Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Neuralgia
go back to main search page
Accession:DOID:9005968 term browser browse the term
Definition:Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Synonyms:exact_synonym: Atypical Neuralgia;   Atypical Neuralgias;   Iliohypogastric Nerve Neuralgia;   Iliohypogastric Nerve Neuralgias;   Ilioinguinal Neuralgia;   Ilioinguinal Neuralgias;   Nerve Pain;   Nerve Pains;   Neuralgias;   Neurodynia;   Neurodynias;   Neuropathic Pain;   Neuropathic Pains;   Paroxysmal Nerve Pain;   Paroxysmal Nerve Pains;   Perineal Neuralgia;   Perineal Neuralgias;   Stump Neuralgia;   Stump Neuralgias;   Supraorbital Neuralgia;   Supraorbital Neuralgias;   Vidian Neuralgia;   Vidian Neuralgias
 primary_id: MESH:D009437
 xref: EFO:0005762;   EFO:0009430


show annotations for term's descendants           Sort by:
Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A IEP RGD PMID:12946573 RGD:6893571 NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2c adrenoceptor alpha 2C IEP RGD PMID:12946573 RGD:6893571 NCBI chr14:79,695,514...79,697,476
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Aqp9 aquaporin 9 ameliorates IMP RGD PMID:31746418 RGD:152995474 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17442347 PMID:18400411 PMID:19339603 PMID:24133248 NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 ameliorates IMP RGD PMID:24659417 RGD:401940123 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cfl1 cofilin 1 treatment IEP associated with Sciatic Neuropathy RGD PMID:27216618 RGD:11568694 NCBI chr 1:212,227,124...212,230,656
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Ctss cathepsin S IEP
IMP		 RGD PMID:18700000 PMID:17551020 RGD:5686878, RGD:5686911 NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Ctsz cathepsin Z IEP RGD PMID:18700000 RGD:5686878 NCBI chr 3:183,643,077...183,653,847
Ensembl chr 3:163,224,875...163,235,645 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17292584 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17720801 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Drd1 dopamine receptor D1 IEP RGD PMID:22171983 RGD:6907447 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 IMP
IEP		 RGD PMID:22902996 PMID:22171983 RGD:6907443, RGD:6907447 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Foxp3 forkhead box P3 treatment IEP
ISO		 mRNA:increased expression: L4-L5 of the spinal cord RGD PMID:30858084 PMID:30858084 RGD:38599004, RGD:38599004 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gal galanin and GMAP prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment IMP RGD PMID:19922668 RGD:401700384 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 1:267,325,297...267,557,037
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Gja1 gap junction protein, alpha 1 ISO associated with Spinal Cord Injuries; RGD PMID:22951907 RGD:7364890 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IEP RGD PMID:24659417 RGD:401940123 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grk1 G protein-coupled receptor kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr16:82,821,184...82,837,971
Ensembl chr16:76,123,842...76,135,792 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment IEP RGD PMID:24216329 RGD:13792703 NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840219 NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:141,312,368...141,882,274 		JBrowse link
G Hmgb1 high mobility group box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO protein:increased expression:dorsal raphe nucleus RGD PMID:31045847 RGD:405849276 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28011743 NCBI chr  X:115,453,190...115,682,325
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Il10 interleukin 10 treatment IDA
IMP
ISO		 RGD PMID:16949747 PMID:25078297 PMID:24077211 RGD:1598632, RGD:11049468, RGD:7364865 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Itgam integrin subunit alpha M IEP mRNA:increased expression:lumbar vertebra RGD PMID:15145554 RGD:1342461 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Kdr kinase insert domain receptor IEP RGD PMID:20705122 RGD:5684389 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mir135a microRNA 135a ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 7:28,499,166...28,499,265
Ensembl chr 7:26,611,990...26,612,089 		JBrowse link
G Mir135b microRNA 135b ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr13:46,191,018...46,191,114
Ensembl chr13:43,638,857...43,638,953 		JBrowse link
G Mir154 microRNA 154 IMP RGD PMID:31746418 RGD:152995474 NCBI chr 6:134,574,352...134,574,435
Ensembl chr 6:128,752,947...128,753,030 		JBrowse link
G Mir208a microRNA 208a ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr15:32,395,552...32,395,634 JBrowse link
G Mir221 microRNA 221 treatment IMP RGD PMID:27059231 RGD:151347419 NCBI chr  X:6,023,182...6,023,290
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir223 microRNA 223 treatment IDA RGD PMID:28580822 RGD:25824768 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 IEP RGD PMID:23386250 RGD:329337338 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 treatment IEP RGD PMID:23386250 RGD:329337338 NCBI chr15:33,256,912...33,284,522
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Nos1 nitric oxide synthase 1 treatment IDA RGD PMID:23342771 RGD:7257658 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14718584 PMID:18400411 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G P2ry12 purinergic receptor P2Y12 IMP RGD PMID:20665560 RGD:6480524 NCBI chr 2:145,631,487...145,673,194
Ensembl chr 2:143,481,430...143,523,361 		JBrowse link
G Pomc proopiomelanocortin treatment IMP RGD PMID:23624847 RGD:407574732 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30152261 NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19557861 NCBI chr 3:71,553,185...71,701,377
Ensembl chr 3:51,145,146...51,293,516 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 treatment IEP RGD PMID:27059231 RGD:151347419 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase treatment IEP RGD PMID:33746000 RGD:150521727 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 treatment IEP RGD PMID:24979268 RGD:11073677 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 IEP mRNA:increased expression:lumbar vertebra RGD PMID:15145554 RGD:1342461 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20846523 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 5:82,266,436...82,292,858
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
amyotrophic neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Septin9 septin 9 ISO ClinVar Annotator: match by term: Amyotrophic neuralgia | ClinVar Annotator: match by term: Amyotrophy, hereditary neuralgic | ClinVar Annotator: match by term: Hereditary Neuralgic Amyotrophy (HNA) ClinVar PMID:16186812 PMID:17546647 PMID:18492087 PMID:19139049 PMID:19204161 More... NCBI chr10:102,908,557...103,077,789
Ensembl chr10:102,409,711...102,579,055 		JBrowse link
Postherpetic Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IEP mRNA:increased expression:dorsal root ganglion RGD PMID:25880108 RGD:407987076 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr 7:133,860,901...134,034,809
Ensembl chr 7:131,982,480...132,151,292 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr 3:71,553,185...71,701,377
Ensembl chr 3:51,145,146...51,293,516 		JBrowse link
Sciatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 IMP RGD PMID:16176350 RGD:2302154 NCBI chr 1:252,973,818...252,980,873
Ensembl chr 1:243,024,614...243,031,653 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B treatment IDA RGD PMID:22425187 RGD:7245944 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19134
    disease of anatomical entity 18447
      nervous system disease 14354
        peripheral nervous system disease 4385
          Neuralgia 60
            Morton Neuroma 0
            Piriformis Muscle Syndrome + 0
            Postherpetic Neuralgia 3
            Pudendal Neuralgia 0
            Sciatica + 2
            amyotrophic neuralgia 1
            causalgia 0
Path 2
Term Annotations click to browse term
  disease 19134
    disease of anatomical entity 18447
      nervous system disease 14354
        Neurologic Manifestations 10440
          Pain 350
            Neuralgia 60
              Morton Neuroma 0
              Piriformis Muscle Syndrome + 0
              Postherpetic Neuralgia 3
              Pudendal Neuralgia 0
              Sciatica + 2
              amyotrophic neuralgia 1
              causalgia 0
paths to the root