chr 2:173,454,479...173,467,717
Ensembl chr 2:173,454,482...173,467,460
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Bcl2
BCL2, apoptosis regulator
treatment
IEP
RGD
PMID:23143152
RGD:10054501
NCBI chr13:22,689,783...22,853,920
G
Bdnf
brain-derived neurotrophic factor
treatment
IEP
RGD
PMID:20417695
RGD:4891138
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
Becn1
beclin 1
treatment
IMP
RGD
PMID:22108007
RGD:11561900
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Bnip3
BCL2 interacting protein 3
IEP
protein:increased expression:brain
RGD
PMID:17379825
RGD:9685412
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
G
Bnip3l
BCL2 interacting protein 3 like
IEP
RGD
PMID:15902200 PMID:21029239
RGD:2314138 , RGD:9068917
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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C3
complement C3
IEP ISO
protein:increased expression:plasma CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:23199288 PMID:22103620
RGD:7175514
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
G
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
IEP
RGD
PMID:14688616
RGD:1358416
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Casp3
caspase 3
treatment
IDA IEP
RGD
PMID:21891976 PMID:26868427 PMID:23143152
RGD:10053704 , RGD:13782346 , RGD:10054501
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp6
caspase 6
IEP
RGD
PMID:26868427
RGD:13782346
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp9
caspase 9
treatment
IEP
RGD
PMID:26868427
RGD:13782346
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Ccl2
C-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:12374626 PMID:23043544 PMID:25257527
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccl7
C-C motif chemokine ligand 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Cd36
CD36 molecule
treatment
ISO
RGD
PMID:25216018
RGD:11041113
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd86
CD86 molecule
IEP
protein:increased expression:brain subventricular zone, microglial cell (rat)
RGD
PMID:19053043
RGD:2313025
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Cdk5
cyclin-dependent kinase 5
ISO
RGD
PMID:24920629
RGD:13782375
NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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Cldn5
claudin 5
treatment
IEP
RGD
PMID:24842554
RGD:13204729
NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
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Crh
corticotropin releasing hormone
IEP
protein:decreased expression:median eminence of hypothalamus (rat)
RGD
PMID:21741032
RGD:5490538
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Crp
C-reactive protein
ISO
RGD
PMID:15545914
RGD:9585995
NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
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Crtc1
CREB regulated transcription coactivator 1
treatment
IEP
RGD
PMID:20417695
RGD:4891138
NCBI chr16:18,988,197...19,046,913
Ensembl chr16:18,988,250...19,043,381
G
Csf3
colony stimulating factor 3
treatment
ISO IEP
mRNA, protein:increased expression:brain:
RGD
PMID:19298757 PMID:15530654
RGD:11039420 , RGD:11039425
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
RGD
PMID:10825390
RGD:632989
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl2
C-X-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
G
Cxcr2
C-X-C motif chemokine receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
G
Cxcr3
C-X-C motif chemokine receptor 3
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:10825390
RGD:632989
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
IEP
RGD
PMID:23002367
RGD:14700877
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Dicer1
dicer 1 ribonuclease III
IEP
mRNA:decreased expression:brain:
RGD
PMID:26294080
RGD:11553310
NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
G
Dnmt1
DNA methyltransferase 1
ISO
RGD
PMID:11726790
RGD:9588643
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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Dnmt3a
DNA methyltransferase 3 alpha
IMP
RGD
PMID:23516428
RGD:9589049
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
G
Dynll1
dynein light chain LC8-type 1
IEP
RGD
PMID:9522364
RGD:13208524
NCBI chr12:41,312,367...41,314,742
Ensembl chr12:41,312,367...41,314,741
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Edn1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17197033
