Regulators of G protein signaling (RGS) act as GAPs to accelerate the slow GTPase activity of Galpha subunits of heterotrimeric G proteins, thus inhibiting the signaling they mediate. RGS members involved in antagonizing Casr activity include RGS2 – a GAP for Galphaq, RGS4 and RGS5 – GAPs for Galphai and/or Galphaq, and RGS12 – a GAP for Galpha12/13. The genes are listed with aliases in parentheses, full names and links to gene report pages:

Rgs2 – regulator of G-protein signaling 2
Rgs4 (RGP4) – regulator of G-protein signaling 4
Rgs5 (MST105) – regulatory of G-protein signaling 5
Rgs12 – regulator of G-protein signaling 12