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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Transplant Rejection
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Accession:DOID:9004283 term browser browse the term
Definition:A process in which a transplant recipient's immune system attacks the transplanted organ or tissue. The rejection can be hyperacute (occurring within a few minutes), acute (occurring within days to months), or chronic (occurring over many years).


show annotations for term's descendants           Sort by:
Transplant Rejection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B treatment ISO human construct in rat model RGD PMID:27732750 RGD:329322881 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458 		JBrowse link
G Apoa1 apolipoprotein A1 ISO protein:decreased expression:plasma RGD PMID:21730889 RGD:7241209 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Arrb1 arrestin, beta 1 IEP mRNA:decreased expression:blood, leukocyte RGD PMID:21193245 RGD:13506894 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 IEP mRNA, protein:decreased expression:blood, leukocyte, monocyte RGD PMID:21193245 RGD:13506894 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Bag6 BAG cochaperone 6 susceptibility ISO DNA:haplotype: :rs10484558(human) RGD PMID:25111513 RGD:14390152 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 susceptibility ISO kidney;DNA:snp:promoter:g.-2518A>G (human) RGD PMID:12239249 PMID:14662900 RGD:8548879, RGD:8657367 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO RGD PMID:20688906 RGD:7241797 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO RGD PMID:14662900 RGD:8657367 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 treatment IEP RGD PMID:23498802 PMID:23446583 RGD:8552228, RGD:8552231 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd274 CD274 molecule ISO RGD PMID:14662900 RGD:8657367 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd4 Cd4 molecule treatment IMP
ISO		 RGD PMID:1704648 PMID:11081762 RGD:10058956, RGD:10058974 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Cd40 CD40 molecule disease_progression
treatment		 ISO
IMP		 associated with Diabetes Mellitus, Experimental RGD PMID:15221125 PMID:14698004 PMID:21472009 RGD:7248441, RGD:8547788, RGD:7248755 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand treatment ISO
IMP		 protein:increased expression:blood, T cell
associated with Diabetes Mellitus		 RGD PMID:22948742 PMID:15808676 PMID:10949194 PMID:15016184 RGD:7248420, RGD:8547783, RGD:7248719, RGD:7248598 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit IEP RGD PMID:25121092 RGD:151347544 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit IEP RGD PMID:25121092 RGD:151347544 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Col1a2 collagen type I alpha 2 chain ISO mRNA:increased expression:kidney RGD PMID:20150539 RGD:7248773 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col3a1 collagen type III alpha 1 chain ISO mRNA:increased expression:kidney RGD PMID:20150539 RGD:7248773 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Csf1 colony stimulating factor 1 ISO
IEP		 mRNA:increased expression:kidney RGD PMID:19196448 PMID:11981428 RGD:7257570, RGD:7257590 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:24056626 RGD:151665812 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:18589159 RGD:11039422 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 susceptibility ISO
IMP		 DNA:SNP: :rs231775, korean(human)
DNA:SNP: :rs733618, chinese(human)		 RGD PMID:12096784 PMID:20940051 PMID:22418270 PMID:18074399 PMID:14551031 RGD:7204515, RGD:7204678, RGD:7204671, RGD:7204518, RGD:7204516 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 severity ISO RGD PMID:28245475 RGD:27095950 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 ISO DNA:SNP:promoter:g.-2668G>A (rs2671222) (human) RGD PMID:21452410 RGD:7257676 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 IMP
IEP		 RGD PMID:15840022 PMID:22882432 RGD:7257683, RGD:7257690 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) treatment IMP RGD PMID:8443191 RGD:11040447 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
G Ece1 endothelin converting enzyme 1 IMP RGD PMID:10401760 RGD:7244165 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 ISO RGD PMID:10656876 RGD:9685445 NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 treatment IEP RGD PMID:31828147 RGD:35316072 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit treatment IMP RGD PMID:27784285 RGD:126781722 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Faslg Fas ligand IEP mRNA, protein:increased expression:liver RGD PMID:10357921 RGD:14700698 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fcgr2a Fc gamma receptor 2A treatment ISO RGD PMID:10762218 RGD:9588604 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967 		JBrowse link
