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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:vascular endothelial growth factor signaling pathway
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Accession:PW:0000243 term browser browse the term
Definition:The VEGF family plays key roles in angiogenesis and lymphangiogenesis. Through their receptors, VEGFs can initiate a diverse and complex network of signaling cascades. Deregulation of VEGF-mediated pathways, mostly through upregulation of VEGF expression, has been implicated in a number of conditions, primarily cancer.
Synonyms:related_synonym: Signaling by VEGF;   VEGF signaling pathways;   vascular endothelial growth factor receptor signaling pathway
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show annotations for term's descendants           Sort by:
vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap1 A-kinase anchoring protein 1 ISO PID PID:200188 NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:04370 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:04370 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Arf1 ADP-ribosylation factor 1 ISO PID PID:200188 NCBI chr10:43,997,983...44,014,543
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG rno:04370 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO PID PID:200188 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Calm1 calmodulin 1 ISO PID PID:200188 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 ISO PID PID:200188 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 		JBrowse link
G Calm3 calmodulin 3 ISO PID PID:200188 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 ISO PID PID:200188 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Casp9 caspase 9 IEA KEGG rno:04370 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cav1 caveolin 1 ISO PID PID:200188 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200188 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IMP RGD PMID:14693680 RGD:1580560 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdc42 cell division cycle 42 ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdh5 cadherin 5 ISO PID PID:200188 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Chp1 calcineurin-like EF-hand protein 1 IEA KEGG rno:04370 NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251 		JBrowse link
G Chp2 calcineurin-like EF hand protein 2 IEA KEGG rno:04370 NCBI chr 1:176,757,945...176,772,443
Ensembl chr 1:176,757,876...176,772,139 		JBrowse link
G Ctnna1 catenin alpha 1 ISO PID PID:200188 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910 		JBrowse link
G Ctnnb1 catenin beta 1 ISO PID PID:200188 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dnm2 dynamin 2 ISO PID PID:200188 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 ISS RGD PMID:14597660 RGD:1334466 NCBI chr19:52,867,914...52,907,169
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 TAS
ISS		 RGD PMID:12876291 PMID:14597660 RGD:727754, RGD:1334466 NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 ISS RGD PMID:14597660 RGD:1334466 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 ISO PID PID:200188 NCBI chr10:17,232,735...17,330,584
Ensembl chr10:17,227,181...17,330,571 		JBrowse link
G Fes FES proto-oncogene, tyrosine kinase ISO PID PID:200188 NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 IMP
ISO		 PID
RGD		 PMID:15785231 PMID:16633338 PID:200109 PID:200188, RGD:1626621, RGD:2298727 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 IMP
ISO		 This is VGFR-3 PID
RGD		 PMID:11683876 PID:200109, RGD:727326 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO PID
RGD		 PMID:17658244 PID:200188, RGD:2298729 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO PID PID:200188 NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236 		JBrowse link
G Grb10 growth factor receptor bound protein 10 ISO PID PID:200188 NCBI chr14:86,495,054...86,602,815
Ensembl chr14:86,495,054...86,602,806 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200188 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate ISO PID PID:200188 NCBI chr10:105,739,617...105,757,838
Ensembl chr10:105,739,296...105,757,835 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha TAS
IMP		 RGD PMID:9398602 PMID:18614764 RGD:625724, RGD:2301848 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hras HRas proto-oncogene, GTPase IEA KEGG rno:04370 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO PID PID:200188 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO PID PID:200188 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IEA KEGG rno:04370 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO PID PID:200188 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755 		JBrowse link
G Itgav integrin subunit alpha V ISO PID PID:200188 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO PID PID:200188 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Kdr kinase insert domain receptor IMP
IEA
ISO		 VEGFR-2 KEGG
PID
