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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:amphetamine abuse
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Accession:DOID:670 term browser browse the term
Definition:Disorders related or resulting from use of amphetamines.
Synonyms:exact_synonym: Amphetamine Addiction;   Amphetamine Dependence;   Amphetamine-Related Disorders;   Disorder, Amphetamine-Related
 primary_id: MESH:D019969;   RDO:0007302
 xref: ICD9CM:305.7
For additional species annotation, visit the Alliance of Genome Resources.


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amphetamine abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16470869 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr10:39,654,771...39,717,592
Ensembl chr10:39,655,455...39,719,312
JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20799992 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Ak5 adenylate kinase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 2:257,671,772...257,864,385
Ensembl chr 2:257,671,772...257,864,385
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15982448 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aoah acyloxyacyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr17:45,872,414...46,115,026
Ensembl chr17:45,872,414...46,115,004
JBrowse link
G Arrb2 arrestin, beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17233643 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Astn2 astrotactin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:81,179,614...82,168,528
Ensembl chr 5:81,179,605...82,168,427
JBrowse link
G Bdnf brain-derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20736000 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cchcr1 coiled-coil alpha-helical rod protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr20:3,730,968...3,745,721
Ensembl chr20:3,730,955...3,740,009
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cdh13 cadherin 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103
JBrowse link
G Cfh complement factor H ISO
IEP
protein:increased expression:serum:
protein:increased expression:serum, hippocampus:
RGD PMID:22871478, PMID:22871478 RGD:7364944, RGD:7364944 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Col28a1 collagen type XXVIII alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 4:34,048,074...34,198,558
Ensembl chr 4:34,048,533...34,194,764
JBrowse link
G Comt catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274053 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Csmd1 CUB and Sushi multiple domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr16:77,152,823...78,850,222
Ensembl chr16:78,539,489...78,850,222
JBrowse link
G Cubn cubilin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr17:80,584,921...80,807,181
Ensembl chr17:80,584,878...80,807,243
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18280655 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 7:78,642,016...78,651,763
Ensembl chr 7:78,649,875...78,650,906
JBrowse link
G Drd1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18363855 PMID:19444617 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18363855 PMID:18555060 PMID:19940168 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19940168 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Drd4 dopamine receptor D4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274053 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Ephx1 epoxide hydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19598248 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Fkbp15 FKBP prolyl isomerase family member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:78,133,357...78,229,311
Ensembl chr 5:78,133,886...78,183,122
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19689456 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15772696 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:17356005 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Grm2 glutamate metabotropic receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20211215 NCBI chr 8:115,344,999...115,358,628
Ensembl chr 8:115,344,999...115,358,046
JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19254865 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15729709 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18186040 PMID:19254865 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Hdac8 histone deacetylase 8 IEP mRNA:decreased expression:striatum (rat) RGD PMID:25452209 RGD:9681719 NCBI chr  X:72,163,777...72,370,058
Ensembl chr  X:72,163,777...72,370,044
JBrowse link
G Hs3st4 heparan sulfate-glucosamine 3-sulfotransferase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:193,834,007...194,240,806 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO CTD Direct Evidence: therapeutic CTD PMID:10780831 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19689456 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20705401 NCBI chr 5:157,501,202...157,518,870
Ensembl chr 5:157,503,040...157,518,631
JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr19:12,481,563...12,945,320
Ensembl chr19:12,481,540...12,942,963
JBrowse link
G Lingo2 leucine rich repeat and Ig domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:51,466,367...51,638,161 JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr13:102,693,679...102,724,120
Ensembl chr13:102,698,546...102,721,218
JBrowse link
G Mtarc2 mitochondrial amidoxime reducing component 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr13:102,724,266...102,755,511
Ensembl chr13:102,724,348...102,756,174
JBrowse link
G Myo5b myosin Vb ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr18:70,426,865...70,729,985
Ensembl chr18:70,427,007...70,729,030
JBrowse link
G Nos1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15542708 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19566775 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16402083 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G PCOLCE2 procollagen C-endopeptidase enhancer 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 8:103,459,219...103,484,557
Ensembl chr 8:103,459,161...103,484,535
JBrowse link
G Pde4b phosphodiesterase 4B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pde4d phosphodiesterase 4D ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pde6c phosphodiesterase 6C ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:256,822,099...256,885,879
Ensembl chr 1:256,822,334...256,877,810
JBrowse link
G Pdyn prodynorphin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16529859 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Pick1 protein interacting with PRKCA 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17606663 NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840
JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:15659235 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Prdm2 PR/SET domain 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:161,769,587...161,879,150
Ensembl chr 5:161,770,653...161,879,133
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Prokr2 prokineticin receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20576534 NCBI chr 3:125,006,180...125,021,020
Ensembl chr 3:125,009,260...125,017,377
JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr16:23,212,165...23,789,414
Ensembl chr16:23,447,366...23,781,604
JBrowse link
G Raly RALY heterogeneous nuclear ribonucleoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 3:150,322,834...150,387,345
Ensembl chr 3:150,323,116...150,387,332
JBrowse link
G Rapgef5 Rap guanine nucleotide exchange factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 6:145,387,890...145,625,243
Ensembl chr 6:145,546,595...145,625,236
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19689456 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgs17 regulator of G-protein signaling 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:42,491,566...42,587,735
Ensembl chr 1:42,492,761...42,587,721
JBrowse link
G Serpina5 serpin family A member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 6:127,753,152...127,772,403
Ensembl chr 6:127,766,470...127,772,420
JBrowse link
G Sgcz sarcoglycan zeta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr16:57,136,433...58,206,350 JBrowse link
G Sh3rf3 SH3 domain containing ring finger 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr20:28,355,671...28,720,020
Ensembl chr20:28,572,242...28,717,243
JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12931138 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19689456 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Slc6a9 solute carrier family 6 member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17582620 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
G Smyd3 SET and MYND domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr13:97,330,120...97,807,813 JBrowse link
G Snca synuclein alpha treatment IMP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:15542733 PMID:32278788, PMID:20551914 RGD:13506280 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:239,741,572...240,757,583
Ensembl chr 1:240,355,149...240,757,583
JBrowse link
G Usp48 ubiquitin specific peptidase 48 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:155,935,102...156,002,722
Ensembl chr 5:155,934,490...156,002,721
JBrowse link
G Zfp385d zinc finger protein 385D ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr15:6,200,825...7,249,168
Ensembl chr15:6,200,829...6,587,367
JBrowse link
G Zfp423 zinc finger protein 423 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr19:20,147,201...20,405,999
Ensembl chr19:20,147,037...20,406,003
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16085
    Chemically-Induced Disorders 1200
      substance-related disorder 614
        amphetamine abuse 76
Path 2
Term Annotations click to browse term
  disease 16085
    disease of anatomical entity 15340
      nervous system disease 10967
        central nervous system disease 9119
          brain disease 8448
            disease of mental health 6088
              substance-related disorder 614
                substance abuse 180
                  amphetamine abuse 76
paths to the root