G Foxp3 forkhead box P3 treatment ISO mRNA:increased expression:liver RGD PMID:17414718 PMID:21199671 PMID:28457422 RGD:38456005, RGD:38599144, RGD:38549577 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration IEP RGD PMID:22819311 RGD:9685732 NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 treatment IDA RGD PMID:28596681 RGD:13504864 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO associated with Hemoglobinopathies;DNA:deletion:: (human) RGD PMID:20348973 RGD:10450792 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO RGD PMID:23435265 RGD:7244382 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 ISO
IEP		 mRNA:increased expression:Leukocytes, Mononuclear:
mRNA,protein:increased expression:lung:		 RGD PMID:22172823 PMID:24508263 RGD:7245954, RGD:9686116 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IEP RGD PMID:23953577 RGD:12910541 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Ifng interferon gamma ISO RGD PMID:22564629 RGD:7364833 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment IEP
IMP		 mRNA:increased expression:kidney RGD PMID:19249479 PMID:20500684 RGD:7495769, RGD:4892204 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 treatment ISO
IDA		 RGD PMID:22564629 PMID:17275523 PMID:23870834 RGD:7364833, RGD:11049523, RGD:7364994 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 treatment ISO
IEP
IDA		 mRNA:increased expression:liver RGD PMID:17902182 PMID:17532783 PMID:17331844 RGD:8549629, RGD:10402939, RGD:8549647 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il15 interleukin 15 IEP mRNA:increased expression:liver RGD PMID:17532783 RGD:10402939 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il17a interleukin 17A treatment ISO
IMP
IEP		 protein:increased expression:liver, serum (rat) RGD PMID:20651239 PMID:23429965 PMID:21043049 RGD:9068426, RGD:9068938, RGD:4781440 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18 interleukin 18 IMP RGD PMID:21962809 RGD:8655943 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il18bp interleukin 18 binding protein IMP RGD PMID:21962809 RGD:8655943 NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963 		JBrowse link
G Il1b interleukin 1 beta severity ISO DNA:snp:intron:g.3962C>T (human) RGD PMID:22663993 PMID:8094579 RGD:7175098, RGD:7401188 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO cornea transplant; human protein in a mouse model RGD PMID:9175817 RGD:8549799 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 treatment ISO
IMP		 RGD PMID:22564629 PMID:18089405 PMID:3291556 RGD:7364833, RGD:10047078, RGD:8662936 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il21 interleukin 21 ISO associated with hepatitis B;DNA:SNPs, haplotype:intron, CDS:1472G>T, 5250C>T (rs2055979, rs4833837) (human) RGD PMID:23656167 RGD:127285550 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il2rb interleukin 2 receptor subunit beta ameliorates ISO RGD PMID:9293878 RGD:42733040 NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054 		JBrowse link
G Il5 interleukin 5 treatment IDA RGD PMID:11267027 RGD:11354977 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il7 interleukin 7 IEP mRNA:increased expression:liver RGD PMID:17532783 RGD:10402939 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Itga4 integrin subunit alpha 4 treatment ISO RGD PMID:9721793 RGD:9698437 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Kdr kinase insert domain receptor ISO RGD PMID:22997228 RGD:8549738 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase IEP mRNA:increased expression:liver: RGD PMID:9862859 RGD:12910749 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Klrk1 killer cell lectin like receptor K1 IEP RGD PMID:20306467 RGD:9685184 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459 		JBrowse link
G Lta lymphotoxin alpha treatment IEP
IMP		 RGD PMID:8356596 PMID:2338821 RGD:8548835, RGD:8548836 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:22845765 RGD:7241226 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming IEP RGD PMID:12717211 RGD:7349372 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Muc4 mucin 4, cell surface associated IEP RGD PMID:12717211 RGD:7349372 NCBI chr11:68,008,245...68,053,242 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IMP cornea RGD PMID:22149555 RGD:7240566 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkbia NFKB inhibitor alpha treatment ISO
IEP		 RGD PMID:19399405 PMID:31828147 RGD:10413870, RGD:35316072 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP RGD PMID:29218089 RGD:13504718 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A treatment ISO RGD PMID:23826817 RGD:7297054 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO protein:decreased activity:blood, mononuclear cell RGD PMID:10959477 RGD:7174721 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Pdcd1 programmed cell death 1 severity ISO mRNA:increased expression:leukocytes, Mononuclear: RGD PMID:21518556 PMID:17198268 PMID:17489865 RGD:7248673, RGD:9589063, RGD:9589060 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Pdgfd platelet derived growth factor D IEP RGD PMID:19213942 RGD:9854642 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IMP RGD PMID:10458478 RGD:1625382 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 IMP RGD PMID:17311089 RGD:8693431 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Plat plasminogen activator, tissue type susceptibility ISO protein:increased expression:plasma (human) RGD PMID:11423054 RGD:11541079 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase ISO mRNA, protein:increased expression:kidney (human) RGD PMID:14531820 RGD:7241140 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Prrc2a proline-rich coiled-coil 2A susceptibility ISO DNA:haplotype: :rs11538264(human) RGD PMID:25111513 RGD:14390152 NCBI chr20:3,658,391...3,674,143