RGD		 PMID:9442048 PMID:18614764 PMID:17658244 PMID:16633338 PMID:15785231 More... PID:200109 PID:200188 rno:04370, RGD:729081, RGD:2301848, RGD:2298729, RGD:2298727, RGD:1626621, RGD:2292019 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kras KRAS proto-oncogene, GTPase IEA KEGG rno:04370 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 ISO PID PID:200188 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200188 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 IEA KEGG rno:04370 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 IEA KEGG rno:04370 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 IEA KEGG rno:04370 NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568 		JBrowse link
G Myof myoferlin ISO PID PID:200188 NCBI chr 1:235,673,666...235,822,413
Ensembl chr 1:235,673,666...235,822,334 		JBrowse link
G Nck1 NCK adaptor protein 1 ISO PID
RGD		 PMID:17658244 PID:200188, RGD:2298729 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 ISO PID PID:200188 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase ISO PID PID:200188 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 IEA KEGG rno:04370 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 IEA KEGG rno:04370 NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 IEA KEGG rno:04370 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 IEA KEGG rno:04370 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nras NRAS proto-oncogene, GTPase IEA KEGG rno:04370 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Nrp1 neuropilin 1 ISS
ISO		 PID
RGD		 PMID:15563310 PMID:16633338 PID:200109, RGD:1334463, RGD:2298727 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrp2 neuropilin 2 ISO PID PID:200109 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 ISO PID PID:200188 NCBI chr11:68,708,070...68,766,622
Ensembl chr11:68,707,969...68,768,816 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200188 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pgf placental growth factor TAS
ISO		 RGD PMID:7706320 PMID:16633338 RGD:633657, RGD:2298727 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04370 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04370 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04370 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04370 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04370 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pla2g10 phospholipase A2, group X IEA KEGG rno:04370 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000 		JBrowse link
G Pla2g12a phospholipase A2, group XIIA IEA KEGG rno:04370 NCBI chr 2:218,436,450...218,452,760
Ensembl chr 2:218,436,513...218,452,740 		JBrowse link
G Pla2g12b phospholipase A2, group XIIB IEA KEGG rno:04370 NCBI chr20:27,369,196...27,389,517
Ensembl chr20:27,370,266...27,388,743 		JBrowse link
G Pla2g1b phospholipase A2 group IB IEA KEGG rno:04370 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226 		JBrowse link
G Pla2g2a phospholipase A2 group IIA IEA KEGG rno:04370 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pla2g2c phospholipase A2, group IIC IEA KEGG rno:04370 NCBI chr 5:150,959,365...150,981,388
Ensembl chr 5:150,959,182...150,981,377 		JBrowse link
G Pla2g2d phospholipase A2, group IID IEA KEGG rno:04370 NCBI chr 5:151,016,010...151,022,531
Ensembl chr 5:151,018,870...151,022,525 		JBrowse link
G Pla2g2f phospholipase A2, group IIF IEA KEGG rno:04370 NCBI chr 5:150,986,788...150,993,175
Ensembl chr 5:150,986,788...150,993,175 		JBrowse link
G Pla2g3 phospholipase A2, group III IEA KEGG rno:04370 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913 		JBrowse link
G Pla2g4a phospholipase A2 group IVA IEA KEGG rno:04370 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pla2g4b phospholipase A2 group IVB IEA KEGG rno:04370 NCBI chr 3:107,004,238...107,013,853
Ensembl chr 3:107,005,489...107,013,853 		JBrowse link
G Pla2g4e phospholipase A2, group IVE IEA KEGG rno:04370 NCBI chr 3:107,132,540...107,198,609
Ensembl chr 3:107,132,541...107,198,233 		JBrowse link
G Pla2g4f phospholipase A2, group IVF IEA KEGG rno:04370 NCBI chr 3:107,249,053...107,266,201
Ensembl chr 3:107,250,075...107,264,689 		JBrowse link
G Pla2g5 phospholipase A2, group V IEA KEGG rno:04370 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Pla2g6 phospholipase A2 group VI IEA KEGG rno:04370 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114 		JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO
IEA		 KEGG
PID
RGD		 PMID:17658244 PID:200188 rno:04370, RGD:2298729 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Plcg2 phospholipase C, gamma 2 IEA KEGG rno:04370 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha IEA KEGG rno:04370 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta IEA KEGG rno:04370 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981 		JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma IEA KEGG rno:04370 NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha IEA KEGG rno:04370 NCBI chr14:91,556,743...91,606,230
Ensembl chr14:91,604,121...91,606,907 		JBrowse link
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta IEA KEGG rno:04370 NCBI chr 5:64,026,903...64,027,898
Ensembl chr 5:64,026,903...64,032,548 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO PID PID:200188 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 ISO PID PID:200188 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 ISO PID PID:200188 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO PID PID:200188 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 ISO PID PID:200188 NCBI chr 7:129,963,105...129,980,532
