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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (

Term:corticotropin-releasing hormone signaling pathway
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Accession:PW:0000493 term browser browse the term
Definition:Corticotropin-releasing hormone is secreted by the hypothalamus in response to stress or fear and signaling through its receptors stimulates secretion of corticotropic (adrenocorticotropic, ACTH) hormone by the anterior pituitary. ACTH is one of the cleavage products of pro-opiomelanocortin (POMC).
Synonyms:related_synonym: CRH

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corticotropin-releasing hormone signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 ISO RGD PMID:16918397 RGD:5147673 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:16918397 RGD:5147673 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Crh corticotropin releasing hormone TAS
RGD PMID:12942143 PMID:16484629 RGD:1358326, RGD:5147387 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crhbp corticotropin releasing hormone binding protein ISO RGD PMID:16484629 RGD:5147387 NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 TAS
RGD PMID:12942143 PMID:16484629 RGD:1358326, RGD:5147387 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 TAS
RGD PMID:12942143 PMID:16484629 RGD:1358326, RGD:5147387 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
JBrowse link
G Gnas GNAS complex locus ISO RGD PMID:16484629 RGD:5147387 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:16484629 RGD:5147387 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:16484629 RGD:5147387 NCBI chr17:9,177,018...9,192,644
Ensembl chr17:9,177,019...9,192,644
JBrowse link
G Ucn urocortin ISO RGD PMID:16484629 RGD:5147387 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950
JBrowse link
G Ucn2 urocortin 2 ISO RGD PMID:16484629 RGD:5147387 NCBI chr 8:109,637,624...109,639,173
Ensembl chr 8:109,638,285...109,639,172
JBrowse link
G Ucn3 urocortin 3 ISO RGD PMID:16484629 RGD:5147387 NCBI chr17:66,309,952...66,315,571
Ensembl chr17:66,309,371...66,315,990
JBrowse link

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  pathway 6100
    signaling pathway 2646
      hormone signaling pathway 624
        peptide and protein hormone signaling pathway 439
          corticotropin-releasing hormone signaling pathway 12
paths to the root