Rhoa (ras homolog family member A) - Rat Genome Database
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Gene: Rhoa (ras homolog family member A) Rattus norvegicus
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Symbol: Rhoa
Name: ras homolog family member A
RGD ID: 619921
Description: Exhibits several functions, including GTPase activity; Rho GDP-dissociation inhibitor binding activity; and purine ribonucleoside binding activity. Involved in several processes, including generation of neurons; intracellular signal transduction; and positive regulation of apoptotic process. Localizes to axon; cytosol; and membrane. Used to study membranous glomerulonephritis. Biomarker of asthma; fetal alcohol syndrome; hypertension; obesity; and pulmonary hypertension. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; INTERACTS WITH (R)-mevalonic acid; (S)-(-)-perillyl alcohol; 1-octadec-9-enoylglycero-3-phosphate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Arha; Arha2; MGC72339; plysia ras-related homolog A2; ras homolog gene family, member A; transforming protein RhoA
Orthologs:
Homo sapiens (human) : RHOA (ras homolog family member A)  HGNC  Alliance
Mus musculus (house mouse) : Rhoa (ras homolog family member A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rhoa (ras homolog family member A)
Pan paniscus (bonobo/pygmy chimpanzee) : RHOA (ras homolog family member A)
Canis lupus familiaris (dog) : RHOA (ras homolog family member A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rhoa (ras homolog family member A)
Sus scrofa (pig) : RHOA (ras homolog family member A)
Chlorocebus sabaeus (African green monkey) : RHOA (ras homolog family member A)
Heterocephalus glaber (naked mole-rat) : Rhoa (ras homolog family member A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08117,082,440 - 117,116,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,431,244 - 116,464,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,319,010 - 108,327,586 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abnormalities, Drug-Induced  (ISO)
alopecia  (ISO)
Animal Disease Models  (ISO)
asthma  (IEP)
autosomal recessive limb-girdle muscular dystrophy type 2P  (ISO)
Brain Injuries  (IEP)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (IEP,ISO)
Cocaine-Related Disorders  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Craniofacial Abnormalities  (ISO)
cutaneous T cell lymphoma  (ISO)
Diabetes Mellitus, Experimental  (IDA)
ectodermal dysplasia  (ISO)
esophageal carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Liver Cirrhosis  (IEP)
Facial Ectodermal Dysplasia  (ISO)
fetal alcohol syndrome  (IEP)
Fibrosis  (IEP)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
hypertension  (IEP)
Hypopigmentation  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
Left Ventricular Hypertrophy  (IMP)
Leukoencephalopathies  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
membranous glomerulonephritis  (IMP)
multiple sclerosis  (ISO)
Myocardial Reperfusion Injury  (IEP)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neurocutaneous Syndromes  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP)
Optic Nerve Injuries  (IEP)
ovarian carcinoma  (ISO)
peripheral T-cell lymphoma  (ISO)
proteinuria  (ISO)
pulmonary hypertension  (IEP)
Stomach Neoplasms  (ISO)
T-Cell Lymphoma  (ISO)
tooth disease  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (EXP,ISO)
(S)-(-)-perillyl alcohol  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
8-(4-chlorophenylthio)-cAMP  (EXP)
8-(4-chlorophenylthio)-cGMP  (ISO)
9-cis-retinoic acid  (ISO)
acetylcholine  (EXP)
Aescin  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
atropine  (ISO)
beclomethasone  (EXP)
benzo[a]pyrene  (ISO)
beryllium sulfate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brimonidine tartrate  (EXP)
bufalin  (ISO)
cadmium dichloride  (EXP,ISO)
calcidiol  (EXP)
Calpeptin  (ISO)
carvone  (ISO)
casticin  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
chloropicrin  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP)
Deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
everolimus  (ISO)
farnesol  (EXP,ISO)
farnesyl diphosphate  (ISO)
fasudil hydrochloride  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
flavonol  (ISO)
flubendazole  (ISO)
fluvastatin  (EXP,ISO)
folic acid  (ISO)
gallic acid  (ISO)
geranylgeraniol  (EXP,ISO)
glucose  (EXP)
glycodeoxycholic acid  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
GTP  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (EXP)
haloperidol  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
kainic acid  (EXP)
kanamycin A  (ISO)
KT 5823  (ISO)
latrunculin B  (EXP)
lipopolysaccharide  (EXP,ISO)
lovastatin  (EXP,ISO)
LY294002  (EXP)
mebendazole  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
methotrexate  (ISO)
methylmercury chloride  (EXP)
mevastatin  (ISO)
myrtenol  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
nonanoic acid  (ISO)
oroxylin A  (EXP)
p-cresol  (ISO)
p-menthan-3-ol  (ISO)
pamidronate  (ISO)
paracetamol  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perillic acid  (ISO)
perillyl alcohol  (EXP,ISO)
perillyl aldehyde  (ISO)
phenylephrine  (EXP)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 12,13-dibutanoate  (EXP)
pirinixic acid  (EXP)
prednisolone  (EXP)
progesterone  (EXP)
quercetin  (ISO)
quinpirole  (ISO)
raloxifene  (EXP)
ramipril  (EXP)
resveratrol  (EXP,ISO)
Risedronate sodium  (EXP,ISO)
Ro 31-8220  (EXP)
rotenone  (EXP,ISO)
sevoflurane  (EXP)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
terbinafine  (ISO)
thalidomide  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-piceid  (EXP)
trichostatin A  (EXP)
Triptolide  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
U-73122  (EXP)
uranium atom  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
warfarin  (ISO)
Y-27632  (ISO)
zaragozic acid A  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IBA,ISO,TAS)
actin cytoskeleton reorganization  (ISO,ISS)
actin filament organization  (IBA)
alpha-beta T cell lineage commitment  (ISO)
androgen receptor signaling pathway  (ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
apical junction assembly  (ISO,ISS)
apolipoprotein A-I-mediated signaling pathway  (ISO)
beta selection  (ISO)
cell adhesion  (ISO)
cell differentiation  (ISO)
cell junction assembly  (ISO,ISS)
cell migration  (IBA,ISO,ISS)
cell morphogenesis  (ISO)
cell-matrix adhesion  (ISO)
cellular response to chemokine  (ISO,ISS)
cellular response to cytokine stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to progesterone stimulus  (NAS)
cerebral cortex cell migration  (ISO)
cleavage furrow formation  (ISO,ISS)
cortical cytoskeleton organization  (IBA)
cytoplasmic microtubule organization  (ISO)
cytoskeleton organization  (ISO)
embryonic cleavage  (ISO)
endothelial cell migration  (ISO)
endothelial tube lumen extension  (ISO)
establishment of epithelial cell apical/basal polarity  (ISO,ISS)
establishment or maintenance of actin cytoskeleton polarity  (ISO)
establishment or maintenance of cell polarity  (IBA)
forebrain radial glial cell differentiation  (ISO)
GTP metabolic process  (IDA)
meiotic spindle organization  (ISO)
mitotic cleavage furrow formation  (ISO,ISS)
mitotic spindle assembly  (ISO)
negative chemotaxis  (ISO)
negative regulation of cell death  (IMP)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell size  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (IMP)
negative regulation of intracellular steroid hormone receptor signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron differentiation  (IMP)
negative regulation of neuron projection development  (IGI)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
neuron projection morphogenesis  (IEP)
odontogenesis  (ISO)
ossification involved in bone maturation  (ISO)
polar body extrusion after meiotic divisions  (ISO)
positive regulation of actin filament polymerization  (IMP)
positive regulation of alpha-beta T cell differentiation  (ISO)
positive regulation of cell adhesion  (IEP)
