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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Neuralgia
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Accession:DOID:9005968 term browser browse the term
Definition:Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Synonyms:exact_synonym: Atypical Neuralgia;   Atypical Neuralgias;   Iliohypogastric Nerve Neuralgia;   Iliohypogastric Nerve Neuralgias;   Ilioinguinal Neuralgia;   Ilioinguinal Neuralgias;   Nerve Pain;   Nerve Pains;   Neuralgias;   Neurodynia;   Neurodynias;   Neuropathic Pain;   Neuropathic Pains;   Paroxysmal Nerve Pain;   Paroxysmal Nerve Pains;   Perineal Neuralgia;   Perineal Neuralgias;   Stump Neuralgia;   Stump Neuralgias;   Supraorbital Neuralgia;   Supraorbital Neuralgias;   Vidian Neuralgia;   Vidian Neuralgias
 primary_id: MESH:D009437;   RDO:0004660
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A IEP RGD PMID:12946573 RGD:6893571 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Adra2c adrenoceptor alpha 2C IEP RGD PMID:12946573 RGD:6893571 NCBI chr14:75,471,143...75,472,846
Ensembl chr14:75,471,143...75,472,846
JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17442347 PMID:18400411 PMID:19339603 PMID:24133248 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
JBrowse link
G Cfl1 cofilin 1 treatment IEP associated with Sciatic Neuropathy RGD PMID:27216618 RGD:11568694 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
JBrowse link
G Ctss cathepsin S IEP
IMP
RGD PMID:18700000 PMID:17551020 RGD:5686878, RGD:5686911 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Ctsz cathepsin Z IEP RGD PMID:18700000 RGD:5686878 NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17292584 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17720801 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Drd1 dopamine receptor D1 IEP RGD PMID:22171983 RGD:6907447 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 IMP
IEP
RGD PMID:22902996 PMID:22171983 RGD:6907443, RGD:6907447 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Foxp3 forkhead box P3 treatment IEP
ISO
mRNA:increased expression: L4-L5 of the spinal cord RGD PMID:30858084 PMID:30858084 RGD:38599004, RGD:38599004 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Gal galanin and GMAP prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Gfra1 GDNF family receptor alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 1:257,315,682...257,552,004 JBrowse link
G Gja1 gap junction protein, alpha 1 ISO associated with Spinal Cord Injuries; RGD PMID:22951907 RGD:7364890 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Grk1 G protein-coupled receptor kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr16:76,122,501...76,135,792
Ensembl chr16:76,123,842...76,135,792
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment IEP RGD PMID:24216329 RGD:13792703 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Grm5 glutamate metabotropic receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840219 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Hmgb1 high mobility group box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28011743 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Il10 interleukin 10 treatment IDA
IMP
ISO
RGD PMID:16949747 PMID:25078297 PMID:24077211 RGD:1598632, RGD:11049468, RGD:7364865 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Itgam integrin subunit alpha M IEP mRNA:increased expression:lumbar vertebra RGD PMID:15145554 RGD:1342461 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Kdr kinase insert domain receptor IEP RGD PMID:20705122 RGD:5684389 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Mir135a microRNA 135a ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 7:26,611,990...26,612,089
Ensembl chr 7:26,611,990...26,612,089
JBrowse link
G Mir135b microRNA 135b ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr13:43,638,857...43,638,953
Ensembl chr13:43,638,857...43,638,953
JBrowse link
G Mir208a microRNA 208a ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr15:28,425,570...28,425,652 JBrowse link
G Mir223 microRNA 223 treatment IDA RGD PMID:28580822 RGD:25824768 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996
JBrowse link
G Nos1 nitric oxide synthase 1 treatment IDA RGD PMID:23342771 RGD:7257658 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14718584 PMID:18400411 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G P2ry12 purinergic receptor P2Y12 IMP RGD PMID:20665560 RGD:6480524 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30152261 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19557861 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tgfb1 transforming growth factor, beta 1 treatment IEP RGD PMID:24979268 RGD:11073677 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr4 toll-like receptor 4 IEP mRNA:increased expression:lumbar vertebra RGD PMID:15145554 RGD:1342461 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20846523 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 5:77,253,881...77,277,078
Ensembl chr 5:77,251,373...77,277,421
JBrowse link
amyotrophic neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Septin9 septin 9 ISO
ISS
ClinVar Annotator: match by term: Hereditary Neuralgic Amyotrophy (HNA)
ClinVar Annotator: match by term: Hereditary neuralgic amyotrophy
OMIM:162100
ClinVar
MouseDO
PMID:16186812 PMID:17546647 PMID:18492087 PMID:19139049 PMID:19204161 More... NCBI chr10:102,409,798...102,579,056
Ensembl chr10:102,409,711...102,579,055
JBrowse link
Postherpetic Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn8a sodium voltage-gated channel alpha subunit 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
JBrowse link
Sciatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 IMP RGD PMID:16176350 RGD:2302154 NCBI chr 1:243,024,611...243,031,749
Ensembl chr 1:243,024,614...243,031,653
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B treatment IDA RGD PMID:22425187 RGD:7245944 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17207
    disease of anatomical entity 16553
      nervous system disease 12101
        peripheral nervous system disease 2533
          Neuralgia 47
            Morton Neuroma 0
            Piriformis Muscle Syndrome + 0
            Postherpetic Neuralgia 2
            Pudendal Neuralgia 0
            Sciatica + 2
            amyotrophic neuralgia 1
            causalgia 0
Path 2
Term Annotations click to browse term
  disease 17207
    disease of anatomical entity 16553
      nervous system disease 12101
        Neurologic Manifestations 5446
          Pain 306
            Neuralgia 47
              Morton Neuroma 0
              Piriformis Muscle Syndrome + 0
              Postherpetic Neuralgia 2
              Pudendal Neuralgia 0
              Sciatica + 2
              amyotrophic neuralgia 1
              causalgia 0
paths to the root