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Egr1
early growth response 1
IEP
RGD
PMID:22645329
RGD:10395314
NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
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Egr2
early growth response 2
IEP
RGD
PMID:22645329
RGD:10395314
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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Egr4
early growth response 4
IEP
RGD
PMID:22645329
RGD:10395314
NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
G
Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
treatment
IDA IMP
RGD
PMID:23669639 PMID:19763736
RGD:10395346 , RGD:10755569
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
G
Elane
elastase, neutrophil expressed
treatment
IMP
RGD
PMID:10700596
RGD:10450546
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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Eng
endoglin
ISO
RGD
PMID:24876084
RGD:11041171
NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
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Epcam
epithelial cell adhesion molecule
IEP
RGD
PMID:15950761
RGD:11038820
NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
G
Ephb2
Eph receptor B2
treatment
IEP ISO
mRNA,protein:increased expression: cortex, cerebral cortex subventricular zone
RGD
PMID:16321245 PMID:16321245
RGD:1642069 , RGD:1642069
NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
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Epn1
Epsin 1
IEP
protein:increased degradation:brain
RGD
PMID:19240038
RGD:13461853
NCBI chr 1:68,742,491...68,760,507
Ensembl chr 1:68,742,789...68,758,874
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Epo
erythropoietin
treatment
ISO
RGD
PMID:20833153 PMID:20547143
RGD:10400898 , RGD:10401066
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
G
Ercc6
ERCC excision repair 6, chromatin remodeling factor
IEP
RGD
PMID:9974119
RGD:10401103
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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F11
coagulation factor XI
ISO
RGD
PMID:16533887
RGD:11041786
NCBI chr16:46,986,107...47,009,015
Ensembl chr16:46,986,107...47,008,437
G
F12
coagulation factor XII
treatment
ISO
RGD
PMID:16533887 PMID:16533887
RGD:11041786 , RGD:11041786
NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
G
F2
coagulation factor II
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29651748
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
G
Fadd
Fas associated via death domain
treatment
ISO IEP
RGD
PMID:18950622 PMID:23378241
RGD:11341807 , RGD:11344885
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
G
Fgf21
fibroblast growth factor 21
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Gabra6
gamma-aminobutyric acid type A receptor subunit alpha6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
IDA
RGD
PMID:25882840
RGD:13792686
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
G
Gdnf
glial cell derived neurotrophic factor
treatment
IMP
RGD
PMID:29497380
RGD:40925919
NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
G
Ghrl
ghrelin and obestatin prepropeptide
treatment
IDA
RGD
PMID:19352052
RGD:9850083
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
G
Ghsr
growth hormone secretagogue receptor
IMP
RGD
PMID:19352052
RGD:9850083
NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
G
Grin1
glutamate ionotropic receptor NMDA type subunit 1
treatment
IEP
RGD
PMID:26674869
RGD:11068571
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
G
Grn
granulin precursor
treatment
ISO
RGD
PMID:23972823
RGD:10401661
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
G
Grpel1
GrpE-like 1, mitochondrial
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:12505684
RGD:632868
NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200
G
Gsk3b
glycogen synthase kinase 3 beta
treatment
IDA
RGD
PMID:28440874
RGD:13792734
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Hamp
hepcidin antimicrobial peptide
IEP
mRNA, protein:increased expression:cerebral cortex, hippocampus, corpus striatum
RGD
PMID:21957487
RGD:11041635
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
G
Has2
hyaluronan synthase 2
IEP
mRNA:increased expression:brain
RGD
PMID:11283406
RGD:9588631
NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
G
Hdac4
histone deacetylase 4
treatment
IEP
mRNA,protein:decreased expression:brain:
