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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:vascular endothelial growth factor signaling pathway
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Accession:PW:0000243 term browser browse the term
Definition:The VEGF family plays key roles in angiogenesis and lymphangiogenesis. Through their receptors, VEGFs can initiate a diverse and complex network of signaling cascades. Deregulation of VEGFs mediated pathways, mostly through upregulation of VEGFs expression, has been implicated in a number of conditions, primarily cancer.
Synonyms:related_synonym: KEGG:04370;   PID:200109;   PID:200188;   VEGF signaling pathways

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vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap1 A-kinase anchoring protein 1 ISO PID PID:200188 NCBI chr10:76,151,013...76,183,987
Ensembl chr10:76,151,038...76,166,276
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:04370 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:04370 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Arf1 ADP-ribosylation factor 1 ISO PID PID:200188 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG rno:04370 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO PID PID:200188 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Calm1 calmodulin 1 ISO PID PID:200188 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 ISO PID PID:200188 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Calm3 calmodulin 3 ISO PID PID:200188 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 ISO PID PID:200188 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601
JBrowse link
G Casp9 caspase 9 IEA KEGG rno:04370 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cav1 caveolin 1 ISO PID PID:200188 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200188 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IMP RGD PMID:14693680 RGD:1580560 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdc42 cell division cycle 42 ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdh5 cadherin 5 ISO PID PID:200188 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Chp1 calcineurin-like EF-hand protein 1 IEA KEGG rno:04370 NCBI chr 3:111,354,506...111,389,998
Ensembl chr 3:111,354,506...111,389,989
JBrowse link
G Chp2 calcineurin-like EF hand protein 2 IEA KEGG rno:04370 NCBI chr 1:192,169,634...192,173,228
Ensembl chr 1:192,169,841...192,173,253
JBrowse link
G Ctnna1 catenin alpha 1 ISO PID PID:200188 NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960
JBrowse link
G Ctnnb1 catenin beta 1 ISO PID PID:200188 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Dnm2 dynamin 2 ISO PID PID:200188 NCBI chr 8:22,458,869...22,540,649
Ensembl chr 8:22,458,899...22,540,524
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 ISS RGD PMID:14597660 RGD:1334466 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 TAS
ISS
RGD PMID:12876291, PMID:14597660 RGD:727754, RGD:1334466 NCBI chr 1:83,969,456...83,977,665
Ensembl chr 1:83,969,457...83,977,236
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 ISS RGD PMID:14597660 RGD:1334466 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 ISO PID PID:200188 NCBI chr10:17,542,374...17,640,718
Ensembl chr10:17,542,374...17,640,718
JBrowse link
G Fes FES proto-oncogene, tyrosine kinase ISO PID PID:200188 NCBI chr 1:142,174,648...142,183,884
Ensembl chr 1:142,174,648...142,183,884
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 IMP
ISO
PID PMID:15785231, PMID:16633338 PID:200109 PID:200188, RGD:1626621, RGD:2298727 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 IMP
ISO
This is VGFR-3 PID PMID:11683876 PID:200109, RGD:727326 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO PID PMID:17658244 PID:200188, RGD:2298729 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO PID PID:200188 NCBI chr19:30,794,290...30,903,819
Ensembl chr19:30,794,571...30,902,008
JBrowse link
G Grb10 growth factor receptor bound protein 10 ISO PID PID:200188 NCBI chr14:92,021,851...92,122,249
Ensembl chr14:92,021,851...92,117,923
JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200188 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate ISO PID PID:200188 NCBI chr10:109,638,944...109,657,460
Ensembl chr10:109,638,767...109,657,456
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha TAS
IMP
RGD PMID:9398602, PMID:18614764 RGD:625724, RGD:2301848 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hras HRas proto-oncogene, GTPase IEA KEGG rno:04370 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO PID PID:200188 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO PID PID:200188 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IEA KEGG rno:04370 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO PID PID:200188 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Itgav integrin subunit alpha V ISO PID PID:200188 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb3 integrin subunit beta 3 ISO PID PID:200188 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Kdr kinase insert domain receptor IMP
IEA
ISO
VEGFR-2 KEGG
PID
PMID:9442048, PMID:18614764, PMID:17658244, PMID:16633338, PMID:18221855, PMID:15785231 PID:200109 PID:200188 rno:04370, RGD:729081, RGD:2301848, RGD:2298729, RGD:2298727, RGD:2292019, RGD:1626621 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kras KRAS proto-oncogene, GTPase IEA KEGG rno:04370 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 ISO PID PID:200188 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200188 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 IEA KEGG rno:04370 NCBI chr 7:130,109,214...130,120,918