Ensembl chr20:3,658,695...3,674,130 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 severity IEP protein:increased expression:liver, kidney (rat) RGD PMID:22834313 RGD:9854627 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512 		JBrowse link
G Raet1l retinoic acid early transcript 1L IEP RGD PMID:20306467 RGD:9685184 NCBI chr 1:1,979,433...1,984,410
Ensembl chr 1:1,979,443...1,984,410 		JBrowse link
G Raet1ll1 retinoic acid early transcript 1L like 1 IEP RGD PMID:20306467 RGD:9685184 NCBI chr 1:1,397,219...1,437,802
Ensembl chr 1:1,397,230...1,402,656 		JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 treatment IDA RGD PMID:18178058 RGD:9835362 NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit treatment IEP RGD PMID:31828147 RGD:35316072 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit treatment IMP RGD PMID:23196258 RGD:7777161 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G RT1-Bb RT1 class II, locus Bb IDA RGD PMID:1547813 RGD:7421554 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G RT1-CE13 RT1 class I, locus CE13 treatment ISO human peptide in rat model; HLA-B7 RGD PMID:9233694 RGD:7387273 NCBI chr20:3,314,830...3,318,106 JBrowse link
G Sell selectin L ISO RGD PMID:11095659 RGD:7175511 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Slc5a7 solute carrier family 5 member 7 IEP protein:increased expression:kidney, mononuclear cell RGD PMID:19201987 RGD:9999387 NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258 		JBrowse link
G Spi1 Spi-1 proto-oncogene treatment IMP RGD PMID:24282365 RGD:9586451 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO DNA:SNP: :rs7574865 (human) RGD PMID:21237270 RGD:7207871 NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tbxa2r thromboxane A2 receptor IMP RGD PMID:7964472 RGD:11059606 NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176 		JBrowse link
G Tlr2 toll-like receptor 2 ISO
IEP		 liver;DNA:SNP: :p.R753Q (human)
kidney		 RGD PMID:22042224 PMID:20038715 PMID:20090572 PMID:20628182 PMID:20628182 RGD:7207901, RGD:7240555, RGD:7240554, RGD:7240551, RGD:7240551 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 ISO pancreatic islet RGD PMID:20642685 PMID:20038715 RGD:7240548, RGD:7240555 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr9 toll-like receptor 9 susceptibility ISO kidney; DNA:snp:exon:g.+2848G>A rs352140 (human, North Indian) RGD PMID:22251233 RGD:7246885 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor treatment IMP
ISO
IEP		 protein:increased expression:heart,serum: RGD PMID:2038191 PMID:2338821 PMID:8094579 PMID:2038191 RGD:7394793, RGD:8548836, RGD:7401188, RGD:7394793 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B IEP RGD PMID:19298452 RGD:7245520 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tpmt thiopurine S-methyltransferase ISO RGD PMID:24121523 RGD:11038722 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709 		JBrowse link
G Tpo thyroid peroxidase ISO RGD PMID:19506389 RGD:7207487 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 treatment IEP RGD PMID:31828147 RGD:35316072 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Xdh xanthine dehydrogenase treatment IMP RGD PMID:24768926 RGD:13209011 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Cardiac Allograft Vasculopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor IEP RGD PMID:9916935 RGD:11341701 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K ISO RGD PMID:21489814 RGD:155260371 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Pdgfd platelet derived growth factor D ISO RGD PMID:19213942 RGD:9854642 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
Chronic Allograft Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor treatment IEP RGD PMID:22217518 PMID:23769041 RGD:7245568, RGD:8695995 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G C3 complement C3 treatment IDA RGD PMID:25122638 RGD:11040803 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cd40 CD40 molecule treatment IDA RGD PMID:22826618 RGD:11352297 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand treatment IDA liver RGD PMID:22826618 RGD:11352297 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G F7 coagulation factor VII treatment ISO human protein in a rat model RGD PMID:12095034 RGD:11049508 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G Hmgb1 high mobility group box 1 treatment IEP RGD PMID:22217518 RGD:7245568 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ameliorates IMP RGD PMID:24312257 