RGD
PMID:23480850
RGD:9681449
NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
G
Hdac5
histone deacetylase 5
treatment
IEP
mRNA,protein:decreased expression:brain:
RGD
PMID:23480850
RGD:9681449
NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
G
Hdac9
histone deacetylase 9
IEP
mRNA:increased expression:brain:
RGD
PMID:23480850
RGD:9681449
NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
G
Hif1a
hypoxia inducible factor 1 subunit alpha
treatment
IDA
RGD
PMID:21029239
RGD:9068917
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Hmgb1
high mobility group box 1
treatment
IEP
RGD
PMID:23480850
RGD:9681449
NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
G
Hmox1
heme oxygenase 1
treatment
IEP IDA ISO
RGD
PMID:24252362 PMID:23870531 PMID:20888632
RGD:10755587 , RGD:10755755 , RGD:10755588
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hp
haptoglobin
IEP
RGD
PMID:22103620
RGD:7175514
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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Hspa4
heat shock protein family A (Hsp70) member 4
IMP ISO
rat gene in mouse model
RGD
PMID:17473852 PMID:21709150
RGD:5688754 , RGD:6218961
NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
G
Hspd1
heat shock protein family D (Hsp60) member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
G
Htra2
HtrA serine peptidase 2
IEP ISO
protein:increased expression:brain, cytosol (rat) protein:increased expression:brain, cytosol (mouse)
RGD
PMID:16978742 PMID:15306124
RGD:2314385 , RGD:5688372
NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
G
Hvcn1
hydrogen voltage-gated channel 1
IMP
RGD
PMID:31250553
RGD:14985213
NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141
G
Hvcn1em2Mcwi
hydrogen voltage-gated channel 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:31250553
RGD:14985213
G
Icam1
intercellular adhesion molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Igf1
insulin-like growth factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
treatment
ISO
RGD
PMID:16286924
RGD:10045955
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
G
Il11
interleukin 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
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Il13
interleukin 13
IEP
protein:increased expression:cerebral cortex
RGD
PMID:23028794
RGD:7204480
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
G
Il1b
interleukin 1 beta
treatment
IEP ISO
protein:increased expression:cerebral cortex (rat) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:25257527 PMID:23028794 PMID:29498696 PMID:24916922
RGD:7204480 , RGD:13792833 , RGD:10450594
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1rn
interleukin 1 receptor antagonist
treatment
ISO
human gene in a rat model
RGD
PMID:7790404
RGD:8551708
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
G
Il22
interleukin 22
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186
G
Il4
interleukin 4
IEP
protein:increased expression:cerebral cortex
RGD
PMID:23028794
RGD:7204480
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il5
interleukin 5
IEP
RGD
PMID:23028794
RGD:7204480
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
G
Il6
interleukin 6
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12374626 PMID:21940958 PMID:25257527 PMID:29498696
RGD:13792833
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Il6r
interleukin 6 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
G
Il6st
interleukin 6 cytokine family signal transducer
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
G
Il7r
interleukin 7 receptor
IEP
protein:increased expression:brain:
RGD
PMID:30676545
RGD:151347693
NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
G
Ina
internexin neuronal intermediate filament protein, alpha
ISO
RGD
PMID:29967576
RGD:27226878
NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330
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Irf4
interferon regulatory factor 4
IEP
RGD
PMID:25652434
RGD:11530061
NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
G
Mag
myelin-associated glycoprotein
treatment
IMP
RGD
PMID:15678116
RGD:9685232
NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656
G
Mapk1
mitogen activated protein kinase 1
treatment
IDA
RGD
PMID:27152455
RGD:13800881
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
treatment
IDA
RGD
PMID:27152455
RGD:13800881