positive regulation of cell growth  (IEP,IMP)
positive regulation of cell migration  (IEP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of cytokinesis  (ISO,ISS)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO,ISS)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of lipase activity  (ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron differentiation  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of podosome assembly  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO,ISS)
positive regulation of smooth muscle contraction  (IMP)
positive regulation of stress fiber assembly  (ISO)
positive regulation of T cell migration  (ISO,ISS)
positive regulation of translation  (IEP)
positive regulation of vascular associated smooth muscle contraction  (ISO)
positive regulation of vasoconstriction  (IEP)
regulation of actin cytoskeleton organization  (IBA,ISO)
regulation of actin polymerization or depolymerization  (IEP)
regulation of calcium ion transport  (IMP)
regulation of cell migration  (ISO,ISS)
regulation of cell shape  (IBA)
regulation of dendrite development  (IMP)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of modification of postsynaptic actin cytoskeleton  (ISO)
regulation of modification of synaptic structure  (IMP)
regulation of neural precursor cell proliferation  (ISO)
regulation of neuron projection development  (ISO)
regulation of osteoblast proliferation  (ISO)
regulation of systemic arterial blood pressure by endothelin  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to amino acid  (IEP)
response to drug  (IDA,IEP)
response to ethanol  (IEP)
response to glucocorticoid  (IEP)
response to glucose  (IEP)
response to hypoxia  (IEP)
response to mechanical stimulus  (IEP)
Rho protein signal transduction  (IDA,ISO,ISS)
Roundabout signaling pathway  (ISO,ISS)
skeletal muscle satellite cell migration  (ISS)
skeletal muscle tissue development  (ISO)
spindle localization  (ISO)
stress fiber assembly  (IBA,ISO,ISS)
stress-activated protein kinase signaling cascade  (IMP)
substantia nigra development  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
trabecula morphogenesis  (ISO)
wound healing, spreading of cells  (ISS)

Cellular Component

Molecular Function

References

References - curated
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Additional References at PubMed
PMID:1328215   PMID:1643657   PMID:8617235   PMID:8625410   PMID:9214622   PMID:10699171   PMID:11877460   PMID:12477932   PMID:12699088   PMID:12706482   PMID:12761501   PMID:12777392  
PMID:12777804   PMID:12816757   PMID:12874183   PMID:12893655   PMID:14614988   PMID:14622110   PMID:14634067   PMID:14657280   PMID:15048014   PMID:15071095   PMID:15093731   PMID:15140945  
PMID:15169791   PMID:15173202   PMID:15192268   PMID:15220352   PMID:15249579   PMID:15308673   PMID:15467718   PMID:15489334   PMID:15513955   PMID:15572519   PMID:15601624   PMID:15607750  
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PMID:18332105   PMID:18434385   PMID:18457998   PMID:18469113   PMID:18474218   PMID:18556119   PMID:18562481   PMID:18599801   PMID:18614015   PMID:18621909   PMID:18625710   PMID:18667438  
PMID:18765661   PMID:18824598   PMID:18829532   PMID:18854312   PMID:18981818   PMID:19027829   PMID:19056867   PMID:19085564   PMID:19122172   PMID:19147496   PMID:19209406   PMID:19289122  
PMID:19331812   PMID:19340932   PMID:19524873   PMID:19605563   PMID:19629561   PMID:19635168   PMID:19692654   PMID:19716825   PMID:19723805   PMID:19734146   PMID:19747063   PMID:19755152  
PMID:19759375   PMID:19782033   PMID:19787194   PMID:19799911   PMID:19887681   PMID:19897743   PMID:19934221   PMID:19956681   PMID:20086008   PMID:20139061   PMID:20208559   PMID:20368814  
PMID:20369389   PMID:20380579   PMID:20387077   PMID:20435455   PMID:20442409   PMID:20458337   PMID:20472763   PMID:20507639   PMID:20599954   PMID:20696841   PMID:20807316   PMID:20970835  
PMID:20974804   PMID:20978008   PMID:21131638   PMID:21147877   PMID:21187345   PMID:21411727   PMID:21423176   PMID:21454546   PMID:21511701   PMID:21525037   PMID:21543326   PMID:21545816  