Ensembl chr 7:129,963,105...129,980,561 		JBrowse link
G Prkca protein kinase C, alpha ISO
IEA		 KEGG
PID
RGD		 PMID:17658244 PID:200188 rno:04370, RGD:2298729 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta ISO
IEA		 KEGG
RGD		 PMID:17658244 rno:04370, RGD:2298729 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcd protein kinase C, delta IMP
ISO		 PID
RGD		 PMID:15541367 PID:200188, RGD:2298730 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkcg protein kinase C, gamma IEA KEGG rno:04370 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Prkcz protein kinase C, zeta ISO RGD PMID:17658244 RGD:2298729 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEA KEGG rno:04370 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO
IEA		 KEGG
RGD		 PMID:17658244 rno:04370, RGD:2298729 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO PID PID:200188 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID PID:200188 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO PID PID:200188 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J ISO PID PID:200188 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Pxn paxillin ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr12:41,060,791...41,107,962
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Rac1 Rac family small GTPase 1 IEA KEGG rno:04370 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rac2 Rac family small GTPase 2 IEA KEGG rno:04370 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G RGD1560225 similar to nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 IEA KEGG rno:04370
G RGD1564956 similar to calcium binding protein P22 IEA KEGG rno:04370 NCBI chr 5:68,570,894...68,571,875
Ensembl chr 5:68,571,232...68,571,819 		JBrowse link
G RGD1565588 similar to calcium binding protein P22 IEA KEGG rno:04370
G Rhoa ras homolog family member A ISO PID PID:200188 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 ISO PID PID:200188 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Sh2d2a SH2 domain containing 2A ISO
IEA		 KEGG
PID
RGD		 PMID:17658244 PID:200188 rno:04370, RGD:2298729 NCBI chr 2:173,312,253...173,318,810
Ensembl chr 2:173,312,253...173,318,810 		JBrowse link
G Shb SH2 domain containing adaptor protein B ISO PID PID:200188 NCBI chr 5:59,678,066...59,785,443
Ensembl chr 5:59,678,216...59,785,538 		JBrowse link
G Shc2 SHC adaptor protein 2 IEA KEGG rno:04370 NCBI chr 7:10,066,705...10,088,926
Ensembl chr 7:10,066,705...10,088,926 		JBrowse link
G Sphk1 sphingosine kinase 1 IEA KEGG rno:04370 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Sphk2 sphingosine kinase 2 IEA KEGG rno:04370 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO
IEA		 PID
KEGG		 PID:200188 rno:04370 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Vcl vinculin ISO PID PID:200188 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606 		JBrowse link
G Vegfa vascular endothelial growth factor A IDA
IEA
IMP
ISO		 KEGG
RGD		 PMID:12181492 PMID:16160062 PMID:18614764 PMID:16633338 PMID:18221855 More... rno:04370, RGD:625593, RGD:2301956, RGD:2301848, RGD:2298727, RGD:2292019, RGD:1626621 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfb vascular endothelial growth factor B ISS
ISO		 RGD PMID:15563310 PMID:16633338 RGD:1334463, RGD:2298727 NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944 		JBrowse link
G Vegfc vascular endothelial growth factor C IMP
ISO		 PID
RGD		 PMID:11683876 PMID:16633338 PID:200109, RGD:727326, RGD:2298727 NCBI chr16:37,712,408...37,827,657
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
G Vegfd vascular endothelial growth factor D IMP
ISO		 This is the VEGF-D PID
RGD		 PMID:11683876 PMID:16633338 PID:200109, RGD:727326, RGD:2298727 NCBI chr  X:30,073,122...30,108,413
Ensembl chr  X:30,074,163...30,108,295 		JBrowse link
G Vtn vitronectin ISO PID PID:200188 NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810 		JBrowse link
altered vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 Fms related receptor tyrosine kinase 4 ISS RGD PMID:15563310 RGD:1334463 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770 		JBrowse link
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdr kinase insert domain receptor IMP RGD PMID:18221855 RGD:2292019 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 Fms related receptor tyrosine kinase 4 ISS RGD PMID:15563310 RGD:1334463 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770 		JBrowse link
G Kdr kinase insert domain receptor IMP RGD PMID:18221855 RGD:2292019 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6100
    signaling pathway 2646
      growth factor signaling pathway 523
        vascular endothelial growth factor signaling pathway 137
          altered vascular endothelial growth factor signaling pathway + 3
Path 2
Term Annotations click to browse term
  pathway 6100
    regulatory pathway 3875
      homeostasis pathway 1774
        cardiovascular system homeostasis pathway 421
          vascular endothelial growth factor signaling pathway 137
            altered vascular endothelial growth factor signaling pathway + 3
paths to the root