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mapt
microtubule-associated protein tau
treatment
IEP IDA ISO
RGD
PMID:28886009 PMID:25903928 PMID:28886009
RGD:13800886 , RGD:13800913 , RGD:13800886
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Mir107
microRNA 107
IEP
RNA:increased expression:brain
RGD
PMID:26294080
RGD:11553310
NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853
G
Mmp9
matrix metallopeptidase 9
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19309543 PMID:24842554
RGD:13204729
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mt3
metallothionein 3
IEP
protein:decreased expression:brain
RGD
PMID:8869568
RGD:9685807
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
G
Mtor
mechanistic target of rapamycin kinase
treatment
IEP IDA
RGD
PMID:24583056 PMID:21185267 PMID:23777415
RGD:10040971 , RGD:10041016 , RGD:10040974
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Nae1
NEDD8 activating enzyme E1 subunit 1
IEP
RGD
PMID:21386696
RGD:13801046
NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371
G
Nampt
nicotinamide phosphoribosyltransferase
treatment
IMP
RGD
PMID:28495827
RGD:13781880
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
G
Ncam1
neural cell adhesion molecule 1
treatment
ISO IMP
RGD
PMID:32962079 PMID:29497380
RGD:40924633 , RGD:40925919
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
G
Nefh
neurofilament heavy chain
ISO
RGD
PMID:29967576
RGD:27226878
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
G
Nefl
neurofilament light chain
ISO
protein:increased expression:brain
RGD
PMID:29967576
RGD:27226878
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
G
Nefm
neurofilament medium chain
ISO
protein:altered expression:brain
RGD
PMID:29967576
RGD:27226878
NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
G
Nfe2l2
NFE2 like bZIP transcription factor 2
treatment
IDA
RGD
PMID:23880501 PMID:24466583
RGD:10412696 , RGD:10412714
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
G
Nfkbia
NFKB inhibitor alpha
treatment
IEP
RGD
PMID:21122797
RGD:10413868
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Ngf
nerve growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:10408807
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
G
Ngfr
nerve growth factor receptor
treatment
IDA
RGD
PMID:22678884
RGD:10413900
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
G
Nod2
nucleotide-binding oligomerization domain containing 2
treatment
IEP
RGD
PMID:24842554
RGD:13204729
NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
G
Nos2
nitric oxide synthase 2
IEP ISO
protein:increased expression:brain (rat) mRNA:increased expression:brain (mouse)
RGD
PMID:21959178 PMID:22020035
RGD:5508751 , RGD:5509037
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nqo1
NAD(P)H quinone dehydrogenase 1
treatment
IEP
protein:increased expression:brain
RGD
PMID:21120604 PMID:25069640
RGD:5133239 , RGD:11035212
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Nrg1
neuregulin 1
treatment
ISO
RGD
PMID:20691195
RGD:10449015
NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
G
Ogg1
8-oxoguanine DNA glycosylase
treatment
IEP
associated with Hypertension
RGD
PMID:17920569
RGD:8657395
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
G
Park7
Parkinsonism associated deglycase
treatment
ISO
RGD
PMID:17882163
RGD:13463450
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
G
Parp1
poly (ADP-ribose) polymerase 1
treatment
ISO IDA IEP
RGD
PMID:21311064 PMID:25882840 PMID:23143152 PMID:23801245
RGD:5683909 , RGD:13792686 , RGD:10054501 , RGD:11073732
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pawr
pro-apoptotic WT1 regulator
treatment
ISO IEP
protein:increased expression:brain:
RGD
PMID:16403464 PMID:19352052 PMID:11323519
RGD:9835380 , RGD:9850083 , RGD:9835381
NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
G
Pdgfra
platelet derived growth factor receptor alpha
treatment
IDA
RGD
PMID:16917016
RGD:11084934
NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
G
Pdgfrb
platelet derived growth factor receptor beta
treatment
IDA
RGD
PMID:16917016
RGD:11084934
NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
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Plat
plasminogen activator, tissue type
IEP ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:12297567 PMID:17690543 PMID:18453163 PMID:20547619 PMID:29651748 PMID:14512838 More...