PMID:21572420   PMID:21584655   PMID:21647708   PMID:21676004   PMID:21816966   PMID:21935930   PMID:21946234   PMID:21956892   PMID:21976490   PMID:21978755   PMID:22019888   PMID:22136148  
PMID:22152812   PMID:22275376   PMID:22405202   PMID:22411227   PMID:22427691   PMID:22433866   PMID:22498718   PMID:22685604   PMID:22727353   PMID:22740689   PMID:22865386   PMID:22891260  
PMID:22926577   PMID:22986787   PMID:22987919   PMID:23012358   PMID:23237297   PMID:23241886   PMID:23258382   PMID:23269647   PMID:23325464   PMID:23361995   PMID:23376485   PMID:23413252  
PMID:23457552   PMID:23484083   PMID:23536606   PMID:23564082   PMID:23624614   PMID:23696743   PMID:23726972   PMID:23918799   PMID:24096734   PMID:24292258   PMID:24335996   PMID:24352656  
PMID:24625528   PMID:24637663   PMID:24660528   PMID:24742984   PMID:24872317   PMID:24984203   PMID:25106095   PMID:25121106   PMID:25261755   PMID:25268128   PMID:25318874   PMID:25398325  
PMID:25485583   PMID:25499974   PMID:25502873   PMID:25515214   PMID:25712270   PMID:25783350   PMID:25794483   PMID:25807302   PMID:25911094   PMID:25922200   PMID:26191148   PMID:26350504  
PMID:26391686   PMID:26392029   PMID:26529257   PMID:26572638   PMID:26787017   PMID:26820678   PMID:26846716   PMID:27003208   PMID:27093550   PMID:27094551   PMID:27126736   PMID:27288754  
PMID:27336844   PMID:27693126   PMID:27734223   PMID:27842221   PMID:27893610   PMID:27917469   PMID:28054559   PMID:28078487   PMID:28235057   PMID:28277985   PMID:28526517   PMID:28665545  
PMID:28673614   PMID:29029794   PMID:29070491   PMID:29522098   PMID:29791873   PMID:29940159   PMID:29953931   PMID:29991018   PMID:30790506   PMID:31029634   PMID:31173168   PMID:31570889  


Genomics

Comparative Map Data
Rhoa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08117,082,440 - 117,116,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,431,244 - 116,464,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,319,010 - 108,327,586 (+)NCBICelera
Cytogenetic Map8q32NCBI
RHOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,359,145 - 49,412,998 (-)EnsemblGRCh38hg38GRCh38
GRCh38349,359,145 - 49,411,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,396,569 - 49,449,526 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,371,582 - 49,424,530 (-)NCBINCBI36hg18NCBI36
Build 34349,371,584 - 49,424,530NCBI
Celera349,361,450 - 49,414,313 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,456,057 - 49,509,248 (-)NCBIHuRef
CHM1_1349,349,379 - 49,402,297 (-)NCBICHM1_1
Rhoa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,183,359 - 108,215,142 (+)NCBI
GRCm389108,306,160 - 108,337,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,306,129 - 108,337,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,208,536 - 108,240,270 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,164,298 - 108,196,026 (+)NCBImm8
Celera9107,915,249 - 107,947,041 (+)NCBICelera
Cytogenetic Map9F1-F2NCBI
Rhoa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,300,462 - 1,347,451 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,300,821 - 1,347,453 (-)NCBIChiLan1.0ChiLan1.0
RHOA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,362,698 - 50,584,600 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBI
RHOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,824,575 - 39,887,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,824,552 - 39,888,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rhoa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,000,050 - 1,045,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,918,836 - 32,003,722 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,918,484 - 31,991,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,149,494 - 35,160,516 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2210,757,337 - 10,772,704 (-)Ensembl
ChlSab1.12210,757,381 - 10,809,257 (-)NCBI
Rhoa
(Heterocephalus glaber - naked mole-rat)
No map positions available.