Ensembl chr 7:130,109,663...130,120,579
JBrowse link
G Mapk13 mitogen activated protein kinase 13 IEA KEGG rno:04370 NCBI chr20:6,018,374...6,027,467
Ensembl chr20:6,018,374...6,027,473
JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 IEA KEGG rno:04370 NCBI chr 8:116,012,126...116,046,012
Ensembl chr 8:116,012,121...116,045,954
JBrowse link
G Myof myoferlin ISO PID PID:200188 NCBI chr 1:256,585,410...256,734,727
Ensembl chr 1:256,585,410...256,734,730
JBrowse link
G Nck1 NCK adaptor protein 1 ISO PID PMID:17658244 PID:200188, RGD:2298729 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Nck2 NCK adaptor protein 2 ISO PID PID:200188 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase ISO PID PID:200188 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 IEA KEGG rno:04370 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 IEA KEGG rno:04370 NCBI chr 3:165,241,750...165,374,644
Ensembl chr 3:165,245,238...165,360,292
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 IEA KEGG rno:04370 NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 IEA KEGG rno:04370 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Nos3 nitric oxide synthase 3 ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nras NRAS proto-oncogene, GTPase IEA KEGG rno:04370 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Nrp1 neuropilin 1 ISS
ISO
PID PMID:15563310, PMID:16633338 PID:200109, RGD:1334463, RGD:2298727 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nrp2 neuropilin 2 ISO PID PID:200109 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 ISO PID PID:200188 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200188 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pgf placental growth factor TAS
ISO
RGD PMID:7706320, PMID:16633338 RGD:633657, RGD:2298727 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04370 NCBI chr 8:107,275,849...107,381,088
Ensembl chr 8:107,275,725...107,380,933
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04370 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04370 NCBI chr16:20,415,109...20,424,982
Ensembl chr16:20,416,432...20,424,980
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04370 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04370 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Pla2g10 phospholipase A2, group X IEA KEGG rno:04370 NCBI chr10:1,509,732...1,520,970
Ensembl chr10:1,509,732...1,520,970
JBrowse link
G Pla2g12a phospholipase A2, group XIIA IEA KEGG rno:04370 NCBI chr 2:235,311,664...235,327,972
Ensembl chr 2:235,311,719...235,327,972
JBrowse link
G Pla2g12b phospholipase A2, group XIIB IEA KEGG rno:04370 NCBI chr20:28,989,440...29,007,967
Ensembl chr20:28,989,491...29,007,968
JBrowse link
G Pla2g1b phospholipase A2 group IB IEA KEGG rno:04370 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Pla2g2a phospholipase A2 group IIA IEA KEGG rno:04370 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Pla2g2c phospholipase A2, group IIC IEA KEGG rno:04370 NCBI chr 5:157,163,672...157,187,654
Ensembl chr 5:157,165,341...157,187,643
JBrowse link
G Pla2g2d phospholipase A2, group IID IEA KEGG rno:04370 NCBI chr 5:157,222,636...157,228,795
Ensembl chr 5:157,222,636...157,228,791
JBrowse link
G Pla2g2f phospholipase A2, group IIF IEA KEGG rno:04370 NCBI chr 5:157,192,047...157,217,265
Ensembl chr 5:157,193,053...157,199,441
JBrowse link
G Pla2g3 phospholipase A2, group III IEA KEGG rno:04370 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Pla2g4a phospholipase A2 group IVA IEA KEGG rno:04370 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Pla2g4b phospholipase A2 group IVB IEA KEGG rno:04370 NCBI chr 3:111,824,919...111,833,526
Ensembl chr 3:111,825,162...111,834,210
JBrowse link
G Pla2g4e phospholipase A2, group IVE IEA KEGG rno:04370 NCBI chr 3:111,952,396...112,018,470
Ensembl chr 3:111,952,348...111,994,337
JBrowse link
G Pla2g4f phospholipase A2, group IVF IEA KEGG rno:04370 NCBI chr 3:112,068,617...112,083,978
Ensembl chr 3:112,072,330...112,084,144
JBrowse link
G Pla2g5 phospholipase A2, group V IEA KEGG rno:04370 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Pla2g6 phospholipase A2 group VI IEA KEGG rno:04370 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO
IEA
KEGG
PID
PMID:17658244 PID:200188 rno:04370, RGD:2298729 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Plcg2 phospholipase C, gamma 2 IEA KEGG rno:04370 NCBI chr19:50,039,410...50,173,543
Ensembl chr19:50,045,020...50,173,220
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha IEA KEGG rno:04370 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta IEA KEGG rno:04370 NCBI chr15:4,209,702...4,236,895
Ensembl chr15:4,209,703...4,236,895
JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma IEA KEGG rno:04370 NCBI chr15:51,896,427...51,968,075
Ensembl chr15:51,896,615...51,967,897
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha IEA KEGG rno:04370 NCBI chr14:100,311,224...100,360,879
Ensembl chr14:100,311,173...100,360,879
JBrowse link
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta IEA KEGG rno:04370 NCBI chr 5:64,945,583...64,946,578
Ensembl chr 5:64,945,583...64,946,580