RGD:1580876
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
G
Plau
plasminogen activator, urokinase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11677890 PMID:15181847 PMID:17702958
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
G
Pld1
phospholipase D1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
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Prkcg
protein kinase C, gamma
ISO
RGD
PMID:14688616
RGD:1358416
NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
treatment
ISO
RGD
PMID:24159062
RGD:11100027
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Ptprz1
protein tyrosine phosphatase, receptor type Z1
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:15869933
RGD:9590118
NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218
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Reln
reelin
severity
ISO
RGD
PMID:16438965
RGD:13207538
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
G
Rgma
repulsive guidance molecule BMP co-receptor a
treatment
IEP IMP
RGD
PMID:21840379 PMID:23275173
RGD:9850121 , RGD:9850122
NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918
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Rpl28
ribosomal protein L28
IEP
RGD
PMID:16805800
RGD:6480229
NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032
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Runx1
RUNX family transcription factor 1
IAGP
mRNA:increased expression:brain
RGD
PMID:24672479
RGD:11251714
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
G
S100a5
S100 calcium binding protein A5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 2:176,095,332...176,099,546
Ensembl chr 2:176,097,539...176,099,546
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Serpine1
serpin family E member 1
IEP
RGD
PMID:14512838
RGD:1580876
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serpinf1
serpin family F member 1
treatment
IDA
RGD
PMID:22714093
RGD:8655545
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
G
Serpinh1
serpin family H member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
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Shh
sonic hedgehog signaling molecule
treatment
ISO
RGD
PMID:22324418
RGD:12879461
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
G
Sirt1
sirtuin 1
treatment
IMP ISO
RGD
PMID:23600725 PMID:23600725
RGD:9585664 , RGD:9585664
NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
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Slc12a2
solute carrier family 12 member 2
treatment
IMP ISO
protein:increased expression:brain:
RGD
PMID:12535773 PMID:27798271
RGD:1580583 , RGD:14398833
NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
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Slc2a1
solute carrier family 2 member 1
treatment
IEP
RGD
PMID:9419067
RGD:12879855
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc9a1
solute carrier family 9 member A1
treatment
IMP
RGD
PMID:31250553
RGD:14985213
NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
G
Slpi
secretory leukocyte peptidase inhibitor
treatment
IEP
RGD
PMID:14500739
RGD:9999390
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
G
Smo
smoothened, frizzled class receptor
treatment
IMP
RGD
PMID:23696546 PMID:23499832
RGD:12832759 , RGD:12879404
NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829
G
Smox
spermine oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30576531
NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710
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Snap91
synaptosome associated protein 91
IEP
protein:increased degradation:brain
RGD
PMID:19240038
RGD:13461853
NCBI chr 8:87,738,056...87,852,690
Ensembl chr 8:87,738,824...87,852,367
G
Sod1
superoxide dismutase 1
treatment
IDA IEP
mRNA, protein:increased expression:cerebral cortex (rat)
RGD
PMID:22001340 PMID:22133807
RGD:8657021 , RGD:8657023
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Sphk2
sphingosine kinase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:23043544
NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
G
Stat3
signal transducer and activator of transcription 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tgfb1
transforming growth factor, beta 1
IEP
RGD
PMID:31409163
RGD:14995477
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Th
tyrosine hydroxylase
IEP
protein:decreased expression:substantia nigra pars compacta, neuron (rat)
RGD
PMID:21366664
RGD:5128609
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
G
Tnf
tumor necrosis factor
treatment
IEP IMP
RGD
PMID:24916922 PMID:15647744 PMID:29498696
RGD:10450594 , RGD:13825261 , RGD:13792833
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfaip6
TNF alpha induced protein 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
G
Tnfrsf1a
TNF receptor superfamily member 1A
IMP
RGD
PMID:15647744
RGD:13825261
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Trem1
triggering receptor expressed on myeloid cells 1
ameliorates
IDA
RGD
PMID:32736673
RGD:127284860
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
G
Upp1
uridine phosphorylase 1
IEP
mRNA, protein:increased expression:brain (rat)
RGD
PMID:18457515
RGD:2317094
NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462
G
Vegfa
vascular endothelial growth factor A
treatment
IMP
RGD
PMID:29497380
RGD:40925919
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Xdh
xanthine dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
G
App
amyloid beta precursor protein
ISO
protein:decreased expression:cerebrospinal fluid:
RGD
PMID:1677459
RGD:10054257
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
G
Bax
BCL2 associated X, apoptosis regulator
treatment
IEP
RGD
PMID:18938189
RGD:10054050
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
treatment
IEP
RGD
PMID:18938189
RGD:10054050
NCBI chr13:22,689,783...22,853,920
G
G6pd
glucose-6-phosphate dehydrogenase
treatment
IEP
RGD
PMID:21279683
RGD:10449132
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Il2
interleukin 2
severity
ISO
protein:increased secretion:mononuclear cell:
RGD
PMID:8586980
RGD:10047081
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all