Position Markers
Arha2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X19,913,673 - 19,914,376NCBIRnor6.0
Rnor_5.0X20,664,754 - 20,665,457UniSTSRnor5.0
RGSC_v3.4X40,043,445 - 40,044,148UniSTSRGSC3.4
CeleraX19,980,633 - 19,981,336UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map16q12.5UniSTS
WI-18922  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.08117,115,990 - 117,116,135NCBIRnor6.0
Rnor_5.08116,464,678 - 116,464,823UniSTSRnor5.0
Celera8108,328,407 - 108,328,552UniSTS
Cytogenetic Map16q12.5UniSTS
D3S1330E  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.08117,115,661 - 117,115,769NCBIRnor6.0
Rnor_5.08116,464,349 - 116,464,457UniSTSRnor5.0
Celera8108,328,078 - 108,328,186UniSTS
Cytogenetic Map16q12.5UniSTS
UniSTS:532286  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.08117,115,803 - 117,116,185NCBIRnor6.0
Rnor_5.08116,464,491 - 116,464,873UniSTSRnor5.0
Celera8108,328,220 - 108,328,602UniSTS
Cytogenetic Map16q12.5UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)844458129118087517Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)865717449128033050Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)872849686117849686Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight as a percentage of body weight (CMO:0000654)874917593121080545Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)876103982127182642Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)878805083123805083Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)878805083123805083Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)878805083123805083Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)878805083123805083Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)880697934125697934Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)883894304128894304Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)889058229132243842Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)895963141122354314Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102051964133307652Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8104682575133307652Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)8104682575133307652Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8107769005129956433Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:94
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000071664
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3
Medium 3 43 57 41 19 41 8 11 74 35 41 8 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071664   ⟹   ENSRNOP00000066672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)Ensembl
RefSeq Acc Id: NM_057132   ⟹   NP_476473
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,106,577 - 117,115,169 (+)NCBI
Rnor_5.08116,431,244 - 116,464,932 (+)NCBI
Celera8108,319,010 - 108,327,586 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243699   ⟹   XP_006243761
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,082,440 - 117,116,244 (+)NCBI
Rnor_5.08116,431,244 - 116,464,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243700   ⟹   XP_006243762
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,082,469 - 117,116,244 (+)NCBI
Rnor_5.08116,431,244 - 116,464,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243701   ⟹   XP_006243763
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,082,869 - 117,116,244 (+)NCBI
Rnor_5.08116,431,244 - 116,464,932 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_476473   ⟸   NM_057132
- Peptide Label: precursor
- UniProtKB: P61589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243761   ⟸   XM_006243699
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243762   ⟸   XM_006243700
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243763   ⟸   XM_006243701
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066672   ⟸   ENSRNOT00000071664

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696296
Promoter ID:EPDNEW_R6820
Type:single initiation site
Name:Rhoa_1
Description:ras homolog family member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,106,673 - 117,106,733EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619921 AgrOrtholog
Ensembl Genes ENSRNOG00000050519 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000066672 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071664 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598621 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117273 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72339 IMAGE-MGC_LOAD
NCBI Gene 117273 ENTREZGENE
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rhoa PhenoGen
PROSITE RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.107401 ENTREZGENE
UniProt O35791_RAT UniProtKB/TrEMBL
  P61589 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-12 Rhoa  ras homolog family member A  Rhoa  ras homolog gene family, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Rhoa  ras homolog gene family, member A      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Rhoa  ras homolog gene family, member A      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-02-25   ras homolog gene family, member A  Rhoa  plysia ras-related homolog A2  Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Rhoa  plysia ras-related homolog A2  Arha2    Symbol and Name updated 1299863 APPROVED
2002-08-07 Arha2  plysia ras-related homolog A2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease be involved in the cerebral vascular pathogenesis 632250
gene_expression expressed in 804G rat bladder carcinoma cells 628348
gene_process decreases both expression levels and activities of dystrophin-glycoprotein complex (DGC) in muscle atrophy 625642
gene_process regulates actin cytoskeleton 628348
gene_regulation transiently activated by the CNF1 toxin produced by uropathogenic Escherichia coli (UPEC) strains; this restricted activation is a direct consequence of the cell-mediated degradation of the toxin-activated forms 628348
gene_regulation expression level modulated by release of NO in vascular smooth muscle cells 1304269
 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.