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO PID PID:200188 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 ISO PID PID:200188 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 ISO PID PID:200188 NCBI chr12:46,316,298...46,326,789
Ensembl chr12:46,316,236...46,326,790
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO PID PID:200188 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 ISO PID PID:200188 NCBI chr 7:140,489,499...140,506,925
Ensembl chr 7:140,489,492...140,546,908
JBrowse link
G Prkca protein kinase C, alpha ISO
IEA
KEGG
PID
PMID:17658244 PID:200188 rno:04370, RGD:2298729 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta ISO
IEA
KEGG PMID:17658244 rno:04370, RGD:2298729 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta IMP
ISO
PID PMID:15541367 PID:200188, RGD:2298730 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkcg protein kinase C, gamma IEA KEGG rno:04370 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Prkcz protein kinase C, zeta ISO RGD PMID:17658244 RGD:2298729 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEA KEGG rno:04370 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO
IEA
KEGG PMID:17658244 rno:04370, RGD:2298729 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO PID PID:200188 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID PID:200188 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO PID PID:200188 NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J ISO PID PID:200188 NCBI chr 3:79,233,519...79,390,956
Ensembl chr 3:79,233,525...79,390,956
JBrowse link
G Pxn paxillin ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Rac1 Rac family small GTPase 1 IEA KEGG rno:04370 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rac2 Rac family small GTPase 2 IEA KEGG rno:04370 NCBI chr 7:119,769,708...119,797,111
Ensembl chr 7:119,783,849...119,797,098
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G RGD1560225 similar to nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 IEA KEGG rno:04370
G RGD1564956 similar to calcium binding protein P22 IEA KEGG rno:04370 NCBI chr 5:70,747,534...70,749,967 JBrowse link
G RGD1565588 similar to calcium binding protein P22 IEA KEGG rno:04370 NCBI chr 4:6,477,461...6,479,158 JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200188 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 ISO PID PID:200188 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Sh2d2a SH2 domain containing 2A ISO
IEA
KEGG
PID
PMID:17658244 PID:200188 rno:04370, RGD:2298729 NCBI chr 2:187,218,851...187,225,000
Ensembl chr 2:187,218,851...187,225,002
JBrowse link
G Shb SH2 domain containing adaptor protein B ISO PID PID:200188 NCBI chr 5:60,970,650...61,077,881
Ensembl chr 5:60,971,257...61,077,627
JBrowse link
G Shc2 SHC adaptor protein 2 IEA KEGG rno:04370 NCBI chr 7:12,948,952...12,971,174
Ensembl chr 7:12,948,952...12,971,174
JBrowse link
G Sphk1 sphingosine kinase 1 IEA KEGG rno:04370 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Sphk2 sphingosine kinase 2 IEA KEGG rno:04370 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO
IEA
PID
KEGG
PID:200188 rno:04370 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Vcl vinculin ISO PID PID:200188 NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702
JBrowse link
G Vegfa vascular endothelial growth factor A IDA
IEA
IMP
ISO
KEGG PMID:12181492, PMID:16160062, PMID:18614764, PMID:16633338, PMID:18221855, PMID:15785231 rno:04370, RGD:625593, RGD:2301956, RGD:2301848, RGD:2298727, RGD:2292019, RGD:1626621 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfb vascular endothelial growth factor B ISS
ISO
RGD PMID:15563310, PMID:16633338 RGD:1334463, RGD:2298727 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link
G Vegfc vascular endothelial growth factor C IMP
ISO
PID PMID:11683876, PMID:16633338 PID:200109, RGD:727326, RGD:2298727 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Vegfd vascular endothelial growth factor D IMP
ISO
This is the VEGF-D PID PMID:11683876, PMID:16633338 PID:200109, RGD:727326, RGD:2298727 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
G Vtn vitronectin ISO PID PID:200188 NCBI chr10:65,767,960...65,771,040
Ensembl chr10:65,767,053...65,771,038
JBrowse link
altered vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 Fms related receptor tyrosine kinase 4 ISS RGD PMID:15563310 RGD:1334463 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599
JBrowse link
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdr kinase insert domain receptor IMP RGD PMID:18221855 RGD:2292019 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 Fms related receptor tyrosine kinase 4 ISS RGD PMID:15563310 RGD:1334463 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599
JBrowse link
G Kdr kinase insert domain receptor IMP RGD PMID:18221855 RGD:2292019 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6102
    signaling pathway 2645
      growth factor signaling pathway 523
        vascular endothelial growth factor signaling pathway 137
          altered vascular endothelial growth factor signaling pathway + 3
Path 2
Term Annotations click to browse term
  pathway 6102
    regulatory pathway 3879
      homeostasis pathway 1775
        cardiovascular system homeostasis pathway 422
          vascular endothelial growth factor signaling pathway 137
            altered vascular endothelial growth factor signaling pathway + 3
paths to the root