RGD:401700379 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment IDA RGD PMID:23985719 RGD:10041002 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Tnf tumor necrosis factor treatment IMP RGD PMID:24598936 RGD:10450586 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Chronic Allograft Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 IEP RGD PMID:20176611 RGD:11541086 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Alb albumin disease_progression ISO RGD PMID:24370342 RGD:11035281 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO RGD PMID:17298994 RGD:7241819 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccn2 cellular communication network factor 2 disease_progression IEP mRNA, protein:increased expression:kidney (rat) RGD PMID:19921985 RGD:150517553 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Clu clusterin treatment IEP RGD PMID:22494435 RGD:9068431 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cs citrate synthase treatment IDA RGD PMID:20005400 RGD:243048470 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:22845765 RGD:7241226 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp7 matrix metallopeptidase 7 treatment IDA RGD PMID:18209025 RGD:9685339 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Pdgfa platelet derived growth factor subunit A IEP RGD PMID:11889420 RGD:11080974 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP mRNA:increased expression:kidney: RGD PMID:15785371 PMID:11889420 RGD:10449491, RGD:11080974 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IEP RGD PMID:11889420 RGD:11080974 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IEP RGD PMID:11889420 RGD:11080974 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Plau plasminogen activator, urokinase ISO protein:increased secretion:T lymphocyte (human) RGD PMID:16387096 RGD:7241259 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO protein:increased expression:kidney: RGD PMID:16221712 RGD:13208600 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Serpine1 serpin family E member 1 treatment ISO protein:increased expression:kidney: RGD PMID:16221712 PMID:18192922 RGD:13208600, RGD:13208601 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
Chronic Lung Allograft Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 IEP mRNA:increased expression:lung RGD PMID:22305384 RGD:10395369 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
Corneal Graft Rejection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule treatment IMP RGD PMID:22300371 RGD:41412184 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd4 Cd4 molecule treatment IMP RGD PMID:1358194 RGD:10059315 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO human gene in a rat model RGD PMID:23723965 RGD:9684950 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
heart transplant rejection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fto FTO, alpha-ketoglutarate dependent dioxygenase ISO DNA:SNP: :rs17817449 (human) RGD PMID:30408245 RGD:329845888 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
Primary Graft Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn2 cellular communication network factor 2 exacerbates IEP protein:increased expression:urine (rat) RGD PMID:19921985 RGD:150517553 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cd40lg CD40 ligand treatment ISO RGD PMID:12244161 RGD:7248713 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Gata2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Gpx3 glutathione peroxidase 3 treatment ISO RGD PMID:29290803 RGD:401827126 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP RGD PMID:22617707 PMID:10666412 RGD:8547722, RGD:11520779 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 treatment IDA RGD PMID:21911153 RGD:11049478 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Npy neuropeptide Y IEP mRNA, protein:decreased expression:blood, mononuclear cell RGD PMID:18981110 RGD:10448956 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Pf4 platelet factor 4 ameliorates IDA RGD PMID:24986443 RGD:329901907 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Selp selectin P ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Senp1 SUMO specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598 		JBrowse link
G Tnf tumor necrosis factor treatment IEP liver RGD PMID:18972563 RGD:15023490 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19047
    disease of anatomical entity 18381
      immune system disease 4931
        Transplant Rejection 124
          Chronic Allograft Dysfunction + 28
          Corneal Graft Rejection 3
          Primary Graft Dysfunction 12
          heart transplant rejection 1
Path 2
Term Annotations click to browse term
  disease 19047
    disease of anatomical entity 18381
      Immune & Inflammatory Diseases 5742
        immune system disease 4931
          Transplant Rejection 124
            Chronic Allograft Dysfunction + 28
            Corneal Graft Rejection 3
            Primary Graft Dysfunction 12
            heart transplant rejection 1
paths to the root